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Article: Vititculture in the Netherlands

Konsten, J.

Mosel-Anruf / Schriften der Weinbruderschaft Mosel-Saar-Ruwer e.V.

2016 , Issue 46, Page(s) 137–143

Abstract: Erste Nachweise für Weinbau in der Nähe von Maastricht gehen bis ins 10. Jahrhundert zurück; dort erlebte er seine Blüte im 14. und 15. Jahrhundert an den Hängen der Maas, ehe er dann in der "Kleinen Eiszeit" offenbar verschwand. Später wird er wieder ... ...

Title variant	Der Weinbau in den Niederlanden
Abstract	Erste Nachweise für Weinbau in der Nähe von Maastricht gehen bis ins 10. Jahrhundert zurück; dort erlebte er seine Blüte im 14. und 15. Jahrhundert an den Hängen der Maas, ehe er dann in der "Kleinen Eiszeit" offenbar verschwand. Später wird er wieder forciert, um schließlich um 1900 von der Reblaus vernichtet zu werden. Erst in der zweiten Hälfte des 20. Jahrhunderts gelangte er wieder zu Bedeutung, vor allem in Limburg in der SE-Ecke der heutigen Niederlande. Der heutige Weinbau und die Weinproduktion auf der etwa 250 Hektar großen Fläche werden beschrieben. Es gibt keine Genossenschaft oder Maschinenringe, vielmehr arbeiten die etwa 40 Winzerbetriebe selbständig bis zum Flaschenweinverkauf, wenngleich sie in einer losen "Confrerie" fachlichen Austausch pflegen. Unter den angebauten Sorten finden sich auch etliche Neuzüchtungen (z.B. Regent). Trotz hoher Produktionskosten und Flaschenpreisen bis 15 Euro gibt es keine Absatzprobleme: Hauptkunde ist die heimische Gastronomie. Eine Ausdehnung der Rebfläche ist nicht zu erwarten, jedoch ist man bestrebt, bald die EU-Kriterien zur Erzeugung von Qualitätswein zu erfüllen. [35086]
Language	German
Document type	Article
Database	Viticulture and Oenology Abstracts

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Article: Internal herniation of the abdominal wall.

Bloemen, Arthur / J Keijzers, Marlies / L M Konsten, Joop / Aarts, Frits / Vogelaar, F Jeroen

Clinical case reports

2019 Volume 7, Issue 3, Page(s) 575–576

Abstract: A symptomatic arcuate line hernia should be considered in patients with acute lower abdominal complaints. This rare internal herniation is caused by a sharp ending of the posterior aponeurotic sheath of the rectus muscle, rather than the more common ... ...

Abstract	A symptomatic arcuate line hernia should be considered in patients with acute lower abdominal complaints. This rare internal herniation is caused by a sharp ending of the posterior aponeurotic sheath of the rectus muscle, rather than the more common gradual delineation, and can cause strangulation or incarceration of abdominal contents.
Language	English
Publishing date	2019-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2008
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Article ; Online: Preoperative handgrip strength is not associated with complications and health-related quality of life after surgery for colorectal cancer.

van Heinsbergen, M / Konsten, J L / Bours, M J L / Bouvy, N D / Weijenberg, M P / Janssen-Heijnen, M L

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13005

Abstract: Colorectal cancer (CRC) treatment is associated with a high morbidity which may result in a reduced health-related quality of life (HRQoL). The pre-operative measurement of handgrip strength (HGS) might be a tool to predict the patient's outcome after ... ...

Abstract	Colorectal cancer (CRC) treatment is associated with a high morbidity which may result in a reduced health-related quality of life (HRQoL). The pre-operative measurement of handgrip strength (HGS) might be a tool to predict the patient's outcome after CRC surgery. The aim of this study was to evaluate the association of pre-operative HGS with the occurrence of postoperative complications and postoperative HRQoL. Stage I to III CRC patients ≥ 18 years were included at diagnosis. Demographic and clinical data as well as HGS were collected before start of treatment. HGS was classified as weak if it was below the gender-specific 25th percentile of our study population; otherwise HGS was classified as normal. The occurrence of postoperative complications within 30 days after surgery was collected from medical records. Cancer-specific HRQoL was measured 6 weeks after treatment using the EORTC QLQ-C30 and the EORTC QLQ-CR29 questionnaire. Of 295 patients who underwent surgical treatment for CRC, 67 (23%) patients had a weak HGS while 228 (77%) patients had normal HGS. 118 patients (40%) developed a postoperative complication. Complications occurred in 37% of patients with a weak HGS and in 41% of patients with a normal HGS (p = 0.47). After adjustment for age, sex, ASA, BMI and TNM, no significant associations between pre-operative HGS and the occurrence of postoperative complications and between HGS and HRQoL were found. We conclude that a single pre-operative HGS measurement was not associated with the occurrence of postoperative complications or post-treatment HRQoL in stage I-III CRC patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/physiopathology ; Colorectal Neoplasms/surgery ; Female ; Hand Strength ; Humans ; Male ; Middle Aged ; Netherlands ; Postoperative Period ; Quality of Life
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-69806-1
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Article ; Online: Bowel dysfunction after sigmoid resection underestimated: Multicentre study on quality of life after surgery for carcinoma of the rectum and sigmoid.

van Heinsbergen, M / Janssen-Heijnen, M L / Leijtens, J W / Slooter, G D / Konsten, J L

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2018 Volume 44, Issue 8, Page(s) 1261–1267

Abstract: Aim: The Low Anterior Resection Syndrome (LARS) severely affects quality of life (QoL) after rectal cancer surgery. There are no data about functional complaints after sigmoid cancer surgery. We investigated LARS and QoL in patients with a resection for ...

Abstract	Aim: The Low Anterior Resection Syndrome (LARS) severely affects quality of life (QoL) after rectal cancer surgery. There are no data about functional complaints after sigmoid cancer surgery. We investigated LARS and QoL in patients with a resection for sigmoid cancer versus patients who had surgery for rectal cancer. Methods: 506 patients after resection for rectal or sigmoid cancer who were at least one year colostomy-free were included between January 2008 and December 2013. Bowel function was assessed by the LARS-Score. QoL was assessed by the EORTC QLQ-C30 and -CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories. Results: 412 respondents (81.5%) could be included for the analyses. The median interval since treatment was 5 years, and the median age at the follow-up point was 72 years. Major LARS increased significantly with decreasing tumour height from one fifth in sigmoid carcinoma to 90% in low rectum carcinoma. Female gender (OR = 2.162; 95% CI: 1.349-3.467), postoperative temporary diverting stoma (OR = 3.457; 95% CI: 2.019-5.919) and tumours located in the middle (OR = 3.193; 95% CI: 1.696-6.010) or lower rectum (OR = 8.247; 95% CI: 1.672-40.678) were independently associated with the development of major LARS. Patients with major LARS fared significantly worse in most QOL domains. Conclusions: For the first time, we found that functional abdominal complaints after sigmoid surgery are a major problem, with a negative effect on QoL, even 5 years after treatment. Patients need to be adequately informed about these long-term complaints.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Colon, Sigmoid/surgery ; Defecation/physiology ; Digestive System Surgical Procedures/adverse effects ; Fecal Incontinence/etiology ; Fecal Incontinence/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/physiopathology ; Quality of Life ; Rectal Neoplasms/physiopathology ; Rectal Neoplasms/surgery ; Rectum/surgery ; Surveys and Questionnaires ; Syndrome
Language	English
Publishing date	2018
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2018.05.003
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Article: Classical operative therapy for Zenker's diverticulum.

Ummels, C / Konsten, J / Janzing, H / Sassen, S

Acta chirurgica Belgica

2007 Volume 107, Issue 5, Page(s) 557–559

Abstract: Zenker's diverticulum is a rare disease usually described in elderly patients. The "gold standard" is endoscopic treatment. We describe a 77-year-old patient treated by classical operative therapy. Patient history showed weight loss of 22 kilograms ... ...

Abstract	Zenker's diverticulum is a rare disease usually described in elderly patients. The "gold standard" is endoscopic treatment. We describe a 77-year-old patient treated by classical operative therapy. Patient history showed weight loss of 22 kilograms within a year. Physical examination showed a swelling in the neck of 7 by 2 centimeters. Gastroscopic examination demonstrated a Zenker's diverticulum, but this could not be passed with the scope. Classical surgical resection was performed with excellent results 6 months after surgery.
MeSH term(s)	Aged ; Digestive System Surgical Procedures ; Esophageal Diseases/diagnostic imaging ; Esophageal Diseases/etiology ; Humans ; Male ; Radiography ; Zenker Diverticulum/complications ; Zenker Diverticulum/diagnostic imaging ; Zenker Diverticulum/surgery
Language	English
Publishing date	2007-12-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	210274-2
ISSN	0001-5458
ISSN	0001-5458
DOI	10.1080/00015458.2007.11680123
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Article ; Online: Associations between the Geriatric-8 and 4-meter gait speed test and subsequent delivery of adjuvant chemotherapy in older patients with colon cancer.

Beukers, K / Bessems, S A M / van de Wouw, A J / van den Berkmortel, F W P J / Belgers, H J / Konsten, J L M / Sipers, W M W H / Janssen-Heijnen, M L G

Journal of geriatric oncology

2021 Volume 12, Issue 8, Page(s) 1166–1172

Abstract: Objectives: Feasible screening methods are important to identify older patients who might benefit from adjuvant chemotherapy. The aim of this study was to investigate the associations between the outcomes of screening for frailty with the Geriatric-8 ... ...

Abstract	Objectives: Feasible screening methods are important to identify older patients who might benefit from adjuvant chemotherapy. The aim of this study was to investigate the associations between the outcomes of screening for frailty with the Geriatric-8 questionnaire (G8) and the 4-meter gait speed test (4MGST) and subsequent delivery of adjuvant chemotherapy and treatment tolerance in older patients with colon cancer. Material and methods: This retrospective multicentre study included all patients aged ≥70 with primary colon carcinoma who underwent elective surgery between May 2016 and December 2018 and for whom adjuvant chemotherapy was indicated. Data were analysed using multivariate regression models. Results: 97 (73.5%) of 132 eligible patients were screened by the G8 and 85 (64.4%) by the 4MGST. In univariate analyses, patients who scored indicative for frailty on both the G8 (≤14) and the 4MGST (>4 s) significantly more often did not proceed with adjuvant chemotherapy than patients who scored fit on both instruments (OR = 5.10, p = 0.01). After adjustment for gender, stage, and postoperative complications, the OR decreased to 4.22 (p = 0.04). Tolerance of treatment was very high (93%) and did not differ between screening groups. Conclusion: Although patients who scored indicative for frailty on both the G8 and the 4MGST significantly more often did not proceed with adjuvant chemotherapy, it is still unknown whether the G8 and the 4MGST are reliable tools for identifying patients who are at high risk for severe chemotoxicity. Nonetheless, this study shows that current selection for adjuvant chemotherapy among older patients with colon cancer is safe with low rates of severe chemotoxicity.
MeSH term(s)	Aged ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Geriatric Assessment ; Humans ; Retrospective Studies ; Walking Speed
Language	English
Publishing date	2021-05-15
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2021.05.004
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Article: Hemorrhoidectomy vs. Lord's method: 17-year follow-up of a prospective, randomized trial.

Konsten, J / Baeten, C G

Diseases of the colon and rectum

2000 Volume 43, Issue 4, Page(s) 503–506

Abstract: Purpose: A prospective, randomized trial was performed between 1979 and 1981 comparing anal dilation and hemorrhoidectomy for hemorrhoidal disease at the Maastricht University Hospital. The aim of this study was to update that trial to assess long-term ... ...

Abstract	Purpose: A prospective, randomized trial was performed between 1979 and 1981 comparing anal dilation and hemorrhoidectomy for hemorrhoidal disease at the Maastricht University Hospital. The aim of this study was to update that trial to assess long-term outcome and complications such as fecal incontinence. Methods: A total of 138 patients with second-degree and third-degree hemorrhoids entered the study. Median follow-up was 17 (range, 8.4-18.3) years and was achieved for 118 (86 percent) patients. Group A (n = 35) underwent hemorrhoidectomy and Group B (n = 39) was treated with anal dilation and aftertreatment (original Lord's procedure), whereas Group C (n = 44) had dilation only. Fourteen of these patients died. Results: Recurrent hemorrhoids were noted for 26 percent of the patients treated with hemorrhoidectomy, for 46 percent with operative dilation with the postoperative dilation program, and for 39 percent with operative dilation without the postoperative program. The percentage of repeated treatment for the three subgroups was 11, 23, and 18 percent, respectively. The continence status remained more or less the same during the first year. However, 17 years later the anal stretch procedures caused various incontinence disorders in 52 percent of these patients. Significance was found for incontinence of flatus (from 11 to 30 patients; P = 0.04) in the anal dilation groups. Conclusions: Hemorrhoidectomy can be considered to be a safe procedure for treatment of hemorrhoidal disease, with excellent long-term results. Anal dilation is associated with a high percentage of complaints of fecal incontinence. The procedure should be abandoned.
MeSH term(s)	Adult ; Aged ; Anal Canal/pathology ; Anal Canal/surgery ; Dilatation/adverse effects ; Fecal Incontinence/etiology ; Female ; Follow-Up Studies ; Hemorrhoids/pathology ; Hemorrhoids/surgery ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Prospective Studies ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2000-04
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1007/bf02237194
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Article ; Online: Awareness and management of low anterior resection syndrome: A Dutch national survey among colorectal surgeons and specialized nurses.

Thomas, Gwendolyn / van Heinsbergen, Maarten / van der Heijden, Joost / Slooter, Gerrit / Konsten, Joop / Maaskant, Sabrina

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2018 Volume 45, Issue 2, Page(s) 174–179

Abstract: Introduction: Substantial progress has been made in the treatment of rectal cancer in the past two decades. Low anterior resection is a cornerstone in current treatment, combined with neo-adjuvant (chemo-) radiation in selected cases. However, side ... ...

Abstract	Introduction: Substantial progress has been made in the treatment of rectal cancer in the past two decades. Low anterior resection is a cornerstone in current treatment, combined with neo-adjuvant (chemo-) radiation in selected cases. However, side effects such as increased frequency, urgency and incontinence are seen in a majority of patients postoperatively. These symptoms, referred to as low anterior resection syndrome (LARS), have a severe impact on quality of life. Management of LARS is complex, and surgeons seem to underestimate and misinterpret the impact of symptoms associated with LARS. Aim and methods: We investigated the awareness and management of LARS in The Netherlands, conducting a national survey in which colorectal surgeons and colorectal care nurses were asked for their views on this complex syndrome. Results: 242 health-care professionals participated in the survey. Most participants estimate the prevalence of major LARS is 20-40% after low anterior resection (LAR); a severe underestimation of actual prevalence - around 70%. Only 10% of surgeons use LARS screening tools in the preoperative period, and fewer than half of surgeons use LARS scores before or after a LAR. Although most surgeons inform their patients preoperatively about the changes in bowel function that they may experience after rectal cancer treatment, a majority of these surgeons indicate more information and patient counselling would improve the quality of life of their patients. Discussion: Impact and prevalence of LARS is underestimated by their physicians. Uniform clinical guidelines should be developed to guide physicians in adequate management of patients with LARS.
MeSH term(s)	Adult ; Attitude of Health Personnel ; Awareness ; Digestive System Surgical Procedures ; Female ; Humans ; Male ; Middle Aged ; Netherlands/epidemiology ; Postoperative Complications/epidemiology ; Postoperative Complications/therapy ; Prevalence ; Quality of Life ; Rectal Neoplasms/surgery ; Risk Factors ; Surveys and Questionnaires ; Syndrome
Language	English
Publishing date	2018-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2018.11.001
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Article ; Online: Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors.

van Heinsbergen, M / den Haan, N / Maaskant-Braat, A J / Melenhorst, J / Belgers, E H / Leijtens, J W / Bloemen, J G / Rutten, H J / Bouvy, N D / Janssen-Heijnen, M L / Konsten, J L

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2019 Volume 22, Issue 2, Page(s) 136–145

Abstract: Aim: Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. ... ...

Abstract	Aim: Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. The aim of this study was to investigate the prevalence of functional abdominal complaints and related QoL after colon cancer surgery compared with patients with similar complaints after rectal cancer surgery. Method: All patients who underwent colorectal cancer resections between January 2008 and December 2015, and who were free of colostomy for at least 1 year, were eligible (n = 2136). Bowel function was assessed by the LARS score, QoL by the EORTC QLQ-C30 and QLQ-CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories. Results: A total of 1495 patients (70.0%) were included in the analyses, of whom 1145 had a colonic and 350 a rectal tumour. Symptoms of LARS were observed in 55% after rectal cancer resection compared with 21% after colon cancer resection. Female gender (OR 1.88, CI 1.392-2.528) and a previous diverting stoma (OR 1.84, CI 1.14-2.97) were independently associated with a higher prevalence of LARS after colon cancer surgery. Patients with LARS after colon cancer surgery performed significantly worse in most QoL domains. Conclusion: The results of this study highlight the presence of LARS-like symptoms after surgery for colonic cancer. Patients suffering from major LARS-like symptoms after colon resection reported the same debilitating effect on their QoL as patients with major LARS after rectal resection. This should be addressed by colorectal cancer specialists in order to adequately inform patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Colectomy/adverse effects ; Colectomy/psychology ; Colonic Neoplasms/psychology ; Colonic Neoplasms/surgery ; Cross-Sectional Studies ; Defecation ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/psychology ; Humans ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/psychology ; Prevalence ; Proctectomy/adverse effects ; Proctectomy/psychology ; Quality of Life ; Rectal Neoplasms/surgery ; Retrospective Studies ; Risk Factors ; Sex Factors ; Syndrome ; Treatment Outcome
Language	English
Publishing date	2019-09-03
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.14818
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Article ; Online: Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy: A Prospective, Multicenter, Observational Study (PERFECT - Trial).

de Jong, Judith J / Latenstein, Carmen S S / Boerma, Djamila / Hazebroek, Eric J / Hirsch, David / Heikens, Joost T / Konsten, Joop / Polat, Fatih / Lantinga, Marten A / van Laarhoven, Cornelis J H M / Drenth, Joost P H / de Reuver, Philip R

Annals of surgery

2020 Volume 275, Issue 6, Page(s) e766–e772

Abstract: Objective: To determine the prevalence of FD and IBS in patients eligible for cholecystectomy and to investigate the association between presence of FD/ IBS and resolution of biliary colic and a pain-free state.: Summary background data: More than 30% ...

Abstract	Objective: To determine the prevalence of FD and IBS in patients eligible for cholecystectomy and to investigate the association between presence of FD/ IBS and resolution of biliary colic and a pain-free state. Summary background data: More than 30% of patients with symptomatic cholecystolithiasis reports persisting pain postcholecystectomy. Coexistence of FD/IBS may contribute to this unsatisfactory outcome. Methods: We conducted a multicenter, prospective, observational study (PERFECT-trial). Patients ≥18 years with abdominal pain and gallstones were included at 5 surgical outpatient clinics between 01/2018 and 04/2019. Follow-up was 6 months. Primary outcomes were prevalence of FD/IBS, and the difference between resolution of biliary colic and pain-free state in patients with and without FD/IBS. FD/IBS was defined by the Rome IV criteria, biliary colic by the Rome III criteria, and pain-free by an Izbicki Pain Score ≤10 and visual analogue scale ≤4. Results: We included 401 patients with abdominal pain and gallstones (assumed eligible for cholecystectomy), mean age 52 years, 76% females. Of these, 34.9% fulfilled criteria for FD/IBS. 64.1% fulfilled criteria for biliary colic and 74.9% underwent cholecystectomy, with similar operation rates in patients with and without FD/IBS. Postcholecystectomy, 6.1% of patients fulfilled criteria for biliary colic, with no significant difference between those with and without FD/IBS at baseline (4.9% vs 8.6%, P = 0.22). Of all patients, 56.8% was pain-free after cholecystectomy, 40.7% of FD/IBS-group vs 64.4% of no FD/IBS-group, P < 0.001. Conclusions: One third of patients eligible for cholecystectomy fulfil criteria for FD/IBS. Biliary colic is reported by only a few patients postcholecys-tectomy, whereas nonbiliary abdominal pain persists in >40%, particularly in those with FD/IBS precholecystectomy. Clinicians should take these symptom-dependent outcomes into account in their shared decision-making process. Trial registration: The Netherlands Trial Register NTR-7307. Registered on 18 June 2018.
MeSH term(s)	Abdominal Pain/epidemiology ; Abdominal Pain/etiology ; Cholecystectomy ; Colic/epidemiology ; Colic/etiology ; Colic/surgery ; Dyspepsia/complications ; Dyspepsia/etiology ; Female ; Gallstones/complications ; Gallstones/surgery ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/epidemiology ; Male ; Middle Aged ; Prospective Studies
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004453
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