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  1. Article: Special Issue on Metabolic Adaptations in Cardiac and Skeletal Muscle during Acute and Chronic Exercise.

    Kolwicz, Stephen C

    Metabolites

    2023  Volume 13, Issue 9

    Abstract: Research in the field of exercise physiology has evolved dramatically over the last century [ ... ]. ...

    Abstract Research in the field of exercise physiology has evolved dramatically over the last century [...].
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13091015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ketone Body Metabolism in the Ischemic Heart.

    Kolwicz, Stephen C

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 789458

    Abstract: Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance. These findings ... ...

    Abstract Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance. These findings have certainly renewed interest in the use of ketogenic diets and exogenous supplementation in an effort to improve overall health and disease. However, given the prevalence of ischemic heart disease and myocardial infarctions, these strategies may not be ideal for individuals with coronary artery disease. Although research studies have clearly defined changes in fatty acid and glucose metabolism during ischemia and reperfusion, the role of ketone body metabolism in the ischemic and reperfused myocardium is less clear. This review will provide an overview of ketone body metabolism, including the induction of ketosis via physiological or nutritional strategies. In addition, the contribution of ketone body metabolism in healthy and diseased states, with a particular emphasis on ischemia-reperfusion (I-R) injury will be discussed.
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.789458
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  3. Article: Editorial: Mitochondrial control of cell fate.

    Gong, Guohua / Zhang, Huiliang / Kolwicz, Stephen C

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1302075

    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1302075
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  4. Article: An "Exercise" in Cardiac Metabolism.

    Kolwicz, Stephen C

    Frontiers in cardiovascular medicine

    2018  Volume 5, Page(s) 66

    Abstract: Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and ...

    Abstract Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and relies heavily on glucose metabolism, primarily achieved by an acceleration in glycolysis. Moreover, it has been suggested that the chronically lipid overloaded heart augments fatty acid oxidation and triglyceride synthesis to an even greater degree and, thus, develops a lipotoxic phenotype. In comparison, classic studies in exercise physiology have provided a basis for the acute metabolic changes that occur during physical activity. During an acute bout of exercise, whole body glucose metabolism increases proportionately to intensity while fatty acid metabolism gradually increases throughout the duration of activity, particularly during moderate intensity. However, the studies in chronic exercise training are primarily limited to metabolic adaptations in skeletal muscle or to the mechanisms that govern physiological signaling pathways in the heart. Therefore, the purpose of this review is to discuss the precise changes that chronic exercise training elicits on cardiac metabolism, particularly on substrate utilization. Although conflicting data exists, a pattern of enhanced fatty oxidation and normalization of glycolysis emerges, which may be a therapeutic strategy to prevent or regress the metabolic phenotype of the hypertrophied heart. This review also expands on the metabolic adaptations that chronic exercise training elicits in amino acid and ketone body metabolism, which have become of increased interest recently. Lastly, challenges with exercise training studies, which could relate to several variables including model, training modality, and metabolic parameter assessed, are examined.
    Language English
    Publishing date 2018-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2018.00066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response to Comment on Kolwicz et al. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress. Diabetes 2015;64:2817-2827.

    Kolwicz, Stephen C

    Diabetes

    2016  Volume 65, Issue 4, Page(s) e19–20

    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Letter
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi15-0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Lipid partitioning during cardiac stress.

    Kolwicz, Stephen C

    Biochimica et biophysica acta

    2016  Volume 1861, Issue 10, Page(s) 1472–1480

    Abstract: It is well documented that fatty acids serve as the primary fuel substrate for the contracting myocardium. However, extensive research has identified significant changes in the myocardial oxidation of fatty acids during acute or chronic cardiac stress. ... ...

    Abstract It is well documented that fatty acids serve as the primary fuel substrate for the contracting myocardium. However, extensive research has identified significant changes in the myocardial oxidation of fatty acids during acute or chronic cardiac stress. As a result, the redistribution or partitioning of fatty acids due to metabolic derangements could have biological implications. Fatty acids can be stored as triacylglycerols, serve as critical components for biosynthesis of phospholipid membranes, and form the potent signaling molecules, diacylglycerol and ceramides. Therefore, the contribution of lipid metabolism to health and disease is more intricate than a balance of uptake and oxidation. In this review, the available data regarding alterations that occur in endogenous cardiac lipid pathways during the pathological stressors of ischemia-reperfusion and pathological hypertrophy/heart failure are highlighted. In addition, changes in endogenous lipids observed in exercise training models are presented for comparison. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk.
    MeSH term(s) Animals ; Cardiovascular Diseases/metabolism ; Fatty Acids/metabolism ; Humans ; Lipid Metabolism ; Models, Animal ; Myocardium/metabolism ; Myocardium/pathology ; Stress, Physiological
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2016.03.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Exercise regulates cardiac metabolism: Sex does matter.

    Yang, Tingting / Hu, Meiyu / Spanos, Michail / Li, Guoping / Kolwicz, Stephen C / Xiao, Junjie

    Journal of sport and health science

    2022  Volume 11, Issue 4, Page(s) 418–420

    MeSH term(s) Exercise/physiology ; Physical Exertion
    Language English
    Publishing date 2022-06-07
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2673028-5
    ISSN 2213-2961 ; 2095-2546
    ISSN (online) 2213-2961
    ISSN 2095-2546
    DOI 10.1016/j.jshs.2022.06.002
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  8. Article ; Online: Sex differences in endurance exercise capacity and skeletal muscle lipid metabolism in mice.

    Holcomb, Lola E / Rowe, Patrick / O'Neill, Caitlin C / DeWitt, Elizabeth A / Kolwicz, Stephen C

    Physiological reports

    2022  Volume 10, Issue 3, Page(s) e15174

    Abstract: Previous studies suggest that sex differences in lipid metabolism exist with females demonstrating a higher utilization of lipids during exercise, which is mediated partly by increased utilization of muscle triglycerides. However, whether these changes ... ...

    Abstract Previous studies suggest that sex differences in lipid metabolism exist with females demonstrating a higher utilization of lipids during exercise, which is mediated partly by increased utilization of muscle triglycerides. However, whether these changes in lipid metabolism contribute directly to endurance exercise performance is unclear. Therefore, the objective of this study was to investigate the contribution of exercise substrate metabolism to sex differences in endurance exercise capacity (EEC) in mice. Male and female C57BL/6-NCrl mice were subjected to an EEC test until exhaustion on a motorized treadmill. The treadmill was set at a 10% incline, and the speed gradually increased from 10.2 m/min to 22.2 m/min at fixed intervals for up to 2.5 h. Tissues and blood were harvested in mice immediately following the EEC. A cohort of sedentary, non-exercised male and female mice were used as controls. Females outperformed males by ~25% on the EEC. Serum levels of both fatty acids and ketone bodies were ~50% higher in females at the end of the EEC. In sedentary female mice, skeletal muscle triglyceride content was significantly greater compared to sedentary males. Gene expression analysis demonstrated that genes involved in skeletal muscle fatty acid oxidation were significantly higher in females with no changes in genes associated with glucose uptake or ketone body oxidation. The findings suggest that female mice have a higher endurance exercise capacity and a greater ability to mobilize and utilize fatty acids for energy.
    MeSH term(s) Animals ; Female ; Ketone Bodies/blood ; Ketone Bodies/metabolism ; Lipid Metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Physical Conditioning, Animal/methods ; Running ; Sex Characteristics ; Triglycerides/blood ; Triglycerides/metabolism
    Chemical Substances Ketone Bodies ; Triglycerides
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Lipid partitioning during cardiac stress

    Kolwicz, Stephen C

    Biochimica et biophysica acta. 2016 Oct., v. 1861, no. 10

    2016  

    Abstract: It is well documented that fatty acids serve as the primary fuel substrate for the contracting myocardium. However, extensive research has identified significant changes in the myocardial oxidation of fatty acids during acute or chronic cardiac stress. ... ...

    Abstract It is well documented that fatty acids serve as the primary fuel substrate for the contracting myocardium. However, extensive research has identified significant changes in the myocardial oxidation of fatty acids during acute or chronic cardiac stress. As a result, the redistribution or partitioning of fatty acids due to metabolic derangements could have biological implications. Fatty acids can be stored as triacylglycerols, serve as critical components for biosynthesis of phospholipid membranes, and form the potent signaling molecules, diacylglycerol and ceramides. Therefore, the contribution of lipid metabolism to health and disease is more intricate than a balance of uptake and oxidation. In this review, the available data regarding alterations that occur in endogenous cardiac lipid pathways during the pathological stressors of ischemia–reperfusion and pathological hypertrophy/heart failure are highlighted. In addition, changes in endogenous lipids observed in exercise training models are presented for comparison. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk.
    Keywords beta oxidation ; biosynthesis ; ceramides ; diacylglycerols ; exercise ; fatty acids ; fuels ; heart failure ; hypertrophy ; models ; myocardium ; oxidation ; phospholipids ; triacylglycerols
    Language English
    Dates of publication 2016-10
    Size p. 1472-1480.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1388-1981
    DOI 10.1016/j.bbalip.2016.03.028
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Ketogenic Diets and Exercise Performance.

    Harvey, Kristin L / Holcomb, Lola E / Kolwicz, Stephen C

    Nutrients

    2019  Volume 11, Issue 10

    Abstract: The ketogenic diet (KD) has gained a resurgence in popularity due to its purported reputation for fighting obesity. The KD has also acquired attention as an alternative and/or supplemental method for producing energy in the form of ketone bodies. Recent ... ...

    Abstract The ketogenic diet (KD) has gained a resurgence in popularity due to its purported reputation for fighting obesity. The KD has also acquired attention as an alternative and/or supplemental method for producing energy in the form of ketone bodies. Recent scientific evidence highlights the KD as a promising strategy to treat obesity, diabetes, and cardiac dysfunction. In addition, studies support ketone body supplements as a potential method to induce ketosis and supply sustainable fuel sources to promote exercise performance. Despite the acceptance in the mainstream media, the KD remains controversial in the medical and scientific communities. Research suggests that the KD or ketone body supplementation may result in unexpected side effects, including altered blood lipid profiles, abnormal glucose homeostasis, increased adiposity, fatigue, and gastrointestinal distress. The purpose of this review article is to provide an overview of ketone body metabolism and a background on the KD and ketone body supplements in the context of obesity and exercise performance. The effectiveness of these dietary or supplementation strategies as a therapy for weight loss or as an ergogenic aid will be discussed. In addition, the recent evidence that indicates ketone body metabolism is a potential target for cardiac dysfunction will be reviewed.
    MeSH term(s) Diet, Ketogenic/methods ; Dietary Supplements ; Exercise/physiology ; Humans ; Ketone Bodies/pharmacology ; Obesity/diet therapy ; Obesity/metabolism ; Performance-Enhancing Substances/pharmacology ; Physical Functional Performance
    Chemical Substances Ketone Bodies ; Performance-Enhancing Substances
    Language English
    Publishing date 2019-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11102296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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