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  1. Article ; Online: Connecting axons and dendrites: An oblique view.

    Jamann, Nora / Kole, Maarten H P

    Neuron

    2022  Volume 110, Issue 9, Page(s) 1438–1440

    Abstract: Cortical pyramidal neurons receive thousands of synaptic inputs and transform these into action potential output. In this issue of Neuron, Lafourcade et al. (2022) demonstrate that distinct long-range projections to retrosplenial cortex pyramidal neurons ...

    Abstract Cortical pyramidal neurons receive thousands of synaptic inputs and transform these into action potential output. In this issue of Neuron, Lafourcade et al. (2022) demonstrate that distinct long-range projections to retrosplenial cortex pyramidal neurons are coupled to diverse modes of dendritic integration.
    MeSH term(s) Action Potentials/physiology ; Axons/physiology ; Dendrites/physiology ; Neurons/physiology ; Pyramidal Cells/physiology
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  2. Article ; Online: Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes.

    Kole, Koen / Voesenek, Bas J B / Brinia, Maria E / Petersen, Naomi / Kole, Maarten H P

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 7598

    Abstract: Parvalbumin-expressing ( ... ...

    Abstract Parvalbumin-expressing (PV
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-35350-x
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  3. Article ; Online: Sodium channel endocytosis drives axon initial segment plasticity.

    Fréal, Amélie / Jamann, Nora / Ten Bos, Jolijn / Jansen, Jacqueline / Petersen, Naomi / Ligthart, Thijmen / Hoogenraad, Casper C / Kole, Maarten H P

    Science advances

    2023  Volume 9, Issue 37, Page(s) eadf3885

    Abstract: Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated ... ...

    Abstract Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated sodium channels, but the molecular mechanisms regulating their plasticity remain largely unknown. Here, we developed genetic tools to label endogenous sodium channels and their scaffolding protein, to reveal their nanoscale organization and longitudinally image AIS plasticity in hippocampal neurons in slices and primary cultures. We find that
    MeSH term(s) Axon Initial Segment ; Sodium Channels ; Action Potentials ; Cluster Analysis ; Endocytosis
    Chemical Substances Sodium Channels
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf3885
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  4. Article ; Online: Robust adaptive optics for localization microscopy deep in complex tissue.

    Siemons, Marijn E / Hanemaaijer, Naomi A K / Kole, Maarten H P / Kapitein, Lukas C

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 3407

    Abstract: Single-Molecule Localization Microscopy (SMLM) provides the ability to determine molecular organizations in cells at nanoscale resolution, but in complex biological tissues, where sample-induced aberrations hamper detection and localization, its ... ...

    Abstract Single-Molecule Localization Microscopy (SMLM) provides the ability to determine molecular organizations in cells at nanoscale resolution, but in complex biological tissues, where sample-induced aberrations hamper detection and localization, its application remains a challenge. Various adaptive optics approaches have been proposed to overcome these issues, but the exact performance of these methods has not been consistently established. Here we systematically compare the performance of existing methods using both simulations and experiments with standardized samples and find that they often provide limited correction or even introduce additional errors. Careful analysis of the reasons that underlie this limited success enabled us to develop an improved method, termed REALM (Robust and Effective Adaptive Optics in Localization Microscopy), which corrects aberrations of up to 1 rad RMS using 297 frames of blinking molecules to improve single-molecule localization. After its quantitative validation, we demonstrate that REALM enables to resolve the periodic organization of cytoskeletal spectrin of the axon initial segment even at 50 μm depth in brain tissue.
    MeSH term(s) Algorithms ; Animals ; Brain/pathology ; COS Cells ; Chlorocebus aethiops ; Microscopy, Fluorescence/instrumentation ; Optics and Photonics/methods ; Rats ; Single Molecule Imaging/instrumentation ; Single Molecule Imaging/methods ; Software
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23647-2
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  5. Book ; Thesis: CA3 pyramidal neuron correlates of stress response

    Kole, Maarten H. P.

    analyses of form and function

    2003  

    Author's details Maarten H. P. Kole
    Keywords Stressreaktion ; Hippocampus ; Pyramidenbahn ; Synaptische Erregungsübertragung ; Tiermodell
    Subject Vegetative Stressreaktion ; Stressverarbeitung ; Stress ; Physiologische Stressreaktion ; Stressantwort ; Erregungsübertragung ; Tractus corticospinalis ; Fasciculus pyramidalis ; Riechzentrum ; Olfactory center ; Hippokampus
    Language English
    Size 121 S. : Ill., graph. Darst., 24 cm
    Edition 1. Aufl.
    Publisher Cuvillier
    Publishing place Göttingen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Groningen, Univ., Diss., 2003
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT014656780
    ISBN 3-89873-898-1 ; 978-3-89873-898-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 1543 order for loan Magazin

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  6. Article ; Online: Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition.

    Dubey, Mohit / Pascual-Garcia, Maria / Helmes, Koke / Wever, Dennis D / Hamada, Mustafa S / Kushner, Steven A / Kole, Maarten H P

    eLife

    2022  Volume 11

    Abstract: Parvalbumin-positive ( ... ...

    Abstract Parvalbumin-positive (PV
    MeSH term(s) Animals ; Cerebral Cortex/physiology ; Female ; Interneurons/physiology ; Male ; Mice ; Myelin Sheath/metabolism ; Parvalbumins/metabolism ; Pyramidal Cells/physiology
    Chemical Substances Parvalbumins
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73827
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  7. Article ; Online: Experience shapes chandelier cell function and structure in the visual cortex.

    Seignette, Koen / Jamann, Nora / Papale, Paolo / Terra, Huub / Porneso, Ralph O / de Kraker, Leander / van der Togt, Chris / van der Aa, Maaike / Neering, Paul / Ruimschotel, Emma / Roelfsema, Pieter R / Montijn, Jorrit S / Self, Matthew W / Kole, Maarten H P / Levelt, Christiaan N

    eLife

    2024  Volume 12

    Abstract: Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we ... ...

    Abstract Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we found that V1 ChCs predominantly receive monosynaptic input from local layer 5 pyramidal cells and higher-order cortical regions. Two-photon calcium imaging and convolutional neural network modeling revealed that ChCs are visually responsive but weakly selective for stimulus content. In mice running in a virtual tunnel, ChCs respond strongly to events known to elicit arousal, including locomotion and visuomotor mismatch. Repeated exposure of the mice to the virtual tunnel was accompanied by reduced visual responses of ChCs and structural plasticity of ChC boutons and axon initial segment length. Finally, ChCs only weakly inhibited pyramidal cells. These findings suggest that ChCs provide an arousal-related signal to layer 2/3 pyramidal cells that may modulate their activity and/or gate plasticity of their axon initial segments during behaviorally relevant events.
    MeSH term(s) Animals ; Mice ; Neurons ; Pyramidal Cells ; Visual Cortex ; Interneurons ; Arousal
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91153
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  8. Article ; Online: First node of Ranvier facilitates high-frequency burst encoding.

    Kole, Maarten H P

    Neuron

    2011  Volume 71, Issue 4, Page(s) 671–682

    Abstract: In central neurons the first node of Ranvier is located at the first axonal branchpoint, ∼ 100 μm from the axon initial segment where synaptic inputs are integrated and converted into action potentials (APs). Whether the first node contributes to this ... ...

    Abstract In central neurons the first node of Ranvier is located at the first axonal branchpoint, ∼ 100 μm from the axon initial segment where synaptic inputs are integrated and converted into action potentials (APs). Whether the first node contributes to this signal transformation is not well understood. Here it was found that in neocortical layer 5 axons, the first branchpoint is required for intrinsic high-frequency (≥ 100 Hz) AP bursts. Furthermore, block of nodal Na(+) channels or axotomy of the first node in intrinsically bursting neurons depolarized the somatic AP voltage threshold (∼ 5 mV) and eliminated APs selectively within a high-frequency cluster in response to steady currents or simulated synaptic inputs. These results indicate that nodal persistent Na(+) current exerts an anterograde influence on AP initiation in the axon initial segment, revealing a computational role of the first node of Ranvier beyond conduction of the propagating AP.
    MeSH term(s) Action Potentials/physiology ; Animals ; Axons/physiology ; Axons/ultrastructure ; Axotomy ; Dendrites/physiology ; Dendrites/ultrastructure ; Male ; Neurons/physiology ; Neurons/ultrastructure ; Patch-Clamp Techniques ; Rats ; Rats, Wistar ; Sodium Channels/metabolism
    Chemical Substances Sodium Channels
    Language English
    Publishing date 2011-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2011.06.024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  9. Article: Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons.

    Hamada, Mustafa S / Popovic, Marko A / Kole, Maarten H P

    Frontiers in cellular neuroscience

    2017  Volume 11, Page(s) 45

    Abstract: In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will ...

    Abstract In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will need to reliably propagate over long distances and regions of geometrical inhomogeneity like branch points (BPs) to rapidly depolarize the presynaptic terminals and confer temporally precise synaptic transmission. While axon pathologies such as demyelinating diseases are well established to impede the fidelity of AP propagation along internodes, to which extent myelin loss affects propagation along BPs and axon collaterals is not well understood. Here, using the cuprizone demyelination model, we performed optical voltage-sensitive dye (VSD) imaging from control and demyelinated layer 5 pyramidal neuron axons. In the main axon, we find that myelin loss switches the modality of AP propagation from rapid saltation towards a slow continuous wave. The duration of single AP waveforms at BPs or nodes was, however, only slightly briefer. In contrast, by using two-photon microscopy-guided loose-seal patch recordings from axon collaterals we revealed a presynaptic AP broadening in combination with a reduced velocity and frequency-dependent failure. Finally, internodal myelin loss was also associated with
    Language English
    Publishing date 2017-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2017.00045
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  10. Article ; Online: Ultrastructural Axon-Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation.

    van den Bosch, Aletta M R / Hümmert, Sophie / Steyer, Anna / Ruhwedel, Torben / Hamann, Jörg / Smolders, Joost / Nave, Klaus-Armin / Stadelmann, Christine / Kole, Maarten H P / Möbius, Wiebke / Huitinga, Inge

    Annals of neurology

    2023  Volume 93, Issue 4, Page(s) 856–870

    Abstract: Objective: Changes in the normal-appearing white matter (NAWM) in multiple sclerosis (MS) may contribute to disease progression. Here, we systematically quantified ultrastructural and subcellular characteristics of the axon-myelin unit in MS NAWM and ... ...

    Abstract Objective: Changes in the normal-appearing white matter (NAWM) in multiple sclerosis (MS) may contribute to disease progression. Here, we systematically quantified ultrastructural and subcellular characteristics of the axon-myelin unit in MS NAWM and determined how this correlates with low-grade inflammation.
    Methods: Human brain tissue obtained with short postmortem delay and fixation at autopsy enables systematic quantification of ultrastructural characteristics. In this study, we performed high-resolution immunohis tochemistry and quantitative transmission electron microscopy to study inflammation and ultrastructural characteristics of the axon-myelin unit in MS NAWM (n = 8) and control white matter (WM) in the optic nerve.
    Results: In the MS NAWM, there were more activated and phagocytic microglia cells (HLA
    Interpretation: These data suggest that in MS NAWM myelin detachment and uncompact myelin wrapping occurs, potassium channels are unmasked at the nodes of Ranvier, and axonal energy demand is increased, or mitochondrial transport is stagnated, accompanied by increased presence of activated and phagocytic microglia and T cells. These subclinical alterations to the axon-myelin unit in MS NAWM may contribute to disease progression. ANN NEUROL 2023;93:856-870.
    MeSH term(s) Humans ; Multiple Sclerosis/complications ; Myelin Sheath ; Axons ; Brain ; White Matter ; Inflammation/complications ; Disease Progression ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26585
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    Zs.MO 478: Show issues

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