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Article: Genomic Regions and Candidate Genes Linked to Capped Hock in Pig.

Getmantseva, Lyubov / Kolosova, Maria / Bakoev, Faridun / Zimina, Anna / Bakoev, Siroj

2021 Volume 11, Issue 6

Abstract: Capped hock affects the exterior of pedigree pigs, making them unsalable and resulting in a negative impact on the efficiency of pig-breeding centers. The purpose of this paper was to carry out pilot studies aimed at finding genomic regions and genes ... ...

Abstract	Capped hock affects the exterior of pedigree pigs, making them unsalable and resulting in a negative impact on the efficiency of pig-breeding centers. The purpose of this paper was to carry out pilot studies aimed at finding genomic regions and genes linked to the capped hock in pigs. The studies were carried out on Landrace pigs (n = 75) and Duroc pigs (n = 70). To identify genomic regions linked to capped hock in pigs, we used smoothing FST statistics. Genotyping was performed with GeneSeek
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11060510
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of genetic differentiation and search for candidate genes for reproductive traits in pigs.

Колосова, Мария / Radyuk, Anastasia / Romanets, Elena / Bakoev, Siroj / Romanets, Timofey / Kolosova, Maria / Kolosov, Anatoly / Bakoev, Faridun / Tretiakova, Olga / Usatov, Alexander / Getmantseva, Lyubov

Animal bioscience

2024

Abstract: Objective: The use of molecular genetic methods in pig breeding can significantly increase the efficiency of breeding and breeding work. We applied the Fst method, the main focus of the work was on the search for common options related to the number of ... ...

Abstract	Objective: The use of molecular genetic methods in pig breeding can significantly increase the efficiency of breeding and breeding work. We applied the Fst method, the main focus of the work was on the search for common options related to the number of born piglets and the weight of born piglets, since today the urgent task is to prevent a decrease in the weight of piglets at birth while maintaining high fertility of sows. Methods: One approach is to scan the genome, followed by an assessment of Fst and identification of selectively selected regions. We chose Large White sows (n=237) with the same conditions of keeping and feeding. The data were collected from the sows across three farrowing. For genotyping, we used GeneSeek® GGP Porcine HD Genomic Profiler v1, which included 68,516 SNPs evenly distributed with an average spacing of 25 kb (Illumina Inc, San Diego, CA, USA). Results: Based on the results of the Fst analysis, 724 variants representing selection signals for the signs BALWT, BALWT1, NBA and TNB (weight of piglets born alive, average weight of the 1st piglets born alive, total number born alive, total number born. At the same time, 18 common variants have been identified that are potential markers for both the number of piglets at birth and the weight of piglets at birth, which is extremely important for breeding work to improve reproductive characteristics in sows. Conclusion: Оur work resulted in identification of variants associated with the reproductive characteristics of pigs. Moreover, we identified, variants which are potential markers for both the number of piglets at birth and the weight of piglets at birth, which is extremely important for breeding work to improve reproductive performance in sows.
Language	English
Publishing date	2024-01-20
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2765-0189
ISSN	2765-0189
DOI	10.5713/ab.23.0297
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Article ; Online: Detection of ADB-BUTINACA Metabolites in Human Urine, Blood, Kidney and Liver.

Kavanagh, Pierce / Pechnikov, Alexandr / Nikolaev, Ivan / Dowling, Geraldine / Kolosova, Mariia / Grigoryev, Andrej

Journal of analytical toxicology

2021 Volume 46, Issue 6, Page(s) 641–650

Abstract: The N-butyl indazole derivative, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H-indazole-3-carboxamide (ADB-BUTINACA or ADB-BINACA), currently a drug of abuse in Russia, is reported to have a cannabinoid receptor potency and efficacy almost three ... ...

Abstract	The N-butyl indazole derivative, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H-indazole-3-carboxamide (ADB-BUTINACA or ADB-BINACA), currently a drug of abuse in Russia, is reported to have a cannabinoid receptor potency and efficacy almost three times higher than JWH-018. ADB-BUTINACA was detected in blood from patients with suspected drug intoxications, as well as in blood, kidney and liver samples collected during postmortem investigations. Using liquid chromatography-time-of-flight-mass spectrometry, a number of ADB-BUTINACA metabolites were tentatively identified in urine samples. These include products of mono- and dihydroxylation, hydroxylation of the N-butyl side chain and dehydrogenation, formation of a dihydrodiol, hydrolysis of the terminal amide group, N-dealkylation of the indazole and a combination of these reactions. The dihydrodiol was found to be the predominant metabolite, with its chromatographic peak area exceeding those of other metabolites by almost an order of magnitude. For the routine analysis of blood, liver and kidney samples, the dihydrodiol and monohydroxylated metabolites along with the parent compound are recommended as target analytes. The same metabolites in free and glucuronidated forms are also recommended for analytical confirmation in urine samples.
MeSH term(s)	Cannabinoids/analysis ; Humans ; Indazoles/analysis ; Kidney/chemistry ; Liver/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Cannabinoids ; Indazoles
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	752391-9
ISSN	1945-2403 ; 0146-4760
ISSN (online)	1945-2403
ISSN	0146-4760
DOI	10.1093/jat/bkab088
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Zs.A 1333: Show issues

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Article ; Online: Survey of SNPs Associated with Total Number Born and Total Number Born Alive in Pig.

Bakoev, Siroj / Getmantseva, Lyubov / Bakoev, Faridun / Kolosova, Maria / Gabova, Valeria / Kolosov, Anatoly / Kostyunina, Olga

Genes

2020 Volume 11, Issue 5

Abstract: Reproductive productivity depend on a complex set of characteristics. The number of piglets at birth (Total number born, Litter size, TNB) and the number of alive piglets at birth (Total number born alive, NBA) are the main indicators of the reproductive ...

Abstract	Reproductive productivity depend on a complex set of characteristics. The number of piglets at birth (Total number born, Litter size, TNB) and the number of alive piglets at birth (Total number born alive, NBA) are the main indicators of the reproductive productivity of sows in pig breeding. Great hopes are pinned on GWAS (Genome-Wide Association Studies) to solve the problems associated with studying the genetic architecture of reproductive traits of pigs. This paper provides an overview of international studies on SNP (Single nucleotide polymorphism) associated with TNB and NBA in pigs presented in PigQTLdb as "Genome map association". Currently on the base of Genome map association results 306 SNPs associated with TNB (218 SNPs) and NBA (88 SNPs) have been identified and presented in the Pig QTLdb database. The results are based on research of pigs such as Large White, Yorkshire, Landrace, Berkshire, Duroc and Erhualian. The presented review shows that most SNPs found in chromosome areas where candidate genes or QTLs (Quantitative trait locus) have been identified. Further research in the given direction will allow to obtain new data that will become an impulse for creating breakthrough breeding technologies and increase the production efficiency in pig farming.
MeSH term(s)	Animals ; Breeding ; Chromosomes/genetics ; Female ; Genome-Wide Association Study ; Genotype ; Litter Size/genetics ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; Quantitative Trait Loci/genetics ; Reproduction/genetics ; Sus scrofa/genetics ; Swine/genetics
Language	English
Publishing date	2020-04-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11050491
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Article: PigLeg: prediction of swine phenotype using machine learning.

Bakoev, Siroj / Getmantseva, Lyubov / Kolosova, Maria / Kostyunina, Olga / Chartier, Duane R / Tatarinova, Tatiana V

PeerJ

2020 Volume 8, Page(s) e8764

Abstract: Industrial pig farming is associated with negative technological pressure on the bodies of pigs. Leg weakness and lameness are the sources of significant economic loss in raising pigs. Therefore, it is important to identify the predictors of limb ... ...

Abstract	Industrial pig farming is associated with negative technological pressure on the bodies of pigs. Leg weakness and lameness are the sources of significant economic loss in raising pigs. Therefore, it is important to identify the predictors of limb condition. This work presents assessments of the state of limbs using indicators of growth and meat characteristics of pigs based on machine learning algorithms. We have evaluated and compared the accuracy of prediction for nine ML classification algorithms (Random Forest, K-Nearest Neighbors, Artificial Neural Networks, C50Tree, Support Vector Machines, Naive Bayes, Generalized Linear Models, Boost, and Linear Discriminant Analysis) and have identified the Random Forest and K-Nearest Neighbors as the best-performing algorithms for predicting pig leg weakness using a small set of simple measurements that can be taken at an early stage of animal development. Measurements of Muscle Thickness, Back Fat amount, and Average Daily Gain were found to be significant predictors of the conformation of pig limbs. Our work demonstrates the utility and relative ease of using machine learning algorithms to assess the state of limbs in pigs based on growth rate and meat characteristics.
Language	English
Publishing date	2020-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.8764
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Article ; Online: Finding Predictors of Leg Defects in Pigs Using CNV-GWAS.

Getmantseva, Lyubov / Kolosova, Maria / Fede, Kseniia / Korobeinikova, Anna / Kolosov, Anatoly / Romanets, Elena / Bakoev, Faridun / Romanets, Timofey / Yudin, Vladimir / Keskinov, Anton / Bakoev, Siroj

Genes

2023 Volume 14, Issue 11

Abstract: One of the most important areas of modern genome research is the search for meaningful relationships between genetic variants and phenotypes. In the livestock field, there has been research demonstrating the influence of copy number variants (CNVs) on ... ...

Abstract	One of the most important areas of modern genome research is the search for meaningful relationships between genetic variants and phenotypes. In the livestock field, there has been research demonstrating the influence of copy number variants (CNVs) on phenotypic variation. Despite the wide range in the number and size of detected CNVs, a significant proportion differ between breeds and their functional effects are underestimated in the pig industry. In this work, we focused on the problem of leg defects in pigs (lumps/growths in the area of the hock joint on the hind legs) and focused on searching for molecular genetic predictors associated with this trait for the selection of breeding stock. The study was conducted on Large White pigs using three CNV calling tools (PennCNV, QuantiSNP and R-GADA) and the CNVRanger association analysis tool (CNV-GWAS). As a result, the analysis identified three candidate CNVRs associated with the formation of limb defects. Subsequent functional analysis suggested that all identified CNVs may act as potential predictors of the hock joint phenotype of pigs. It should be noted that the results obtained indicate that all significant regions are localized in genes (CTH, SRSF11, MAN1A1 and LPIN1) responsible for the metabolism of amino acids, fatty acids, glycerolipids and glycerophospholipids, thereby related to the immune response, liver functions, content intramuscular fat and animal fatness. These results are consistent with previously published studies, according to which a predisposition to the formation of leg defects can be realized through genetic variants associated with the functions of the liver, kidneys and hematological characteristics.
MeSH term(s)	Swine/genetics ; Animals ; Genome-Wide Association Study ; Genotype ; Genome ; Phenotype ; DNA Copy Number Variations
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14112054
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Article ; Online: Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification.

Kolosov, Anatoly / Getmantseva, Lyubov / Kolosova, Maria / Romanets, Timofey / Bakoev, Nekruz / Romanets, Elena / Bakoeva, Ilona / Kostyunina, Olga / Prytkov, Yuri / Tretiakova, Olga / Bakoev, Siroj

Genes

2022 Volume 13, Issue 2

Abstract: Pigs are strategically important animals for the agricultural industry. An assessment of genetic differentiation between pigs, undergone and not undergone to selection intensification, is of particular interest. Our research was conducted on two groups ... ...

Abstract	Pigs are strategically important animals for the agricultural industry. An assessment of genetic differentiation between pigs, undergone and not undergone to selection intensification, is of particular interest. Our research was conducted on two groups of Large White pigs grown on the same farm but in different years. A total of 165 samples were selected with 78 LW_А (
MeSH term(s)	Animals ; Genome ; Genomics/methods ; Homozygote ; Phenotype ; Russia ; Swine/genetics
Language	English
Publishing date	2022-01-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13020197
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Article: Effect of the GDF9 gene on the weight of lambs at birth

Bakoev, Lyubov Getmantseva Nekruz / Shirokova, Nadezhda / Kolosova, Maria / Bakoev, Siroj / Kolosov, Anatoly / Usatov, Aleksander / Shevtsova, Varvara / Kolosov, Yuri

Bulgarian journal of agricultural science

2019 Volume 25, Issue 1, Page(s) 153

Document type	Article
ZDB-ID	1306706-0
ISSN	1310-0351
Database	Current Contents Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Z 6253: Show issues

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Article: [Effect of the I(f) channel blocker ivabradine on the parameters of external respiration function in patients with chronic obstructive pulmonary disease in its stable course period].

Komlev, A D / Kuziaev, A I / Laskin, G M / Kuzenkova, V E / Kolosova, M V

Terapevticheskii arkhiv

2010 Volume 82, Issue 3, Page(s) 23–25

Abstract: Aim: To evaluate the effect of the I(f) channel blocker ivabradine on bronchial patency and the volume parameters of external respiration function in patients with chronic obstructive pulmonary disease (COPD) in remission in order to determine whether ... ...

Abstract	Aim: To evaluate the effect of the I(f) channel blocker ivabradine on bronchial patency and the volume parameters of external respiration function in patients with chronic obstructive pulmonary disease (COPD) in remission in order to determine whether the drug may be used in patients with coronary heart disease (CHD) concurrent with COPD. Subjects and methods: Heart rate, bronchial patency, and lung volume were studied by body plethysmography in 59 patients with COPD before and 14 days after administration of ivabradine in a daily dose of 10 mg. Results: The I(f) channel blocker ivabradine that is a highly selective bradycardiac agent fails to affect the velocity and volume parameters of external respiration function, thus it may be used to treat CHD concurrent with COPD. Conclusion: The I(f) channel blocker ivabradine exerts no effect on external respiration function parameters (bronchial patency, volume parameters) and it can find clinical use in the treatment of angina pectoris and chronic heart failure in patients with CHD concurrent with COPD.
MeSH term(s)	Aged ; Benzazepines/administration & dosage ; Benzazepines/adverse effects ; Benzazepines/therapeutic use ; Cardiovascular Agents/administration & dosage ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/therapeutic use ; Cyclic Nucleotide-Gated Cation Channels/antagonists & inhibitors ; Electrocardiography ; Female ; Heart Rate/drug effects ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/complications ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/metabolism ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiration/drug effects ; Respiratory Function Tests
Chemical Substances	Benzazepines ; Cardiovascular Agents ; Cyclic Nucleotide-Gated Cation Channels ; ivabradine (3H48L0LPZQ)
Language	Russian
Publishing date	2010
Publishing country	Russia (Federation)
Document type	Clinical Trial ; English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 79: Show issues

Location:
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Sostav lipidov membran éritrotsitov i ikh biofizicheskie kharakteristiki u deteĭ s insulinzavisimym sakharnym diabetom v protsesse terapii.

Kolosova, M V / Novitskiĭ, V V / Stepovaia, E A

Klinicheskaia laboratornaia diagnostika

2001 , Issue 1, Page(s) 10–12

Abstract: Chronic secondary hyperglycemia in children with insulin insufficiency is characterized by quantitative and qualitative changes in membrane lipid spectrum and increased microviscosity of deep layers of peripheral blood erythrocyte membrane lipid bilayer. ...

Title translation	Composition of erythrocyte membrane lipids and their biophysical parameters in children with insulin-dependent diabetes during therapy.
Abstract	Chronic secondary hyperglycemia in children with insulin insufficiency is characterized by quantitative and qualitative changes in membrane lipid spectrum and increased microviscosity of deep layers of peripheral blood erythrocyte membrane lipid bilayer. Traditional combined therapy does not normalize these parameters, which can lead to vascular complications in children with insulin-dependent diabetes mellitus.
MeSH term(s)	Child ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/therapy ; Erythrocyte Membrane/chemistry ; Fluorescence ; Humans ; Lipid Bilayers/chemistry ; Lipids/chemistry ; Viscosity
Chemical Substances	Lipid Bilayers ; Lipids
Language	Russian
Publishing date	2001-01-22
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1155086-7
ISSN	0869-2084
ISSN	0869-2084
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Zs.B 1140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 647: Show issues

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