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  1. Article ; Online: Graphene Oxide Membrane Reactor for Electrochemical Deuteration Reactions.

    Sahroni, Imam / Kodama, Taiga / Ahmad, Muhammad Sohail / Nakahara, Takeru / Inomata, Yusuke / Kida, Tetsuya

    Nano letters

    2024  Volume 24, Issue 12, Page(s) 3590–3597

    Abstract: The deuteration of organic molecules is considerably important in organic and medicinal chemistry. An electrochemical membrane reactor using proton-conducting graphene oxide (GO) nanosheets was developed to synthesize valuable deuterium-labeled products ... ...

    Abstract The deuteration of organic molecules is considerably important in organic and medicinal chemistry. An electrochemical membrane reactor using proton-conducting graphene oxide (GO) nanosheets was developed to synthesize valuable deuterium-labeled products via an efficient hydrogen-to-deuterium (H/D) exchange under mild conditions at ambient temperature and atmospheric pressure. Deuterons (D
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Selective Detection of CO Using Proton-Conducting Graphene Oxide Membranes with Pt-Doped SnO

    Sonda, Kosuke / Kodama, Taiga / Wea Siga, Maria Drira / Masumoto, Keigo / Iwai, Masaru / Fadil, Muhammad / Ahmad, Muhammad Sohail / Christopher Agutaya, Jonas Karl / Inomata, Yusuke / Quitain, Armando T / Hardiansyah, Andri / Kida, Tetsuya

    ACS applied materials & interfaces

    2023  

    Abstract: To reduce the risk of carbon monoxide (CO) poisoning, there is a strong need for small, compact gas sensors to detect and monitor CO at ppm concentrations. In this study, we focused on detecting CO with electrochemical sensors based on proton-conducting ... ...

    Abstract To reduce the risk of carbon monoxide (CO) poisoning, there is a strong need for small, compact gas sensors to detect and monitor CO at ppm concentrations. In this study, we focused on detecting CO with electrochemical sensors based on proton-conducting graphene oxide (GO) nanosheets at room temperature. We found that a Ce-doped GO nanosheet membrane fitted with the sensing electrode composed of Pt (10 wt %)-doped SnO
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c10349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrochemical Detection of Ethanol in Air Using Graphene Oxide Nanosheets Combined with Au-WO

    Fauzi, Aynul Sakinah Ahmad / Hamidah, Nur Laila / Kitamura, Shota / Kodama, Taiga / Sonda, Kosuke / Putri, Ghina Kifayah / Shinkai, Takeshi / Ahmad, Muhammad Sohail / Inomata, Yusuke / Quitain, Armando T / Kida, Tetsuya

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 9

    Abstract: Detection, monitoring, and analysis of ethanol are important in various fields such as health care, food industries, and safety control. In this study, we report that a solid electrolyte gas sensor based on a proton-conducting membrane is promising for ... ...

    Abstract Detection, monitoring, and analysis of ethanol are important in various fields such as health care, food industries, and safety control. In this study, we report that a solid electrolyte gas sensor based on a proton-conducting membrane is promising for detecting ethanol in air. We focused on graphene oxide (GO) as a new solid electrolyte because it shows a high proton conductivity at room temperature. GO nanosheets are synthesized by oxidation and exfoliation of expanded graphite via the Tour's method. GO membranes are fabricated by stacking GO nanosheets by vacuum filtration. To detect ethanol, Au-loaded WO
    MeSH term(s) Electrochemical Techniques/methods ; Ethanol ; Gold/chemistry ; Graphite/chemistry ; Metal Nanoparticles/chemistry ; Protons
    Chemical Substances Protons ; graphene oxide ; Ethanol (3K9958V90M) ; Gold (7440-57-5) ; Graphite (7782-42-5)
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22093194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rapid formation of size-controlled three dimensional hetero-cell aggregates using micro-rotation flow for spheroid study.

    Ota, Hiroki / Kodama, Taiga / Miki, Norihisa

    Biomicrofluidics

    2011  Volume 5, Issue 3, Page(s) 34105–3410515

    Abstract: Spheroids that are formed from aggregated cells have enhanced biological function compared to individual cells. In particular, hetero-spheroids composed of different types of cells, such as hepatocytes and endothelial cells, express tissue specific ... ...

    Abstract Spheroids that are formed from aggregated cells have enhanced biological function compared to individual cells. In particular, hetero-spheroids composed of different types of cells, such as hepatocytes and endothelial cells, express tissue specific functions at a high level, which is advantageous for more precise drug screening and biological research. In this study, we propose rapid formation of size-controlled three-dimensional hetero-cell aggregates consisting of hepatocytes and endothelial cells using micro-rotation flow. Based on previous data, these aggregates are expected to ultimately become hetero-spheroids. The hepatocytes are coated with collagen gel films less than 200 nm thick, which were experimentally verified to increase adhesion strength between hepatocytes and endothelial cells. Gel-coated hepatocytes and endothelial cells are collected in an array by micro-rotational flow, thereby forming hetero-cell aggregates within 2 min. This array allowed the size of the three-dimensional cell aggregates to be hydrodynamically controlled, with standard deviations of less than 19%, by varying the cell density of the medium without altering the device geometry. Endothelial cells were successfully and uniformly dispersed in the aggregates. The proposed microfluidic device, with its capability of rapidly forming size-controlled hetero-cell aggregates, will offer an efficient experimental platform for future hetero-spheroid study that will contribute to drug screening and regenerative medicine.
    Language English
    Publishing date 2011-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 1932-1058
    ISSN (online) 1932-1058
    DOI 10.1063/1.3609969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Round-tip dielectrophoresis-based tweezers for single micro-object manipulation

    Kodama, Taiga / Osaki, Toshihisa / Kawano, Ryuji / Kamiya, Koki / Miki, Norihisa / Takeuchi, Shoji

    Biosensors & bioelectronics. 2013 Sept. 15, v. 47

    2013  

    Abstract: In this paper, we present an efficient methodology to manipulate a single micro-object using round-tip positive dielectrophoresis-based tweezers. The tweezers consist of a glass needle with a round-tip and a pair of thin gold-film electrodes. The round- ... ...

    Abstract In this paper, we present an efficient methodology to manipulate a single micro-object using round-tip positive dielectrophoresis-based tweezers. The tweezers consist of a glass needle with a round-tip and a pair of thin gold-film electrodes. The round-tip, which has a radius of 3µm, is formed by melting a finely pulled glass needle and concentrates the electric field at the tip of the tweezers, which allows the individual manipulation of single micro-objects. The tweezers successfully captured, conveyed, and positioned single cell-sized liposomes with diameters of 5–23µm, which are difficult to manipulate with conventional manipulation methodologies, such as optical tweezers or glass micropipettes, due to the similarities between their optical properties and those of the media, as well as the ease with which they are deformed or broken. We used Stokes’ drag theory to experimentally evaluate the positive dielectrophoresis (pDEP) force generated by the tweezers as a function of the liposome size, the content of the surrounding media, and the applied AC voltage and frequency. The results agreed with the theoretically deduced pDEP force. Finally, we demonstrated the separation of labeled single cells from non-labeled cells with the tweezers. This device can be used as an efficient tool for precisely and individually manipulating biological micro-objects that are typically transparent and flexible.
    Keywords biosensors ; dielectrophoresis ; electric field ; electrodes ; glass ; melting ; optical properties
    Language English
    Dates of publication 2013-0915
    Size p. 206-212.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2013.03.022
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A portable lipid bilayer system for environmental sensing with a transmembrane protein.

    Kawano, Ryuji / Tsuji, Yutaro / Kamiya, Koki / Kodama, Taiga / Osaki, Toshihisa / Miki, Norihisa / Takeuchi, Shoji

    PloS one

    2014  Volume 9, Issue 7, Page(s) e102427

    Abstract: This paper describes a portable measurement system for current signals of an ion channel that is composed of a planar lipid bilayer. A stable and reproducible lipid bilayer is formed in outdoor environments by using a droplet contact method with a ... ...

    Abstract This paper describes a portable measurement system for current signals of an ion channel that is composed of a planar lipid bilayer. A stable and reproducible lipid bilayer is formed in outdoor environments by using a droplet contact method with a micropipette. Using this system, we demonstrated that the single-channel recording of a transmembrane protein (alpha-hemolysin) was achieved in the field at a high-altitude (∼3623 m). This system would be broadly applicable for obtaining environmental measurements using membrane proteins as a highly sensitive sensor.
    MeSH term(s) Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Environmental Monitoring/instrumentation ; Environmental Monitoring/methods ; Lipid Bilayers/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Lipid Bilayers ; Membrane Proteins
    Language English
    Publishing date 2014-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0102427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Round-tip dielectrophoresis-based tweezers for single micro-object manipulation.

    Kodama, Taiga / Osaki, Toshihisa / Kawano, Ryuji / Kamiya, Koki / Miki, Norihisa / Takeuchi, Shoji

    Biosensors & bioelectronics

    2013  Volume 47, Page(s) 206–212

    Abstract: In this paper, we present an efficient methodology to manipulate a single micro-object using round-tip positive dielectrophoresis-based tweezers. The tweezers consist of a glass needle with a round-tip and a pair of thin gold-film electrodes. The round- ... ...

    Abstract In this paper, we present an efficient methodology to manipulate a single micro-object using round-tip positive dielectrophoresis-based tweezers. The tweezers consist of a glass needle with a round-tip and a pair of thin gold-film electrodes. The round-tip, which has a radius of 3µm, is formed by melting a finely pulled glass needle and concentrates the electric field at the tip of the tweezers, which allows the individual manipulation of single micro-objects. The tweezers successfully captured, conveyed, and positioned single cell-sized liposomes with diameters of 5-23µm, which are difficult to manipulate with conventional manipulation methodologies, such as optical tweezers or glass micropipettes, due to the similarities between their optical properties and those of the media, as well as the ease with which they are deformed or broken. We used Stokes' drag theory to experimentally evaluate the positive dielectrophoresis (pDEP) force generated by the tweezers as a function of the liposome size, the content of the surrounding media, and the applied AC voltage and frequency. The results agreed with the theoretically deduced pDEP force. Finally, we demonstrated the separation of labeled single cells from non-labeled cells with the tweezers. This device can be used as an efficient tool for precisely and individually manipulating biological micro-objects that are typically transparent and flexible.
    MeSH term(s) Cell Tracking ; Gold/chemistry ; Humans ; Liposomes/chemistry ; Micromanipulation/instrumentation ; Micromanipulation/methods ; Optical Tweezers ; Single-Cell Analysis ; Staining and Labeling
    Chemical Substances Liposomes ; Gold (7440-57-5)
    Language English
    Publishing date 2013-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2013.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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