Article ; Online: Therapeutic exploitation of ferroptosis.
Biochemical Society transactions
2024 Volume 52, Issue 2, Page(s) 693–706
Abstract: Pathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic ... ...
| Abstract | Pathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ferroptosis execution. Unleashing these metabolic breaks is currently therapeutically explored to sensitize cancers to ferroptosis inducing anti-cancer therapies. Reversely, these natural ferroptotic defense mechanisms can fail resulting in pathological conditions or diseases such as ischemia-reperfusion injury, multi-organ dysfunction, stroke, infarction, or neurodegenerative diseases. This minireview outlines current ferroptosis-inducing anti-cancer strategies and highlights the detection as well as the therapeutic targeting of ferroptosis in preclinical experimental settings. Herein, we also briefly summarize observations related to LPO, iron and redox deregulation in patients that might hint towards ferroptosis as a contributing factor. |
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| MeSH term(s) | Ferroptosis ; Humans ; Lipid Peroxidation ; Neoplasms/metabolism ; Neoplasms/drug therapy ; Animals ; Iron/metabolism ; Oxidation-Reduction ; Antineoplastic Agents/therapeutic use ; Reperfusion Injury/metabolism ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/drug therapy | |||||
| Chemical Substances | Iron (E1UOL152H7) ; Antineoplastic Agents | |||||
| Language | English | |||||
| Publishing date | 2024-04-17 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 184237-7 | |||||
| ISSN | 1470-8752 ; 0300-5127 | |||||
| ISSN (online) | 1470-8752 | |||||
| ISSN | 0300-5127 | |||||
| DOI | 10.1042/BST20230550 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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