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Article: First Report of

Šoprek, Silvija / Ujević, Josip / Kompes, Gordan / Jurinović, Luka / Tambić Andrašević, Arjana

2023 Volume 11, Issue 8

Abstract: In the era of growing antimicrobial resistance, a threat affecting humans, endangering animals, as well as livelihoods and food security worldwide, we wanted to find possible explanations for its continuous spread from a new perspective. The ubiquity of ... ...

Abstract	In the era of growing antimicrobial resistance, a threat affecting humans, endangering animals, as well as livelihoods and food security worldwide, we wanted to find possible explanations for its continuous spread from a new perspective. The ubiquity of resistance genes requires a One Health approach to finding the explanations for continuous AMR spread. The natural transformability of
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11081884
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia

Šoprek, Silvija / Duvnjak, Sanja / Kompes, Gordan / Jurinović, Luka / Tambić Andrašević, Arjana

Microorganisms. 2022 July 13, v. 10, no. 7

2022

Abstract: Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance in Campylobacter jejuni. C. jejuni can sometimes cause life-threatening and severe systematic infections (bacteremia, meningitis, ... ...

Abstract	Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance in Campylobacter jejuni. C. jejuni can sometimes cause life-threatening and severe systematic infections (bacteremia, meningitis, and other extraintestinal infections) with very few antibiotics left as treatment options. Bearing in mind that C. jejuni is the predominant species in humans, in this paper, we present a study of the C. jejuni differences in antimicrobial resistance and genotype distribution between strains isolated from stool and primary sterile sites. We compared the genomic data obtained through whole genome sequencing (WGS) and phenotypic susceptibility data of C. jejuni strains. Once antimicrobial susceptibility testing of C. jejuni strains was carried out by the broth microdilution method for six of interest, results were compared to the identified genotypic determinants derived from WGS. The high rate of resistance to fluoroquinolones presented in this study is in accordance with national surveillance data. The proportion of strains with acquired resistance was 71% for ciprofloxacin and 20% for tetracycline. When invasive isolates were analysed separately, 40% exhibited MIC values of ciprofloxacin higher than the ECOFFs, suggesting a lower flouroquinolone resistance rate in invasive isolates. All isolates demonstrated wilde-type phenotype for chloramphenicol, erythromycin, gentamicin, and ertapenem. A special focus and review in this study was performed on a group of C.jejuni strains found in primary sterile samples. Apart from demonstrating a lower resistance rate, these isolates seem genetically more uniform, showing epidemiologically more homogenous patterns, which cluster to several clonal complexes, with CC49 being the most represented clonal complex.
Keywords	Campylobacter jejuni ; antibiotic resistance ; antibiotic resistance genes ; bacteremia ; campylobacteriosis ; chloramphenicol ; ciprofloxacin ; ertapenem ; erythromycin ; feces ; genomics ; genotype ; gentamicin ; meningitis ; minimum inhibitory concentration ; monitoring ; phenotype ; tetracycline ; Croatia
Language	English
Dates of publication	2022-0713
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071410
Database	NAL-Catalogue (AGRICOLA)

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Article: Resistome Analysis of

Šoprek, Silvija / Duvnjak, Sanja / Kompes, Gordan / Jurinović, Luka / Tambić Andrašević, Arjana

Microorganisms

2022 Volume 10, Issue 7

Abstract: Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance ... ...

Abstract	Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance in
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071410
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Article: Genetic Diversity and Resistome Analysis of

Jurinović, Luka / Duvnjak, Sanja / Humski, Andrea / Ječmenica, Biljana / Taylor, Louie Thomas / Šimpraga, Borka / Krstulović, Fani / Zelenika, Tajana Amšel / Kompes, Gordan

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Campylobacter ... ...

Abstract	Campylobacter lari
Language	English
Publishing date	2023-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12081310
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Article ; Online: Risk of zoonoses involving slow-growing non-tuberculous mycobacteria: Survey of antimicrobial resistance among strains from domestic and wild animals.

Reil, Irena / Barbić, Ljubo / Kompes, Gordan / Tuk, Maja Zdelar / Duvnjak, Sanja / Cvetnić, Željko / Habrun, Boris / Arapović, Jurica / Špičić, Silvio

Journal of global antimicrobial resistance

2023 Volume 35, Page(s) 6–10

Abstract: Objectives: Non-tuberculous mycobacteria are opportunistic pathogens that cause disease mainly in immunocompromised hosts. The present study assessed the prevalence of antibiotic resistance among such mycobacteria from domestic and wild animals in ... ...

Abstract	Objectives: Non-tuberculous mycobacteria are opportunistic pathogens that cause disease mainly in immunocompromised hosts. The present study assessed the prevalence of antibiotic resistance among such mycobacteria from domestic and wild animals in Croatia sampled during several years within a national surveillance program. Methods: A total of 44 isolates belonging to nine slow-growing species were genotyped and analyzed for susceptibility to 13 antimicrobials often used to treat non-tuberculous mycobacterial infections in humans. Results: Most prevalent resistance was to moxifloxacin (77.3%), doxycycline (76.9%), and rifampicin (76.9%), followed by ciprofloxacin (65.4%), trimethoprim-sulfamethoxazole (65.4%), and linezolid (61.4%). Few isolates were resistant to rifabutin (7.7%) or amikacin (6.8%). None of the isolates was resistant to clarithromycin. Nearly all isolates (86.4%) were resistant to multiple antibiotics. Conclusion: Our findings suggest substantial risk that human populations may experience zoonotic infections with non-tuberculous mycobacteria that will be difficult to treat using the current generation of antibiotics. Future work should clarify how resistance emerges in wild populations of non-tuberculous mycobacteria.
MeSH term(s)	Animals ; Humans ; Nontuberculous Mycobacteria/genetics ; Anti-Bacterial Agents/pharmacology ; Animals, Wild ; Mycobacterium Infections, Nontuberculous/microbiology ; Drug Resistance, Bacterial ; Zoonoses
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-08-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2023.08.002
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Article: Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential.

Reil, Irena / Špičić, Silvio / Barbić, Ljubo / Duvnjak, Sanja / Kompes, Gordan / Benić, Miroslav / Stojević, Dora / Cvetnić, Željko / Arapović, Jurica / Zdelar-Tuk, Maja

Microorganisms

2023 Volume 11, Issue 10

Abstract: Non-tuberculous mycobacteria (NTM) are opportunistic pathogens capable of causing infections in humans and animals. The aim of this study was to demonstrate the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly ... ...

Abstract	Non-tuberculous mycobacteria (NTM) are opportunistic pathogens capable of causing infections in humans and animals. The aim of this study was to demonstrate the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly growing NTM strains representing a potential zoonotic threat to humans. A total of 87 animal isolates belonging to 11 rapidly growing species (visible colonies appear within three to seven days) were genotyped and tested for susceptibility to the 15 most commonly used antibiotics in the treatment of such infections in a human clinic. By determining the antimicrobial susceptibility, the most prevalent resistance was found to cephalosporins (>50%), followed by amoxicillin-clavulanate (31.0%), clarithromycin (23.0%), tobramycin (14.9%) and doxycycline (10.3%). Resistance to imipenem, ciprofloxacin, minocycline and linezolid was notably lower (<7.0%). All tested isolates were susceptible to amikacin and moxifloxacin. The most frequent resistance was proved in the most pathogenic species:
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11102520
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Article: First Report and Characterization of the

Kompes, Gordan / Duvnjak, Sanja / Reil, Irena / Hendriksen, Rene S / Sørensen, Lauge Holm / Zdelar-Tuk, Maja / Habrun, Boris / Cvetnić, Luka / Bagarić, Antonela / Špičić, Silvio

Microorganisms

2023 Volume 11, Issue 10

Abstract: The emergence and rapid spread of the plasmid-mediated colistin- ... ...

Abstract	The emergence and rapid spread of the plasmid-mediated colistin-resistant
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11102442
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Article: Description of

Špičić, Silvio / Duvnjak, Sanja / Papić, Bojan / Reil, Irena / Zrnčić, Snježana / Mihaljević, Željko / Naletilić, Šimun / Zupičić, Ivana Giovanna / Kompes, Gordan / Habrun, Boris / Mareković, Ivana / Zdelar-Tuk, Maja

Frontiers in microbiology

2023 Volume 14, Page(s) 1289182

Abstract: Introduction: Shortly before the mass mortality event of the noble pen shell (: Methods: The strains were identified as members of the genus : Results and discussion: Genome-wide phylogeny and average nucleotide identity (ANI) values confirmed ... ...

Abstract	Introduction: Shortly before the mass mortality event of the noble pen shell ( Methods: The strains were identified as members of the genus Results and discussion: Genome-wide phylogeny and average nucleotide identity (ANI) values confirmed that the studied strains are clearly differentiated from their closest phylogenetic relative
Language	English
Publishing date	2023-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1289182
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Article ; Online: The impact and complete genome characterisation of viruses involved in outbreaks of gastroenteritis in a farrow-to-finish holding.

Brnić, Dragan / Vlahović, Dunja / Gudan Kurilj, Andrea / Maltar-Strmečki, Nadica / Lojkić, Ivana / Kunić, Valentina / Jemeršić, Lorena / Bačani, Ivica / Kompes, Gordan / Beck, Relja / Mikuletič, Tina / Steyer, Andrej

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18780

Abstract: Viral enteric pathogens continuously burden intensive pig farming, causing gastrointestinal diseases of epidemic and endemic nature. The present study investigated two diarrhoea outbreaks on a large farrow-to-finish holding and subsequent circulation of ... ...

Abstract	Viral enteric pathogens continuously burden intensive pig farming, causing gastrointestinal diseases of epidemic and endemic nature. The present study investigated two diarrhoea outbreaks on a large farrow-to-finish holding and subsequent circulation of outbreak-related enteric viruses. These viruses were characterised by whole genome sequencing, and statistical evaluation of the impact on specific production metrics was performed. The results provided evidence that the Porcine epidemic diarrhoea virus-swine enteric coronavirus (PEDV-SeCoV) S gene recombinant strain was responsible for the first outbreak, whilst Rotavirus A (RVA) in a mixed infection with Rotavirus B (RVB) and porcine kobuvirus (PKV) probably caused the second diarrhoea outbreak. Whole genome characterisation revealed a porcine origin of all viruses involved and significant heterogeneity of RVB strain, proposing four novel genotypes and changes in RVB VP1 genotype classification. The statistical evaluation confirmed only a minor disturbance in the number of weaned pigs per sow, with statistical forecasting showing positive trends. A follow-up study corroborated the endemicity of RVA and PKV, in contrast to PEDV-SeCoV. Punctual, comprehensive and timely investigation of diarrhoea outbreaks is a prerequisite for applying adequate pig health and biosecurity management. Calculating such outbreaks' impact on production metrics can potentially shape future decisions on management improvements.
MeSH term(s)	Swine ; Animals ; Female ; Coronavirus Infections ; Swine Diseases/epidemiology ; Follow-Up Studies ; Disease Outbreaks ; Viruses ; Diarrhea/epidemiology ; Diarrhea/veterinary ; Gastroenteritis/epidemiology ; Gastroenteritis/veterinary ; Porcine epidemic diarrhea virus/genetics ; Phylogeny
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45994-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Occurrence of Campylobacter jejuni in Gulls Feeding on Zagreb Rubbish Tip, Croatia; Their Diversity and Antimicrobial Susceptibility in Perspective with Human and Broiler Isolates

Jurinović, Luka / Duvnjak, Sanja / Kompes, Gordan / Šoprek, Silvija / Šimpraga, Borka / Krstulović, Fani / Mikulić, Marina / Humski, Andrea

Pathogens. 2020 Aug. 24, v. 9, no. 9

2020

Abstract: Campylobacteriosis is the most common gastrointestinal bacterial disease in the European Union (EU). Wild birds are one of the natural reservoirs of these pathogens. In this study we tested cloacal swabs of 643 gulls captured on rubbish tip in Zagreb, ... ...

Abstract	Campylobacteriosis is the most common gastrointestinal bacterial disease in the European Union (EU). Wild birds are one of the natural reservoirs of these pathogens. In this study we tested cloacal swabs of 643 gulls captured on rubbish tip in Zagreb, Croatia for the presence of Campylobacter spp. and found 168 Campylobacter positive samples. We used multilocus sequence typing (MLST) to genotype 62 random C. jejuni isolates from gulls, 24 isolates from broiler caeca, 27 isolates from broiler neck skins and 23 human isolates. Altogether, we identified 44 different STs, from which 19 were newly described. Most of the new STs (14) originate from gulls. Although humans and broilers share the majority of STs and isolates from gulls are separated from these, there was one ST present in all three hosts: 45. Additionally antimicrobial susceptibility to six antimicrobials was performed on 123 C. jejuni strains isolated from broiler caeca (n = 22), neck skins of broilers (n = 20), gulls cloacal swabs (n = 50) and human faeces (n = 31) by the broth microdilution method. Results show lower resistance of gull isolates to NAL and CIP, while resistance to TET was as high as in human and broiler isolates.
Keywords	Campylobacter jejuni ; European Union ; Laridae ; anti-infective agents ; antibiotic resistance ; campylobacteriosis ; cecum ; cloaca ; feces ; genotype ; hosts ; humans ; minimum inhibitory concentration ; multilocus sequence typing ; neck ; occurrence ; pathogens ; sampling ; strains ; wild birds ; Croatia
Language	English
Dates of publication	2020-0824
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9090695
Database	NAL-Catalogue (AGRICOLA)

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