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  1. Article ; Online: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic.

    Kolar, Dusan

    European archives of psychiatry and clinical neuroscience

    2020  Volume 271, Issue 2, Page(s) 391–392

    MeSH term(s) COVID-19 ; Emergency Services, Psychiatric ; Facilities and Services Utilization ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-020-01182-3
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  2. Article ; Online: Long-term treatment of depression with intranasal esketamine: Is it justified?

    Kolar, Dusan

    Asian journal of psychiatry

    2020  Volume 54, Page(s) 102232

    MeSH term(s) Administration, Intranasal ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy ; Humans ; Ketamine/therapeutic use
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2020-06-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102232
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  3. Article: Addictive potential of novel treatments for refractory depression and anxiety.

    Kolar, Dusan

    Neuropsychiatric disease and treatment

    2018  Volume 14, Page(s) 1513–1519

    Abstract: Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription ... ...

    Abstract Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription medication addiction. Some of the newer treatment modalities for mood and anxiety disorders may have similar properties to benzodiazepines. The goal of this review was to identify the potential for developing dependence on the novel treatment approaches to treatment-resistant depression and refractory anxiety disorders. PubMed, MEDLINE, PsycINFO, Ovid, Cochrane Library, and Google Scholar were searched. Ketamine is effective in improving symptoms of major depressive disorder, but with no sustained benefits. Long-term use of oral or intranasal ketamine formulations may be associated with the risk of developing dependence. Augmentation of stimulant medication is usually effective for residual symptoms of depression, but the effects are usually short lasting and there is a potential for abuse. Synthetic cannabinoids and medicinal cannabis are increasingly being prescribed for a number of medical conditions, including anxiety disorders, without enough evidence about their efficacy and with the risk of patients developing dependence. In summary, benzodiazepines, ketamine, stimulant medications, and cannabinoids have some common characteristics, including short-lasting benefits and the risk of developing prescription medication addiction with longer use. All of these treatments may raise ethical dilemmas about the appropriateness of prescribing these medications in the long run for patients with depression and anxiety disorders.
    Language English
    Publishing date 2018-06-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S167538
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  5. Article ; Online: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic

    Kolar, Dusan

    European Archives of Psychiatry and Clinical Neuroscience ; ISSN 0940-1334 1433-8491

    2020  

    Keywords Pharmacology (medical) ; Biological Psychiatry ; Psychiatry and Mental health ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00406-020-01182-3
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  6. Article ; Online: Current status of electroconvulsive therapy for mood disorders: a clinical review.

    Kolar, Dusan

    Evidence-based mental health

    2017  Volume 20, Issue 1, Page(s) 12–14

    Abstract: Electroconvulsive therapy (ECT) is an effective treatment for mood disorders and a viable treatment option especially when urgency of clinical situation requires a prompt treatment response. After acute series of ECT, the ECT long-term treatment may be ... ...

    Abstract Electroconvulsive therapy (ECT) is an effective treatment for mood disorders and a viable treatment option especially when urgency of clinical situation requires a prompt treatment response. After acute series of ECT, the ECT long-term treatment may be considered, although this practice may vary significantly between countries or even within the same country, because there is no universal consensus about its indications, duration and frequency of administration. Continuation or maintenance ECT is common in routine clinical practice and clinicians should be aware of the risks of using ECT long term. Neuropsychological assessment should be an essential part of a good clinical practice in ECT services. Cognitive side effects of ECT are sometimes underestimated and may last much longer after completed treatment than it is usually expected. These cognitive impairments associated with ECT may cause significant functional difficulties and prevent patients to return to work. Cognitive assessment during ECT treatment is usually not comprehensive enough and is limited to bedside assessment. A more proactive approach to careful neuropsychological assessment and consideration of combined maintenance medication treatment after ECT are essential.
    MeSH term(s) Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Electroconvulsive Therapy/adverse effects ; Electroconvulsive Therapy/methods ; Electroconvulsive Therapy/standards ; Humans ; Mood Disorders/therapy
    Language English
    Publishing date 2017-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2009065-1
    ISSN 1468-960X ; 1362-0347
    ISSN (online) 1468-960X
    ISSN 1362-0347
    DOI 10.1136/eb-2016-102498
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  7. Article: CRITICAL REVIEW OF AVAILABLE TREATMENT OPTIONS FOR TREATMENT REFRACTORY DEPRESSION AND ANXIETY - CLINICAL AND ETHICAL DILEMMAS.

    Kolar, Dusan / Kolar, Michael V

    Medicinski pregled

    2018  Volume 69, Issue 5-6, Page(s) 171–176

    Abstract: Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting ...

    Abstract Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting improvement in symptoms of depression and anxiety. Beozodiazepines are effective for anxiety symptoms, but with no sustained treatment effects. Other medication treatment options for anxiety disorders are outlined. Ketamine is usually very effective in treating maior depressive disorder but without sustained benefits. Loog-term use may pose a signiticant risk of developing tolerance and dependence. Stimulant medication augmentation for treatment-resistant depression is effective for residual symptoms of depression, but effects are usually short-lasting and it sounds mor as an artificial way of improving energy, alertness and cognitive functioning. Synthetic cannabinoids and medical marijuana are increasingly prescribed for various medical conditions. but more recently also for patients with mood and anxiety disorders. All of these treatments may raise ethical dilemmas about appropriateness of prescribing these medications and a number of questions regarding the optimal treatment for patients with treatment-resistant depression and treatment refractory anxiety disorders.
    MeSH term(s) Anxiety Disorders/therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Ethics ; Humans
    Language English
    Publishing date 2018-04-25
    Publishing country Serbia
    Document type Journal Article ; Review
    ZDB-ID 131108-6
    ISSN 0025-8105
    ISSN 0025-8105
    DOI 10.2298/mpns1606171k
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    Zs.B 878: Show issues Location:
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  8. Article ; Online: Critical review of available treatment options for treatment refractory depression and anxiety - clinical and ethical dilemmas

    Kolar Dušan / Kolar Michael V.

    Medicinski Pregled, Vol 69, Iss 5-6, Pp 171-

    2016  Volume 176

    Abstract: Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting ...

    Abstract Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting improvement in symptoms of depression and anxiety. Benzodiazepines are effective for anxiety symptoms, but with no sustained treatment effects. Other medication treatment options for anxiety disorders are outlined. Ketamine is usually very effective in treating major depressive disorder but without sustained benefits. Long-term use may pose a significant risk of developing tolerance and dependence. Stimulant medication augmentation for treatment-resistant depression is effective for residual symptoms of depression, but effects are usually short-lasting and it sounds more as an artificial way of improving energy, alertness and cognitive functioning. Synthetic cannabinoids and medical marijuana are increasingly prescribed for various medical conditions, but more recently also for patients with mood and anxiety disorders. All of these treatments may raise ethical dilemmas about appropri­ateness of prescribing these medications and a number of questions regarding the optimal treatment for patients with treatment-resistant depression and treatment refractory anxiety disorders.
    Keywords Depressive Disorder ; Treatment-Resistant ; Anxiety Disorders ; Depression ; Treatment Outcome ; Risk Factors ; Benzo­diazepines ; Ketamine ; Pregabalin ; Central Nervous System Stimulants ; Cannabinoids ; Prescription Drug Overuse ; Drug-Related Side Effects and Adverse Reactions ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 150
    Language Serbian
    Publishing date 2016-01-01T00:00:00Z
    Publisher Serbian Medical Society, Society of Physicians of Vojvodina, Novi Sad
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Chlorpromazine-induced status epilepticus

    Momčilović-Kostadinović Dragana / Simonović Periša / Kolar Dušan / Jović Nebojša

    Srpski Arhiv za Celokupno Lekarstvo, Vol 141, Iss 9-10, Pp 667-

    A case report

    2013  Volume 670

    Abstract: Introduction. It is largely known that some antipsychotic agents could have proconvulsive and proepileptogenic effects in some patients and could induce EEG abnormalities as well. However, the association of status epilepticus with certain antipsychotic ... ...

    Abstract Introduction. It is largely known that some antipsychotic agents could have proconvulsive and proepileptogenic effects in some patients and could induce EEG abnormalities as well. However, the association of status epilepticus with certain antipsychotic drugs has been very rarely reported. Case Report. A case of an 18-year-old adolescent girl, with chlorpromazine therapy started for anxiety-phobic disorder was reported. Her personal history disclosed delayed psychomotor development. Shortly after the introduction of the neuroleptic chlorpromazine therapy in minimal daily dose (37.5 mg), she developed myoclonic status epilepticus, confirmed by the EEG records. Frequent, symmetrical bilateral myoclonic jerks and altered behavior were associated with bilateral epileptiform discharges of polyspikes and spike-wave complexes. This epileptic event lasted 3.5 hours and it was stopped by the parenteral administration of valproate and lorazepam; she was EEG monitored until stable remission. Status epilepticus as initial epileptic event induced by neuroleptic agent was not previously reported in our national literature. Conclusion. Introduction of chlorpromazine to a patient without history of seizures is associated with the evolution of an epileptic activity, including the occurrence of status epilepticus. Clinical evaluation of the risk factors possibly related to chlorpromazine-induced seizure is recommended in individual patients before administering this drug.
    Keywords chlorpromazine ; myoclonic status epilepticus ; adolescents ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Social phobia in developmental period

    Kolar Dušan / Bojanin Svetomir

    Srpski Arhiv za Celokupno Lekarstvo, Vol 133, Iss 1-2, Pp 86-

    From theory to therapy

    2005  Volume 90

    Abstract: The contemporary integrative theoretical and therapeutic concepts of social phobia in developmental period have been presented in the study. Besides current neurobiological theories, a very important hypothesis about behavioral inhibition has been ... ...

    Abstract The contemporary integrative theoretical and therapeutic concepts of social phobia in developmental period have been presented in the study. Besides current neurobiological theories, a very important hypothesis about behavioral inhibition has been represented as a predisposition of social phobia. The cognitive-behavioral theories of social phobia are dominant among psychological theories. The integrative concept of social phobia is the most realistic approach to this disorder and the bridge between biological and psychological theories. The interaction between biological and psychological etiological factors is represented through different therapeutical approaches to social phobia. Therapy of social phobia is integrative and involves different therapeutical modalities in different phases of therapy. In integrative psychotherapy, we use cognitive-behavioral therapy, dynamic oriented supportive psychotherapy, psychodynamic psychotherapy and phenomenological-existential psychotherapy. The cognitive-behavioral therapy yields the best results. The medicaments in use are the following: selective serotonin reuptake inhibitors, mono-amine oxidase inhibitors, high-potency benzodiazepines, new antiepileptic drugs and rarely (3-blockers. The combination of integrative psychotherapy and pharmacotherapy is the most optimal therapeutic approach to social phobia. This integrative and to patient adapted treatment will produce the best results in management of children's and adolescent's social phobia.
    Keywords social phobia ; contemporary neurobiological concepts ; psychobiological hypotheses ; integrative psychothera­py ; combined therapy ; Medicine ; R
    Subject code 300
    Language English
    Publishing date 2005-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
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