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Book: Câncer ambiental e ocupacional na América Latina

Koifman, Sergio

= Environmental and occupational cancer in Latin America

(Cadernos de saúde pública ; 14, Supl. 3)

1998

Title variant	Environmental and occupational cancer in Latin America
Author's details	ed. convidado Sergio Koifman
Series title	Cadernos de saúde pública ; 14, Supl. 3
Collection
Keywords	Lateinamerika ; Carcinogenese ; Umweltfaktor ; Arbeitsbedingungen
Subject	Arbeitssituation ; Arbeit ; Arbeitsbedingung ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Umwelteinfluss ; Ökologischer Faktor ; Exogener Faktor ; Standortbedingungen ; Standortfaktor
Language	English ; Portuguese
Size	200 S. : Kt.
Publisher	Escola Nacional de Saúde Pública
Publishing place	Rio de Janeiro
Publishing country	Brazil
Document type	Book
Note	Zsfassung in engl. und portug. Sprache
HBZ-ID	HT009515617
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Cancer incidence in indigenous populations of Western Amazon, Brazil.

Borges, Maria Fernanda de Sousa Oliveira / Koifman, Sergio / Koifman, Rosalina Jorge / da Silva, Ilce Ferreira

Ethnicity & health

2021 Volume 27, Issue 6, Page(s) 1465–1481

Abstract: Objectives: This study aims to estimate a population-based cancer incidence among indigenous populations in the State of Acre, Brazilian Western Amazon, to provide knowledge about cancer epidemiological profiles contributing to healthcare policies and ... ...

Abstract	Objectives: This study aims to estimate a population-based cancer incidence among indigenous populations in the State of Acre, Brazilian Western Amazon, to provide knowledge about cancer epidemiological profiles contributing to healthcare policies and service planning. Although cancer epidemiology in Brazil is well described through incidence and mortality estimate in the general population, cancer estimates among indigenous peoples are still unknown. Design: This is a descriptive study of cancer incidence among the indigenous population (2000-2012) in the State of Acre, Brazil. The sources used were population-based cancer registries of Goiânia, hospital-based cancer registry of Acre, São Paulo, and Porto Velho; Special Indigenous Health Districts databases of Acre, Goiânia, and São Paulo; Mortality Information System, and Rio Branco's public and private laboratories' reports. Standardized Incidence Ratio (SIR) was calculated using cancer incidence rates of Goiânia as reference. Results: From 137 cancer cases, 51.8% occurred in women and 32.1% in people aged 70 + . Among men, the most frequent cancer sites were stomach (25.8%), liver (15.1%), colorectal (7.6%), leukemia (7.6%), and prostate (6.1%). Among women, the most frequent were cervical (50.7%), stomach (8.5%), leukemia (5.6%), liver (4.3%), and breast (4.3%). Among men, there was an excess of cancer cases for stomach (SIR=1.75; 95%CI:1.67-1.83), liver (SIR=1.77; 95%CI:1.66-1.88), and leukemia (SIR=1.64; 95%CI:1.49-1.78). In women, an excess of cancer cases was observed for cervical (SIR=4.49; 95%CI:4.34-4.64) and liver (SIR=2.11; 95%CI:1.88-2.34). A lower cancer incidence for prostate (SIR=0.06; 95%CI:0.05-0.07) and female breast (SIR=0.12; 95%CI:0.11-0.14) was observed. Conclusions: Cervical, stomach, and liver cancers corresponded to 52% of the cases and were highly incident among the Brazilian indigenous population of Western Amazon compared to non-indigenous counterparts. Despite the low frequency of breast and prostate cancer, the fact they were present among indigenous peoples suggests a complex epidemiological transition framework in these populations.
MeSH term(s)	Brazil/epidemiology ; Humans ; Incidence ; Indigenous Peoples ; Leukemia/complications ; Male ; Neoplasms/epidemiology ; Prostatic Neoplasms ; Registries ; Risk Factors
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1497968-8
ISSN	1465-3419 ; 1355-7858
ISSN (online)	1465-3419
ISSN	1355-7858
DOI	10.1080/13557858.2021.1893663
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Article ; Online: Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil.

Piccoli, Camila / Cremonese, Cleber / Koifman, Rosalina / Koifman, Sérgio / Freire, Carmen

Ciencia & saude coletiva

2019 Volume 24, Issue 6, Page(s) 2325–2340

Abstract: This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample ... ...

Abstract	This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.
MeSH term(s)	Adolescent ; Adult ; Agricultural Workers' Diseases/blood ; Agricultural Workers' Diseases/epidemiology ; Blood Cell Count ; Brazil/epidemiology ; Cross-Sectional Studies ; Farmers ; Farms ; Female ; Humans ; Hydrocarbons, Chlorinated/blood ; Hydrocarbons, Chlorinated/toxicity ; Male ; Middle Aged ; Occupational Exposure/adverse effects ; Pesticides/blood ; Pesticides/toxicity ; Young Adult
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticides
Language	English
Publishing date	2019-06-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1413-8123
ISSN (online)	1678-4561
ISSN	1413-8123
DOI	10.1590/1413-81232018246.13142017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile.

Fujimoto, Denys Eiti / Koifman, Sergio

Revista brasileira de hematologia e hemoterapia

2014 Volume 36, Issue 2, Page(s) 115–120

Abstract: Background: Dengue is an infectious disease with a recurring incidence, especially in developing countries. Despite recent economic growth, success in disease control has not been achieved, and dengue has evolved from cyclic epidemic outbreaks to a lack ...

Abstract	Background: Dengue is an infectious disease with a recurring incidence, especially in developing countries. Despite recent economic growth, success in disease control has not been achieved, and dengue has evolved from cyclic epidemic outbreaks to a lack of seasonality. The lack of scientific basis for the proper management of cases with hemorrhagic manifestations, especially regarding transfusion procedures, might contribute to the high death rate in potentially avoidable cases. Objective: The aim of the study was to identify the clinical and laboratory manifestations in hemorrhagic dengue fever treated at the emergency services in Rio Branco, AC, Brazil, as well as to describe transfusion characteristics of patients and identify possible prognostic factors. Methods: A retrospective descriptive study was performed to analyze the distribution of relative frequencies of clinical and laboratory variables. The study was carried out in Rio Branco with confirmed dengue fever cases. Secondary data were obtained by Acre Epidemiological Surveillance teams of cases with bleeding or platelet counts under 100.0 × 10(9)/L. The patients' clinical, laboratory and transfusion data were obtained from hospital records. Results: A total of 90,553 dengue cases were reported of which 7,447 had serologic confirmation; 267 cases had hemorrhagic manifestations and 193 patients were located. Nearly half of the patients had anemia and the mean of the lowest platelet count of these patients was 26.4 × 10(9)/L. Platelet concentrate was transfused in 22.3% of cases with a mean of 7.5 IU/patient, fresh frozen plasma in 21.2% with a mean of 5.2 IU/patient and just 2.6% of patients received concentrated red blood cells with a mean of 3.2 IU/patient. Bleeding led to transfusions. Signs of plasma leakage and cardiopulmonary dysfunction were correlated to unfavorable outcomes. Conclusion: The pattern of clinical and laboratory criteria observed in this investigation does not differ from the literature. Transfusions were used as part of the treatment of dengue hemorrhagic fever manifestations. Some of the clinical manifestations may be related to unfavorable outcomes.
Language	English
Publishing date	2014-03-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105177-X
ISSN	1806-0870 ; 1516-8484
ISSN (online)	1806-0870
ISSN	1516-8484
DOI	10.5581/1516-8484.20140027
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Article ; Online: Thyroid cancer in Brazil: a descriptive study of cases held on hospital-based cancer registries, 2000-2016.

Borges, Anne Karin da Mota / Ferreira, Jeniffer Dantas / Koifman, Sérgio / Koifman, Rosalina Jorge

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

2020 Volume 29, Issue 4, Page(s) e2019503

Abstract: Objective To describe the clinical and epidemiological profile of primary thyroid cancer hospital cases in Brazil. Methods This is a descriptive study of cases held on hospital cancer records who had their first consultation for treatment in the period ... ...

Title translation	Câncer de tireoide no Brasil: estudo descritivo dos casos informados pelos registros hospitalares de câncer, 2000-2016.
Abstract	Objective To describe the clinical and epidemiological profile of primary thyroid cancer hospital cases in Brazil. Methods This is a descriptive study of cases held on hospital cancer records who had their first consultation for treatment in the period 2000-2016 and who were monitored by the hospitals providing those records. Results Of the 52,912 cases, 83.4% were female and 96.9% were differentiated carcinoma cases. The median time to diagnosis was shorter for anaplastic cases (11 days) and for those living in Brazil's Southern region (5 days). Treatment was initiated within 60 days in 88.8% of cases that arrived at the hospitals without diagnosis and in 34.9% of those who arrived with diagnosis. Conclusion The findings are consistent with thyroid cancer epidemiology, with a predominance of female cases and differentiated carcinomas. Analysis of time-to-treatment suggests access difficulties for those who already had diagnosis when they arrived at the hospitals.
MeSH term(s)	Brazil/epidemiology ; Female ; Hospitals ; Humans ; Male ; Registries ; Thyroid Neoplasms/epidemiology
Language	Portuguese
Publishing date	2020-08-19
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2880588-4
ISSN	2237-9622 ; 1679-4974
ISSN (online)	2237-9622
ISSN	1679-4974
DOI	10.5123/s1679-49742020000400012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Serum levels of organochlorine pesticides in blood donors: A biomonitoring survey in the North of Brazil, 2010-2011.

Freire, Carmen / Koifman, Rosalina Jorge / Koifman, Sergio

The Science of the total environment

2017 Volume 598, Page(s) 722–732

Abstract: Data on exposure to organochlorine (OC) pesticides in the Brazilian population are lacking. The purpose of this study was to investigate the distribution of serum levels of OC pesticides in Brazilian blood donors and to determine factors potentially ... ...

Abstract	Data on exposure to organochlorine (OC) pesticides in the Brazilian population are lacking. The purpose of this study was to investigate the distribution of serum levels of OC pesticides in Brazilian blood donors and to determine factors potentially influencing exposure levels. To conduct this biomonitoring survey, blood samples were collected from blood donors attending the Hematherapic Unit in Rio Branco, North of Brazil, in 2010-2011. A total of 1183 (99%) subjects answered to a questionnaire including information on sociodemographics, lifestyle, and dietary habits. Twenty four OC pesticides were measured in serum samples from 978 donors (82%). Associations of OC pesticide serum levels and the number of OCs detected per donor with their potential predictors were explored by logistic and Poisson regression, respectively. Of the 24 OC pesticides analyzed, the highest prevalence was observed for p,p'-dichlorodiphenylethane (p,p'-DDE) (32%), followed by lindane (γ-hexachlorocyclohexane) (20%), heptachlor (16%), and p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) (13%). 95th percentiles of levels of these four OC pesticides were: 3.85ng/mL (p,p'-DDE) (median<0.09ng/mL), 0.09ng/mL (lindane) (median<0.04ng/mL), 0.23ng/mL (heptachlor) (median<0.09ng/mL), and 0.27ng/mL (p,p'-DDT) (median<0.02ng/mL). Factors significantly associated with a more frequent detection of OC pesticides included age, gender, education, and frequency of fish, manioc flour, açai pulp, and Brazil nuts intake. Major predictors of the number of OC pesticides detected were age, marital status, income, education, and frequency of consumption of manioc flour, açai pulp, and Brazil nuts. For the first time in Brazil, a biomonitoring study has assessed the internal doses of OC pesticides in a large sample of the adult population and potential exposure determinants. Except for lindane, which was permitted for use as a wood preservative until 2007 in Brazil, occurrence of OC pesticides was lower than or in the same range as those observed in other countries.
MeSH term(s)	Adolescent ; Adult ; Aged ; Blood Donors ; Brazil ; Environmental Monitoring ; Female ; Humans ; Hydrocarbons, Chlorinated/blood ; Male ; Middle Aged ; Pesticides/blood ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticides
Language	English
Publishing date	2017-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2017.04.128
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 949: Show issues

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Article ; Online: Geração e transmissão da energia elétrica

Koifman Sergio

Cadernos de Saúde Pública, Vol 17, Iss 2, Pp 413-

impacto sobre os povos indígenas no Brasil

2001 Volume 423

Abstract: Este trabalho busca retratar a distribuição de intercorrências nas comunidades indígenas no Brasil associadas à geração e à distribuição da energia elétrica. De acordo com dados da Fundação Nacional do Índio, há 156 áreas geograficamente distribuídas no ... ...

Abstract	Este trabalho busca retratar a distribuição de intercorrências nas comunidades indígenas no Brasil associadas à geração e à distribuição da energia elétrica. De acordo com dados da Fundação Nacional do Índio, há 156 áreas geograficamente distribuídas no país caracterizadas por afetarem, presente ou futuramente, assentamentos indígenas através da expansão do setor elétrico - 65% das quais situadas na Região Norte. As principais reclamações destas comunidades dizem respeito aos efeitos diretos acarretados pelo alagamento originado com a construção das barragens hidroelétricas: submersão de territórios sagrados (como cemitérios); proliferação de mosquitos (ampliando a difusão da malária e de outras doenças infecciosas); escassez de caça; restrição das terras para a agricultura; e a criação de condições facilitadoras da invasão de terras indígenas. O cenário de perspectivas futuras é esboçado em quadro marcado pelo planejamento da construção de novas usinas hidrelétricas - em especial, na região amazônica - com possíveis efeitos similares nas comunidades indígenas.
Keywords	Eletricidade ; Impacto Ambiental ; Índios Sul-Americanos ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2001-01-01T00:00:00Z
Publisher	Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Tópicos em saúde, ambiente e trabalho

Fernandes, Rita de Cassia Pereira / Koifman, Sergio

um olhar ampliado

(Coleção Elivro)

2014

Author's details	Rita de Cássia Pereira Fernandes ... (organizadoras). [Pref. Sergio Koifman]
Series title	Coleção Elivro
Keywords	Environmental health ; Industrial hygiene ; Occupations/Environmental aspects ; Arbeitsschutz ; Umweltschutz ; Gesundheitswesen ; Brasilien
Language	Portuguese
Size	508 S, Ill.,graph. Darst., 24 cm
Publisher	EDUFBA
Publishing place	Salvador
Document type	Book
Note	Contributions from master's theses in the Programa de Pós-Graduação em Saúde, Ambiente e Trabalho, Universidade Federal da Bahia ; Enth. 18 Beitr. ; Includes bibliographical references
ISBN	8523212116 ; 9788523212117
Database	ECONomics Information System

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Article ; Online: Pesticides, depression and suicide: a systematic review of the epidemiological evidence.

Freire, Carmen / Koifman, Sergio

International journal of hygiene and environmental health

2013 Volume 216, Issue 4, Page(s) 445–460

Abstract: It has been suggested that high exposure to pesticides, including poisoning, experienced by agriculture workers and rural residents may result in an elevated risk of psychiatric disorders and suicidal behavior. Epidemiological data supporting this ... ...

Abstract	It has been suggested that high exposure to pesticides, including poisoning, experienced by agriculture workers and rural residents may result in an elevated risk of psychiatric disorders and suicidal behavior. Epidemiological data supporting this hypothesis are very limited. An updated systematic review was conducted in epidemiologic literature on the relationship of pesticide exposure with depression and suicide published over the last 15 years by using MEDLINE database. A total of 11 studies on depression and 14 studies on suicide met inclusion criteria. Depression or other psychiatric disorders have shown increased risks associated with previous pesticide poisoning in 5 studies, with statistically significant odds ratios (OR) ranging from 2.08 to 5.95. Lower risk estimates have been found for chronic pesticide exposure. Among studies on suicide, 4 reports found increased suicide rates in areas with intensive pesticide use (OR between 1.60 and 2.61) compared to areas with lower pesticide use. Occupation in agriculture has shown a significant association with higher suicide risk than other occupational groups in 4 studies (OR between 1.30 and 4.13), but not in one recent report. Regarding specific pesticides, lifetime use of chlorpyrifos was related with increased suicide mortality (OR=2.37) in one study. Scientific evidence of association between pesticide exposure and either depression or suicide has been shown in some populations, in studies using varying epidemiological approaches, but is still very limited and inconclusive. Review of the literature warrants further research to explore such relationships, in particular prospective studies among large samples of high- and low-dose-exposed workers, using detailed exposure assessments, and evaluating other potential sources of psychological stress.
MeSH term(s)	Depression/epidemiology ; Depression/etiology ; Environmental Exposure/adverse effects ; Humans ; Pesticides/toxicity ; Suicide/statistics & numerical data
Chemical Substances	Pesticides
Language	English
Publishing date	2013-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2009176-X
ISSN	1618-131X ; 1438-4639
ISSN (online)	1618-131X
ISSN	1438-4639
DOI	10.1016/j.ijheh.2012.12.003
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Zs.A 5334: Show issues

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Article ; Online: Mortalidade por câncer em populações indígenas no Estado do Acre, Brasil.

Borges, Maria Fernanda de Sousa Oliveira / Koifman, Sergio / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Cadernos de saude publica

2019 Volume 35, Issue 5, Page(s) e00143818

Abstract: The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to ... ...

Title translation	Cancer mortality among indigenous population in Acre State, Brazil.
Abstract	The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brazil/epidemiology ; Cause of Death ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Indians, South American ; Indigenous Peoples/statistics & numerical data ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neoplasms/classification ; Neoplasms/diagnosis ; Neoplasms/mortality ; Population Groups ; Prevalence ; Risk Factors ; Sex Factors ; Young Adult
Language	Portuguese
Publishing date	2019-05-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00143818
Database	MEDical Literature Analysis and Retrieval System OnLINE

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