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Article ; Online: Time course of capillary regression and an expression balance between vascular endothelial growth factor-A and thrombospondin-1 in the soleus muscle of hindlimb unloaded rats.

Tanaka, Masayuki / Kanazashi, Miho / Kondo, Hiroyo / Fujino, Hidemi

2022 Volume 65, Issue 3, Page(s) 350–360

Abstract: Introduction/aims: Skeletal muscle capillaries regress with disuse; however, information on time-dependent changes in the expression of pro- and anti-angiogenic factors in disused muscle is limited. This study aimed to clarify time-dependent changes in ... ...

Abstract	Introduction/aims: Skeletal muscle capillaries regress with disuse; however, information on time-dependent changes in the expression of pro- and anti-angiogenic factors in disused muscle is limited. This study aimed to clarify time-dependent changes in skeletal muscle capillarization, pro-angiogenic vascular endothelial growth factor-A (VEGF-A), and anti-angiogenic thrombospondin-1 (TSP-1) in the soleus muscle of hindlimb unloaded rat. Methods: Eight-week-old male Sprague Dawley rats were randomly divided into four groups corresponding to different hindlimb unloading (HU) duration at 0, 1, 2, and 3 wk. Results: Muscle atrophy and capillary regression worsened in the soleus muscle with longer periods of HU. The VEGF-A protein expression level was lower at week 1 than at week 0. In addition, the value at week 3 was also lower than those at weeks 0, 1, and 2. The TSP-1 protein expression level was higher at week 1 than that at week 0 but was similar at weeks 2 and 3. Moreover, reactive oxygen species, assessed by dihydroethidium fluorescence intensity on cryosection, were higher at weeks 2 and 3 than that at week 0. Discussion: Depending on the HU period, VEGF-A and TSP-1 showed different expression patterns. In the early HU phase, TSP-1 may play an important role in capillary regression. However, when HU extends for a longer period, decreased VEGF-A, and/or increased oxidative stress may be more involved in capillary regression.
MeSH term(s)	Animals ; Capillaries/pathology ; Hindlimb ; Hindlimb Suspension/physiology ; Male ; Muscle, Skeletal/pathology ; Muscular Atrophy/pathology ; Rats ; Rats, Sprague-Dawley ; Thrombospondin 1/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Thrombospondin 1 ; Vascular Endothelial Growth Factor A ; thrombospondin 1, rat ; vascular endothelial growth factor A, rat
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.27478
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Article ; Online: Facilitatory effect of low-pulse repetition frequency ultrasound on release of extracellular vesicles from cultured myotubes.

Ma, Xiaoqi / Yamaguchi, Atomu / Maeshige, Noriaki / Tanida, Kento / Uemura, Mikiko / Lu, Fuwen / Kondo, Hiroyo / Fujino, Hidemi

Journal of medical ultrasonics (2001)

2024

Abstract: Purpose: Extracellular vesicles (EVs) serve as carriers of intracellular factors with therapeutic effects, including tissue regeneration and attenuation of inflammatory responses. The majority of EVs in vivo are derived from skeletal muscle, which is ... ...

Abstract	Purpose: Extracellular vesicles (EVs) serve as carriers of intracellular factors with therapeutic effects, including tissue regeneration and attenuation of inflammatory responses. The majority of EVs in vivo are derived from skeletal muscle, which is reported to have anti-inflammatory effects. While high-intensity pulsed ultrasound (US) irradiation has been shown to promote EV secretion from myotubes, the impact of pulse repetition frequency, a US parameter affecting pulse length, on EV release remains unclear. This study aimed to investigate the impact of pulse repetition frequency of US on the release of EVs from myotubes. Methods: C2C12 myoblasts were used in this study. After differentiation into C2C12 myotubes, US was performed for 5 min at an intensity of 3.0 W/cm Results: US did not cause a reduction in cell viability across all US groups compared to the control. The concentration of EVs was significantly higher in all US groups compared to the control group. In particular, the highest increase was observed in the 1-Hz group on EV concentration as well as intracellular Ca Conclusion: This study investigated the effect of three different pulse repetition frequencies of US on the release of EVs from cultured myotubes. It is concluded that a low-pulse repetition frequency of 1 Hz is the most effective for enhancing EV release from cultured myotubes with pulsed ultrasound.
Language	English
Publishing date	2024-04-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01429-9
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Article ; Online: Beneficial effects of mild hyperbaric oxygen exposure on microcirculation in peripheral tissues in healthy subjects: a pilot study.

Nisa, Badur U / Hirabayashi, Takumi / Maeshige, Noriaki / Kondo, Hiroyo / Fujino, Hidemi

The Journal of sports medicine and physical fitness

2022 Volume 62, Issue 12, Page(s) 1600–1604

Abstract: Background: Exposure to mild hyperbaric oxygen (HBO) increases blood oxygenation by dissolving oxygen into blood plasma and increased oxygen bound to hemoglobin in red blood cells. This research is an attempt to provide insight into the responses of ... ...

Abstract	Background: Exposure to mild hyperbaric oxygen (HBO) increases blood oxygenation by dissolving oxygen into blood plasma and increased oxygen bound to hemoglobin in red blood cells. This research is an attempt to provide insight into the responses of exposure to mild HBO on microcirculation in peripheral tissues. Methods: Fifteen healthy individuals were exposed to normobaric oxygen (1.00 ATA, 20.9% oxygen, NBO) and mild HBO (1.4 ATA, 35-39.5% oxygen) in a mild HBO chamber for 70 minutes under each condition. Peripheral oxygen saturation (SpO<inf>2</inf>), heart rate, blood flow in skin, and hemodynamics in capillaries of finger nailfold were measured under both exposures. Results: The value of SpO<inf>2</inf> was increased from 98% to 100% after mild HBO exposure although that of SpO<inf>2</inf> under NBO was unaltered (P=0.000; P=0.818). Heart rate was decreased after exposure to the mild HBO although that unchanged under the NBO (P=0.000; P=0.706). The mean value of high frequency power in heart rate variability increased after exposure to the mild HBO (P=0.045). Average blood velocity and flow rate in capillaries of finger nailfold were not increased under to NBO whereas those were significantly increased from 92 μm/s to 126 μm/s (P=0.040, P=0.000), and 12247 μm/s to 20926 μm/s after exposure to mild HBO (P<0.05), (P=0.002, P=0.875), respectively. Conclusions: These results indicate that exposure to mild HBO increases blood flow in the capillaries of peripheral tissues by regulating parasympathetic nerve activities through increasing oxygen delivery, oxygen bound to hemoglobin in red blood cells and dissolved oxygen content in plasma.
MeSH term(s)	Humans ; Microcirculation ; Hyperbaric Oxygenation/methods ; Pilot Projects ; Healthy Volunteers ; Oxygen ; Hemoglobins
Chemical Substances	Oxygen (S88TT14065) ; Hemoglobins
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.22.13363-3
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Article ; Online: Enhancement of astaxanthin incorporation by pulsed high-intensity ultrasound in LPS-stimulated macrophages.

Ma, Xiaoqi / Yamaguchi, Atomu / Maeshige, Noriaki / Uemura, Mikiko / Noguchi, Hikari / Kondo, Hiroyo / Fujino, Hidemi

Journal of medical ultrasonics (2001)

2022 Volume 49, Issue 2, Page(s) 125–132

Abstract: Purpose: Ultrasound (US) has been reported to improve the permeability of cell membranes to pharmaceuticals by causing cavitation. Astaxanthin (AX) potently terminates the induction of inflammation, but it has low oral bioavailability, which limits its ... ...

Abstract	Purpose: Ultrasound (US) has been reported to improve the permeability of cell membranes to pharmaceuticals by causing cavitation. Astaxanthin (AX) potently terminates the induction of inflammation, but it has low oral bioavailability, which limits its incorporation in local cells and organs and its therapeutic potential. In this study, we aimed to investigate the contribution of US to AX incorporation to compensate for the limited incorporation of AX, and regulation of the pro-inflammatory factor interleukin-1β (IL-1β) by AX. Methods: Murine bone marrow-derived macrophages were stimulated by lipopolysaccharide (LPS). After 2 h, cells were treated with 10 μM AX and/or pulsed high-intensity US irradiation. The cells were then incubated for another 3 h and harvested. AX incorporation in cells was measured by absorbance, and the expression of IL-1β was measured by qPCR. All values are expressed as means ± standard error of the mean. Results: The combination of AX and US significantly increased AX incorporation in cells compared to AX alone (p < 0.05). In addition, this combination further suppressed the expression of IL-1β compared to AX alone (p < 0.05). Conclusion: Pulsed high-intensity US irradiation combined with AX treatment promoted AX incorporation in cells and enhanced the anti-inflammatory effect on macrophages.
MeSH term(s)	Animals ; Humans ; Inflammation/diagnostic imaging ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Mice ; Xanthophylls/metabolism ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use
Chemical Substances	Lipopolysaccharides ; Xanthophylls ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2022-01-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-022-01189-4
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Article: Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women.

Nisa, Badur Un / Nakanishi, Ryosuke / Tanaka, Minoru / Lin, Hao / Hirabayashi, Takumi / Maeshige, Noriaki / Kondo, Hiroyo / Fujino, Hidemi

Life (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been ... ...

Abstract	Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been conducted on its effects on immunity. The aim of the present study is to investigate the effect of mild HBO on natural killer (NK) cells and cytokines in healthy young women. This crossover randomized control trial was conducted with 16 healthy young women. Participants were randomly exposed to normobaric oxygen (NBO; 1.0 atmospheres absolute (ATA), 20.8% oxygen) and mild HBO conditions (1.4 ATA, 35-40% oxygen, injected 18L oxygen per minute) in a hyperbaric oxygen chamber for 70 min. Heart rate, parasympathetic activity, NK cell count, interleukin (IL)-6, IL-12p70 and derivatives of reactive oxygen metabolites (d-ROMs) were measured before and after both exposures. In the NBO condition, parasympathetic activity remained unchanged, whereas after mild HBO exposure, parasympathetic activity was significantly increased. NK cells remained unchanged after NBO exposure, while NK cells were increased after exposure to mild HBO. Exposure to mild HBO did not increase d-ROM values, IL-6 and IL-12p70 protein levels. These findings suggest that exposure to mild HBO can be a useful protocol to increase NK cells by regulating parasympathetic activity via increasing oxygen delivery.
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13020408
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Article ; Online: Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level.

Yamaguchi, Atomu / Maeshige, Noriaki / Noguchi, Hikari / Yan, Jiawei / Ma, Xiaoqi / Uemura, Mikiko / Su, Dongming / Kondo, Hiroyo / Sarosiek, Kristopher / Fujino, Hidemi

eLife

2023 Volume 12

Abstract: The regulation of inflammatory responses is an important intervention in biological function and macrophages play an essential role during inflammation. Skeletal muscle is the largest organ in the human body and releases various factors which mediate ... ...

Abstract	The regulation of inflammatory responses is an important intervention in biological function and macrophages play an essential role during inflammation. Skeletal muscle is the largest organ in the human body and releases various factors which mediate anti-inflammatory/immune modulatory effects. Recently, the roles of extracellular vesicles (EVs) from a large variety of cells are reported. In particular, EVs released from skeletal muscle are attracting attention due to their therapeutic effects on dysfunctional organs and tissues. Also, ultrasound (US) promotes release of EVs from skeletal muscle. In this study, we investigated the output parameters and mechanisms of US-induced EV release enhancement and the potential of US-treated skeletal muscle-derived EVs in the regulation of inflammatory responses in macrophages. High-intensity US (3.0 W/cm
MeSH term(s)	Humans ; Animals ; Mice ; Calcium/metabolism ; Muscle Fibers, Skeletal/metabolism ; Anti-Inflammatory Agents ; Extracellular Vesicles/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Ultrasonic Waves
Chemical Substances	Calcium (SY7Q814VUP) ; Anti-Inflammatory Agents ; MicroRNAs ; MIRN206 microRNA, human
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.89512
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Article ; Online: Niacin supplementation attenuates the regression of three-dimensional capillary architecture in unloaded female rat skeletal muscle.

Lin, Hao / Xing, Jihao / Pan, Han / Hirabayashi, Takumi / Maeshige, Noriaki / Nakanishi, Ryosuke / Kondo, Hiroyo / Fujino, Hidemi

Physiological reports

2023 Volume 12, Issue 8, Page(s) e16019

Abstract: Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this capillary regression. In this study involving adult female Sprague-Dawley rats, the animals were ... ...

Abstract	Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this capillary regression. In this study involving adult female Sprague-Dawley rats, the animals were randomly assigned to one of four groups: control (CON), hindlimb unloading (HU), NA, and HU with NA supplementation (HU + NA). For a period of 2 weeks, the rats in the HU and HU + NA groups underwent HU, while those in the NA and HU + NA groups received NA (750 mg/kg) twice daily through oral administration. The results demonstrated that HU lowered capillary number, luminal diameter, and capillary volume, as well as decreased succinate dehydrogenase activity, slow fiber composition, and PGC-1α expression within the soleus muscle. However, NA supplementation prevented these alterations in capillary structure due to unloading by stimulating PGC-1α factors and inhibiting mitochondrial dysfunction. Therefore, NA supplementation could serve as a potential therapeutic approach for preserving the capillary network and mitochondrial metabolism of muscle fibers during periods of inactivity.
MeSH term(s)	Rats ; Female ; Animals ; Rats, Sprague-Dawley ; Niacin/pharmacology ; Niacin/metabolism ; Niacin/therapeutic use ; Muscle, Skeletal/metabolism ; Muscular Atrophy/metabolism ; Dietary Supplements ; Hindlimb Suspension/methods
Chemical Substances	Niacin (2679MF687A)
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.16019
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Article ; Online: Protective effects of low-intensity exercise on metabolic oxidative capacity and capillarization in skeletal muscle of non-obese diabetic rats.

Qatamish, Mohammad A / Al-Nassan, Saad M / Kondo, Hiroyo / Fujino, Hidemi

Biomedical research (Tokyo, Japan)

2020 Volume 41, Issue 5, Page(s) 227–236

Abstract: Diabetes mellitus induces skeletal muscle dysfunction, such as decreased metabolic activity and capillarization. This study aimed to investigate the effects of aerobic low intensity exercise training on metabolic oxidative capacity and capillarization in ...

Abstract	Diabetes mellitus induces skeletal muscle dysfunction, such as decreased metabolic activity and capillarization. This study aimed to investigate the effects of aerobic low intensity exercise training on metabolic oxidative capacity and capillarization in skeletal muscle of non-obese diabetic rats. Eleven to twenty-five week-old male non-obese Spontaneous Diabetic Torii (SDT) rats (n = 11) and age-matched healthy male Sprague-Dawley SD rats (n = 11) were randomly assigned to either exercise or sedentary groups. The exercise training was performed on a low-speed motorized treadmill (15 m min
MeSH term(s)	Animals ; Blood Glucose/metabolism ; Body Weight ; Capillaries/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Glycated Hemoglobin A/metabolism ; Hyperglycemia ; Insulin ; Male ; Muscle, Skeletal/metabolism ; Organ Size ; Oxidative Stress ; Oxygen/metabolism ; Physical Conditioning, Animal ; Rats ; Rats, Sprague-Dawley ; Time Factors
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Insulin ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-10-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.41.227
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Article ; Online: Licorice flavonoid oil supplementation promotes a reduction of visceral fat in exercised rats.

Tanaka, Masayuki / Kanazashi, Miho / Kondo, Hiroyo / Ishihara, Akihiko / Fujino, Hidemi

The Journal of sports medicine and physical fitness

2020 Volume 61, Issue 3, Page(s) 480–488

Abstract: Background: The beneficial effect of exercise combined with licorice flavonoid oil supplementation on visceral fat was investigated.: Methods: Male Sprague-Dawley rats were divided into 4 groups: control, exercise (Ex), control with licorice ... ...

Abstract	Background: The beneficial effect of exercise combined with licorice flavonoid oil supplementation on visceral fat was investigated. Methods: Male Sprague-Dawley rats were divided into 4 groups: control, exercise (Ex), control with licorice flavonoid oil supplementation (LFO), and exercise with licorice flavonoid oil supplementation (ExLFO) groups. The rats in the Ex and ExLFO groups ran on a treadmill (20-degree incline at 20 m/min for 30 min/day) 5 times a week for 7 weeks, and those in the LFO and ExLFO groups were orally administered with licorice flavonoid oil daily using a feeding needle. Results: Exercise or licorice flavonoid oil supplementation resulted in the reduction of the visceral fat mass and adipocyte size, respectively. In addition, exercise combined with licorice flavonoid oil supplementation more effectively decreased both measures. Exercise alone increased the β-hydroxyacyl-CoA dehydrogenase (β-HAD) and citrate synthase (CS) activities in the soleus and plantaris muscles, and licorice flavonoid oil supplementation alone increased the hepatic carnitine palmitoyl transferase-2 (CPT-2) activity. Furthermore, the combination of exercise and licorice flavonoid oil supplementation enhanced the both muscular β-HAD and CS activities, and hepatic CPT-2 activity. Conclusions: These results suggest that exercise combined with licorice flavonoid oil supplementation may be effective to decrease visceral adipose tissue via enhancing skeletomuscular and hepatic fatty acids oxidative capacity.
MeSH term(s)	Animals ; Dietary Supplements ; Flavonoids/metabolism ; Flavonoids/pharmacology ; Glycyrrhiza ; Intra-Abdominal Fat ; Lipid Metabolism ; Liver ; Male ; Muscle, Skeletal/drug effects ; Physical Conditioning, Animal/physiology ; Plant Extracts ; Plant Oils/metabolism ; Plant Oils/pharmacology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Flavonoids ; Plant Extracts ; Plant Oils
Language	English
Publishing date	2020-10-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.20.11260-X
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Article ; Online: Mild hyperbaric oxygen exposure attenuates rarefaction of capillary vessels in streptozotocin-induced diabetic soleus muscle in rats.

Tanaka, Masayuki / Kanazashi, Miho / Matsumoto, Tomohiro / Kondo, Hiroyo / Ishihara, Akihiko / Fujino, Hidemi

Biomedical research (Tokyo, Japan)

2021 Volume 42, Issue 1, Page(s) 1–11

Abstract: We examined the effects of mild hyperbaric oxygen (mHBO) exposure on capillary rarefaction in skeletal muscles of rats with diabetes. Streptozotocin (100 mg/kg) was administered to male Wistar rats via the tail vein to prepare a diabetic model. These ... ...

Abstract	We examined the effects of mild hyperbaric oxygen (mHBO) exposure on capillary rarefaction in skeletal muscles of rats with diabetes. Streptozotocin (100 mg/kg) was administered to male Wistar rats via the tail vein to prepare a diabetic model. These rats were divided into 2 groups: the group with mHBO exposure (1.25 atmospheres absolute (ATA) with 36% oxygen; 3 h/day) and the group without mHBO exposure. Age-matched rats were used as the control group. Eight weeks later, the soleus of the rats was removed and then analyzed. With the onset of diabetes mellitus, capillary number, diameter, and volume in the soleus of the rats with diabetes decreased compared with those of the rats in the control group. In addition, increased anti-angiogenic thrombospondin-1 (TSP-1) and decreased pro-angiogenic murine double minute 2 (MDM-2) protein expressions were observed in the rats with diabetes. Alternatively, mHBO exposure attenuated the decrease in capillary diameter and volume in skeletal muscles of rats with diabetes, suppressed the overexpression of TSP-1, and restored the MDM-2 expression. These results indicate the exposure of mHBO partially attenuates capillary rarefaction in diabetic soleus muscle.
MeSH term(s)	Angiogenesis Inhibitors ; Animals ; Body Weight ; Capillaries/drug effects ; Diabetes Mellitus, Experimental/therapy ; Disease Models, Animal ; Hyperbaric Oxygenation/methods ; Male ; Muscle, Skeletal/pathology ; Oxygen/metabolism ; Proto-Oncogene Proteins c-mdm2/biosynthesis ; Rats ; Rats, Wistar ; Streptozocin ; Thrombospondin 1/biosynthesis
Chemical Substances	Angiogenesis Inhibitors ; Thrombospondin 1 ; thrombospondin 1, rat ; Streptozocin (5W494URQ81) ; Mdm2 protein, rat (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-02-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.42.1
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