LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article: Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of Canarium schweinfurthii Engl

    Sokoudjou, Jean Baptiste / Tagousop, Cyrille Ngoufack / Khan, Afsar / Fodouop, Siméon Pierre Chegaing / Atsafack, Serge Secco / Kodjio, Norbert / Atolani, Olubunmi / Gatsing, Donatien

    Natural product research. 2022 May 3, v. 36, no. 9

    2022  

    Abstract: One new tirucallane triterpene named as canarimoic acid (1), and three known analogues: 3β-hydroxytirucalla-8,24-dien-21-oic acid (2), 3α-acetyltirucalla-8,24-diene-21oic acid (3) and 3-oxotirucalla-8,24-dien-21-oic (4) were isolated from the hydro- ... ...

    Abstract One new tirucallane triterpene named as canarimoic acid (1), and three known analogues: 3β-hydroxytirucalla-8,24-dien-21-oic acid (2), 3α-acetyltirucalla-8,24-diene-21oic acid (3) and 3-oxotirucalla-8,24-dien-21-oic (4) were isolated from the hydro-ethanolic crude extract of Canarium schweinfurthii. Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound 3 was the most active (MIC =16 µg/mL) against Salmonella Typhi and Salmonella Typhimurium followed by compound 1 (MIC= 32 µg/mL) against Salmonella Typhi and Salmonella Enteritidis.
    Keywords Canarium schweinfurthii ; Salmonella Enteritidis ; Salmonella Typhi ; Salmonella Typhimurium ; bark ; mass spectrometry ; minimum inhibitory concentration ; research ; triterpenoids
    Language English
    Dates of publication 2022-0503
    Size p. 2363-2369.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1836628
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Correction: Effects of Vitellaria paradoxa (C.F. Gaertn.) Aqueous leaf extract administration on Salmonella typhimurium-infected rats.

    Fodouop, Siméon Pierre Chegaing / Tala, Sedric Donald / Keilah, Lunga Paul / Kodjio, Norbert / Yemele, Mefokou Didiane / Nwabo Kamdje, Armel Herve / Nji-Kah, Bridget / Tchoumboue, Joseph / Gatsing, Donatien

    BMC complementary medicine and therapies

    2023  Volume 23, Issue 1, Page(s) 40

    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Published Erratum
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-023-03846-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii.

    Sokoudjou, Jean Baptiste / Atolani, Olubunmi / Njateng, Guy Sedar Singor / Khan, Afsar / Tagousop, Cyrille Ngoufack / Bitombo, André Nehemie / Kodjio, Norbert / Gatsing, Donatien

    BMC complementary medicine and therapies

    2020  Volume 20, Issue 1, Page(s) 316

    Abstract: Background: Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid ... ...

    Abstract Background: Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and paratyphoid fevers in humans. Due to the growing awareness about drug resistance and toxicities, the use of antibiotics is being discouraged in many countries whilst advocating potent benign alternatives such as phyto-based medicine. The objective of this work was to isolate, characterise the bioactive compounds of Canarium schweinfurthii; and evaluate their anti-salmonellal activity.
    Methods: The hydro-ethanolic extract of Canarium schweinfurthii was fractionated and tested for their anti-salmonellal activity. The most active fractions (i.e. chloroform and ethyl acetate partition fractions) were then explored for their phytochemical constituents. Fractionation on normal phase silica gel column chromatography and size exclusion chromatography on Sephadex LH-20 led to the isolation of four compounds (maniladiol, scopoletin, ethyl gallate and gallic acid) reported for the first time in Canarium schweinfurthii.
    Results: Result indicated that scopoletin and gallic acid had greater activity than the crude extracts and partition fractions. Among the isolated compounds, scopoletin showed the highest inhibitory activity with a MIC of 16 μg/ml against Salmonella Typhimurium and Salmonella Enteritidis.
    Conclusions: The overall results of this study indicates that the hydro-ethanolic extract as well as some of isolated compounds have interesting anti-salmonellal activities that could be further explored for the development of potent therapy for salmonellosis. Furthermore, the study adds credence to the folkloric applications of the plant.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Burseraceae ; Cameroon ; Molecular Structure ; Plant Bark ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Stems ; Salmonella/drug effects
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-020-03100-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of

    Sokoudjou, Jean Baptiste / Tagousop, Cyrille Ngoufack / Khan, Afsar / Fodouop, Siméon Pierre Chegaing / Atsafack, Serge Secco / Kodjio, Norbert / Atolani, Olubunmi / Gatsing, Donatien

    Natural product research

    2020  Volume 36, Issue 9, Page(s) 2363–2369

    Abstract: One new tirucallane triterpene named as canarimoic acid ( ...

    Abstract One new tirucallane triterpene named as canarimoic acid (
    MeSH term(s) Burseraceae ; Plant Bark/chemistry ; Plant Extracts/chemistry ; Triterpenes/chemistry
    Chemical Substances Plant Extracts ; Triterpenes ; tirucallane
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1836628
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

    SOKOUDJOU, Jean Baptiste / ATOLANI, Olubunmi / NJATENG, Guy Sedar Singor / Khān, Āfsar / TAGOUSOP, Cyrille Ngoufack / BITOMBO, André Nehemie / KODJIO, Norbert / GATSING, Donatien

    BMC Complement Med Ther. 2020 Dec., v. 20, no. 1 p.316-316

    2020  

    Abstract: BACKGROUND: Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and ...

    Abstract BACKGROUND: Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and paratyphoid fevers in humans. Due to the growing awareness about drug resistance and toxicities, the use of antibiotics is being discouraged in many countries whilst advocating potent benign alternatives such as phyto-based medicine. The objective of this work was to isolate, characterise the bioactive compounds of Canarium schweinfurthii; and evaluate their anti-salmonellal activity. METHODS: The hydro-ethanolic extract of Canarium schweinfurthii was fractionated and tested for their anti-salmonellal activity. The most active fractions (i.e. chloroform and ethyl acetate partition fractions) were then explored for their phytochemical constituents. Fractionation on normal phase silica gel column chromatography and size exclusion chromatography on Sephadex LH-20 led to the isolation of four compounds (maniladiol, scopoletin, ethyl gallate and gallic acid) reported for the first time in Canarium schweinfurthii. RESULTS: Result indicated that scopoletin and gallic acid had greater activity than the crude extracts and partition fractions. Among the isolated compounds, scopoletin showed the highest inhibitory activity with a MIC of 16 μg/ml against Salmonella Typhimurium and Salmonella Enteritidis. CONCLUSIONS: The overall results of this study indicates that the hydro-ethanolic extract as well as some of isolated compounds have interesting anti-salmonellal activities that could be further explored for the development of potent therapy for salmonellosis. Furthermore, the study adds credence to the folkloric applications of the plant.
    Keywords Canarium schweinfurthii ; Salmonella Enteritidis ; Salmonella Typhimurium ; bark extracts ; birds ; chloroform ; complement ; drug resistance ; ethyl acetate ; ethyl gallate ; fractionation ; gel chromatography ; medicine ; paratyphoid ; phytochemicals ; scopoletin ; therapeutics ; typhoid fever
    Language English
    Dates of publication 2020-12
    Size p. 316.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2662-7671
    DOI 10.1186/s12906-020-03100-5
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Toxicological Profile of the Aqueous Extract of

    Kamsu, Gabriel Tchuente / Djamen Chuisseu, Dieudonné Pascal / Fodouop Chegaing, Siméon Pierre / Laure Feudjio, Huguette Bocanestine / Ndel Famen, Louis-Claire / Kodjio, Norbert / Sokoudjou, Jean Baptiste / Gatsing, Donatien

    Journal of toxicology

    2021  Volume 2021, Page(s) 6646771

    Abstract: ... Tectona ... ...

    Abstract Tectona grandis
    Language English
    Publishing date 2021-04-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495098-1
    ISSN 1687-8205 ; 1687-8191
    ISSN (online) 1687-8205
    ISSN 1687-8191
    DOI 10.1155/2021/6646771
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Effects of Vitellaria paradoxa (C.F. Gaertn.) aqueous leaf extract administration on Salmonella typhimurium-infected rats [Correction: Dec. 2023, 23(1), p. 40]

    Fodouop, Siméon Pierre Chegaing / Tala, Sedric Donald / Keilah, Lunga Paul / Kodjio, Norbert / Yemele, Mefokou Didiane / Nwabo Kamdje, Armel Herve / Nji-kah, Bridget / Tchoumboue, Joseph / Gatsing, Donatien

    BMC Complement Altern Med. 2017 Dec., v. 17, no. 1, p. 160

    2017  , Page(s) 160

    Abstract: BACKGROUND: The present study investigates the effects of Vitellaria paradoxa crude extract administration on Salmonella typhimurium infected Wistar rats. METHODS: Rats were infected by single dose oral administration of Salmonella typhimurium (1.5×10⁸ ... ...

    Abstract BACKGROUND: The present study investigates the effects of Vitellaria paradoxa crude extract administration on Salmonella typhimurium infected Wistar rats. METHODS: Rats were infected by single dose oral administration of Salmonella typhimurium (1.5×10⁸ CFU). Negative control groups were infected and treated orally with distilled water (vehicle), neutral control group were not infected, while the four test groups were treated up to 18 days with 55 mg/kg, 110 mg/kg, 220 mg/kg and 440 mg/kg body weight of aqueous extract of V. paradoxa respectively. The effects of this extract administration on serum markers (total protein, creatinine, transaminases, bilirubin and lipid profile) as well as acute toxicity test and phytochemical screening were also investigated. RESULTS: Following in vivo studies, aqueous extract of V. paradoxa allowed to clear salmonellosis in previously infected rats within twelve days of treatment. Infection has resulted in a significant increase of transaminases activity. Besides, significant decrease was observed in liver and kidney relative weight and their protein content. Nevertheless, administration of this plant extract at higher doses has resulted in the correction of some of these injuries. Results obtained from acute toxicity study showed that mice administered with the aqueous leaf extract exhibited a mild reaction to noise and pinch; excreted watery discharges and the LD₅₀ value was 12.0 g/kg. In addition, the extract showed no toxic effect after 14 days. However, it may have a sedative effect or depressant effect on the central nervous system, may induce a decrease in plasma levels of algogenic substances, and may cause diarrhea at high doses. Phytochemical screening of the extract revealed the presence of flavonoids, alkaloids, tannins, phenols and polyphenols, saponins, anthocyanins, steroids and anthraquinones. CONCLUSIONS: These results support the ethnomedicinal use of V. paradoxa, and suggest that its leave can be used in the management antibacterial phytomedicine.
    Keywords Salmonella Typhimurium ; Vitellaria paradoxa ; acute toxicity ; anthocyanins ; anthraquinones ; bilirubin ; blood serum ; body weight ; central nervous system ; complement ; creatinine ; diarrhea ; kidneys ; leaf extracts ; lipid composition ; liver ; oral administration ; polyphenols ; protein content ; salmonellosis ; saponins ; sedatives ; toxicity testing ; transaminases
    Language English
    Dates of publication 2017-12
    Size p. 160
    Publishing place BioMed Central
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2050429-9
    ISSN 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-017-1643-1
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Effects of Vitellaria paradoxa (C.F. Gaertn.) aqueous leaf extract administration on Salmonella typhimurium-infected rats.

    Fodouop, Siméon Pierre Chegaing / Tala, Sedric Donald / Keilah, Lunga Paul / Kodjio, Norbert / Yemele, Mefokou Didiane / Nwabo Kamdje, Armel Herve / Nji-Kah, Bridget / Tchoumboue, Joseph / Gatsing, Donatien

    BMC complementary and alternative medicine

    2017  Volume 17, Issue 1, Page(s) 160

    Abstract: Background: The present study investigates the effects of Vitellaria paradoxa crude extract administration on Salmonella typhimurium infected Wistar rats.: Methods: Rats were infected by single dose oral administration of Salmonella typhimurium (1.5× ... ...

    Abstract Background: The present study investigates the effects of Vitellaria paradoxa crude extract administration on Salmonella typhimurium infected Wistar rats.
    Methods: Rats were infected by single dose oral administration of Salmonella typhimurium (1.5×10
    Results: Following in vivo studies, aqueous extract of V. paradoxa allowed to clear salmonellosis in previously infected rats within twelve days of treatment. Infection has resulted in a significant increase of transaminases activity. Besides, significant decrease was observed in liver and kidney relative weight and their protein content. Nevertheless, administration of this plant extract at higher doses has resulted in the correction of some of these injuries. Results obtained from acute toxicity study showed that mice administered with the aqueous leaf extract exhibited a mild reaction to noise and pinch; excreted watery discharges and the LD
    Conclusions: These results support the ethnomedicinal use of V. paradoxa, and suggest that its leave can be used in the management antibacterial phytomedicine.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Female ; Humans ; Male ; Mice ; Plant Extracts/administration & dosage ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Salmonella Infections/drug therapy ; Salmonella Infections/microbiology ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/physiology ; Sapotaceae/chemistry
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2017-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-017-1643-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top