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  1. Article ; Online: What patients with advanced cancer experience as helpful in navigating their life with a long-term response: a qualitative study.

    Zwanenburg, Laura C / van der Lee, Marije L / Koldenhof, José J / Suijkerbuijk, Karijn P M / Schellekens, Melanie P J

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 4, Page(s) 222

    Abstract: Purpose: Despite improved survival for people with advanced cancer due to new medical treatments, a growing group of long-term responders (LTRs) has to learn to live with uncertainties that affect several life domains. At the core of their experience, ... ...

    Abstract Purpose: Despite improved survival for people with advanced cancer due to new medical treatments, a growing group of long-term responders (LTRs) has to learn to live with uncertainties that affect several life domains. At the core of their experience, they neither feel like a patient nor feel healthy. Despite growing awareness of LTRs' experiences, learning more about how they cope with their long-term response can provide insight into how to best support them. Our study aimed to gain a deeper understanding what LTRs experience as helpful in navigating life with a long-term response.
    Methods: We conducted an exploratory qualitative study using thematic data analysis. Semi-structured in-depth interviews were conducted with 17 participants with advanced melanoma or lung cancer with confirmed response or long-term stable disease while on immuno- or targeted therapy.
    Results: LTRs reported several strategies to navigate life with a long-term response, for example, by involving the social environment, seeing uncertainty as an opportunity, and being present in the moment. This helped them to reclaim a sense of control, alter their perspective, and reshape their lives according to their values.
    Conclusion: Using different coping strategies enables LTRs to acknowledge both their sick and healthy side. Striking a healthy balance between being oriented on feeling sick or feeling healthy can help LTRs and their close others to navigate life with a long-term response. Healthcare professionals can provide support by recognizing whether LTRs are oriented at feeling sick or healthy, and by actively involving close others during medical appointments.
    MeSH term(s) Humans ; Palliative Care ; Lung Neoplasms ; Patient Acceptance of Health Care ; Qualitative Research
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08398-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Frailty and checkpoint inhibitor toxicity in older patients with melanoma.

    Bruijnen, Cheryl P / Koldenhof, José J / Verheijden, Rik J / van den Bos, Frederiek / Emmelot-Vonk, Mariëlle H / Witteveen, Petronella O / Suijkerbuijk, Karijn P M

    Cancer

    2022  Volume 128, Issue 14, Page(s) 2746–2752

    Abstract: Background: Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) that range from mild to life-threatening. Age itself does not seem to be a predictor for the occurrence of irAEs. It is unknown whether frailty plays a role ... ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) that range from mild to life-threatening. Age itself does not seem to be a predictor for the occurrence of irAEs. It is unknown whether frailty plays a role in the occurrence of irAEs. Therefore, the authors assessed whether irAEs and their sequelae occur more often in frail patients than in fit patients according to the Geriatric 8 (G8) assessment.
    Methods: Patients with melanoma aged 70 years and older who were about to start ICI therapy and were screened with the G8 assessment were enrolled in this prospective, observational study. Patients were classified by the G8 as either fit or frail. The primary outcome was the occurrence of grade ≥3 irAEs.
    Results: In total, 92 patients were included for statistical analyses, 26 (29%) of whom were classified as frail. Grade ≥3 irAEs occurred in 20% of patients. There was no significant difference in the occurrence of grade ≥3 irAEs between fit and frail patients (17% vs 27%; P = .26). Frail patients were admitted to the hospital because of irAEs significantly more often than fit patients (29% vs 54%; P = .02) and showed a trend toward increased length of hospitalization (5 vs 8 days; P = .06) and more frequent use of immunosuppressants or ICI discontinuation for irAEs (36% vs 58%; P = .06).
    Conclusions: Although frailty appears to be unrelated to the occurrence of severe irAEs, it is an indicator of irAE-related adverse sequelae, such as hospital admission. Screening for frailty can be of added value in the shared decision-making process for older patients who qualify for ICI treatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/adverse effects ; Frailty/chemically induced ; Hospitalization ; Humans ; Melanoma/chemically induced ; Melanoma/drug therapy ; Prospective Studies ; Retrospective Studies
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Living in the twilight zone: a qualitative study on the experiences of patients with advanced cancer obtaining long-term response to immunotherapy or targeted therapy.

    Zwanenburg, Laura C / Suijkerbuijk, Karijn P M / van Dongen, Sophie I / Koldenhof, José J / van Roozendaal, Anne S / van der Lee, Marije L / Schellekens, Melanie P J

    Journal of cancer survivorship : research and practice

    2022  Volume 18, Issue 3, Page(s) 750–760

    Abstract: Purpose: The introduction of immunotherapy and targeted therapy has drastically improved the life expectancy of patients with advanced cancer. Despite improved survival, obtaining long-term response can be highly distressing and comes with uncertainties ...

    Abstract Purpose: The introduction of immunotherapy and targeted therapy has drastically improved the life expectancy of patients with advanced cancer. Despite improved survival, obtaining long-term response can be highly distressing and comes with uncertainties that affect several life domains. The aim of this study is to gain a deeper understanding of long-term responders' lived experiences with obtaining long-term response to immunotherapy or targeted therapy.
    Methods: We conducted an exploratory qualitative study using thematic data analysis. Semi-structured in-depth interviews were conducted with 17 patients with advanced melanoma or lung cancer who had a confirmed response to or long-term stable disease while on immunotherapy or targeted therapy.
    Results: Long-term responders are living in a twilight zone, where they neither feel like a patient, nor feel healthy. This impacts their self-image, interactions with their social environment, and feelings of uncertainty. Due to their uncertain life perspective, long-term responders are going back and forth between hope and despair, while they are longing for their 'old' life, several barriers, such as protective behavior of the social environment, force them to adjust to a life with cancer.
    Conclusion: Long-term responders are facing many challenges, such as searching for a renewed identity, dealing with ongoing uncertainty, and having to adapt to a new normal. This emphasizes the importance of providing this new patient group with tailored information and support.
    Implications for cancer survivors: Healthcare professionals can support patients by normalizing their feelings and providing space for varying emotions. Using patient-tailored scan frequencies could help temper fear of progression.
    MeSH term(s) Humans ; Qualitative Research ; Female ; Male ; Middle Aged ; Immunotherapy ; Aged ; Neoplasms/therapy ; Neoplasms/psychology ; Adult ; Molecular Targeted Therapy ; Quality of Life ; Cancer Survivors/psychology ; Lung Neoplasms/therapy ; Lung Neoplasms/psychology ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Adaptation, Psychological
    Language English
    Publishing date 2022-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-022-01306-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Predictive value of each geriatric assessment domain for older patients with cancer: A systematic review.

    Bruijnen, Cheryl P / van Harten-Krouwel, Diny G / Koldenhof, José J / Emmelot-Vonk, Mariëlle H / Witteveen, Petronella O

    Journal of geriatric oncology

    2019  Volume 10, Issue 6, Page(s) 859–873

    Abstract: Background: A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric ... ...

    Abstract Background: A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015. Therefore, the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA.
    Methods: A systematic literature search was performed for publications in English or Dutch between September 2006 and July 2017 addressing the association between individual domains of the GA and mortality, postoperative complications, or systemic treatment-related outcomes in older patients with cancer.
    Results: Eight different domains were evaluated in 46 publications, namely functional status, nutritional status, cognition, mood, physical function, fatigue, social support, and falls. All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies. Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes, and the domain physical function was most often associated with postoperative complications.
    Conclusion: Overall, this review demonstrates that the GA should minimally consist of physical function and nutritional status, when the aim is to predict patients-related outcomes of older patients with cancer, although the results are quite heterogeneous. For the other domains, the findings are too inconsistent to draw conclusions about their overall predictive ability.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Geriatric Assessment/methods ; Geriatrics/methods ; Humans ; Male ; Medical Oncology/methods ; Neoplasms/mortality ; Neoplasms/therapy ; Nutritional Status ; Outcome Assessment, Health Care ; Physical Functional Performance ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2019-03-27
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2019.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cerebrospinal fluid lymphocytosis: a hallmark of neurological complications during checkpoint inhibition.

    Tonk, Erwin H J / Snijders, Tom J / Koldenhof, José J / van Lindert, Anne S R / Suijkerbuijk, Karijn P M

    European journal of cancer (Oxford, England : 1990)

    2019  Volume 121, Page(s) 1–3

    MeSH term(s) Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/immunology ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Ipilimumab/administration & dosage ; Ipilimumab/adverse effects ; Lymphocytosis/cerebrospinal fluid ; Lymphocytosis/chemically induced ; Lymphocytosis/diagnosis ; Male ; Middle Aged ; Neoplasms/cerebrospinal fluid ; Neoplasms/drug therapy ; Neoplasms/pathology ; Nervous System Diseases/cerebrospinal fluid ; Nervous System Diseases/chemically induced ; Nervous System Diseases/diagnosis ; Neurotoxicity Syndromes/cerebrospinal fluid ; Neurotoxicity Syndromes/diagnosis ; Neurotoxicity Syndromes/etiology ; Nivolumab/administration & dosage ; Nivolumab/adverse effects ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; Ipilimumab ; Protein Kinase Inhibitors ; Nivolumab (31YO63LBSN) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2019-09-12
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2019.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  6. Article ; Online: Predicting Anxiety in Hospitalized Cancer Patients.

    van den Brekel, Lieke / van der Baan, Frederieke H / Zweers, Danielle / Koldenhof, José J / Vos, J Bernard H / de Graeff, Alexander / Witteveen, Petronella O / Teunissen, Saskia C C M

    Journal of pain and symptom management

    2020  Volume 60, Issue 3, Page(s) 522–530.e1

    Abstract: Context: Anxiety in patients with cancer is highly prevalent; yet it remains underestimated and inadequately assessed. Little is known about predictors for anxiety in hospitalized patients with cancer. Insight in predictors should improve recognition ... ...

    Abstract Context: Anxiety in patients with cancer is highly prevalent; yet it remains underestimated and inadequately assessed. Little is known about predictors for anxiety in hospitalized patients with cancer. Insight in predictors should improve recognition and enable a targeted approach.
    Objectives: To determine the prevalence of anxiety and predictors for anxiety in hospitalized patients with cancer at different stages of disease.
    Methods: A cross-sectional analysis of patients with cancer admitted to the Utrecht University Medical Center in 2015-2018 was conducted. The Utrecht Symptom Diary, an adapted Dutch version of the Edmonton Symptom Assessment System, was used to assess symptom burden on a numeric rating scale (0 = no symptom and 10 = worst possible symptom). Scores ≥4 were considered clinically relevant. All patients completed the Utrecht Symptom Diary as part of routine care. The first questionnaire after admission was selected. Using multivariable linear regression, the predictive value of potential predictors on anxiety was analyzed.
    Results: In total, 2144 patients were included, of which 22% reported clinically relevant anxiety. The prevalence of anxiety was highest (36%) in patients receiving symptom-directed palliation only. In the total group, female gender, younger age, depressed mood, sleeping problems, dyspnea, and cancer of the head and neck were predictive of anxiety. Throughout all stages of disease, depressed mood was consistently the strongest predictor.
    Conclusion: We found a high prevalence of anxiety in hospitalized patients with cancer. It is recommended to explore anxiety in hospitalized patients with cancer, in particular when they experience depressed mood. Structural use of a symptom diary during hospitalization facilitates the recognition of anxiety and concurrent symptoms.
    MeSH term(s) Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety Disorders ; Cross-Sectional Studies ; Female ; Humans ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Palliative Care
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2020.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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