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  1. Article ; Online: Classics in Neuroimaging: Radioligands for the Vesicular Monoamine Transporter 2.

    Kilbourn, Michael R / Koeppe, Robert A

    ACS chemical neuroscience

    2018  Volume 10, Issue 1, Page(s) 25–29

    Abstract: Positron emission tomography (PET) studies of the monoamine neurotransmitter systems in the human brain employ a variety of radiotracers targeting the many receptors, transporters, and enzymes present in monoaminergic neurons. One of these is the ... ...

    Abstract Positron emission tomography (PET) studies of the monoamine neurotransmitter systems in the human brain employ a variety of radiotracers targeting the many receptors, transporters, and enzymes present in monoaminergic neurons. One of these is the vesicular monoamine transporter 2 (VMAT2), the protein responsible for the energy-dependent accumulation of monoamines into synaptic vesicles. The development of in vivo imaging radiotracers for VMAT2 is a story of starting with a well-characterized clinically used drug (tetrabenazine) which had a pharmacologically active metabolite: that metabolite that was in stepwise fashion refined and modified to provide both carbon-11 and fluorine-18 labeled VMAT2 radiotracers that are now used for human PET studies of neurodegenerative and psychiatric diseases. The design approach taken, which involved understanding the metabolism of the radiotracers and identification of the optimal ligand stereochemistry, are representative of important steps in the general concepts behind successful in vivo radiotracer design for brain imaging agents.
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Carbon Radioisotopes/analysis ; Carbon Radioisotopes/metabolism ; Fluorine Radioisotopes/analysis ; Fluorine Radioisotopes/metabolism ; Humans ; Neuroimaging/methods ; Positron-Emission Tomography/methods ; Radioligand Assay/methods ; Vesicular Monoamine Transport Proteins/analysis ; Vesicular Monoamine Transport Proteins/metabolism
    Chemical Substances Carbon Radioisotopes ; Fluorine Radioisotopes ; SLC18A2 protein, human ; Vesicular Monoamine Transport Proteins ; Fluorine-18 (GZ5I74KB8G)
    Language English
    Publishing date 2018-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.8b00429
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  2. Book ; Thesis: Quantitative functional imaging using dynamic positron computed tomography and rapid parameter estimation techniques

    Koeppe, Robert A.

    1984  

    Author's details by Robert Allen Koeppe
    Size XV, 222 S. : Ill., graph. Darst.
    Publishing country United States
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Madison, Wis., Univ. of Wisconsin, Diss., 1984
    Note Kopie, erschienen im Verl. Univ. Microfilms Internat., Ann Arbor, Mich.
    HBZ-ID HT002900806
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Classifying migraine using PET compressive big data analytics of brain's

    Marino, Simeone / Jassar, Hassan / Kim, Dajung J / Lim, Manyoel / Nascimento, Thiago D / Dinov, Ivo D / Koeppe, Robert A / DaSilva, Alexandre F

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1173596

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1173596
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  4. Article ; Online: Regional serotonin terminal density in aging human brain: A [

    Kanel, Prabesh / Koeppe, Robert A / Kotagal, Vikas / Roytman, Stiven / Muller, Martijn L T M / Bohnen, Nicolaas I / Albin, Roger L

    Aging brain

    2023  Volume 3, Page(s) 100071

    Abstract: There are conflicting results regarding regional age-related changes in serotonin terminal density in human brain. Some imaging studies suggest age-related declines in serotoninergic terminals and perikarya. Other human imaging studies and post-mortem ... ...

    Abstract There are conflicting results regarding regional age-related changes in serotonin terminal density in human brain. Some imaging studies suggest age-related declines in serotoninergic terminals and perikarya. Other human imaging studies and post-mortem biochemical studies suggest stable brain regional serotoninergic terminal densities across the adult lifespan. In this cross-sectional study, we used [
    Language English
    Publishing date 2023-03-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9589
    ISSN (online) 2589-9589
    DOI 10.1016/j.nbas.2023.100071
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  5. Article ; Online: A six-year longitudinal PET study of (+)-[

    Kilbourn, Michael R / Koeppe, Robert A

    Nuclear medicine and biology

    2017  Volume 55, Page(s) 34–37

    Abstract: Introduction: The longitudinal reproducibility of in vivo binding potential measures for [: Methods: Forty-one dynamic [: Results: Same day reproducibility of BP: Conclusions: If the technical variables associated with PET scanner are ... ...

    Abstract Introduction: The longitudinal reproducibility of in vivo binding potential measures for [
    Methods: Forty-one dynamic [
    Results: Same day reproducibility of BP
    Conclusions: If the technical variables associated with PET scanner are consistently maintained, including PET scanner, imaging procedures and radiotracer preparation, in vivo biochemistry can be reproducibly measured in the primate brain over a multi-year period of time.
    Language English
    Publishing date 2017-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2017.08.008
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  6. Article ; Online: Individuals with Alzheimer's disease and low tau burden: Characteristics and implications.

    Landau, Susan M / Lee, JiaQie / Murphy, Alice / Ward, Tyler J / Harrison, Theresa M / Baker, Suzanne L / DeCarli, Charles / Harvey, Danielle / Tosun, Duygu / Weiner, Michael W / Koeppe, Robert A / Jagust, William J

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 3, Page(s) 2113–2127

    Abstract: Introduction: Abnormal amyloid-beta (Aβ) and tau deposition define Alzheimer's Disease (AD), but non-elevated tau is relatively frequent in patients on the AD pathway.: Methods: We examined characteristics and regional patterns of 397 Aβ+ unimpaired ... ...

    Abstract Introduction: Abnormal amyloid-beta (Aβ) and tau deposition define Alzheimer's Disease (AD), but non-elevated tau is relatively frequent in patients on the AD pathway.
    Methods: We examined characteristics and regional patterns of 397 Aβ+ unimpaired and impaired individuals with low tau (A+T-) in relation to their higher tau counterparts (A+T+).
    Results: Seventy-one percent of Aβ+ unimpaired and 42% of impaired Aβ+ individuals were categorized as A+T- based on global tau. In impaired individuals only, A+T- status was associated with older age, male sex, and greater cardiovascular risk. α-synuclein was linked to poorer cognition, particularly when tau was low. Tau burden was most frequently elevated in a common set of temporal regions regardless of T+/T- status.
    Discussion: Low tau is relatively common in patients on the AD pathway and is linked to comorbidities that contribute to impairment. These findings have implications for the selection of individuals for Aβ- and tau-modifying therapies.
    MeSH term(s) Humans ; Male ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Cognition ; Cognitive Dysfunction ; Positron-Emission Tomography ; tau Proteins/metabolism ; Female
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13609
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    Zs.MO 540: Show issues

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  7. Article ; Online: PET Amyloid Analyses.

    Frey, Kirk A / Koeppe, Robert A

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2016  Volume 57, Issue 8, Page(s) 1168–1169

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.116.173989
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    Zs.A 114: Show issues Location:
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  8. Article ; Online: Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis.

    Kanel, Prabesh / Spears, C Chauncey / Roytman, Stiven / Koeppe, Robert A / Frey, Kirk A / Scott, Peter J H / Albin, Roger L / Bohnen, Nicolaas I

    Journal of neural transmission (Vienna, Austria : 1996)

    2022  Volume 129, Issue 12, Page(s) 1469–1479

    Abstract: Prior studies indicate more severe brainstem cholinergic deficits in Progressive Supranuclear Palsy (PSP) compared to Parkinson's disease (PD), but the extent and topography of subcortical deficits remains poorly understood. The objective of this study ... ...

    Abstract Prior studies indicate more severe brainstem cholinergic deficits in Progressive Supranuclear Palsy (PSP) compared to Parkinson's disease (PD), but the extent and topography of subcortical deficits remains poorly understood. The objective of this study is to investigate differential cholinergic systems changes in progressive supranuclear palsy (PSP, n = 8) versus Parkinson's disease (PD, n = 107) and older controls (n = 19) using vesicular acetylcholine transporter [
    MeSH term(s) Humans ; Supranuclear Palsy, Progressive/diagnostic imaging ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Positron-Emission Tomography/methods ; Pedunculopontine Tegmental Nucleus/metabolism ; Cholinergic Agents
    Chemical Substances Cholinergic Agents
    Language English
    Publishing date 2022-10-12
    Publishing country Austria
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-022-02547-9
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  9. Article ; Online: Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease.

    Chou, Kelvin L / Dayalu, Praveen / Koeppe, Robert A / Gilman, Sid / Spears, C Chauncey / Albin, Roger L / Kotagal, Vikas

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 11, Page(s) 2301–2307

    Abstract: Background: Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projections. In MSA, medullary serotoninergic neuron ... ...

    Abstract Background: Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projections. In MSA, medullary serotoninergic neuron pathology is well documented, but serotonin system changes throughout the rest of the brain are less well characterized.
    Objectives: To use serotonin transporter [
    Methods: We performed serotonin transporter PET imaging in 18 patients with MSA, 23 patients with PD, and 16 healthy controls to explore differences in brainstem, subcortical, and cortical regions of interest.
    Results: Patients with MSA showed lower serotonin transporter distribution volume ratios compared with patients with PD in the medulla, raphe pontis, ventral striatum, limbic cortex, and thalamic regions, but no differences in the dorsal striatal, ventral anterior cingulate, or total cortical regions. Controls showed greater cortical serotonin transporter binding compared with PD or MSA groups but lower serotonin transporter binding in the striatum and other relevant basal ganglia regions. There were no regional differences in binding between patients with MSA-parkinsonian subtype (n = 8) and patients with MSA-cerebellar subtype (n = 10). Serotonin transporter distribution volume ratios in multiple different regions of interest showed an inverse correlation with the severity of Movement Disorders Society Unified Parkinson's Disease Rating Scale motor score in patients with MSA but not patients with PD.
    Conclusions: Brainstem and some forebrain subcortical region serotoninergic deficits are more severe in MSA compared with PD and show an MSA-specific correlation with the severity of motor impairments. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Humans ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Multiple System Atrophy/diagnostic imaging ; Positron-Emission Tomography/methods ; Serotonin/metabolism
    Chemical Substances Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29220
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  10. Article ; Online: Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome.

    Albin, Roger L / Minderovic, Christine / Koeppe, Robert A

    eNeuro

    2017  Volume 4, Issue 4

    Abstract: Considerable prior work suggests basal ganglia dysfunction in Tourette syndrome (TS). Analysis of a small number of postmortem specimens suggests deficits of some striatal interneuron populations, including striatal cholinergic interneurons. To assess ... ...

    Abstract Considerable prior work suggests basal ganglia dysfunction in Tourette syndrome (TS). Analysis of a small number of postmortem specimens suggests deficits of some striatal interneuron populations, including striatal cholinergic interneurons. To assess the integrity of striatal cholinergic interneurons in TS, we used [
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0178-17.2017
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