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Article ; Conference proceedings: Metastatic Endometrial Carcinoma of the Paranasal Sinuses with Cribriform Plate Involvement: A Case Report

Kominsky, Evan / Filimonov, Ivan / Filimonov, Andrey / Spock, Todd

Journal of Neurological Surgery Part B: Skull Base

2022 Volume 83, Issue S 01

Event/congress	31st Annual Meeting North American Skull Base Society, Online, 2022-02-18
Language	English
Publishing date	2022-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0042-1743895
Database	Thieme publisher's database

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Zs.A 3425: Show issues

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Article ; Online: Biphenotypic Sinonasal Sarcoma: A Case Report and Review of Literature.

Kominsky, Evan / Boyke, Andre E / Madani, Daniel / Kamat, Ameet / Schiff, Bradley A / Agarwal, Vijay

Ear, nose, & throat journal

2021 Volume 102, Issue 6, Page(s) 385–390

Abstract: Objectives: Biphenotypic sinonasal sarcoma (BSNS), previously low-grade sinonasal sarcoma with neural and myogenic features, is a rare tumor of the sinonasal tract first described in 2012. Due to its rarity, limited literature is available in providing ... ...

Abstract	Objectives: Biphenotypic sinonasal sarcoma (BSNS), previously low-grade sinonasal sarcoma with neural and myogenic features, is a rare tumor of the sinonasal tract first described in 2012. Due to its rarity, limited literature is available in providing clinicians with a standardized treatment regimen, Methods: Online electronic databases include PubMed and Embase where queried for reports of biphenotypic sinonasal sarcoma or low-grade sinonasal sarcoma with neural and myogenic features. Two previously unpublished cases were included in the results. Data including clinical presentation, epidemiologic data, radiologic evaluation, intraoperative details, histopathology, treatment modality, and postoperative follow-up information were included. Results: A total of 100 previously published cases were identified in 12 prior articles. Mean age at presentation was 52.9 years. Extrasinonasal extension was observed in 27.4% of cases with most common site of extension being cribriform plate. Forty-seven cases included treatment details with surgical excision being the most common modality. Recurrence rates were identical for both surgical excision alone and surgical excision with adjuvant radiotherapy (33.3%). Conclusions: Biphenotypic sinonasal sarcoma is a slow-growing tumor that is amenable to surgical resection. Recurrence rates are similar between surgical excision and surgical excision with adjuvant radiation therapy, but limited data in reported cases preclude a determination of treatment superiority.
MeSH term(s)	Humans ; Middle Aged ; Paranasal Sinus Neoplasms/diagnosis ; Paranasal Sinus Neoplasms/therapy ; Paranasal Sinus Neoplasms/pathology ; Sarcoma/diagnosis ; Sarcoma/therapy ; Sarcoma/pathology ; Soft Tissue Neoplasms ; Biomarkers, Tumor
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/0145561321999196
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 107: Show issues

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Article ; Online: Does "Just in Time" teaching of ergonomic principles improve posture of trainees during otologic microscopic surgery?

Gold, Brandon S / Oh, Samuel J / Varelas, Eleni A / Arrighi-Allisan, Annie E / Kominsky, Evan S / Perez, Enrique R / Cosetti, Maura K

American journal of otolaryngology

2022 Volume 44, Issue 1, Page(s) 103682

Abstract: Purpose: Musculoskeletal disorders are prevalent among otolaryngologists and otologists with symptoms starting during residency. Prior data suggested that high-risk joint angles were often adopted at procedure onset, suggesting a detrimental "natural" ... ...

Abstract	Purpose: Musculoskeletal disorders are prevalent among otolaryngologists and otologists with symptoms starting during residency. Prior data suggested that high-risk joint angles were often adopted at procedure onset, suggesting a detrimental "natural" operating position. Despite its importance, dedicated ergonomic teaching is not systematically introduced into residency training. The objective of this study was to compare initial ergonomic positioning during microscopic temporal bone surgery between those who receive "Just in Time" ergonomic teaching prior to starting dissection with those who did not. Materials and methods: This was a pilot, prospective trial in which otolaryngology residents at an urban, multicenter tertiary care academic institution (n = 14) wore ergonomic sensors (inertial measurement units) during microscopic temporal bone lab drilling. Prior to recording, participants were randomized to receive an instructional presentation on ergonomic principles (n = 8, intervention group) or not (n = 6, control group). The inertial measurement units analyzed neck and back angles for the initial 5 min of drilling. Results: Of 14 trainees, 78.6 % had prior experience with otologic microscopic cases and 14.3 % reported prior surgical ergonomic training or instruction. The groups were matched in trainee height (P = 0.54), handedness (P = 0.83), stage of otolaryngology training (P = 0.64), prior otologic microscopic surgery experience (P = 0.35), prior temporal bone drilling experience (P = 0.35), and prior teaching in ergonomic principles (P = 0.47). Junior trainees (PGY 1-3) who did not receive "Just in Time" teaching adopted a posture with significantly higher risk back flexion compared to junior trainees who received the training (25.3° vs. 5.7°, P = 0.04). There was no difference in back positioning among senior trainees (12.6° vs. -5.7°, P = 0.13). While there was a trend towards those in the intervention group adopting safer procedural posture, there was no significant difference in the overall cohort between the intervention and control groups in both neck positioning (-11.0° vs. -19.1°, P = 0.17) and back positioning (8.6° vs. 19.1°, P = 0.18). Conclusions: Musculoskeletal related pain is prevalent among otolaryngologists and otologists with data suggesting that symptoms begin during residency. Targeted "Just in Time" teaching of ergonomic principles is feasible and may be effective for development of healthy postural habits, especially among junior trainees.
MeSH term(s)	Humans ; Prospective Studies ; Ergonomics/methods ; Musculoskeletal Diseases/prevention & control ; Posture ; Otolaryngology ; Occupational Diseases/etiology ; Occupational Diseases/prevention & control
Language	English
Publishing date	2022-10-22
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103682
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1637: Show issues

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Article ; Online: 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma.

Filip, Peter / Lerner, David K / Kominsky, Evan / Schupper, Alexander / Liu, Katherine / Khan, Nazir Mohemmed / Roof, Scott / Hadjipanayis, Constantinos / Genden, Eric / Iloreta, Alfred M C

The Laryngoscope

2023 Volume 134, Issue 2, Page(s) 741–748

Abstract: Objectives: To determine the utility of 5-aminolevulinic acid (5-ALA) fluorescence for resection of head and neck carcinoma.: Methods: In this prospective pilot trial, 5-ALA was administered as an oral suspension 3-5 h prior to induction of ... ...

Abstract	Objectives: To determine the utility of 5-aminolevulinic acid (5-ALA) fluorescence for resection of head and neck carcinoma. Methods: In this prospective pilot trial, 5-ALA was administered as an oral suspension 3-5 h prior to induction of anesthesia for resection of head and neck squamous cell carcinoma (HNSCC). Following resection, 405 nm blue light was applied, and fluorescence of the tumor as well as the surgical bed was recorded. Specimen fluorescence intensity was graded categorically as none (score = 0), mild (1), moderate (2), or robust (3) by the operating surgeon intraoperatively and corroborated with final pathologic diagnosis. Results: Seven patients underwent resection with 5-ALA. Five (83%) were male with an age range of 33-82 years (mean = 60). Sites included nasal cavity (n = 3), oral cavity (n = 3), and the larynx (n = 1). All specimens demonstrated robust fluorescence when 5-ALA was administered 3-5 h preoperatively. 5-ALA fluorescence predicted the presence of perineural invasion, a positive margin, and metastatic lymphadenopathy. Two patients had acute photosensitivity reactions, and one patient had a temporary elevation of hepatic enzymes. Conclusions: 5-ALA induces robust intraoperative fluorescence of HNSCC, capable of demonstrating a positive margin, perineural invasion, and metastatic nodal disease. Although no conclusions are there about the safety of this drug in the head and neck cancer population, our study parallels the extensive safety data in the neurosurgical literature. Future applications may include intraoperative assessment of margin status, diagnostic accuracy, and impacts on survival. Level of evidence: 4 Laryngoscope, 134:741-748, 2024.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Aminolevulinic Acid ; Brain Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Margins of Excision ; Prospective Studies ; Squamous Cell Carcinoma of Head and Neck/surgery ; Surgery, Computer-Assisted ; Pilot Projects
Chemical Substances	Aminolevulinic Acid (88755TAZ87)
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30910
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ul II Zs.82: Show issues

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Article ; Online: The impact of the COVID-19 pandemic on otolaryngologic emergency department visits at two major NYC hospital systems.

Patel, Viraj M / Kominsky, Evan / Tham, Tristan / Bottalico, Danielle / Setzen, Michael / Ferastraoaru, Denisa / Akbar, Nadeem / Fastenberg, Judd H

American journal of otolaryngology

2021 Volume 42, Issue 5, Page(s) 103123

Abstract: Purpose: Since the COVID-19 pandemic began, emergency departments (ED) across the country have seen a significant decrease in patient visits. We aim to evaluate the impact of COVID-19 on ED visits for acute otolaryngologic complaints in New York City, ... ...

Abstract	Purpose: Since the COVID-19 pandemic began, emergency departments (ED) across the country have seen a significant decrease in patient visits. We aim to evaluate the impact of COVID-19 on ED visits for acute otolaryngologic complaints in New York City, one of the first epicenters of the pandemic in the US. Materials and methods: We conducted a retrospective study of patients who presented to the ED with a primary diagnosis of an acute otolaryngologic complaint between March 1 and May 31 in 2019 and 2020. This was a multicenter study, including two tertiary care hospital systems encompassing Manhattan, Bronx, Queens, and Long Island. Results: A total of 10,162 patients were identified. Significantly fewer patients presented to the ED for acute otolaryngologic complaints in 2020 (7332 vs 2830, p < 0.001). The rate of total otolaryngology-related ED visits was decreased by a factor of 0.635 (95% CI 0.6079 to 0.6634). In a subgroup analysis of each individual diagnosis, there was a significant decrease in rate of ED visits for 13 out of 18 diagnoses, including for life-threatening conditions, such as anaphylaxis. There was no significant difference based on which borough in New York City. Pediatric patients (age 0-17) were more significantly impacted by the pandemic compared to other age groups. Conclusion: The COVID-19 pandemic has led to a reduction in the utilization of ED for acute otolaryngologic complaints, including those requiring emergent management, and an even more significant reduction in the pediatric population. Healthcare providers should encourage patients to seek appropriate care, particularly for those illnesses with significant associated morbidity and mortality.
MeSH term(s)	Adolescent ; Adult ; Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Child ; Child, Preschool ; Emergency Service, Hospital ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; New York City ; Otorhinolaryngologic Diseases/diagnosis ; Otorhinolaryngologic Diseases/epidemiology ; Otorhinolaryngologic Diseases/virology ; Retrospective Studies ; Symptom Assessment ; Young Adult
Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2021.103123
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1637: Show issues

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Article ; Online: Omega-3 Fatty Acid Supplementation for the Treatment of Persistent COVID-Related Olfactory Dysfunction.

Lerner, David K / Garvey, Katherine L / Arrighi-Allisan, Annie / Kominsky, Evan / Filimonov, Andrey / Al-Awady, Abdurrahman / Filip, Peter / Liu, Katherine / Ninan, Sen / Spock, Todd / Tweel, Benjamin / van Gerwen, Maaike / Schaberg, Madeleine / Colley, Patrick / Del Signore, Anthony / Govindaraj, Satish / Iloreta, Alfred Marc

American journal of rhinology & allergy

2023 Volume 37, Issue 5, Page(s) 531–540

Abstract: Objective: To evaluate the efficacy of omega-3 fatty acid (O3FA) supplementation in the treatment of COVID-related olfactory dysfunction (OD).: Methods: Patients with laboratory-confirmed or clinically-suspected COVID-19 infection and new-onset OD ... ...

Abstract	Objective: To evaluate the efficacy of omega-3 fatty acid (O3FA) supplementation in the treatment of COVID-related olfactory dysfunction (OD). Methods: Patients with laboratory-confirmed or clinically-suspected COVID-19 infection and new-onset OD from August 2020 to November 2021 were prospectively recruited. Patients with quantitative OD, defined as a brief smell identification test (BSIT) score of 9 or less, were eligible for study inclusion. The experimental group received 2 g of O3FA supplementation, while the control group received an identical placebo to be taken daily for 6 weeks. The primary outcome was a change in BSIT score between the initial and 6-week follow-up tests. Results: One hundred and seventeen patients were included in the analysis, including 57 patients in the O3FA group and 60 in the placebo group. O3FA group patients demonstrated a mean BSIT improvement of 1.12 ± 1.99 compared to 0.68 ± 1.86 in the placebo group ( Conclusion: Among patients with persistent COVID-related OD, our study showed no clear evidence of relative short-term or long-term olfactory recovery among patients receiving high doses of O3FA supplementation.
MeSH term(s)	Humans ; Fatty Acids, Omega-3/therapeutic use ; Smell ; COVID-19/complications ; Olfaction Disorders/drug therapy ; Dietary Supplements
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.1177/19458924231174799
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2542: Show issues

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Article ; Online: Seeking an optimal dose of preoperative corticosteroids in chronic rhinosinusitis with nasal polyposis: A randomized controlled trial.

Kominsky, Evan / Liu, Katherine Y / Ninan, Sen / Arrighi-Allisan, Annie / Filimonov, Andrey / Kidwai, Sarah / Morton, Kathryn / Saini, Alok T / Spock, Todd / Del Signore, Anthony / Govindaraj, Satish / Iloreta, Alfred Marc

American journal of otolaryngology

2022 Volume 43, Issue 4, Page(s) 103476

Abstract: Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no ... ...

Abstract	Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no consensus on the optimal dosing regimen. Methods: A randomized, controlled trial was conducted to compare low, medium, and high dose corticosteroids prior to ESS. Patients with CRSwNP refractory to medical management were randomized to low (N = 8), medium (N = 10), or high (N = 5) dosing regimens of corticosteroids prior to ESS. Baseline disease severity was measured with the 22-item Sino-nasal Outcome Test and Lund-Mackay scores. Modified Lund-Kennedy endoscopic scores (MLKES) were measured at baseline and after corticosteroid treatment. Intraoperative parameters were measured including Boezaart surgical visibility score, intraoperative blood loss, and operative time. Results: Medium dose corticosteroids demonstrated a superior surgical visibility score to low dose and comparable results to high dose, but these results were not significant (p = 0.33). No significant difference was observed between groups for total blood loss (p = 0.15), operative time (p = 0.87), or change in MLKES (p = 0.27). Conclusions: Current recommendations include the use of preoperative corticosteroids in patients with CRSwNP undergoing ESS, but there is no consensus on dose or duration. We did not find a statistically significant difference in surgical field visibility, intraoperative blood loss, or operative time between different dosing regimens. Further studies are needed to evaluate the efficacy of a low-dose preoperative regimen with the goal of reducing cumulative patient exposure to systemic corticosteroids.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Blood Loss, Surgical/prevention & control ; Chronic Disease ; Endoscopy/methods ; Humans ; Nasal Polyps/complications ; Nasal Polyps/drug therapy ; Nasal Polyps/surgery ; Rhinitis/complications ; Rhinitis/drug therapy ; Rhinitis/surgery ; Sinusitis/complications ; Sinusitis/drug therapy ; Sinusitis/surgery ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103476
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1637: Show issues

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Article ; Conference proceedings: Metastatic Endometrial Carcinoma of the Paranasal Sinuses with Cribriform Plate Involvement: A Case Report

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Article ; Online: Biphenotypic Sinonasal Sarcoma: A Case Report and Review of Literature.

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Article ; Online: Does "Just in Time" teaching of ergonomic principles improve posture of trainees during otologic microscopic surgery?

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Article ; Online: 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma.

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Article ; Online: The impact of the COVID-19 pandemic on otolaryngologic emergency department visits at two major NYC hospital systems.

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Article ; Online: Omega-3 Fatty Acid Supplementation for the Treatment of Persistent COVID-Related Olfactory Dysfunction.

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Article ; Online: Seeking an optimal dose of preoperative corticosteroids in chronic rhinosinusitis with nasal polyposis: A randomized controlled trial.

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