Article ; Online: A cohort study of wastewater treatment plant workers: Association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods
Water Research. 2023 Mar., v. 231 p.119625-
2023
Abstract: Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic ... ...
| Abstract | Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLᵢₘᵤₗᵤₛ) and the rFC (endotoxinᵣFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLᵢₘᵤₗᵤₛ₋dₐy and endotoxinᵣFC₋dₐy correlated significantly (r = 0.80, p<0.0001, n = 104), but endotoxinLᵢₘᵤₗᵤₛ₋dₐy was 4.4 (Geometric mean (GM) value) times higher than endotoxinᵣFC₋dₐy (p<0.0001). The endotoxinLᵢₘᵤₗᵤₛ₋dₐy, endotoxinᵣFC₋dₐy, bacteria, and fungal exposure as well as serum levels of CRP₋dₐy (GM=1.4 mg/l) and SAA₋dₐy (GM=12 mg/l) differed between workers. Serum levels of SAAdₐy correlated significantly with CRPdₐy (r = 0.30, p = 0.0068). The serum levels of CRPdₐy were associated significantly with exposure to endotoxinLᵢₘᵤₗᵤₛ₋dₐy. Exposure, SAA and CRP data were also analyzed as av. of each season, and SAAₛₑₐₛₒₙ was associated positively and significantly with endotoxinLᵢₘᵤₗᵤₛ₋ₛₑₐₛₒₙ and endotoxinᵣFC₋ₛₑₐₛₒₙ and negatively with fungalₛₑₐₛₒₙ exposure. In conclusion, CRPdₐy was associated with the endotoxinLᵢₘᵤₗᵤₛ₋dₐy and SAAₛₑₐₛₒₙ with endotoxinLᵢₘᵤₗᵤₛ₋ₛₑₐₛₒₙ and endotoxinᵣFC₋ₛₑₐₛₒₙ exposure. Thus, we hereby document that WWTP workers are exposed to airborne endotoxin which seems to have a negative impact on their health. |
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| Keywords | C-reactive protein ; Limulus ; amyloid ; biomarkers ; blood serum ; cohort studies ; endotoxins ; fungi ; inflammation ; research ; wastewater treatment ; water ; LPS ; MALDI-TOF MS ; Occupational exposure ; Occupational exposure limit ; Wastewater |
| Language | English |
| Dates of publication | 2023-03 |
| Publishing place | Elsevier Ltd |
| Document type | Article ; Online |
| Note | Use and reproduction |
| ZDB-ID | 202613-2 |
| ISSN | 1879-2448 ; 0043-1354 |
| ISSN (online) | 1879-2448 |
| ISSN | 0043-1354 |
| DOI | 10.1016/j.watres.2023.119625 |
| Database | NAL-Catalogue (AGRICOLA) |
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