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  1. Article: [Transdisciplinary Approach for Sarcopenia. Sarcopenia and atherosclerosis].

    Kohara, Katsuhiko

    Clinical calcium

    2014  Volume 24, Issue 10, Page(s) 1487–1492

    Abstract: Risk factors for sarcopenia, including aging, inflammation, oxidative stress, and sedentary life style, are also known as risks for atherosclerosis. Sarcopenia and atherosclerosis relate each other. We found that sarcopenia, especially sarcopenic ... ...

    Abstract Risk factors for sarcopenia, including aging, inflammation, oxidative stress, and sedentary life style, are also known as risks for atherosclerosis. Sarcopenia and atherosclerosis relate each other. We found that sarcopenia, especially sarcopenic visceral obesity in male subjects, was associated with higher arterial stiffness and central blood pressure. We also observed that leptin resistance may underlie the link between sarcopenia, sarcopenic obesity and atherosclerosis. In epidemiological studies, it has been demonstrated sarcopenic indices were associated with cardiovascular death. These findings indicate that sarcopenia could be regarded as risk factor for atherosclerosis and cardiovascular events.
    MeSH term(s) Atherosclerosis/complications ; Blood Pressure ; Humans ; Obesity ; Risk Factors ; Sarcopenia/complications ; Sex Characteristics
    Language Japanese
    Publishing date 2014-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa141014871492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sarcopenic obesity in aging population: current status and future directions for research.

    Kohara, Katsuhiko

    Endocrine

    2013  Volume 45, Issue 1, Page(s) 15–25

    Abstract: The combination of sarcopenia and obesity, an age-related change in body composition, is a concern in the aged society. Sarcopenic obesity is not the combination of two conditions, but is more related to cardio-metabolic and functional abnormalities. ... ...

    Abstract The combination of sarcopenia and obesity, an age-related change in body composition, is a concern in the aged society. Sarcopenic obesity is not the combination of two conditions, but is more related to cardio-metabolic and functional abnormalities. Sarcopenic obesity is associated with more physical functional decline than simple obesity. Sarcopenic obesity may be more insulin resistant, and have a higher risk for metabolic syndrome and atherosclerosis than simple obesity. However, the prevalence of sarcopenic obesity differs substantially among studies because of the lack of a standard definition. For further understanding of the pathophysiological role of sarcopenic obesity, a standardized definition for both sarcopenia and obesity is necessary.
    MeSH term(s) Aging/physiology ; Biomedical Research/trends ; Exercise/physiology ; Humans ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/therapy ; Risk Factors ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Sarcopenia/etiology ; Sarcopenia/therapy ; Weight Reduction Programs
    Language English
    Publishing date 2013-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-013-9992-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Clinical aspect of sarcopenic obesity].

    Kohara, Katsuhiko

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2013  Volume 50, Issue 6, Page(s) 773–775

    MeSH term(s) Aged ; Female ; Humans ; Male ; Obesity/complications ; Risk Factors ; Sarcopenia/complications
    Language Japanese
    Publishing date 2013-12-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.50.773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Clinical aspect of sarcopenia].

    Kohara, Katsuhiko

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2013  Volume 50, Issue 3, Page(s) 352–355

    MeSH term(s) Adolescent ; Adult ; Humans ; Male ; Muscles/anatomy & histology ; Risk Factors ; Sarcopenia/complications ; Sarcopenia/diagnosis
    Language Japanese
    Publishing date 2013-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.50.352
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  5. Article ; Online: Central blood pressure, arterial stiffness and the heart in hypertensive patients.

    Kohara, Katsuhiko

    Hypertension research : official journal of the Japanese Society of Hypertension

    2009  Volume 32, Issue 12, Page(s) 1056–1058

    MeSH term(s) Aortic Diseases/diagnosis ; Aortic Diseases/physiopathology ; Blood Pressure Determination/methods ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/physiopathology
    Language English
    Publishing date 2009-12
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2009.171
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  6. Article: [Clinical characteristics and antihypertensive therapy in hypertension in the elderly].

    Kohara, Katsuhiko

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2007  Volume 44, Issue 2, Page(s) 175–176

    MeSH term(s) Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Pulse
    Chemical Substances Antihypertensive Agents
    Language Japanese
    Publishing date 2007-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.44.175
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  7. Article: Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass in older adults: J-SHIPP study

    Tabara, Yasuharu / Kohara, Katsuhiko / Okada, Yoko / Ohyagi, Yasumasa / Igase, Michiya

    Clinical nutrition. 2020 June, v. 39, no. 6

    2020  

    Abstract: Sarcopenia increases mortality risk in older adults. Loss of skeletal muscle mass is a cardinal feature of sarcopenia. The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass. The present study investigated the usefulness ... ...

    Abstract Sarcopenia increases mortality risk in older adults. Loss of skeletal muscle mass is a cardinal feature of sarcopenia. The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass. The present study investigated the usefulness of CCR in discriminating the risk of low muscle mass and weak muscle strength in an elderly population.The present cross-sectional study included 1,329 apparently healthy community residents aged 60 years or older. The cross-sectional area (CSA) of muscle in the mid-thigh was measured using computed tomography. Clinical data recorded at routine medical check-ups were obtained from each participant's medical record.Mean muscle CSA was 109 ± 24 cm². CCR by quartiles according to sex was strongly associated with muscle CSA (Q1: 104 ± 22, Q2: 108 ± 24, Q3: 110 ± 23, and Q4: 114 ± 25 cm², F = 10.38, P < 0.001). This association was independent of major covariates (Q1: reference, Q2: β = 0.06, P < 0.001, Q3: β = 0.10, P < 0.001, and Q4: β = 0.17, P < 0.001) even in a sex-separated analysis. Although creatinine alone was independently associated with muscle CSA (F = 5.81, P < 0.001), the association was weaker than that of CCR, particularly in the individuals with renal functional decline. Also, CCR was associated with grip strength independently of muscle CSA.CCR was a simple marker of low muscle mass and weak muscle strength in older community-dwelling adults.
    Keywords computed tomography ; creatinine ; cross-sectional studies ; elderly ; mortality ; muscle strength ; muscles ; risk ; sarcopenia ; skeletal muscle
    Language English
    Dates of publication 2020-06
    Size p. 1857-1862.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.07.027
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass in older adults: J-SHIPP study.

    Tabara, Yasuharu / Kohara, Katsuhiko / Okada, Yoko / Ohyagi, Yasumasa / Igase, Michiya

    Clinical nutrition (Edinburgh, Scotland)

    2019  Volume 39, Issue 6, Page(s) 1857–1862

    Abstract: Background: Sarcopenia increases mortality risk in older adults. Loss of skeletal muscle mass is a cardinal feature of sarcopenia. The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass. The present study investigated the ...

    Abstract Background: Sarcopenia increases mortality risk in older adults. Loss of skeletal muscle mass is a cardinal feature of sarcopenia. The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass. The present study investigated the usefulness of CCR in discriminating the risk of low muscle mass and weak muscle strength in an elderly population.
    Methods: The present cross-sectional study included 1,329 apparently healthy community residents aged 60 years or older. The cross-sectional area (CSA) of muscle in the mid-thigh was measured using computed tomography. Clinical data recorded at routine medical check-ups were obtained from each participant's medical record.
    Results: Mean muscle CSA was 109 ± 24 cm
    Conclusion: CCR was a simple marker of low muscle mass and weak muscle strength in older community-dwelling adults.
    MeSH term(s) Age Factors ; Aged ; Aging/blood ; Biomarkers/blood ; Body Composition ; Creatinine/blood ; Cross-Sectional Studies ; Cystatin C/blood ; Female ; Humans ; Japan ; Male ; Middle Aged ; Muscle Strength ; Muscle Weakness/blood ; Muscle Weakness/diagnostic imaging ; Muscle Weakness/physiopathology ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiopathology ; Predictive Value of Tests ; Sarcopenia/blood ; Sarcopenia/diagnostic imaging ; Sarcopenia/physiopathology ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers ; CST3 protein, human ; Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-08-06
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.07.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Study on cognition and prognosis in the elderly].

    Kohara, Katsuhiko

    Nihon rinsho. Japanese journal of clinical medicine

    2006  Volume 64 Suppl 6, Page(s) 425–430

    MeSH term(s) Aged ; Aged, 80 and over ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Antihypertensive Agents/therapeutic use ; Benzimidazoles/therapeutic use ; Cognition Disorders/etiology ; Cognition Disorders/prevention & control ; Double-Blind Method ; Endpoint Determination ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Prognosis ; Randomized Controlled Trials as Topic ; Stroke/etiology ; Stroke/prevention & control ; Tetrazoles/therapeutic use
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Antihypertensive Agents ; Benzimidazoles ; Tetrazoles ; candesartan (S8Q36MD2XX)
    Language Japanese
    Publishing date 2006-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Clinical characteristic of secondary hypertension in the elderly].

    Kohara, Katsuhiko

    Nihon rinsho. Japanese journal of clinical medicine

    2005  Volume 63, Issue 6, Page(s) 1091–1095

    Abstract: The prevalence of secondary hypertension is higher in the elderly population. Renal hypertension is the most prevalent. The prevalence of renovascular hypertension (RVH) increases with age. Since RVH in the elderly is frequently associated with systemic ... ...

    Abstract The prevalence of secondary hypertension is higher in the elderly population. Renal hypertension is the most prevalent. The prevalence of renovascular hypertension (RVH) increases with age. Since RVH in the elderly is frequently associated with systemic atherosclerosis, other atherosclerotic disorders including ischemic heart disease need to be evaluated. The prevalence of primary aldosteronism and Cushing's syndrome decreases with age, while that of pheochromocytoma persists in the elderly population. Due to lack of classical symptoms, special attention should be paid to find pheochromocytoma in the elderly.
    MeSH term(s) Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/epidemiology ; Aged ; Arteriosclerosis/complications ; Cushing Syndrome/complications ; Cushing Syndrome/epidemiology ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/epidemiology ; Hypertension/epidemiology ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension, Renovascular/complications ; Hypertension, Renovascular/diagnosis ; Hypertension, Renovascular/epidemiology ; Hypothyroidism/complications ; Hypothyroidism/epidemiology ; Myocardial Ischemia/complications ; Pheochromocytoma/complications ; Pheochromocytoma/epidemiology ; Prevalence
    Language Japanese
    Publishing date 2005-06
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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