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  1. Article: Goldilocks Procedure without a Vertical Incision and a Comprehensive Literature Review.

    Becker, Hilton / Vazquez, Oscar Adrian / Komberg, Jacob

    Plastic and reconstructive surgery. Global open

    2021  Volume 9, Issue 8, Page(s) e3786

    Abstract: The Goldilocks technique is a postmastectomy breast reconstruction procedure adopted in 2012, which is performed by preserving and de-epithelializing the residual mastectomy flap to create an autologous tissue breast mound using an anchor, inverted T, or ...

    Abstract The Goldilocks technique is a postmastectomy breast reconstruction procedure adopted in 2012, which is performed by preserving and de-epithelializing the residual mastectomy flap to create an autologous tissue breast mound using an anchor, inverted T, or lateral incision. It is utilized in select patients along with the addition of a free nipple graft, fat grafting, and/or tattoo. A novel technique using the Goldilocks procedure offers promising postoperative results as a more aesthetic alternative. The purpose of this study was to perform a literature review on the healing outcomes and patient satisfaction of the Goldilocks procedure along with presenting our approach using a horizontal inframammary incision without a vertical incision.
    Methods: A retrospective chart review of patients presenting to a single surgeon for breast reconstruction surgery using the Goldilocks procedure without a vertical incision from March of 2018 to October of 2020 was performed. A narrative literature review on surgical techniques and outcomes was also conducted.
    Results: Three cases of breast reduction using the Goldilocks procedure without a vertical incision are described. From the literature search, 13 articles inclusive of 222 patients were identified.
    Conclusions: The Goldilocks procedure without a vertical incision can be performed in patients with large breasts for breast reconstruction postmastectomy. It is possible to utilize the superior flap in conjunction with the de-epithelialized inferior flap of the breast and obtain good projection with this method. Furthermore, avoidance of the vertical incision reduces breakdown at the T-junction and is aesthetically beneficial.
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000003786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Alopecia Areata Treated with Advanced Platelet-rich Fibrin Using Micronization.

    Vazquez, Oscar Adrian / Safeek, Rachel H / Komberg, Jacob / Becker, Hilton

    Plastic and reconstructive surgery. Global open

    2022  Volume 10, Issue 1, Page(s) e4032

    Abstract: Platelet-rich plasma (PRP) has been shown to release a multitude of growth factors, but its preparation requires the use of anticoagulants. In contrast, advanced platelet-rich fibrin (aPRF) is produced by centrifuging whole blood and allowing it to clot. ...

    Abstract Platelet-rich plasma (PRP) has been shown to release a multitude of growth factors, but its preparation requires the use of anticoagulants. In contrast, advanced platelet-rich fibrin (aPRF) is produced by centrifuging whole blood and allowing it to clot. The clot contains the platelets, growth factors, and neutrophils, and it is composed of a fibrin matrix that continuously releases more growth factors over a longer time period. Advanced PRF is commonly used in dental and bone grafting procedures, but it is rarely used for cosmetic injectables because its high density makes it difficult to inject through smaller gauge needles. A technique is described whereby aPRF is reduced to an injectable form with micronization and used to treat alopecia areata (AA) in a 28-year-old patient who developed it after symptomatic COVID-19 infection a month before presentation. The patient was vaccinated in between infection, and symptoms were limited to headache and sore throat. He had complete resolution of his AA at 6-month follow-up with only two treatments as opposed to monthly intralesional steroids. We report our results using aPRF for AA with promising results as a possible future treatment for patients with this autoimmune disease.
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article: Free Nipple Graft Breast Reduction without a Vertical Incision.

    Vazquez, Oscar Adrian / Yerke Hansen, Payton / Komberg, Jacob / Slutsky, Hanna L / Becker, Hilton

    Plastic and reconstructive surgery. Global open

    2022  Volume 10, Issue 3, Page(s) e4167

    Abstract: Background: A technique of a free nipple graft with an inframammary incision and no vertical incision offers promising postoperative results as a safe and aesthetic alternative.: Methods: This was a retrospective chart review of patients who ... ...

    Abstract Background: A technique of a free nipple graft with an inframammary incision and no vertical incision offers promising postoperative results as a safe and aesthetic alternative.
    Methods: This was a retrospective chart review of patients who presented to a single surgeon for breast reduction surgery using a free nipple graft with an inframammary incision from June 1999 to March 2021. Baseline patient demographics and clinical information along with postoperative complications were recorded and compared between patients who presented for concomitant reconstruction or just reduction. A narrative literature review on surgical techniques and outcomes was also conducted.
    Results: From the literature search, there have been minimal prior mentions of breast reductions using a free nipple graft with an inframammary incision and no vertical incision. Fifty-five cases were identified for breast reduction surgery in the author's 22-year study period, of which 46 had adequate clinical documentation and follow-up. An estimated 22 patients had either both or one breast reconstructed with opposite side breast reduction, and 24 patients underwent breast reduction alone with free nipple grafting. No implants were used in any of the patients.
    Conclusions: The free nipple graft technique with an inframammary incision can be performed on patients with excessively large or ptotic breasts. It is possible to reduce the volume of the breast and obtain good projection with this method. Furthermore, avoidance of the vertical incision reduces breakdown at the T-junction and is aesthetically beneficial.
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
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  4. Article ; Online: Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

    Shi, Yingxiao / Lin, Shaoyu / Staats, Kim A / Li, Yichen / Chang, Wen-Hsuan / Hung, Shu-Ting / Hendricks, Eric / Linares, Gabriel R / Wang, Yaoming / Son, Esther Y / Wen, Xinmei / Kisler, Kassandra / Wilkinson, Brent / Menendez, Louise / Sugawara, Tohru / Woolwine, Phillip / Huang, Mickey / Cowan, Michael J / Ge, Brandon /
    Koutsodendris, Nicole / Sandor, Kaitlin P / Komberg, Jacob / Vangoor, Vamshidhar R / Senthilkumar, Ketharini / Hennes, Valerie / Seah, Carina / Nelson, Amy R / Cheng, Tze-Yuan / Lee, Shih-Jong J / August, Paul R / Chen, Jason A / Wisniewski, Nicholas / Hanson-Smith, Victor / Belgard, T Grant / Zhang, Alice / Coba, Marcelo / Grunseich, Chris / Ward, Michael E / van den Berg, Leonard H / Pasterkamp, R Jeroen / Trotti, Davide / Zlokovic, Berislav V / Ichida, Justin K

    Nature medicine

    2018  Volume 24, Issue 3, Page(s) 313–325

    Abstract: An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), we ... ...

    Abstract An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), we found that repeat-expanded C9ORF72 was haploinsufficient in ALS. We found that C9ORF72 interacted with endosomes and was required for normal vesicle trafficking and lysosomal biogenesis in motor neurons. Repeat expansion reduced C9ORF72 expression, triggering neurodegeneration through two mechanisms: accumulation of glutamate receptors, leading to excitotoxicity, and impaired clearance of neurotoxic dipeptide repeat proteins derived from the repeat expansion. Thus, cooperativity between gain- and loss-of-function mechanisms led to neurodegeneration. Restoring C9ORF72 levels or augmenting its function with constitutively active RAB5 or chemical modulators of RAB5 effectors rescued patient neuron survival and ameliorated neurodegenerative processes in both gain- and loss-of-function C9ORF72 mouse models. Thus, modulating vesicle trafficking was able to rescue neurodegeneration caused by the C9ORF72 repeat expansion. Coupled with rare mutations in ALS2, FIG4, CHMP2B, OPTN and SQSTM1, our results reveal mechanistic convergence on vesicle trafficking in ALS and FTD.
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Disease Models, Animal ; Endosomes/genetics ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Gene Expression Regulation/genetics ; Haploinsufficiency/genetics ; Humans ; Introns/genetics ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Mutation ; Nerve Degeneration/genetics ; Nerve Degeneration/physiopathology ; rab5 GTP-Binding Proteins/genetics
    Chemical Substances C9orf72 Protein ; rab5 GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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