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Article: Clovamide and Its Derivatives-Bioactive Components of

Kolodziejczyk-Czepas, Joanna

2024 Volume 13, Issue 7

Abstract: Clovamide ( ...

Abstract	Clovamide (
Language	English
Publishing date	2024-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13071118
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Article ; Online: Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity-A Review.

Kolodziejczyk-Czepas, Joanna / Czepas, Jan

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin, responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are also involved in many other physiological and pathological ... ...

Abstract	Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin, responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are also involved in many other physiological and pathological processes, including immune response, extracellular matrix degradation, cell migration, and tissue remodeling. Both the impaired and enhanced activity of fibrinolytic proteins may result in serious physiological consequences: prothrombotic state or excessive bleeding, respectively. However, current medicine offers very few options for treating fibrinolytic disorders, particularly in the case of plasmin inhibition. Although numerous attempts have been undertaken to identify natural or to develop engineered fibrinolytic system modulators, structural similarities within serine proteases of the hemostatic system and pleiotropic activity of fibrinolytic proteins constitute a serious problem in discovering anti- or profibrinolytic agents that could precisely affect the target molecules and reduce the risk of side effects. Therefore, this review aims to present a current knowledge of various classes of natural inhibitors and stimulators of the fibrinolytic system being well-defined low-molecular plant secondary metabolites or constituents of plant extracts as well as plant peptides. This work also discusses obstacles caused by low specificity of most of natural compounds and, hence, outlines recent trends in studies aimed at finding more efficient modulators of plasmin activity, including investigation of modifications of natural pharmacophore templates.
MeSH term(s)	Fibrinolysin ; Fibrinolysis ; Serine Endopeptidases ; Hemostasis ; Phytochemicals/pharmacology
Chemical Substances	Fibrinolysin (EC 3.4.21.7) ; Serine Endopeptidases (EC 3.4.21.-) ; Phytochemicals
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041677
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Article ; Online: A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors-A Special Emphasis on Anti-Obesity Action.

Liudvytska, Oleksandra / Kolodziejczyk-Czepas, Joanna

Nutrients

2022 Volume 14, Issue 10

Abstract: The currently available anti-obesity therapies encounter many associated risks and side effects often causing the ineffectiveness of treatment. Therefore, various plant-derived substances have been extensively studied as a promising support or even an ... ...

Abstract	The currently available anti-obesity therapies encounter many associated risks and side effects often causing the ineffectiveness of treatment. Therefore, various plant-derived substances have been extensively studied as a promising support or even an alternative for existing anti-obesity therapies. This review is dealing with the anti-obesity potential of edible and ethnomedicinal rhubarb species and emerging possible role of the rhubarb-derived extracts or individual compounds in the prevention of obesity and perspectives for their use in an anti-obesity treatment. A special emphasis is put on the most popular edible specimens, i.e.,
MeSH term(s)	Cardiovascular Diseases/prevention & control ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Heart Disease Risk Factors ; Humans ; Obesity/drug therapy ; Rheum/chemistry ; Risk Factors
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14102053
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Article ; Online: Anti-inflammatory and antioxidant actions of extracts from Rheum rhaponticum and Rheum rhabarbarum in human blood plasma and cells in vitro.

Liudvytska, Oleksandra / Bandyszewska, Magdalena / Skirecki, Tomasz / Krzyżanowska-Kowalczyk, Justyna / Kowalczyk, Mariusz / Kolodziejczyk-Czepas, Joanna

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115111

Abstract: Rheum rhaponticum L. (rhapontic rhubarb) and Rheum rhabarbarum L. (garden rhubarb) are edible and medicinal rhubarb species used for many centuries in traditional medicine. This work is focused on the biological activity of extracts from petioles and ... ...

Abstract	Rheum rhaponticum L. (rhapontic rhubarb) and Rheum rhabarbarum L. (garden rhubarb) are edible and medicinal rhubarb species used for many centuries in traditional medicine. This work is focused on the biological activity of extracts from petioles and roots of R. rhaponticum and R. rhabarbarum as well as rhapontigenin and rhaponticin, typical stilbenes present in these rhubarbs, in a context of their effects on blood physiology and cardiovascular health. Anti-inflammatory properties of the examined substances were evaluated in human peripheral blood mononuclear cells (PBMCs) and THP1-ASC-GFP inflammasome reporter cells. Due to the coexistence of inflammation and oxidative stress in cardiovascular diseases, the study design included also antioxidant assays. This part of the work involved the assessment of the protective efficiency of the examined substances against the peroxynitrite-triggered damage to human blood plasma components, including fibrinogen, a protein of critical importance for blood clotting and maintaining the haemostatic balance. Pre-incubation of PBMCs with the examined substances (1-50 μg/mL) considerably decreased the synthesis of prostaglandin E
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Rheum/chemistry ; Leukocytes, Mononuclear ; Anti-Inflammatory Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Plasma ; Fibrinogen
Chemical Substances	Antioxidants ; Anti-Inflammatory Agents ; Plant Extracts ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-07-06
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115111
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Article: The Effects of

Rutkowska, Magdalena / Kolodziejczyk-Czepas, Joanna / Olszewska, Monika Anna

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 12

Abstract: ... Sorbus ... ...

Abstract	Sorbus aucuparia
Language	English
Publishing date	2021-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10122009
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Article: Comparative Study of the Effects of Atypical Antipsychotic Drugs on Plasma and Urine Biomarkers of Oxidative Stress in Schizophrenic Patients.

Dietrich-Muszalska, Anna / Kolodziejczyk-Czepas, Joanna / Nowak, Pawel

Neuropsychiatric disease and treatment

2021 Volume 17, Page(s) 555–565

Abstract: Purpose: Evidence that antipsychotic drugs (ADs) can affect oxidative stress estimated with various biomarkers in schizophrenic patients is controversial and limited. Therefore, in the present study, we assessed the ability of six atypical ADs ( ... ...

Abstract	Purpose: Evidence that antipsychotic drugs (ADs) can affect oxidative stress estimated with various biomarkers in schizophrenic patients is controversial and limited. Therefore, in the present study, we assessed the ability of six atypical ADs (clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone) used in schizophrenia treatment to modulate oxidative damage to different biomolecules such as lipids and proteins. Patients and methods: We measured the levels of oxidative stress markers in plasma and urine: total antioxidant capacity by FRAP (according to a modified method of Benzie & Strain), thiobarbituric acid reactive species - TBARS (spectrophotometric method), 4-hydroxy-2-nonenal (4-HNE) (OxiSelect™ HNE Adduct Competitive ELISA Kit), 3-nitrotyrosine (3-NT) (OxiSelect™ Nitrotyrosine ELISA Kit) in plasma, and F2-isoprostanes (BIOXYTECH Results: Our results showed that in schizophrenic patients levels of lipid peroxidation markers (TBARS, F2-isoprostanes) were higher than in healthy subjects but FRAP in schizophrenic patients was lower than in healthy controls and increased after 4-week treatment with tested ADs. A 4-week treatment with ADs caused the improvement of psychopathology symptoms estimated by Positive and Negative Syndrome Scale (PANSS) that was accompanied by decreased lipid peroxidation (F2-isoprostanes, TBARS; p=2.9x10 Conclusion: Atypical antipsychotics especially clozapine, olanzapine and quetiapine demonstrate the effective outcome of antipsychotic treatment, beneficial antioxidative action by reducing lipid peroxidation and increased total plasma antioxidant activity.
Language	English
Publishing date	2021-02-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S283395
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Article: Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential

Kolodziejczyk-Czepas, Joanna / Liudvytska, Oleksandra

Phytochemistry reviews. 2021 June, v. 20, no. 3

2021

Abstract: The Rheum genus (Polygonaceae) covers about 60 species of rhubarbs, including specimens with a long ethnomedicinal history in Asia, Europe and other regions of the world. The work reviews available literature (until March, 2020) on phytochemical profile, ...

Abstract	The Rheum genus (Polygonaceae) covers about 60 species of rhubarbs, including specimens with a long ethnomedicinal history in Asia, Europe and other regions of the world. The work reviews available literature (until March, 2020) on phytochemical profile, ethnomedicinal recommendations, biological activities, pharmacological uses and future prospects for therapeutic applications of Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb). Although the above species are well-known vegetables, scientific interest in these plants is a relatively new issue; most of evidence of their biological activities and therapeutic potential derives from the last 15 years. Rhubarbs contain numerous bioactive substances, belonging to diverse groups of phytochemicals, e.g. stilbenes, anthraquinones and flavonoids. The registered special extract of R. rhaponticum (ERr731®) is administered to alleviate the menopause-related complaints. Furthermore, both ethnomedicinal surveys and recent studies on bioactive substances from rhubarbs indicate that these plants may have significantly broader range of beneficial effects such as antioxidant, anti-inflammatory, antimicrobial and cardioprotective activities.
Keywords	Rheum rhabarbarum ; Rheum rhaponticum ; anthraquinones ; antioxidants ; chemical constituents of plants ; flavonoids ; gardens ; rhubarb ; stilbenes ; therapeutics ; Asia ; Europe
Language	English
Dates of publication	2021-06
Size	p. 589-607.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	2065661-0
ISSN	1572-980X ; 1568-7767
ISSN (online)	1572-980X
ISSN	1568-7767
DOI	10.1007/s11101-020-09715-3
Database	NAL-Catalogue (AGRICOLA)

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Article: The Effects of Sorbus aucuparia L. Fruit Extracts on Oxidative/Nitrative Modifications of Human Fibrinogen, Impact on Enzymatic Properties of Thrombin, and Hyaluronidase Activity In Vitro

Rutkowska, Magdalena / Kolodziejczyk-Czepas, Joanna / Olszewska, Monika Anna

Antioxidants. 2021 Dec. 18, v. 10, no. 12

2021

Abstract: Sorbus aucuparia L. fruits (rowanberries) are food products with acknowledged nutritional value, high phenolic content, and traditional application in diabetes. In this study, the effects of rowanberry extracts (phytochemically standardised, i.a., by LC- ... ...

Abstract	Sorbus aucuparia L. fruits (rowanberries) are food products with acknowledged nutritional value, high phenolic content, and traditional application in diabetes. In this study, the effects of rowanberry extracts (phytochemically standardised, i.a., by LC-MS/MS) on some aspects of plasma haemostasis and vascular conditions were evaluated in vitro as possible mechanisms connected with cardiovascular complications of diabetes. The analyses of structural modifications of human fibrinogen under oxidative stress conditions (C-ELISA, SDS-PAGE and Western blot) revealed that the extracts (at a concentration of 1–5 µg/mL) considerably reduced the nitration of tyrosine residues and formation of high-molecular-weight aggregates. Moreover, they inhibited the enzymatic activity of thrombin (both amidolytic and proteolytic). Additionally, some promising outcomes might be expected regarding endothelial functions from the extracts ability to inhibit hyaluronidase. Parallel experiments on model polyphenols and correlation studies formed the basis for determining the contribution of different compounds, including hydroxycinnamic acid derivatives, flavonols, and low- or high-molecular-weight flavan-3-ols derivatives (proanthocyanidins), to the observed effects. The possible synergistic activity of individual constituents was also noticed. These results broaden the knowledge on the biological activity of rowanberries, partly confirming their health-promoting properties, and indicating that their functional applications might be promising.
Keywords	Sorbus aucuparia ; Western blotting ; bioactive properties ; coumaric acids ; diabetes ; enzyme activity ; fibrinogen ; flavanols ; flavonols ; fruits ; health promotion ; hemostasis ; humans ; hyaluronoglucosaminidase ; nutritive value ; oxidative stress ; polyacrylamide gel electrophoresis ; proanthocyanidins ; proteolysis ; synergism ; thrombin ; tyrosine
Language	English
Dates of publication	2021-1218
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10122009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trifolium species - the latest findings on chemical profile, ethnomedicinal use and pharmacological properties.

Kolodziejczyk-Czepas, Joanna

The Journal of pharmacy and pharmacology

2016 Volume 68, Issue 7, Page(s) 845–861

Abstract: Objectives: Clovers (Trifolium, Fabaceae) have a long history of use in folk medicine. Furthermore, during last 3 years, a considerable growth in scientific interest in these plants has been observed. This article summarizes and critically reviews an ... ...

Abstract	Objectives: Clovers (Trifolium, Fabaceae) have a long history of use in folk medicine. Furthermore, during last 3 years, a considerable growth in scientific interest in these plants has been observed. This article summarizes and critically reviews an over 3-year progress of knowledge of ethnomedicinal use, phytochemical profile, physiological effects and possible therapeutic action of various clover species. It contains the latest literature (over 80 papers), originated from international databases (MEDLINE/PubMed, Science Direct/Elsevier, Springer Link, Wiley Online Library) and reports from other international and local scientific periodicals. Key findings: Traditional uses of T. pratense and T. repens have been confirmed, while the folk medicine recommendations for administration of other clovers such as T. burchellianum, T. fragiferum, T. hybridum, T. minus and T. purpureum were reported for the first time. Furthermore, several other clover species were also investigated in terms of their antioxidant, antimicrobial and phytoestrogenic effects for the first time. Only T. alexandrinum, T. pratense and T. medium were examined in animal studies. Summary: Besides T. pratense, other clovers may be a rich source of bioactive phytochemicals. However, in contradiction to red clover, the therapeutic use of other clovers is still limited by the lack of in-vivo evidence.
MeSH term(s)	Animals ; Humans ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Trifolium/chemistry
Chemical Substances	Phytochemicals ; Plant Extracts
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1111/jphp.12568
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Article ; Online: Effects of Rheum rhaponticum and Rheum rhabarbarum extracts on haemostatic activity of blood plasma components and endothelial cells in vitro

Liudvytska, Oleksandra / Ponczek, Michał B. / Krzyżanowska-Kowalczyk, Justyna / Kowalczyk, Mariusz / Balcerczyk, Aneta / Kolodziejczyk-Czepas, Joanna

Journal of Ethnopharmacology. 20232023 Oct. 16, May 16, v. 315 p.116562-

2023

Abstract: Traditional medicine recommends the use of Rheum rhaponticum L. and R. rhabarbarum L. to treat over thirty complaints, including disorders related to the cardiovascular system such as heartache, pains in the pericardium, epistaxis and other types of ... ...

Abstract	Traditional medicine recommends the use of Rheum rhaponticum L. and R. rhabarbarum L. to treat over thirty complaints, including disorders related to the cardiovascular system such as heartache, pains in the pericardium, epistaxis and other types of haemorrhage, blood purification as well as disorders of venous circulation. This work was dedicated to examining for the first time the effects of extracts from petioles and roots of R. rhaponticum and R. rhabarbarum, as well as two stilbene compounds (rhapontigenin and rhaponticin) on the haemostatic activity of endothelial cells and functionality of blood plasma components of the haemostatic system. The study was based on three main experimental modules, including the activity of proteins of the human blood plasma coagulation cascade and the fibrinolytic system as well as analyses of the haemostatic activity of human vascular endothelial cells. Additionally, interactions of the main components of the rhubarb extracts with crucial serine proteases of the coagulation cascade and fibrinolysis (i.e. thrombin, the coagulation factor Xa and plasmin) were analyzed in silico. The examined extracts displayed anticoagulant properties and significantly reduced the tissue factor-induced clotting of human blood plasma (by about 40%). Inhibitory effects of the tested extracts on thrombin and the coagulation factor Xa (FXa) were found as well. For the extracts, the IC₅₀ was ranging from 20.26 to 48.11 μg/ml. Modulatory effects on the haemostatic response of endothelial cells, including the release of von Willebrand factor, tissue-type plasminogen activator and the plasminogen activator inhibitor-1, have been also found. Our results indicated for the first time that the examined Rheum extracts influenced the haemostatic properties of blood plasma proteins and endothelial cells, with the prevalence of the anticoagulant action. The anticoagulant effect of the investigated extracts may be partly attributed to the inhibition of the FXa and thrombin activities, the key serine proteases of the blood coagulation cascade.
Keywords	Rheum rhabarbarum ; Rheum rhaponticum ; anticoagulant activity ; anticoagulants ; blood circulation ; blood coagulation ; blood plasma ; coagulation ; computer simulation ; fibrinolysis ; hemorrhage ; humans ; pericardium ; plasmin ; plasminogen activator ; plasminogen activator inhibitors ; rhubarb ; stilbenes ; thrombin ; traditional medicine ; Endothelium ; Haemostasis ; HR-QTOF/MS ; Multivariate analyses ; Anthraquinones ; Taxifolin ; Total polyphenol content
Language	English
Dates of publication	2023-0516
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116562
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