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  1. Article: Daptomycin Liposomes Exhibit Enhanced Activity against Staphylococci Biofilms Compared to Free Drug.

    Gkartziou, Foteini / Plota, Maria / Kypraiou, Charikleia / Gauttam, Iti / Kolonitsiou, Fevronia / Klepetsanis, Pavlos / Spiliopoulou, Iris / Antimisiaris, Sophia G

    Pharmaceutics

    2024  Volume 16, Issue 4

    Abstract: The purpose of the present study was to investigate the anti-staphylococcal activity of liposomal daptomycin against four biofilm- ... ...

    Abstract The purpose of the present study was to investigate the anti-staphylococcal activity of liposomal daptomycin against four biofilm-producing
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16040459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clonal dissemination and resistance genes among

    Papadimitriou-Olivgeris, Matthaios / Kolonitsiou, Fevronia / Militsopoulou, Maria / Spiliopoulou, Iris / Giormezis, Nikolaos

    AIMS microbiology

    2022  Volume 8, Issue 3, Page(s) 292–299

    Abstract: Treatment ... ...

    Abstract Treatment of
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1888
    ISSN (online) 2471-1888
    DOI 10.3934/microbiol.2022021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficacy of Fosfomycin-Containing Regimens for Treatment of Bacteremia Due to Pan-Drug Resistant

    Assimakopoulos, Stelios F / Karamouzos, Vassilis / Eleftheriotis, Gerasimos / Lagadinou, Maria / Bartzavali, Christina / Kolonitsiou, Fevronia / Paliogianni, Fotini / Fligou, Fotini / Marangos, Markos

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020286
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  4. Article ; Online: Laboratory Surveillance of

    Spiliopoulou, Anastasia / Giannopoulou, Ioanna / Assimakopoulos, Stelios F / Jelastopulu, Eleni / Bartzavali, Christina / Marangos, Markos / Paliogianni, Fotini / Kolonitsiou, Fevronia

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 11

    Abstract: Multidrug- ... ...

    Abstract Multidrug-resistant
    Language English
    Publishing date 2023-11-19
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8110503
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  5. Article ; Online: Acid-fast bacteria as causative agents of skin and soft tissue infections: case presentations and literature review.

    Spiliopoulou, Anastasia / Kyriakou, Georgia / Georgiou, Sophia / Lekkou, Alexandra / Leonidou, Lydia / Militsopoulou, Maria / Papadogeorgaki, Eleni / Christofidou, Myrto / Kolonitsiou, Fevronia / Paliogianni, Fotini

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2023  Volume 65, Page(s) e29

    Abstract: Acid-fast bacteria can be implicated in skin and soft tissue infections. Diagnostic identification can be challenging or not feasible by routine laboratory techniques, especially if there is no access to the Matrix Assisted Laser Desorption Ionization ... ...

    Abstract Acid-fast bacteria can be implicated in skin and soft tissue infections. Diagnostic identification can be challenging or not feasible by routine laboratory techniques, especially if there is no access to the Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) technology. Here, we present two cases of skin and soft tissue infections caused by two different acid-fast bacteria, Nocardia brasiliensis and Mycobacterium marinum. They both grew on Löwenstein-Jensen medium, Sabouraud agar medium and blood agar medium. Both bacteria appeared acid-fast by Ziehl-Neelsen stain and Gram-positive by Gram stain. The identification was performed by MALDI-TOF MS and gene analysis. N. brasiliensis and nontuberculous mycobacterium M. marinum represent rare pathogens that cause severe skin and soft tissue infections. Failure to identify the causative agent and subsequent inappropriate or inadequate treatment may lead to severe complications or even disseminated disease, especially in immunocompromised individuals.
    MeSH term(s) Humans ; Agar ; Soft Tissue Infections/diagnosis ; Bacteria/chemistry ; Culture Media/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Mycobacterium marinum
    Chemical Substances Agar (9002-18-0) ; Culture Media
    Language English
    Publishing date 2023-04-14
    Publishing country Brazil
    Document type Review ; Journal Article
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/S1678-9946202365029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 292: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Fungemia due to rare non-Candida yeasts between 2018 and 2021 in a Greek tertiary care university hospital.

    Spiliopoulou, Anastasia / Lekkou, Alexandra / Vrioni, Georgia / Leonidou, Lydia / Cogliati, Massimo / Christofidou, Myrto / Marangos, Markos / Kolonitsiou, Fevronia / Paliogianni, Fotini

    Journal de mycologie medicale

    2023  Volume 33, Issue 3, Page(s) 101386

    Abstract: Introduction: Non-Candida yeasts, although rare, are increasingly encountered and recognized as a growing threat.: Methods: Cases of bloodstream infections (BSIs) due to non-Candida yeasts (NCYs) during the last four years (2018-2021) are presented.!# ...

    Abstract Introduction: Non-Candida yeasts, although rare, are increasingly encountered and recognized as a growing threat.
    Methods: Cases of bloodstream infections (BSIs) due to non-Candida yeasts (NCYs) during the last four years (2018-2021) are presented.
    Results: During the study period, 16 cases caused by non-Candida yeasts out of 400 cases of yeast BSIs were recorded, corresponding to an incidence of 4%. Yeasts that were isolated included Cryptococcus spp (4 isolates-25%), Rhodotorula mucilaginosa (2 isolates-12.5%), Trichosporon asahii (7 isolates-43.75%) and Saccharomyces cerevisiae (3 isolates-18.75%). Predisposing factors involved mostly hematological malignancies, long term hospitalization or major surgical interventions. Most isolates, 15 out of 16 were susceptible to amphotericin B. Voriconazole was the most active azole in vitro. All isolates, except Saccharomyces spp., were resistant to echinocandins.
    Discussion: Early recognition of rare yeasts as causative agents of BSIs and prompt initiation of appropriate treatment based on current guidelines and expertise remain crucial in efficient patient management.
    MeSH term(s) Humans ; Fungemia/drug therapy ; Fungemia/epidemiology ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Greece ; Tertiary Healthcare ; Yeasts ; Sepsis ; Saccharomyces cerevisiae ; Hospitals ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-04-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2023.101386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Melanonychia Striata: Nail Alterations during Pregnancy.

    Plachouri, Kerasia-Maria / Kolonitsiou, Fevronia / Georgiou, Sophia

    Skinmed

    2019  Volume 17, Issue 6, Page(s) 413–414

    Abstract: A 35-year-old Greek woman (Fitzpatrick Skin Type IV) presented to our clinic 4 months after the delivery of her first child with nail changes that were first noted during pregnancy. During the 12th week of pregnancy, homogenous dark brown streaks ... ...

    Abstract A 35-year-old Greek woman (Fitzpatrick Skin Type IV) presented to our clinic 4 months after the delivery of her first child with nail changes that were first noted during pregnancy. During the 12th week of pregnancy, homogenous dark brown streaks appeared first on the nails of her right second and third fingers (Figure 1a, b) and later on her right fourth toenail (Figure 2a). During the following weeks, she developed similar changes on the second and fourth toenails (Figure 2b). The streaks were uniformly brown, with distinct margins and width of 2-5 mm. There was no pigmentation in the periungual skin (Hutchinson sign) of the affected nails. The direct microscopic examination, cultures, and polymerase chain reaction (PCR) were negative for dermatophytes. The nail changes had not resolved after delivery. Throughout the gestational period, she had developed alveolar hyperpigmentation, but no other changes including the lack of multiple lentigines. During her pregnancy, she had taken calcium supplements from the 8th week until delivery, magnesium and iron supplements throughout pregnancy, as well as progesterone 100 mg daily (Utrogestan®, Besins Healthcare Ltd) from the 8th week through the 12th week. She was otherwise healthy and had no previous pigmentation disorders, chronic diseases, or any other pregnancy complications. There was no family history of pigmentation disorders.
    MeSH term(s) Adult ; Female ; Humans ; Hyperpigmentation/diagnosis ; Hyperpigmentation/pathology ; Nail Diseases/diagnosis ; Nail Diseases/pathology ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/pathology
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2171125-2
    ISSN 1751-7125 ; 1540-9740
    ISSN (online) 1751-7125
    ISSN 1540-9740
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6041: Show issues Location:
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  8. Article ; Online: Role of source control in critically ill candidemic patients: a multicenter retrospective study.

    Marangos, Markos / Ioannou, Petros / Senn, Laurence / Spiliopoulou, Anastasia / Tzalis, Sotiris / Kolonitsiou, Fevronia / Valta, Maria / Kokkini, Sofia / Pagani, Jean-Luc / Stafylaki, Dimitra / Paliogianni, Fotini / Fligou, Fotini / Kofteridis, Diamantis P / Lamoth, Frédéric / Papadimitriou-Olivgeris, Matthaios

    Infection

    2024  

    Abstract: Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.: ...

    Abstract Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.
    Methods: Multicenter retrospective study.
    Setting: This retrospective study was conducted in Intensive Care Units from three European university hospitals from 2015 to 2021. Adult patients with at least one positive blood culture for Candida spp. were included. Patients who did not require source control were excluded. Primary outcome was 14-day mortality.
    Results: A total of 409 episodes of candidemia were included. Most candidemias were catheter related (173; 41%), followed by unknown origin (170; 40%). Septic shock developed in 43% episodes. Overall, 14-day mortality rate was 29%. In Cox proportional hazards regression model, septic shock (P 0.001; HR 2.20, CI 1.38-3.50), SOFA score ≥ 10 points (P 0.008; HR 1.83, CI 1.18-2.86), and prior SARS-CoV-2 infection (P 0.003; HR 1.87, CI 1.23-2.85) were associated with 14-day mortality, while combined early appropriate antifungal treatment and source control (P < 0.001; HR 0.15, CI 0.08-0.28), and early source control without appropriate antifungal treatment (P < 0.001; HR 0.23, CI 0.12-0.47) were associated with better survival compared to those without neither early appropriate antifungal treatment nor source control.
    Conclusion: Early source control was associated with better outcome among candidemic critically ill patients.
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-024-02222-z
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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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  9. Article ; Online: Invasive Candida kefyr infection presenting as pyelonephritis in an ICU hospitalized COVID-19 patient: Case report and review of the literature.

    Spiliopoulou, Anastasia / Kolonitsiou, Fevronia / Vrioni, Georgia / Tsoupra, Stamatia / Lekkou, Alexandra / Paliogianni, Fotini

    Journal de mycologie medicale

    2021  Volume 32, Issue 2, Page(s) 101236

    Abstract: Candida kefyr (Kluyveromyces marxianus), an ascomycetous environmental yeast, occasionally isolated from dairy products, represents an uncommon but emerging pathogen in immunocompromised patients. Herein, we present a case of C. kefyr pyelonephritis in a ...

    Abstract Candida kefyr (Kluyveromyces marxianus), an ascomycetous environmental yeast, occasionally isolated from dairy products, represents an uncommon but emerging pathogen in immunocompromised patients. Herein, we present a case of C. kefyr pyelonephritis in a 41-year-old, previously immunocompetent, patient who was hospitalized in an COVID-19 ICU. Pyelonephritis was associated with caliectasis and obstruction due to possible fungus ball formation. Predisposing factors included ICU stay, use of broad spectrum antibiotics and steroids, central venous catheterization, mechanical ventilation and urologic manipulation. Susceptibility testing revealed high MIC values to amphotericin B. Infection was effectively controlled by prolonged administration of fluconazole without further surgical intervention. COVID-19 complicated with invasive candidiasis is an increasingly observed clinical situation that warrants high suspicion index and careful evaluation of laboratory data.
    MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; COVID-19/complications ; Candida ; Candidiasis ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/drug therapy ; Fluconazole/therapeutic use ; Humans ; Intensive Care Units ; Kluyveromyces ; Pyelonephritis/diagnosis ; Pyelonephritis/drug therapy
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2021-12-23
    Publishing country France
    Document type Case Reports ; Review
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2021.101236
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    Zs.A 3148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: A Seven-Year Microbiological and Molecular Study of Bacteremias Due to Carbapenemase-Producing

    Papadimitriou-Olivgeris, Matthaios / Bartzavali, Christina / Karachalias, Eleftherios / Spiliopoulou, Anastasia / Tsiata, Ekaterini / Siakallis, Georgios / Assimakopoulos, Stelios F / Kolonitsiou, Fevronia / Marangos, Markos

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: Background: Ceftazidime/avibactam (CZA) is a new option for the treatment of KPC-producing Klebsiella pneumoniae. The aim of this study was to determine resistance patterns and carbapenemase genes among K. pneumoniae (CP-Kp) bacteremic isolates before ... ...

    Abstract Background: Ceftazidime/avibactam (CZA) is a new option for the treatment of KPC-producing Klebsiella pneumoniae. The aim of this study was to determine resistance patterns and carbapenemase genes among K. pneumoniae (CP-Kp) bacteremic isolates before and after CZA introduction. Methods: K. pneumoniae from blood cultures of patients being treated in a Greek university hospital during 2015−21 were included. PCR for blaKPC, blaVIM, blaNDM and blaOXA-48 genes was performed. Results: Among 912 K. pneumoniae bacteremias: 725 (79.5%) were due to carbapenemase-producing isolates; 488 (67.3%) carried blaKPC; 108 (14.9%) blaVIM; 100 (13.8%) blaNDM; and 29 (4%) carried a combination of blaKPC, blaVIM or blaNDM. The incidence of CP-Kp bacteremias was 59 per 100,000 patient-days. The incidence of CP-Kp changed from a downward pre-CZA trend to an upward trend in the CZA period (p = 0.007). BSIs due to KPC-producing isolates showed a continuous downward trend in the pre-CZA and CZA periods (p = 0.067), while BSIs due to isolates carrying blaVIM or blaNDM changed from a downward trend in the pre-CZA to an upward trend in the CZA period (p < 0.001). Conclusions: An abrupt change in the epidemiology of CP-Kp was observed in 2018, due to the re-emergence of VIM-producing isolates after the suppression of KPC-producing ones via the use of CZA.
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11101414
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