Article ; Online: Longitudinal study on respiratory viral co-infections in the presence or absence of clinical manifestation in infants aged 0-2 years.
Japanese journal of infectious diseases
2014 Volume 67, Issue 3, Page(s) 216–220
Abstract: We conducted a long-term follow-up study between December 2005 and February 2007 on 4 immunocompetent infants, who repeatedly presented with respiratory symptoms, using PCR-based techniques targeting 14 viruses related to acute respiratory tract ... ...
Abstract | We conducted a long-term follow-up study between December 2005 and February 2007 on 4 immunocompetent infants, who repeatedly presented with respiratory symptoms, using PCR-based techniques targeting 14 viruses related to acute respiratory tract infection. Of 38 specimens, 30 were collected from symptomatic infants and 8 were collected when respiratory symptoms were absent. Overall, one or more respiratory viruses were detected in 94.7% (36/38) of the specimens. Of the 36 PCR-positive specimens, 77.8% (28/36) were positive for more than one virus. Most of these co-infections were double infections (55.6% or 20/36). Of note, co-infections with 4 and 3 viruses were observed in 3 (8.3% or 3/36) and 5 (13.9% or 5/36) specimens, respectively. Of the 8 specimens collected from the 4 infants when apparent respiratory symptoms were absent, 7 (87.5%) were positive for respiratory viruses. Respiratory viral co-infections were also frequent and found in 5 of the specimens (62.5%). However, apparent correlation between disease severity and co-infection was undetectable due to the limit of the number of cases studied. Taken together, this longitudinal study revealed that respiratory viral co-infections were not infrequent in infants aged 0-2 years, regardless of the presence of respiratory symptoms (62.5-77.8%). |
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MeSH term(s) | Coinfection/epidemiology ; Coinfection/virology ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Japan/epidemiology ; Longitudinal Studies ; Male ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Virus Diseases/epidemiology ; Virus Diseases/virology ; Viruses/classification ; Viruses/genetics ; Viruses/isolation & purification |
Keywords | covid19 |
Language | English |
Publishing date | 2014-05-02 |
Publishing country | Japan |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1478383-6 |
ISSN | 1884-2836 ; 1344-6304 |
ISSN (online) | 1884-2836 |
ISSN | 1344-6304 |
DOI | 10.7883/yoken.67.216 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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