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  1. Article ; Online: Strengthening neurosurgical care for patients with severe traumatic brain injury: Authors' reply.

    Clark, David / Joannides, Alexis / Kolias, Angelos / Hutchinson, Peter

    The Lancet. Neurology

    2022  Volume 21, Issue 10, Page(s) 871–872

    MeSH term(s) Brain Injuries, Traumatic/surgery ; Glasgow Coma Scale ; Humans
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00355-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
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  2. Article ; Online: Meeting the need: capacity building and social responsibility in neurosurgery.

    Lippa, Laura / Kolias, Angelos

    Acta neurochirurgica

    2020  Volume 162, Issue 5, Page(s) 983–984

    MeSH term(s) Africa South of the Sahara ; Capacity Building ; Neurosurgery ; Social Responsibility ; Sweden
    Language English
    Publishing date 2020-03-13
    Publishing country Austria
    Document type Editorial ; Comment
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-020-04285-x
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  3. Article ; Online: Dexamethasone should not be given to people with a chronic subdural haematoma.

    Saul, Helen / Gursul, Deniz / Cassidy, Samantha / Hutchinson, Peter / Kolias, Angelos

    BMJ (Clinical research ed.)

    2022  Volume 377, Page(s) o1302

    Abstract: The studyHutchinson P, Edlmann E, Bulters D, et al. Trial of dexamethasone for chronic subdural haematoma. ...

    Abstract The studyHutchinson P, Edlmann E, Bulters D, et al. Trial of dexamethasone for chronic subdural haematoma.
    MeSH term(s) Dexamethasone/adverse effects ; Hematoma, Subdural, Chronic/drug therapy ; Humans
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o1302
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  4. Article ; Online: Towards a core outcome set for cranioplasty following traumatic brain injury and stroke 'A systematic review of reported outcomes'.

    Mee, H / Castano Leon, A / Anwar, F / Grieve, K / Owen, N / Turner, C / Whiting, G / Viaroli, E / Timofeev, I / Helmy, A / Kolias, A / Hutchinson, P

    Brain & spine

    2023  Volume 3, Page(s) 101735

    Abstract: Background: There is wide-ranging published literature around cranioplasty following traumatic brain injury (TBI) and stroke, but the heterogeneity of outcomes limits the ability for meta-analysis. Consensus on appropriate outcome measures has not been ... ...

    Abstract Background: There is wide-ranging published literature around cranioplasty following traumatic brain injury (TBI) and stroke, but the heterogeneity of outcomes limits the ability for meta-analysis. Consensus on appropriate outcome measures has not been reached, and given the clinical and research interest, a core outcome set (COS) would be beneficial.
    Objectives: To collate outcomes currently reported across the cranioplasty literature which will subsequently be used in developing a cranioplasty COS.
    Methods: This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. All full-text English studies with more than ten patients (prospective) or more than 20 patients (retrospective) published after 1990 examining outcomes in CP were eligible for inclusion.
    Results: The review included 205 studies from which 202 verbatim outcomes were extracted, grouped into 52 domains, and categorised into one or more of the OMERACT 2.0 framework core area(s). The total numbers of studies that reported outcomes in the core areas are 192 (94%) pathophysiological manifestations/ 114 (56%) resource use/economic impact/ 94 (46%) life impact/mortality 20 (10%). In addition, there are 61 outcome measures used in the 205 studies across all domains.
    Conclusion: This study shows considerable heterogeneity in the types of outcomes used across the cranioplasty literature, demonstrating the importance and necessity of developing a COS to help standardise reporting across the literature.
    Language English
    Publishing date 2023-05-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2023.101735
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  5. Article: External Hydrocephalus After Traumatic Brain Injury: Retrospective Study of 102 Patients.

    Gergelé, Laurent / Manet, Romain / Kolias, A / Czosnyka, Marek / Lalou, A / Smielewski, Peter / Hutchinson, Peter J / Czosnyka, Zofia H

    Acta neurochirurgica. Supplement

    2021  Volume 131, Page(s) 35–38

    Abstract: Introduction: External hydrocephalus (EH) refers to impairment of extra-axial cerebrospinal fluid flow with enlargement of the subarachnoid space (SAS) and concomitant raised intracranial pressure (ICP). It is often confused with a subdural hygroma and ... ...

    Abstract Introduction: External hydrocephalus (EH) refers to impairment of extra-axial cerebrospinal fluid flow with enlargement of the subarachnoid space (SAS) and concomitant raised intracranial pressure (ICP). It is often confused with a subdural hygroma and overlooked, particularly when there is no ventricular enlargement. In this study, we aimed to describe the epidemiology of EH in a large population of adults with traumatic brain injury (TBI).
    Methods: This observational, retrospective cohort study was conducted in adult patients who were admitted with TBI to the Department of Clinical Neuroscience at Addenbrooke's Hospital (Cambridge, UK) over a period of 3 years (2014-2017). Patients were included in the study if they had ICP monitoring and at least three CT scans within the first 21 days to assess SAS evolution. Patients who underwent a decompressive craniectomy were excluded. SAS was assessed individually on each CT scan by two independent investigators. ICP data were analysed with ICM+ software (Cambridge Enterprise Ltd., Cambridge, UK). Short-term and 6-month outcomes were examined. The groups of patients with and without EH were compared.
    Results: Of the 102 patients included in the study, 30.4% developed EH after a delay of 2.98 ± 2.4 days. The initial Glasgow Coma Scale (GCS) scores did not differ between patients with and without EH. Subarachnoid haemorrhage was found to be the main risk factor for EH. Patients with EH required a significantly longer period of mechanical ventilation (+6.9 days), were more likely to have a tracheostomy (55% versus 33%), and had a longer stay in the intensive care unit (+8.5 days). ICP was higher during the 48 h after diagnosis of EH than during the previous 48 h. EH survivors had a lower mean Glasgow Outcome Scale Extended (GOS-E) score (4.6 versus 5.9, P = 0.031) and were more likely to receive a permanent shunt for secondary hydrocephalus (17.4% versus 1.8%, odds ratio 7.1).
    Conclusion: In adults with TBI, EH remains insufficiently understood and probably underdiagnosed. This study showed that it is a frequent complication of TBI, with significant clinical consequences.
    MeSH term(s) Adult ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/epidemiology ; Decompressive Craniectomy ; Glasgow Coma Scale ; Humans ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/epidemiology ; Hydrocephalus/etiology ; Intracranial Hypertension/surgery ; Intracranial Pressure ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-04-09
    Publishing country Austria
    Document type Journal Article
    ISSN 0065-1419
    ISSN 0065-1419
    DOI 10.1007/978-3-030-59436-7_8
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  6. Article ; Online: Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing De Novo and Transformational Origins.

    Edlmann, Ellie / Whitfield, Peter C / Kolias, Angelos / Hutchinson, Peter J

    Journal of neurotrauma

    2021  Volume 38, Issue 18, Page(s) 2580–2589

    Abstract: Chronic subdural hematoma (CSDH) is a common neurosurgical pathology, yet conflicting opinions exist concerning the pathophysiological processes involved. Many consider CSDH a product of an aged acute subdural hematoma (ASDH) secondary to trauma. Serial ... ...

    Abstract Chronic subdural hematoma (CSDH) is a common neurosurgical pathology, yet conflicting opinions exist concerning the pathophysiological processes involved. Many consider CSDH a product of an aged acute subdural hematoma (ASDH) secondary to trauma. Serial imaging, however, has demonstrated CSDH formation in patients without any initial ASDH. To understand the relevance of acute hemorrhage in a cohort of patients with CSDH, transformation from an ASDH were categorized as CSDH-acute transformed (CSDH-AT) and those without any acute hemorrhage at the outset as CSDH-
    MeSH term(s) Aged ; Aged, 80 and over ; Atrophy ; Brain/pathology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Cohort Studies ; Disease Progression ; Female ; Hematoma, Subdural, Chronic/diagnostic imaging ; Hematoma, Subdural, Chronic/etiology ; Humans ; Kaplan-Meier Estimate ; Male ; Retrospective Studies ; Subdural Effusion/complications ; Subdural Effusion/diagnostic imaging ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2020.7574
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2016: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: In Reply: Operationalizing Global Neurosurgery Research in Neurosurgical Journals.

    Servadei, Franco / Cannizzaro, Delia / Thango, Nqobile / Kolias, Angelos / Hutchinson, Peter / Esene, Ignatius / Rubiano, Andres

    Neurosurgery

    2022  Volume 90, Issue 6, Page(s) e195–e196

    MeSH term(s) Bibliometrics ; Humans ; Neurosurgery ; Neurosurgical Procedures ; Periodicals as Topic
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002002
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  8. Article: Predictors of Cerebrospinal Fluid Leak Following Dural Repair in Spinal Intradural Surgery.

    Jiang, Lei / Budu, Alexandru / Khan, Muhammad Shuaib / Goacher, Edward / Kolias, Angelos / Trivedi, Rikin / Francis, Jibin

    Neurospine

    2023  Volume 20, Issue 3, Page(s) 783–789

    Abstract: Objective: We aim to compare the effectiveness of dural closure techniques in preventing cerebrospinal fluid (CSF) leaks following surgery for intradural lesions and seek to identify additional factors associated with CSF leaks. Surgical management of ... ...

    Abstract Objective: We aim to compare the effectiveness of dural closure techniques in preventing cerebrospinal fluid (CSF) leaks following surgery for intradural lesions and seek to identify additional factors associated with CSF leaks. Surgical management of spinal intradural lesions involves durotomy which requires a robust repair to prevent postoperative CSF leakage. The ideal method of dural closure and the efficacy of sealants has not been established in literature.
    Methods: We performed a retrospective analysis of all intradural spinal cases performed at a tertiary spine centre from 1 April 2015 to 29 January 2020 and collected data on patient bio-profile, dural repair technique, and CSF leak rates. Multivariate analysis was performed to identify predictors for postoperative CSF leak.
    Results: A total of 169 cases were reported during the study period. There were 15 cases in which postoperative CSF leak was reported (8.87%). Multivariate analysis demonstrated that patient age (odds ratio [OR], 0.942; 95% confidence interval [CI], 0.891-0.996), surgical indication listed in the "others" category (OR, 44.608; 95% CI, 1.706-166.290) and dural closure with suture, sealant and patch (OR, 22.235; 95% CI, 2.578-191.798) were factors associated with CSF leak. Postoperative CSF leak was associated with the risk of surgical site infection with a likelihood ratio of 8.704 (χ² (1) = 14.633, p < 0.001).
    Conclusion: Identifying predictors for CSF leaks can assist in the counselling of patients with regard to surgical risk and expected postoperative recovery.
    Language English
    Publishing date 2023-09-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2346432.216
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  9. Article ; Online: Is dementia more likely following traumatic brain injury? A systematic review.

    Hanrahan, John Gerrard / Burford, Charlotte / Nagappan, Palani / Adegboyega, Gideon / Rajkumar, Shivani / Kolias, Angelos / Helmy, Adel / Hutchinson, Peter John

    Journal of neurology

    2023  Volume 270, Issue 6, Page(s) 3022–3051

    Abstract: Background: The association between traumatic brain injury (TBI) and dementia is controversial, and of growing importance considering the ageing demography of TBI.: Objective: To review the scope and quality of the existing literature investigating ... ...

    Abstract Background: The association between traumatic brain injury (TBI) and dementia is controversial, and of growing importance considering the ageing demography of TBI.
    Objective: To review the scope and quality of the existing literature investigating the relationship between TBI and dementia.
    Methods: We conducted a systematic review following PRISMA guidelines. Studies that compared TBI exposure and dementia risk were included. Studies were formally assessed for quality with a validated quality-assessment tool.
    Results: 44 studies were included in the final analysis. 75% (n = 33) were cohort studies and data collection was predominantly retrospective (n = 30, 66.7%). 25 studies (56.8%) found a positive relationship between TBI and dementia. Clearly defined and valid measures of assessing TBI history were lacking (case-control studies-88.9%, cohort studies-52.9%). Most studies failed to justify a sample size (case-control studies-77.8%, cohort studies-91.2%), blind assessors to exposure (case-control-66.7%) or blind assessors to exposure status (cohort-3.00%). Studies that identified a relationship between TBI and dementia had a longer median follow-up time (120 months vs 48 months, p = 0.022) and were more likely to use validated TBI definitions (p = 0.01). Studies which clearly defined TBI exposure (p = 0.013) and accounted for TBI severity (p = 0.036) were also more likely to identify an association between TBI and dementia. There was no consensus method by which studies diagnosed dementia and neuropathological confirmation was only available in 15.5% of studies.
    Conclusions: Our review suggests a relationship between TBI and dementia, but we are unable to predict the risk of dementia for an individual following TBI. Our conclusions are limited by heterogeneity in both exposure and outcome reporting and by poor study quality. Future studies should; (a) use validated methods to define TBI, accounting for TBI severity; (b) follow consensus agreement on criteria for dementia diagnosis; and (c) undertake follow-up that is both longitudinal, to determine if there is a progressive neurodegenerative change or static post-traumatic deficit, and of sufficient duration.
    MeSH term(s) Humans ; Retrospective Studies ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/epidemiology ; Cohort Studies ; Case-Control Studies ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/etiology
    Language English
    Publishing date 2023-02-22
    Publishing country Germany
    Document type Systematic Review ; Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-023-11614-4
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  10. Article ; Online: Correction: Intracranial pressure: current perspectives on physiology and monitoring.

    Hawryluk, Gregory W J / Citerio, Giuseppe / Hutchinson, Peter / Kolias, Angelos / Meyfroidt, Geert / Robba, Chiara / Stocchetti, Nino / Chesnut, Randall

    Intensive care medicine

    2023  Volume 49, Issue 3, Page(s) 384

    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-06977-1
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