Article ; Online: Heterochronic regulation of lung development
2019 Volume 33, Issue 11, Page(s) 12008–12018
Abstract: The heterochronic gene Lin28 regulates diverse developmental processes. It was shown previously that global Lin28A overexpression during mouse embryogenesis results in perinatal lethality. However, the reason for this early lethality has not been ... ...
| Abstract | The heterochronic gene Lin28 regulates diverse developmental processes. It was shown previously that global Lin28A overexpression during mouse embryogenesis results in perinatal lethality. However, the reason for this early lethality has not been elucidated. Here, we showed that Lin28A overexpression prevents normal lung development |
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| MeSH term(s) | Animals ; Cell Differentiation/genetics ; Cell Proliferation/genetics ; Cluster Analysis ; Embryonic Development/genetics ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Developmental ; Lung/cytology ; Lung/embryology ; Lung/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice, Transgenic ; MicroRNAs/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Signal Transduction/genetics ; Time Factors | ||||||||||
| Chemical Substances | Lin-28 protein, mouse ; MicroRNAs ; RNA-Binding Proteins ; mirnlet7 microRNA, mouse | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2019-08-07 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 639186-2 | ||||||||||
| ISSN | 1530-6860 ; 0892-6638 | ||||||||||
| ISSN (online) | 1530-6860 | ||||||||||
| ISSN | 0892-6638 | ||||||||||
| DOI | 10.1096/fj.201802702R | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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