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  1. Article ; Online: Integrated analysis revealing the role of TET3-mediated MUC13 promoter hypomethylation in hepatocellular carcinogenesis.

    Kong, Ruijiao / Zhang, Hui / Jia, Yin / Man, Qiuhong / Liu, Shanrong

    Epigenomics

    2023  Volume 14, Issue 24, Page(s) 1579–1591

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Line, Tumor ; DNA Methylation ; Cell Transformation, Neoplastic/genetics ; Neoplastic Stem Cells/metabolism ; Mucins/genetics ; Mucins/metabolism ; Dioxygenases/genetics
    Chemical Substances MUC13 protein, human ; Mucins ; TET3 protein, human (EC 1.-) ; Dioxygenases (EC 1.13.11.-)
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2022-0395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma.

    Kong, Ruijiao / Wei, Wenxin / Man, Qiuhong / Chen, Liang / Jia, Yin / Zhang, Hui / Liu, Zixin / Cheng, Kai / Mao, Chuanbin / Liu, Shanrong

    Cancer letters

    2023  Volume 578, Page(s) 216442

    Abstract: Hepatocellular carcinoma (HCC) is often associated with poor outcomes due to lung metastasis. ICAM- ... ...

    Abstract Hepatocellular carcinoma (HCC) is often associated with poor outcomes due to lung metastasis. ICAM-1
    MeSH term(s) Humans ; Animals ; Mice ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Cell Line, Tumor ; Lung Neoplasms/metabolism ; Hypoxia/genetics ; Neoplastic Stem Cells/metabolism ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Cell Proliferation ; Tumor Microenvironment ; Hydro-Lyases/genetics ; Hydro-Lyases/metabolism ; Co-Repressor Proteins/genetics
    Chemical Substances Intercellular Adhesion Molecule-1 (126547-89-5) ; MicroRNAs ; CDYL protein, human (EC 4.2.1.-) ; Hydro-Lyases (EC 4.2.1.-) ; Co-Repressor Proteins ; EIF4A3 protein, human (EC 3.6.1.-) ; EEF1A2 protein, human
    Language English
    Publishing date 2023-10-16
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Serum Ferritin in Geriatric Individuals in the Shanghai Region: Distribution, Correlations, and Reference Intervals.

    Wang, Ying / Yu, Xueying / Fan, Jiahui / Huang, Man / Fu, Yan / Zhang, Hui / Kong, Ruijiao / Man, Qiuhong

    Clinical laboratory

    2023  Volume 69, Issue 8

    Abstract: Background: Serum ferritin levels have a clinical application in diagnosing diseases. However, the clinical standard levels and distribution characteristics of serum ferritin based on reference intervals (RIs) in the geriatric Han Chinese population in ... ...

    Abstract Background: Serum ferritin levels have a clinical application in diagnosing diseases. However, the clinical standard levels and distribution characteristics of serum ferritin based on reference intervals (RIs) in the geriatric Han Chinese population in the East China region have not previously been well reported. This work aimed to investigate the correlation between serum ferritin levels and 14 metabolic markers, analyse the distribution of serum ferritin, and establish serum ferritin RIs for geriatric (> 60 years) individuals in Shanghai.
    Methods: Four hundred and sixty-nine healthy Chinese Han subjects (age, 61 - 95 years; median, 71 years) were recruited from the Health Examination Center of Shanghai Fourth People's Hospital in 2021. Serum ferritin was measured on a Roche Cobas 8000 e602, and 14 biochemical parameters were measured on a Siemens Atellica CH-930 to analyse distributions and correlations and to establish serum ferritin RIs for the elderly population in Shanghai.
    Results: Serum ferritin levels were significantly different between genders (p = 0.06). The established RIs for serum ferritin were 24.44 - 627.09 ng/mL and 48.18 - 554.88 ng/mL in males and females, respectively. Correlation analyses revealed that ferritin levels were correlated with 7 parameters, including body mass index (BMI, p = 0.02), gamma-glutamyl transferase (GGT, p < 0.01), alanine aminotransferase (ALT, p < 0.01), triglycerides (TGs, p < 0.01), high-density lipoprotein (HDL, p < 0.01), total protein (TP, p < 0.01) and prealbumin (PAB, p < 0.01). When the participants were further divided by BMI, aspartate aminotransferase (AST) was an additional variable that was positively correlated only in the overweight/obese group (p = 0.04), while globulin (GLO) was an additional variable that was positively correlated only in the other group (p < 0.01).
    Conclusions: Nutrition and metabolism may play a great role in the regulation of serum ferritin levels in geriatric individuals in vivo. The RIs established for serum ferritin may provide precise references for further studies on ferritin-related disease in geriatric individuals.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; China ; Ferritins/blood ; Obesity ; Reference Values ; Triglycerides ; East Asian People
    Chemical Substances Ferritins (9007-73-2) ; Triglycerides
    Language English
    Publishing date 2023-08-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.221223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.170: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 25: Show issues

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  4. Article: Methylation Status of the

    Liu, Shupeng / Cheng, Kai / Zhang, Hui / Kong, Ruijiao / Wang, Shuo / Mao, Chuanbin / Liu, Shanrong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 5, Page(s) 1903035

    Abstract: Cancer stem cells (CSCs) are the main cause of tumor development, metastasis, and relapse. CSCs are thus considered promising targets for cancer therapy. However, it is hard to eradicate CSCs due to their inherent plasticity and heterogeneity, and the ... ...

    Abstract Cancer stem cells (CSCs) are the main cause of tumor development, metastasis, and relapse. CSCs are thus considered promising targets for cancer therapy. However, it is hard to eradicate CSCs due to their inherent plasticity and heterogeneity, and the underlying mechanism of the switch between non-CSCs and CSCs remains unclear. Here, it is shown that miR-135a combined with SMYD4 activates Nanog expression and induces the switch of non-CSCs into CSCs. The miR-135a level, once elevated, lowers the methylation level of the CG5 site in the
    Language English
    Publishing date 2020-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.201903035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Erratum: Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.

    Chen, Liang / Kong, Ruijiao / Wu, Cong / Wang, Shuo / Liu, Zixin / Liu, Shupeng / Li, Shuiping / Chen, Tian / Mao, Chuanbin / Liu, Shanrong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 9, Page(s) 2000890

    Abstract: This corrects the article DOI: 10.1002/advs.201900949.]. ...

    Abstract [This corrects the article DOI: 10.1002/advs.201900949.].
    Language English
    Publishing date 2020-05-06
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202000890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.

    Chen, Liang / Kong, Ruijiao / Wu, Cong / Wang, Shuo / Liu, Zixin / Liu, Shupeng / Li, Shuiping / Chen, Tian / Mao, Chuanbin / Liu, Shanrong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2019  Volume 7, Issue 4, Page(s) 1900949

    Abstract: Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self-renewal is discovered by a circRNA, circ-MALAT1, which is ... ...

    Abstract Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self-renewal is discovered by a circRNA, circ-MALAT1, which is produced by back-splicing of a long noncoding RNA, MALAT1. Circ-MALAT1 is highly expressed in CSCs from clinical hepatocellular carcinoma samples under the mediation of an RNA-binding protein, AUF1. Surprisingly, circMALAT1 functions as a brake in ribosomes to retard PAX5 mRNA translation and promote CSCs' self-renewal by forming an unprecedented ternary complex with both ribosomes and mRNA. The discovered braking mechanism of a circRNA, termed mRNA braking, along with its more traditional role of miRNA sponging, uncovers a dual-faceted pattern of circRNA-mediated post-transcriptional regulation for maintaining a specific cell state.
    Language English
    Publishing date 2019-12-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.201900949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Vitro Modeling of Human Germ Cell Development Using Pluripotent Stem Cells.

    Zhao, Yuncheng / Ye, Shicheng / Liang, Dongli / Wang, Pengxiang / Fu, Jing / Ma, Qing / Kong, Ruijiao / Shi, Linghong / Gong, Xueping / Chen, Wei / Ding, Wubin / Yang, Wenjing / Zhu, Zijue / Chen, Huixing / Sun, Xiaoxi / Zhu, Jun / Li, Zheng / Wang, Yuan

    Stem cell reports

    2018  Volume 10, Issue 2, Page(s) 509–523

    Abstract: Due to differences across species, the mechanisms of cell fate decisions determined in mice cannot be readily extrapolated to humans. In this study, we developed a feeder- and xeno-free culture protocol that efficiently induced human pluripotent stem ... ...

    Abstract Due to differences across species, the mechanisms of cell fate decisions determined in mice cannot be readily extrapolated to humans. In this study, we developed a feeder- and xeno-free culture protocol that efficiently induced human pluripotent stem cells (iPSCs) into PLZF+/GPR125+/CD90+ spermatogonium-like cells (SLCs). These SLCs were enriched with key genes in germ cell development such as MVH, DAZL, GFRα1, NANOS3, and DMRT1. In addition, a small fraction of SLCs went through meiosis in vitro to develop into haploid cells. We further demonstrated that this chemically defined induction protocol faithfully recapitulated the features of compromised germ cell development of PSCs with NANOS3 deficiency or iPSC lines established from patients with non-obstructive azoospermia. Taken together, we established a powerful experimental platform to investigate human germ cell development and pathology related to male infertility.
    MeSH term(s) Animals ; Azoospermia/genetics ; Azoospermia/pathology ; Cell Culture Techniques ; Cell Differentiation/genetics ; Feeder Cells/cytology ; Gene Expression Regulation, Developmental/genetics ; Germ Cells/cytology ; Germ Cells/growth & development ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/pathology ; Infertility, Male/genetics ; Infertility, Male/pathology ; Male ; Meiosis/genetics ; Mice ; Mouse Embryonic Stem Cells/cytology ; RNA-Binding Proteins/genetics ; Species Specificity ; Spermatogonia/cytology ; Spermatogonia/growth & development ; Spermatogonia/pathology ; Transcription Factors/genetics
    Chemical Substances DAZL protein, human ; DMRT1 protein ; Gfra1 protein, mouse ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; NANOS3 protein, human ; RNA-Binding Proteins ; Transcription Factors
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2018.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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