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  1. Article ; Online: Disseminated and penile mpox with histopathologic correlation: Two separate case reports.

    Koh, Stephen S / Youssef, Sherry M / Baghchechi, Mohsen / Chang, Crystal T / Kolev, Johann / Shay, Anthony C / Lau, Sean K / Cassarino, David S

    Journal of cutaneous pathology

    2023  Volume 50, Issue 10, Page(s) 873–877

    Abstract: The 2022-2023 mpox outbreak is a global worldwide concern, especially since the virus was previously mainly localized regionally in Central and West Africa. The infection is typically self-limiting and transmitted by close contact/exposure with infected ... ...

    Abstract The 2022-2023 mpox outbreak is a global worldwide concern, especially since the virus was previously mainly localized regionally in Central and West Africa. The infection is typically self-limiting and transmitted by close contact/exposure with infected material. Recent cases have been known to present atypically without prodromal symptoms and initially with skin lesions. The histopathology of mpox lesions is rarely reported. Here, we present two middle-aged males presenting initially with painless skin lesions confirmed for mpox by nucleic acid amplification assay. Skin biopsies of the lesion were available for clinicopathologic correlation. Histopathology demonstrated ulceration with viral cytopathologic changes.
    MeSH term(s) Male ; Middle Aged ; Humans ; Mpox (monkeypox) ; Biopsy ; Cytology
    Language English
    Publishing date 2023-07-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1043: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Real-World Impact of the Accelerate PhenoTest BC Kit on Patients With Bloodstream Infections in the Improving Outcomes and Antimicrobial Stewardship Study: A Quasiexperimental Multicenter Study.

    Bhalodi, Amira A / MacVane, Shawn H / Ford, Bradley / Ince, Dilek / Kinn, Patrick M / Percival, Kelly M / Bremmer, Derek N / Carr, Dustin R / Walsh, Thomas L / Bhatti, Micah M / Shelburne, Samuel A / Humphries, Romney M / Wolfe, Kaleb / Rosenbaum, Eric R / Dare, Ryan K / Kolev, Johann / Madhusudhan, Meghan / Ben-Aderet, Michael A / Morgan, Margie A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 75, Issue 2, Page(s) 269–277

    Abstract: Background: Bloodstream infections (BSIs) are a leading cause of morbidity and mortality. The Improving Outcomes and Antimicrobial Stewardship study seeks to evaluate the impact of the Accelerate PhenoTest BC Kit (AXDX) on antimicrobial use and clinical ...

    Abstract Background: Bloodstream infections (BSIs) are a leading cause of morbidity and mortality. The Improving Outcomes and Antimicrobial Stewardship study seeks to evaluate the impact of the Accelerate PhenoTest BC Kit (AXDX) on antimicrobial use and clinical outcomes in BSIs.
    Methods: This multicenter, quasiexperimental study compared clinical and antimicrobial stewardship metrics, prior to and after implementation of AXDX, to evaluate the impact this technology has on patients with BSIs. Laboratory and clinical data from hospitalized patients with BSIs (excluding contaminants) were compared between 2 arms, 1 that underwent testing on AXDX (post-AXDX) and 1 that underwent alternative organism identification and susceptibility testing (pre-AXDX). The primary outcomes were time to optimal therapy (TTOT) and 30-day mortality.
    Results: A total of 854 patients with BSIs (435 pre-AXDX, 419 post-AXDX) were included. Median TTOT was 17.2 hours shorter in the post-AXDX arm (23.7 hours) compared with the pre-AXDX arm (40.9 hours; P<.0001). Compared with pre-AXDX, median time to first antimicrobial modification (24.2 vs 13.9 hours; P<.0001) and first antimicrobial deescalation (36.0 vs 27.2 hours; P=.0004) were shorter in the post-AXDX arm. Mortality (8.7% pre-AXDX vs 6.0% post-AXDX), length of stay (7.0 pre-AXDX vs 6.5 days post-AXDX), and adverse drug events were not significantly different between arms. Length of stay was shorter in the post-AXDX arm (5.4 vs 6.4 days; P=.03) among patients with gram-negative bacteremia.
    Conclusions: For BSIs, use of AXDX was associated with significant decreases in TTOT, first antimicrobial modification, and time to antimicrobial deescalation.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Antimicrobial Stewardship ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Gram-Negative Bacterial Infections/drug therapy ; Humans
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  3. Article ; Online: Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

    Javvadi, Prashanthi / Hertan, Lauren / Kosoff, Rachelle / Datta, Tatini / Kolev, Johann / Mick, Rosemarie / Tuttle, Stephen W / Koumenis, Constantinos

    Cancer research

    2010  Volume 70, Issue 5, Page(s) 1941–1950

    Abstract: Curcumin, a plant polyphenol, is a widely studied chemopreventive agent with demonstrated antitumor activities in preclinical studies and low toxicity profiles in multiple clinical trials against human malignancies. We previously showed that curcumin ... ...

    Abstract Curcumin, a plant polyphenol, is a widely studied chemopreventive agent with demonstrated antitumor activities in preclinical studies and low toxicity profiles in multiple clinical trials against human malignancies. We previously showed that curcumin radiosensitizes cervical tumor cells without increasing the cytotoxic effects of radiation on normal human fibroblasts. Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells. Stable knockdown of TxnRd1 in both HeLa and FaDu cells nearly abolished curcumin-mediated radiosensitization. TxnRd1 knockdown cells showed decreased radiation-induced reactive oxygen species and sustained extracellular signal-regulated kinase 1/2 activation, which we previously showed was required for curcumin-mediated radiosensitization. Conversely, overexpressing catalytically active TxnRd1 in HEK293 cells, with low basal levels of TxnRd1, increased their sensitivity to curcumin alone and to the combination of curcumin and ionizing radiation. These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/radiotherapy ; Cell Transformation, Neoplastic/metabolism ; Curcumin/pharmacology ; Enzyme Activation ; Gene Knockdown Techniques ; HeLa Cells ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Radiation-Sensitizing Agents/pharmacology ; Reactive Oxygen Species/metabolism ; Thioredoxin Reductase 1/antagonists & inhibitors ; Thioredoxin Reductase 1/biosynthesis ; Thioredoxin Reductase 1/deficiency ; Thioredoxin Reductase 1/genetics
    Chemical Substances Antineoplastic Agents ; Radiation-Sensitizing Agents ; Reactive Oxygen Species ; TXNRD1 protein, human (EC 1.8.1.9) ; Thioredoxin Reductase 1 (EC 1.8.1.9) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2010-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-09-3025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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