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  1. Article ; Online: New antimalarial fusarochromanone analogs produced by the fungal strain Fusarium sp. FKI-9521.

    Watanabe, Yoshihiro / Arakawa, Emi / Kondo, Naozumi / Nonaka, Kenichi / Ikeda, Akari / Hirose, Tomoyasu / Sunazuka, Toshiaki / Hokari, Rei / Ishiyama, Aki / Iwatsuki, Masato

    The Journal of antibiotics

    2023  Volume 76, Issue 7, Page(s) 384–391

    Abstract: Two new antimalarial compounds, named deacetyl fusarochromene (1) and 4'-O-acetyl fusarochromanone (2), were discovered from the static fungal cultured material of Fusarium sp. FKI-9521 isolated from feces of a stick insect (Ramulus mikado) together with ...

    Abstract Two new antimalarial compounds, named deacetyl fusarochromene (1) and 4'-O-acetyl fusarochromanone (2), were discovered from the static fungal cultured material of Fusarium sp. FKI-9521 isolated from feces of a stick insect (Ramulus mikado) together with three known compounds fusarochromanone (3), 3'-N-acetyl fusarochromanone (4), and 5 (fusarochromene or banchromene). The structures of 1 and 2 were elucidated as new analogs of 3 by MS and NMR analyses. The absolute configurations of 1, 2, and 4 were determined by chemical derivatization. All five compounds showed moderate in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/chemistry ; Fusarium ; Chloroquine/pharmacology ; Chromones ; Plasmodium falciparum
    Chemical Substances Antimalarials ; fusarochromanone (FM54X8S89O) ; Chloroquine (886U3H6UFF) ; Chromones
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-023-00617-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
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  2. Article: Metapochonia hahajimaensis (Clavicipitaceae, Hypocreales), a new species from soil in Hahajima Island, Tokyo, Japan

    Kondo, Naozumi / Tokiwa, Toshiyuki / Sato, Kotaro / Ōmura, Satoshi / Nonaka, Kenichi

    The Mycological Society of Japan Mycoscience. 2020 Nov., v. 61, no. 6

    2020  

    Abstract: A new species, Metapochonia hahajimaensis is proposed. Three isolates were obtained from soil samples collected from Hahajima, Ogasawara Islands, Tokyo, Japan. Using a combination of morphological characteristics and multigene (ITS, SSU, LSU, TEF) ... ...

    Abstract A new species, Metapochonia hahajimaensis is proposed. Three isolates were obtained from soil samples collected from Hahajima, Ogasawara Islands, Tokyo, Japan. Using a combination of morphological characteristics and multigene (ITS, SSU, LSU, TEF) phylogenics, the isolates were identified as a Metapochonia species which were previously undescribed. The new species is distinguished from the closely-related M. bulbillosa and M. goniodes or other Metapochonia taxa by conidial size and colonial characteristics.
    Keywords Clavicipitaceae ; Eragrostis tef ; Goniodes ; Japan ; conidia ; islands ; new species ; soil ; soil sampling
    Language English
    Dates of publication 2020-11
    Size p. 337-341.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 1285813-4
    ISSN 1618-2545 ; 1340-3540
    ISSN (online) 1618-2545
    ISSN 1340-3540
    DOI 10.1016/j.myc.2020.06.001
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    In stock of ZB MED Bonn / Germany

    Z 7628: Show issues

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  3. Article: Simplicillium spumae (Cordycipitaceae, Hypocreales), a new hyphomycetes from aquarium foam in Japan

    Kondo, Naozumi / Iwasaki, Hiromu / Tokiwa, Toshiyuki / Ōmura, Satoshi / Nonaka, Kenichi

    The Mycological Society of Japan Mycoscience. 2020 May, v. 61, no. 3

    2020  

    Abstract: Five Simplicillium isolates were obtained from foam generated in an aquarium in Minato-ku, Tokyo, Japan. Using a combination of micro-morphological characteristics and multigene (ITS, SSU, LSU, TEF) phylogenics, the isolates were identified as S. ... ...

    Abstract Five Simplicillium isolates were obtained from foam generated in an aquarium in Minato-ku, Tokyo, Japan. Using a combination of micro-morphological characteristics and multigene (ITS, SSU, LSU, TEF) phylogenics, the isolates were identified as S. subtropicum and a new species which were previously undescribed. Simplicillium spumae, which is a new species, differs from known Simplicillium species in the morphology of their conidia and conidiophores.
    Keywords Cordycipitaceae ; Hyphomycetes ; aquariums ; conidia ; conidiophores ; foams ; internal transcribed spacers ; new species ; Japan
    Language English
    Dates of publication 2020-05
    Size p. 116-121.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1285813-4
    ISSN 1618-2545 ; 1340-3540
    ISSN (online) 1618-2545
    ISSN 1340-3540
    DOI 10.1016/j.myc.2020.02.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7628: Show issues

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  4. Article ; Online: Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.

    Honma, Sota / Kimishima, Aoi / Kimishima, Atsushi / Honsho, Masako / Kojima, Hiroki / Tokiwa, Toshiyuki / Nishitomi, Atsuka / Kato, Satoshi / Kondo, Naozumi / Araki, Yasuko / Takahashi, Tadashi / Chinen, Takumi / Usui, Takeo / Fuji, Shin-Ichi / Ito, Kotaro / Asami, Yukihiro

    Bioscience, biotechnology, and biochemistry

    2024  

    Abstract: We found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the ...

    Abstract We found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the target compound by the introduction of a global secondary metabolism regulator, laeA to the strain, which led to the successful isolation of ten-folds greater amount of MS-347a (1) than Aspergillus sp. FKI-5362. Compound 1 was not effective against Candida albicans and the detailed anti-fungal activity of 1 remains unverified. After our anti-fungal activity screening, 1 was found to inhibit the growth of broad plant pathogenic fungal species belonging to the Ascomycota. It is noteworthy that 1 showed little insecticidal activity against silkworms, suggesting its selective biological activity against plant pathogenic fungi. Our study implies that the combination strategy of multidrug-sensitive yeast and the introduction of laeA is useful for new anti-fungal drug discovery.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbae050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4647: Show issues Location:
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  5. Article ; Online: Re-evaluation and a Structure-Activity Relationship Study for the Selective Anti-anaerobic Bacterial Activity of Luminamicin toward Target Identification.

    Kimishima, Aoi / Negami, Sota / Tsuruoka, Iori / Tsutsumi, Hayama / Matsui, Hidehito / Sugamata, Miho / Kondo, Naozumi / Honsho, Masako / Sakai, Kazunari / Honma, Sota / Naher, Kamrun / Watanabe, Yoshihiro / Iwatsuki, Masato / Inahashi, Yuki / Hanaki, Hideaki / Asami, Yukihiro

    ACS infectious diseases

    2023  Volume 9, Issue 8, Page(s) 1602–1609

    Abstract: Luminamicin ( ...

    Abstract Luminamicin (
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Confluenine G, a new compound from a basidiomycetous yeast Moesziomyces sp. FKI-9540 derived from the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae).

    Kondo, Naozumi / Sakai, Kazunari / Kimishima, Aoi / Hokari, Rei / Honsho, Masako / Sato, Mai / Naher, Kamrun / Yuge, Hidetaka / Iwatsuki, Masato / Nonaka, Kenichi / Asami, Yukihiro

    Bioscience, biotechnology, and biochemistry

    2022  Volume 86, Issue 7, Page(s) 949–954

    Abstract: Most natural products derived from microorganisms have been sought from actinomycetes and filamentous fungi. As an attempt to develop new microbial resources in the exploratory research for natural products, we searched for new compounds from unexploited ...

    Abstract Most natural products derived from microorganisms have been sought from actinomycetes and filamentous fungi. As an attempt to develop new microbial resources in the exploratory research for natural products, we searched for new compounds from unexploited microbial taxa presumed to have biosynthetic gene clusters. A new compound confluenine G (1) and a known compound (2Z)-2-octyl-2-pentenedioic acid (2) were isolated from a cultured broth of basidiomycetous yeast, Moesziomyces sp. FKI-9540, derived from the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae). Based on the results of HR-ESI-MS and NMR analyses, the planar structure of 1 was elucidated. Confluenine G (1) was a new analog of nitrogen-oxidized isoleucine and had rare substructures with oxime and hydroxamic acid in molecule.
    MeSH term(s) Animals ; Biological Products ; DNA, Fungal ; Lepidoptera ; Moths/genetics ; Ustilaginales ; Viperidae ; Yeasts
    Chemical Substances Biological Products ; DNA, Fungal
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbac062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4647: Show issues Location:
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