Article ; Online: Combining radiation and immunotherapy: a new systemic therapy for solid tumors?
2014 Volume 2, Issue 9, Page(s) 831–838
Abstract: With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved ... ...
| Abstract | With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. In this manner, clinicians hope to induce a phenomenon known as the abscopal effect, whereby localized radiation results in immune-mediated tumor regression in disease sites well outside of the radiation field. Herein, we present a comprehensive overview of the early clinical and preclinical evidence behind this approach. |
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| MeSH term(s) | Animals ; Antigens, Neoplasm/immunology ; Combined Modality Therapy ; Humans ; Immune System ; Immunotherapy/methods ; Mice ; Neoplasms/therapy ; Radiotherapy | |||||
| Chemical Substances | Antigens, Neoplasm | |||||
| Language | English | |||||
| Publishing date | 2014-09-03 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review | |||||
| ZDB-ID | 2732489-8 | |||||
| ISSN | 2326-6074 ; 2326-6066 | |||||
| ISSN (online) | 2326-6074 | |||||
| ISSN | 2326-6066 | |||||
| DOI | 10.1158/2326-6066.CIR-14-0069 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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