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  1. Article ; Online: Secukinumab treatment of hidradenitis suppurativa: questions remain.

    Maul, Julia-Tatjana / Kolios, Antonios G A / Thomsen, Simon Francis / Ring, Hans Christian

    Lancet (London, England)

    2024  Volume 403, Issue 10427, Page(s) 616–617

    MeSH term(s) Humans ; Hidradenitis Suppurativa/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Severity of Illness Index
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01616-1
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  2. Article ; Online: Regulatory T cells in young transgender people give clues to the pathogenesis of lupus.

    Kolios, Antonios G A / Tsokos, George C

    The Lancet. Rheumatology

    2022  Volume 4, Issue 10, Page(s) e652–e654

    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Transgender Persons
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00254-5
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  3. Article ; Online: Interleukin-2 and regulatory T cells in rheumatic diseases.

    Kolios, Antonios G A / Tsokos, George C / Klatzmann, David

    Nature reviews. Rheumatology

    2021  Volume 17, Issue 12, Page(s) 749–766

    Abstract: Failure of regulatory T ( ... ...

    Abstract Failure of regulatory T (T
    MeSH term(s) Humans ; Interleukin-2/therapeutic use ; Rheumatic Diseases/therapy ; T-Lymphocytes, Regulatory
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-021-00707-x
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  4. Article ; Online: Skin-kidney crosstalk in SLE.

    Kolios, Antonios G A / Tsokos, George C

    Nature reviews. Rheumatology

    2021  Volume 17, Issue 5, Page(s) 253–254

    MeSH term(s) Humans ; Kidney ; Lupus Erythematosus, Systemic ; Skin
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-021-00588-0
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  5. Article ; Online: New therapeutic approaches in systemic lupus erythematosus.

    Kolios, Antonios G A / Yoshida, Nobuya / Tsokos, George C

    Current opinion in rheumatology

    2020  Volume 33, Issue 2, Page(s) 181–189

    Abstract: Purpose of review: This review gives an overview of the recently published clinical trials in systemic lupus erythematosus (SLE).: Recent findings: Our continuously improving understanding of the cellular and molecular mechanisms, which are involved ... ...

    Abstract Purpose of review: This review gives an overview of the recently published clinical trials in systemic lupus erythematosus (SLE).
    Recent findings: Our continuously improving understanding of the cellular and molecular mechanisms, which are involved in the pathogenesis of SLE, has inspired the performance of multiple clinical trials in an attempt to modify recognized targets. Here, we summarize results obtained from recent trials, which used monoclonal antibodies blocking cytokines, blockers of costimulatory molecules or deleting immune cells, small drug inhibitors of kinases and replenishment of cytokines.
    Summary: The therapeutic options for patients with SLE grow continuously and in parallel it raises the need for pathogenetic mechanism-based precision medicine so that we may select the right treatment for the right patient.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Cytokines ; Humans ; Lupus Erythematosus, Systemic/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Cytokines
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000772
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  6. Article: A Novel Heterozygous Desmoplakin Variant Causes Cardiocutaneous Syndrome with Arrhythmogenic Cardiomyopathy and Palmoplantar Keratosis.

    Çimen, Tolga / Medeiros-Domingo, Argelia / Kolios, Antonios / Akdiş, Deniz / Anwer, Shehab / Tanner, Felix C / Brunckhorst, Corinna / Duru, Firat / Saguner, Ardan M

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Cardiocutaneous syndrome (CCS) is often caused by genetic variants in desmoplakin ( ...

    Abstract Cardiocutaneous syndrome (CCS) is often caused by genetic variants in desmoplakin (
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030913
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  7. Article: Psoriasis - effiziente Diagnose und Therapie.

    Kolios, Antonios G A / Cozzio, Antonio

    Praxis

    2016  Volume 105, Issue 16, Page(s) 953–959

    MeSH term(s) Biopsy ; Combined Modality Therapy ; Comorbidity ; Humans ; Psoriasis/diagnosis ; Psoriasis/pathology ; Psoriasis/therapy ; Skin/pathology
    Language German
    Publishing date 2016-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a002435
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  8. Article: Unerwünschte Arzneimittelwirkungen: So reagiert die Haut

    Kolios, Antonios

    Der Allgemeinarzt

    2012  Volume 34, Issue 16, Page(s) 44

    Language German
    Document type Article
    ZDB-ID 603653-3
    ISSN 0172-7249
    Database Current Contents Medicine

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  9. Article ; Online: The prevalence of obstructive sleep apnea in sarcoidosis and its impact on sleepiness, fatigue, and sleep-associated quality of life: a cross-sectional study with matched controls (the OSASA study).

    Roeder, Maurice / Sievi, Noriane A / Schneider, Alexandra / Osswald, Martin / Malesevic, Stefan / Kolios, Antonios / Nilsson, Jakob / Kohler, Malcolm / Franzen, Daniel

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2022  Volume 18, Issue 10, Page(s) 2415–2422

    Abstract: Study objectives: Patients with sarcoidosis experience fatigue and excessive daytime sleepiness (EDS). However, the underlying pathomechanism is unclear. Studies suggested undiagnosed obstructive sleep apnea (OSA) to be an important contributor, but ... ...

    Abstract Study objectives: Patients with sarcoidosis experience fatigue and excessive daytime sleepiness (EDS). However, the underlying pathomechanism is unclear. Studies suggested undiagnosed obstructive sleep apnea (OSA) to be an important contributor, but reliable data on prevalence and impact of OSA in sarcoidosis are scarce.
    Methods: 71 adult patients with sarcoidosis, 1-to-1 matched to 71 adult controls according to sex, age, and body mass index were included. Participants underwent structured interviews (including Epworth Sleepiness Scale [ESS], Fatigue Assessment Scale [FAS], and Functional Outcome of Sleep Questionnaire [FOSQ-30]) and level-3 respiratory polygraphy. OSA was defined as apnea-hypopnea index ≥ 5 events/h. Prevalence of OSA was assessed and possible risk factors for OSA in sarcoidosis were investigated.
    Results: Mild OSA (AHI ≥ 5 events/h) was prevalent in 32 (45%) sarcoidosis patients vs 22 (31%) controls (
    Conclusions: The risk for mild OSA is 2.5-fold higher in sarcoidosis patients compared with matched controls. OSA seems not to be the reason for increased sleepiness or fatigue in sarcoidosis. Risk factors such as body mass index, sex, neck circumference, and NoSAS score can be used to screen for OSA in sarcoidosis patients.
    Clinical trial registration: Registry: ClinicalTrials.gov; Name: Obstructive Sleep Apnoea in Sarcoidosis (OSASA); URL: https://clinicaltrials.gov/ct2/history/NCT04156789?V_2=View; Identifier: NCT04156789.
    Citation: Roeder M, Sievi NA, Schneider A, et al. The prevalence of obstructive sleep apnea in sarcoidosis and its impact on sleepiness, fatigue, and sleep-associated quality of life: a cross-sectional study with matched controls (the OSASA study).
    MeSH term(s) Adult ; Cross-Sectional Studies ; Disorders of Excessive Somnolence/diagnosis ; Fatigue/complications ; Humans ; Prevalence ; Quality of Life ; Sarcoidosis/complications ; Sarcoidosis/epidemiology ; Sleep ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Sleepiness
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10140
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  10. Article ; Online: Therapeutic potential of interleukin-2 in autoimmune diseases.

    Yuan, Yeshuang / Kolios, Antonios G A / Liu, Yudong / Zhang, Bo / Li, Hao / Tsokos, George C / Zhang, Xuan

    Trends in molecular medicine

    2022  Volume 28, Issue 7, Page(s) 596–612

    Abstract: Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in the immune system. Therefore, restoration of the immune balance represents a promising therapeutic target in autoimmune diseases. Interleukin-2 (IL-2) can promote ... ...

    Abstract Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in the immune system. Therefore, restoration of the immune balance represents a promising therapeutic target in autoimmune diseases. Interleukin-2 (IL-2) can promote the expansion and differentiation of different immune cell subsets dose-dependently. At high doses, IL-2 can promote the differentiation and expansion of effector and memory T cells, whereas at low doses, IL-2 can promote the differentiation, survival, and function of regulatory T (T
    MeSH term(s) Autoimmune Diseases ; Humans ; Immune Tolerance ; Interleukin-2/pharmacology ; Interleukin-2/therapeutic use ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.04.010
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