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  1. Article: Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers.

    Aoki, Kaoru / Ideta, Hirokazu / Komatsu, Yukiko / Tanaka, Atsushi / Kito, Munehisa / Okamoto, Masanori / Takahashi, Jun / Suzuki, Shuichiro / Saito, Naoto

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative ... ...

    Abstract Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative treatment options are available, such as joint arthroplasty, autologous bone grafting, and allogeneic bone grafting. Although various biodegradable polymers are also being developed as synthetic bone material in scaffolds for regenerative medicine, the clinical application of commercial synthetic bone products with comparable performance to that of calcium phosphate bioceramics have yet to be realized. This review discusses the status quo of bone-regeneration therapy using artificial bone composed of calcium phosphate bioceramics such as β-tricalcium phosphate (βTCP), carbonate apatite, and hydroxyapatite (HA), in addition to the recent use of calcium phosphate bioceramics, biodegradable polymers, and their composites. New research has introduced potential materials such as octacalcium phosphate (OCP), biologically derived polymers, and synthetic biodegradable polymers. The performance of artificial bone is intricately related to conditions such as the intrinsic material, degradability, composite materials, manufacturing method, structure, and signaling molecules such as growth factors and cells. The development of new scaffold materials may offer more efficient bone regeneration.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11020180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Two-Staged Reconstruction of Extensor Tendons After Wide Resection of Clear Cell Sarcoma at the Anterior Ankle: A Case Report.

    Komatsu, Yukiko / Takazawa, Akira / Kito, Munehisa / Yamazaki, Hiroshi / Takahashi, Jun / Kato, Hiroyuki

    JBJS case connector

    2023  Volume 13, Issue 3

    Abstract: Case: A 23-year-old woman sustained a skin defect in the anterior ankle involving the extensor retinaculum (ER) and 10 cm of extensor tendons (ETs) after a wide resection of clear cell sarcoma. The skin defect was reconstructed with free latissimus ... ...

    Abstract Case: A 23-year-old woman sustained a skin defect in the anterior ankle involving the extensor retinaculum (ER) and 10 cm of extensor tendons (ETs) after a wide resection of clear cell sarcoma. The skin defect was reconstructed with free latissimus dorsi flap, ER with tensor fascia lata, and ETs with 2-staged tendon reconstruction using silicone rod interposition, followed by semitendinosus and gracilis tendon grafts. Four years postoperatively, she achieved 92% of ankle and 70% of great toe motion of the contralateral side.
    Conclusion: This reconstruction technique was useful for a large soft-tissue defect at the anterior ankle.
    MeSH term(s) Female ; Humans ; Young Adult ; Adult ; Ankle ; Sarcoma, Clear Cell/surgery ; Ankle Joint ; Tendons ; Plastic Surgery Procedures
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI 10.2106/JBJS.CC.22.00776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Muscle strength and functional recovery for soft-tissue sarcoma of the thigh: a prospective study.

    Tanaka, Atsushi / Okamoto, Masanori / Kito, Munehisa / Yoshimura, Yasuo / Aoki, Kaoru / Suzuki, Shuichiro / Takazawa, Akira / Komatsu, Yukiko / Ideta, Hirokazu / Ishida, Takaaki / Takahashi, Jun

    International journal of clinical oncology

    2023  Volume 28, Issue 7, Page(s) 922–927

    Abstract: Background: This study aimed to investigate changes in muscle strength and functional outcome before and after surgery for soft-tissue sarcoma of the thigh and to examine the timing of recovery.: Methods: From 2014 to 2019, 15 patients who underwent ... ...

    Abstract Background: This study aimed to investigate changes in muscle strength and functional outcome before and after surgery for soft-tissue sarcoma of the thigh and to examine the timing of recovery.
    Methods: From 2014 to 2019, 15 patients who underwent multiple resections of the thigh muscle for soft-tissue sarcoma of the thigh were included in this study. The muscle strength was measured with an isokinetic dynamometer for the knee joint and with a hand-held dynamometer for the hip joint. The functional outcome assessment was based on the Musculoskeletal Tumor Society (MSTS) score, Toronto Extremity Salvage Score (TESS), European Quality of Life-5 Dimensions (EQ-5D), and maximum walking speed (MWS). All measurements were conducted preoperatively and at 3, 6, 12, 18, and 24 months postoperatively, and the ratio of postoperative to preoperative value was used. A repeated-measures analysis of variance was performed to compare changes over time and to investigate the recovery plateau. Correlations between changes in muscle strength and functional outcomes were also examined.
    Results: The muscle strength of the affected limb, MSTS score, TESS, EQ-5D, and MWS were significantly decreased at 3 months postoperatively. The recovery plateau was subsequently reached at 12 months postoperatively. The changes in muscle strength of the affected limb and functional outcome showed a significant correlation.
    Conclusions: The estimated postoperative recovery for soft-tissue sarcoma of the thigh is 12 months after surgery.
    MeSH term(s) Humans ; Thigh/surgery ; Thigh/pathology ; Prospective Studies ; Quality of Life ; Muscle Strength ; Sarcoma/surgery ; Sarcoma/pathology ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Treatment Outcome
    Language English
    Publishing date 2023-05-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-023-02348-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Does re-ossification after palliative radiotherapy for spinal bone metastases help maintain vertebral body height?

    Kito, Munehisa / Tsukahara, Yoshinori / Okamoto, Masanori / Fukazawa, Ayumu / Ikegami, Shota / Tanaka, Atsushi / Komatsu, Yukiko / Ideta, Hirokazu / Aoki, Kaoru / Fujinaga, Yasunari / Takahashi, Jun

    The spine journal : official journal of the North American Spine Society

    2023  Volume 23, Issue 10, Page(s) 1540–1548

    Abstract: Background context: After palliative radiotherapy of spinal bone metastases, re-ossification is sometimes observed in bone with osteolytic changes. However, it remains unknown whether the re-ossification that is observed after radiotherapy is associated ...

    Abstract Background context: After palliative radiotherapy of spinal bone metastases, re-ossification is sometimes observed in bone with osteolytic changes. However, it remains unknown whether the re-ossification that is observed after radiotherapy is associated with preservation of vertebral body height.
    Purpose: To investigate whether re-ossification observed after palliative radiotherapy can contribute to the preservation of vertebral body height.
    Study design: This is a retrospective observational study.
    Patients sample: We investigated 111 vertebral bodies in 54 patients that underwent palliative radiotherapy at a single center for painful osteolytic/mixed metastatic spinal tumors in solid tumors between 2016 and 2020.
    Outcome measures: The outcome measures were the presence of re-ossification and vertebral body height reduction on the CT image.
    Methods: Re-ossification was evaluated according to the MD Anderson response classification criteria, and sagittal CT images were used to evaluate vertebral body height. A vertebral body ID was assigned to the irradiated vertebral body, and continuous CT images obtained for each vertebral body ID were evaluated. The median number of evaluation periods for each vertebral body was 4, and the total number of periods was 463. Logistic regression analysis was performed to investigate factors related to the occurrence of vertebral body height reduction before the subsequent CT. As a subanalysis, factors related to re-ossification were investigated.
    Results: The following primary cancer types were observed: lung cancer, 41 vertebral bodies; breast cancer, 19; renal cell cancer, 15; other, 36. A total of 62.2% showed re-ossification. The median time to confirmation of re-ossification by CT was 2 months. Factors significantly associated with vertebral body height reduction were presence of vertebral body height reduction before radiotherapy (odds ratio [OR] 6.8, 95% confidence interval [CI] 2.0-63, p=.01) and no re-ossification (OR 137, 95% CI 22-3469, p<.01). Factors associated with re-ossification were the type of cancer and total radiation dose. Those with lung cancer and those with a total radiation dose of 20 Gy or less were more prone to re-ossification.
    Conclusions: Re-ossification was observed in 62.2% of vertebral bodies after palliative radiotherapy for painful osteolytic/mixed metastatic spinal tumors. The re-ossification group demonstrated significantly less vertebral body height reduction when compared with the non-re-ossification group. The presence of re-ossification may potentially serve an important role in maintaining vertebral body height.
    MeSH term(s) Humans ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/radiotherapy ; Spinal Neoplasms/complications ; Vertebral Body/pathology ; Osteogenesis ; Spine/diagnostic imaging ; Spine/pathology ; Lung Neoplasms
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2023.06.389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Influence of the adductor compartment resection on muscle strength and postoperative function in soft-tissue sarcoma of the thigh.

    Tanaka, Atsushi / Okamoto, Masanori / Kito, Munehisa / Yoshimura, Yasuo / Aoki, Kaoru / Suzuki, Shuichiro / Takazawa, Akira / Komatsu, Yukiko / Ishida, Takaaki / Takahashi, Jun

    Japanese journal of clinical oncology

    2021  Volume 52, Issue 4, Page(s) 370–374

    Abstract: Objective: To predict the muscle strength and postoperative function for soft-tissue sarcoma arising from the adductor compartment of the thigh.: Methods: Between 2003 and 2019, 17 cases that underwent resection of the adductor muscle group (adductor ...

    Abstract Objective: To predict the muscle strength and postoperative function for soft-tissue sarcoma arising from the adductor compartment of the thigh.
    Methods: Between 2003 and 2019, 17 cases that underwent resection of the adductor muscle group (adductor longus, adductor magnus, adductor brevis, gracilis and pectineus) for soft-tissue sarcoma in the adductor compartment of the thigh were included. The muscle strength was measured with an isokinetic dynamometer for the knee joint and with a hand-held dynamometer for the hip joint (ratio of affected to unaffected side). The Musculoskeletal Tumor Society score, Toronto Extremity Salvage Score, European Quality of Life-5 Dimensions and maximum walking speed were used to assess postoperative function and examine correlations with muscle strength.
    Results: In 13 cases that underwent an isolated resection of the adductor compartment, reduced adduction strength correlated with increased number of resected muscles in the adductor muscle group (P < 0.001). Postoperative function was maintained, showing no correlations with adduction strength. In four cases that underwent combined resections of other compartments, a decrease was observed in adduction strength as well as the muscle strength of other resected muscles, in addition to a decline in postoperative function. In the 4 or 5 adductor muscle resection group, the comparison between isolated and combined resection revealed comparable results for adduction strength but a significant decrease in postoperative function for the combined resection group.
    Conclusions: Postoperative function can be preserved for isolated adductor compartment resection. Combined resections of multiple muscles in other compartments and most adductor muscles may result in decreased postoperative function.
    MeSH term(s) Humans ; Muscle Strength ; Muscle, Skeletal/pathology ; Quality of Life ; Sarcoma/pathology ; Sarcoma/surgery ; Soft Tissue Neoplasms/surgery ; Thigh/pathology
    Language English
    Publishing date 2021-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyab207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1298: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Distal femoral impaction bone grafting in revision for tumor endoprosthesis.

    Kito, Munehisa / Okamoto, Masanori / Aoki, Kaoru / Tanaka, Atsushi / Komatsu, Yukiko / Suzuki, Shuichiro / Takazawa, Akira / Yoshimura, Yasuo / Takahashi, Jun

    The Knee

    2021  Volume 29, Page(s) 42–48

    Abstract: Background: Reconstruction using tumor endoprosthesis has been widely used in cases with large bone defects caused by bone and soft tissue tumor resection of the distal femur which extend into the knee joint. However, reconstruction failure can lead to ... ...

    Abstract Background: Reconstruction using tumor endoprosthesis has been widely used in cases with large bone defects caused by bone and soft tissue tumor resection of the distal femur which extend into the knee joint. However, reconstruction failure can lead to major problems in the long term. We have been performing impaction bone grafting with allogeneic cancellous bone during revision surgery for tumor endoprosthesis of the distal femur to compensate for the thinness and fragility of the remaining femur. The aim of this study is to examine the surgical method, problems, and clinical outcomes of revision surgery with impaction bone grafting.
    Methods: Three patients who underwent revision surgery for tumor endoprosthesis using impaction bone grafting at our institution with more than 2 years of follow-up were included.
    Results: Union between the graft and host bone were achieved in all cases. The mean time to radiographic union was 1.0 year (0.6-1.5 years). Although intraoperative penetration to the anterior cortex of the distal femur occurred in 2 cases, there were no postoperative fractures. There were no failures of tumor endoprosthesis at final observation.
    Conclusion: Good short-term results were observed in 3 patients who underwent revision tumor endoprosthesis with impaction bone grafting following a bone and soft tissue tumor resection of the distal femur. The method was considered to be a useful treatment option. Impaction bone grafting is an established surgical option that can be applied to revision surgery for tumor endoprosthesis.
    Language English
    Publishing date 2021-02-04
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1200476-5
    ISSN 1873-5800 ; 0968-0160
    ISSN (online) 1873-5800
    ISSN 0968-0160
    DOI 10.1016/j.knee.2021.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4043: Show issues Location:
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  7. Article: [A case report of a patient with advanced rectal cancer who was administered chemotherapy in collaboration with a clinical pathway and visiting nursing care].

    Iwata, Seiichiro / Imai, Shinsuke / Mochiduki, Hirohiko / Watanabe, Keiichi / Imazeki, Makiko / Ueno, Mariko / Kaneko, Junko / Komatsu, Yukiko / Taguchi, Yoshiko / Watanabe, Yoshiko / Hirata, Keiko / Suzuki, Chikako

    Gan to kagaku ryoho. Cancer & chemotherapy

    2006  Volume 33 Suppl 2, Page(s) 361–363

    Abstract: Recently, chemotherapy for the treatment of colorectal cancer was widely administered in Japan. Many various ideas were necessary to perform safe and efficient chemotherapy at our hospital. We experienced that even a patient with intellectual disability ... ...

    Abstract Recently, chemotherapy for the treatment of colorectal cancer was widely administered in Japan. Many various ideas were necessary to perform safe and efficient chemotherapy at our hospital. We experienced that even a patient with intellectual disability could have chemotherapy carry out smoothly in collaboration with a clinical pathway and visiting nursing care. The patient was a 63-year-old man who underwent low anterior resection of the rectum for advanced rectal cancer on April 2004. Multiple liver metastases had appeared in November 2004. Chemotherapy was administered because of the liver metastases. However, it was difficult to manage the side effect of the chemotherapy and we could not get cooperation from his family. A visiting nursing care was employed in cooperation with outpatient nursing for managing of the side effect. IFL regimen was carried out using a clinical pathway. The response became PD after 5 courses of an IFL regimen. The regimen was changed to FOLFOX4 on April 2005. No adverse events were seen beyond grade 2 during 10 courses of FOLFOX4 regimen.
    MeSH term(s) Ambulatory Care ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Community Health Nursing ; Cooperative Behavior ; Critical Pathways ; Drug Administration Schedule ; Fluorouracil/administration & dosage ; Humans ; Leucovorin/administration & dosage ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Organoplatinum Compounds/administration & dosage ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery
    Chemical Substances Organoplatinum Compounds ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
    Language Japanese
    Publishing date 2006-12
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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