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  1. Article ; Online: [Biophysical and Biochemical Research of Animal Rhodopsins].

    Kojima, Keiichi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2021  Volume 141, Issue 10, Page(s) 1155–1160

    Abstract: Opsins (also called animal rhodopsins) are universal photoreceptive proteins that provide the molecular basis of visual and nonvisual photoreception in animals, including humans. Opsins consist of seven helical α-transmembrane domains and use retinal, a ... ...

    Abstract Opsins (also called animal rhodopsins) are universal photoreceptive proteins that provide the molecular basis of visual and nonvisual photoreception in animals, including humans. Opsins consist of seven helical α-transmembrane domains and use retinal, a derivative of vitamin A, as a chromophore. In many opsins, light absorption triggers photo-isomerization from 11-cis retinal to all-trans retinal, resulting in activation via dynamic structural changes in the protein moiety. Activated opsins stimulate cognate trimeric G proteins to induce signal transduction cascades in cells. Recently, molecular and physiological analyses of diverse opsins have progressively advanced. This review introduces the molecular basis and physiological functions of opsins. Based on the functions of opsins, I will discuss the potential of opsins as target molecules to treat and prevent visual and nonvisual diseases such as sleep disorder and depression.
    MeSH term(s) Amino Acid Motifs ; Animals ; Biophysical Phenomena ; Depression/etiology ; Depression/prevention & control ; Depression/therapy ; GTP-Binding Proteins/metabolism ; Humans ; Molecular Targeted Therapy ; Mutation ; Opsins/chemistry ; Opsins/genetics ; Opsins/physiology ; Protein Domains ; Receptors, G-Protein-Coupled/metabolism ; Retinaldehyde/chemistry ; Rhodopsin ; Signal Transduction ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/prevention & control ; Sleep Wake Disorders/therapy ; Vision Disorders/etiology ; Vision Disorders/prevention & control ; Vision Disorders/therapy ; Vision, Ocular/physiology
    Chemical Substances Opsins ; Receptors, G-Protein-Coupled ; Rhodopsin (9009-81-8) ; GTP-Binding Proteins (EC 3.6.1.-) ; Retinaldehyde (RR725D715M)
    Language Japanese
    Publishing date 2021-10-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.21-00144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  2. Article ; Online: Convergent evolution of animal and microbial rhodopsins.

    Kojima, Keiichi / Sudo, Yuki

    RSC advances

    2023  Volume 13, Issue 8, Page(s) 5367–5381

    Abstract: Rhodopsins, a family of photoreceptive membrane proteins, contain retinal as a chromophore and were firstly identified as reddish pigments from frog retina in 1876. Since then, rhodopsin-like proteins have been identified mainly from animal eyes. In 1971, ...

    Abstract Rhodopsins, a family of photoreceptive membrane proteins, contain retinal as a chromophore and were firstly identified as reddish pigments from frog retina in 1876. Since then, rhodopsin-like proteins have been identified mainly from animal eyes. In 1971, a rhodopsin-like pigment was discovered from the archaeon
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra07073a
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  3. Article ; Online: Correction: Convergent evolution of animal and microbial rhodopsins.

    Kojima, Keiichi / Sudo, Yuki

    RSC advances

    2023  Volume 13, Issue 11, Page(s) 7222–7224

    Abstract: This corrects the article DOI: 10.1039/D2RA07073A.]. ...

    Abstract [This corrects the article DOI: 10.1039/D2RA07073A.].
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90016a
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  4. Article ; Online: Expression of microbial rhodopsins in

    Kojima, Keiichi / Sudo, Yuki

    STAR protocols

    2021  Volume 3, Issue 1, Page(s) 101046

    Abstract: Microbial rhodopsins are photoreceptive membrane proteins showing various light-dependent biological activities. Styrene-maleic acid (SMA) copolymers spontaneously form nanoscale lipid particles containing membrane proteins and associated lipids without ... ...

    Abstract Microbial rhodopsins are photoreceptive membrane proteins showing various light-dependent biological activities. Styrene-maleic acid (SMA) copolymers spontaneously form nanoscale lipid particles containing membrane proteins and associated lipids without detergent, and can be used to characterize membrane molecules. Here, we provide a protocol to functionally express a thermally stable rhodopsin,
    MeSH term(s) Escherichia coli/genetics ; Maleates ; Membrane Proteins ; Rhodopsin ; Rhodopsins, Microbial/genetics
    Chemical Substances Maleates ; Membrane Proteins ; Rhodopsins, Microbial ; Rhodopsin (9009-81-8) ; maleic acid (91XW058U2C)
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.101046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Convergent mechanism underlying the acquisition of vertebrate scotopic vision.

    Kojima, Keiichi / Yanagawa, Masataka / Imamoto, Yasushi / Yamano, Yumiko / Wada, Akimori / Shichida, Yoshinori / Yamashita, Takahiro

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107175

    Abstract: High sensitivity of scotopic vision (vision in dim light conditions) is achieved by the rods' low background noise, which is attributed to a much lower thermal activation rate ( ... ...

    Abstract High sensitivity of scotopic vision (vision in dim light conditions) is achieved by the rods' low background noise, which is attributed to a much lower thermal activation rate (k
    MeSH term(s) Animals ; Rhodopsin/metabolism ; Rhodopsin/chemistry ; Night Vision/physiology ; Retinal Cone Photoreceptor Cells/metabolism ; Retinal Cone Photoreceptor Cells/physiology ; Retinal Rod Photoreceptor Cells/metabolism ; Retinal Rod Photoreceptor Cells/physiology ; Lizards/physiology ; Lizards/metabolism ; Evolution, Molecular ; Vertebrates ; Light
    Chemical Substances Rhodopsin (9009-81-8)
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107175
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    Uc I Zs.108: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults.

    Kojima, Keiichi / Ishikawa, Haruna / Watanabe, Shinji / Nosaka, Naohisa / Mutoh, Tatsushi

    Nutrients

    2023  Volume 15, Issue 14

    Abstract: An adequate nutritional intake is recommended for the prevention of physical frailty and sarcopenia. In particular, medium-chain fatty acids (MCFAs) are reportedly important for muscle strength in nursing home residents. However, the effects of MCFAs on ... ...

    Abstract An adequate nutritional intake is recommended for the prevention of physical frailty and sarcopenia. In particular, medium-chain fatty acids (MCFAs) are reportedly important for muscle strength in nursing home residents. However, the effects of MCFAs on healthy adults at risk for frailty remain unknown. Hence, a randomized, placebo-controlled study was conducted to investigate the effects of 12 weeks of medium-chain triglycerides (MCTs) intake and walking on muscle mass and function in healthy, sedentary, middle-aged and older adults with a low body mass index. Three MCT intake groups with different amounts of octanoic and decanoic acid intake were compared with a control group. After 12 weeks, knee extension strength increased in all groups, with the increases in all MCT intake groups being significantly higher than those in the control group (
    MeSH term(s) Middle Aged ; Humans ; Aged ; Sarcopenia/prevention & control ; Frailty ; Dietary Supplements ; Muscle Strength ; Hand Strength ; Exercise ; Triglycerides/pharmacology ; Muscle, Skeletal ; Double-Blind Method
    Chemical Substances Triglycerides
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15143275
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  7. Article ; Online: Role of Monomer/Tetramer Equilibrium of Rod Visual Arrestin in the Interaction with Phosphorylated Rhodopsin.

    Imamoto, Yasushi / Kojima, Keiichi / Maeda, Ryo / Shichida, Yoshinori / Oka, Toshihiko

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: The phototransduction cascade in vertebrate rod visual cells is initiated by the photoactivation of rhodopsin, which enables the activation of the visual G protein transducin. It is terminated by the phosphorylation of rhodopsin, followed by the binding ... ...

    Abstract The phototransduction cascade in vertebrate rod visual cells is initiated by the photoactivation of rhodopsin, which enables the activation of the visual G protein transducin. It is terminated by the phosphorylation of rhodopsin, followed by the binding of arrestin. Here we measured the solution X-ray scattering of nanodiscs containing rhodopsin in the presence of rod arrestin to directly observe the formation of the rhodopsin/arrestin complex. Although arrestin self-associates to form a tetramer at physiological concentrations, it was found that arrestin binds to phosphorylated and photoactivated rhodopsin at 1:1 stoichiometry. In contrast, no complex formation was observed for unphosphorylated rhodopsin upon photoactivation, even at physiological arrestin concentrations, suggesting that the constitutive activity of rod arrestin is sufficiently low. UV-visible spectroscopy demonstrated that the rate of the formation of the rhodopsin/arrestin complex well correlates with the concentration of arrestin monomer rather than the tetramer. These findings indicate that arrestin monomer, whose concentration is almost constant due to the equilibrium with the tetramer, binds to phosphorylated rhodopsin. The arrestin tetramer would act as a reservoir of monomer to compensate for the large changes in arrestin concentration in rod cells caused by intense light or adaptation.
    MeSH term(s) Rhodopsin/metabolism ; Retinal Rod Photoreceptor Cells/metabolism ; Arrestin/metabolism ; Phosphorylation ; GTP-Binding Proteins/metabolism
    Chemical Substances Rhodopsin (9009-81-8) ; Arrestin ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2023-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054963
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  8. Article ; Online: Detection of Membrane Potential-Dependent Rhodopsin Fluorescence Using Low-Intensity Light Emitting Diode for Long-Term Imaging.

    Kawanishi, Shiho / Kojima, Keiichi / Shibukawa, Atsushi / Sakamoto, Masayuki / Sudo, Yuki

    ACS omega

    2023  Volume 8, Issue 5, Page(s) 4826–4834

    Abstract: Microbial rhodopsin is a family of photoreceptive membrane proteins that commonly consist of a seven-transmembrane domain and a derivative of vitamin-A, retinal, as a chromophore. In 2011, archaeorhodopsin-3 (AR3) was shown to exhibit voltage-dependent ... ...

    Abstract Microbial rhodopsin is a family of photoreceptive membrane proteins that commonly consist of a seven-transmembrane domain and a derivative of vitamin-A, retinal, as a chromophore. In 2011, archaeorhodopsin-3 (AR3) was shown to exhibit voltage-dependent fluorescence changes in mammalian cells. Since then, AR3 and its variants have been used as genetically encoded voltage indicators, in which mostly intense laser stimulation (1-1000 W/cm
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c06980
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  9. Article: Effect of medium-chain triglycerides supplements and walking on health-related quality of life in sedentary, healthy middle-aged, and older adults with low BMIs: a randomized, double-blind, placebo-controlled, parallel-group trial.

    Ishikawa, Haruna / Kojima, Keiichi / Watanabe, Shinji / Nosaka, Naohisa / Mutoh, Tatsushi

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1296896

    Abstract: Introduction: To extend individuals' healthy life expectancies, the improvement of subjective health and quality of life (QOL) has been increasingly prioritized, alongside the improvement of their physical functioning. Reports have indicated that intake ...

    Abstract Introduction: To extend individuals' healthy life expectancies, the improvement of subjective health and quality of life (QOL) has been increasingly prioritized, alongside the improvement of their physical functioning. Reports have indicated that intake of medium-chain triglycerides (MCTs) benefits the physical health of older individuals requiring nursing care, and athletes, and healthy individuals. But there are few studies investigating the effects of MCTs on subjective health and QOL. The present study sought to evaluate the combined effects of 12-week MCTs supplements and moderate-intensity walking exercise on the subjective health and QOL of middle-aged and older adults aged 60-74 with low BMIs (< 24 kg/m
    Methods: A placebo-controlled, double-blind, parallel-group trial was conducted. Three MCTs supplement groups with different doses and fatty acid compositions were compared with a control group. The study used the SF-36v2 questionnaire to assess subjective health and health-related QOL (HRQOL).
    Results: The result showed significant improvements in the scores on subscales of the physical QOL, such as Physical functioning and General health, and summary scores on the mental QOL, compared to the control.
    Conclusion: It is estimated that the combination of continuous intake of MCTs and walking exercise may affect HRQOL and improve subjective physical and mental health in sedentary, healthy, middle-aged and older adults.
    Clinical trial registration: https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000046861, UMIN000046861.
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1296896
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  10. Article ; Online: Demonstration of iodide-dependent UVA-triggered growth inhibition in Saccharomyces cerevisiae cells and identification of its suppressive molecules.

    Ono, Ryota / Saeki, Nozomu / Kojima, Keiichi / Moriya, Hisao / Sudo, Yuki

    Biochemical and biophysical research communications

    2023  Volume 677, Page(s) 1–5

    Abstract: Upon white light illumination, the growth of the budding yeast Saccharomyces cerevisiae was extremely impaired only in the presence of iodide ions, but not fluoride, chloride and bromide ions. Action spectroscopy revealed that the maximum wavelength of ... ...

    Abstract Upon white light illumination, the growth of the budding yeast Saccharomyces cerevisiae was extremely impaired only in the presence of iodide ions, but not fluoride, chloride and bromide ions. Action spectroscopy revealed that the maximum wavelength of the light is around at 373 nm, corresponding to the UVA region. Using a genetic approach, several genes, including OPY1, HEM1, and PAU11, were identified as suppressors of this growth inhibition. This iodide-dependent UVA-triggered growth inhibition method, along with its suppressive molecules, would be beneficial for understanding cell growth processes in eukaryotes and can be utilized for medium sterilization using UVA light.
    MeSH term(s) Saccharomyces cerevisiae/genetics ; Iodides ; Ultraviolet Rays ; Light ; Saccharomyces cerevisiae Proteins/genetics
    Chemical Substances Iodides ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.07.048
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