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Article ; Online: Photon emission spectrum of ion pumps.

Kontos, Antonios / Weiss, Rainer

2023 Volume 94, Issue 3, Page(s) 34503

Abstract: As the sensitivity of gravitational-wave detectors increases, new sources of noise appear. A potential source of noise may arise from charge accumulating on the mirrors of the experiment, the origin of which can be related to UV photons from the ... ...

Abstract	As the sensitivity of gravitational-wave detectors increases, new sources of noise appear. A potential source of noise may arise from charge accumulating on the mirrors of the experiment, the origin of which can be related to UV photons from the surroundings. In order to test one hypothesis, we measured the photon emission spectrum from a type of ion pump that is used in the experiment, an Agilent VacIon Plus 2500 l/s. We found that there is significant emission of UV photons above 5 eV, capable of knocking electrons off mirrors or surrounding surfaces and charging them. Photon emission measurements were taken as a function of gas pressure, ion-pump voltage setting, and type of pumped gas. The overall emission and shape of the measured photon spectrum are consistent with bremsstrahlung as the mechanism for the production of the photons.
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0138917
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Article ; Conference proceedings: Endoscopic Papillectomy : A single center 4-year retrospective study

Tsamakidis, X. / Kypraios, D. / Kontos, A. / Sarimpegioglou, N. / Sachtouris, G. / Ippokratis, P. / Marakis, I. / Manthopoulou, E. / Stavrinidis, S. / Michalopoulou, E. / Papakonstantinou, F. / Giannakopoulos, V. / Tziortziotis, I. / Al-Ountat, M. / Dimitroulopoulos, D.

Endoscopy

2024 Volume 56, Issue S 02

Event/congress	ESGE Days 2024, Berlin, Germany, 2024-04-25
Language	English
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0044-1783917
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Defect characterization in optical coatings using scattered light.

Loglia, Balthazar / Derrick, Emma / Ingraham, Luke / Fraser, Alexandra / Geng, Yutong / Sanger-Johnson, Grace / Colby, Kace / Kontos, Antonios

Applied optics

2023 Volume 62, Issue 22, Page(s) 6046–6052

Abstract: Optical coatings play a vital role in sensing technologies. The development of new coatings that exhibit minimal optical losses requires a detailed understanding of the development of defects within them. Current methods of defect characterization ... ...

Abstract	Optical coatings play a vital role in sensing technologies. The development of new coatings that exhibit minimal optical losses requires a detailed understanding of the development of defects within them. Current methods of defect characterization involve direct microscope imaging or x-ray diffraction studies in the case of crystallites. In this paper, we demonstrate the characterization of coating defects using light scattering, which can yield information about their size, location, and index of refraction. The method requires measuring the scattered power of each individual defect as a function of angle and comparing the data with theoretical models. Finally, we argue that this method can be used for the determination of the defect location within a multi-layer stack.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.496538
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Article ; Online: Rate and risk factors for the conversion of fovea-on to fovea-off rhegmatogenous retinal detachment while awaiting surgery.

Kontos, Andreas / Williamson, Tom H

The British journal of ophthalmology

2017 Volume 101, Issue 8, Page(s) 1011–1015

Abstract: Background/aims: Progression of a fovea-on to a fovea-off rhegmatogenous retinal detachment (RRD) while awaiting surgery is rare.: Methods: A retrospective review of patient records to identify patients in whom a fovea-on retinal detachment at ... ...

Abstract	Background/aims: Progression of a fovea-on to a fovea-off rhegmatogenous retinal detachment (RRD) while awaiting surgery is rare. Methods: A retrospective review of patient records to identify patients in whom a fovea-on retinal detachment at presentation was found to be fovea off at surgery. Results: We identified 10 cases over 14 years which converted from fovea-on to fovea-off RRD while awaiting surgery. This represented 1.1% of RRDs that were fovea on at presentation (n=930). Nine out of 10 patients had superotemporal RRDs extending to at least the vascular arcade at presentation and all had superotemporal breaks within detached retina, which was significantly higher than the rate for other retinal detachments (100% vs 63%, p=0.02). There were 2.4 breaks per eye, similar to other retinal detachments. Six of the 10 patients converted to a fovea-off retinal detachment within a few hours and the rest by the following day. Visual outcomes were good, with eight patients maintaining their presenting visual acuity and two losing one Snellen line. Conclusions: Offering same-day surgery to high-risk fovea-on RRDs may not significantly influence visual outcomes and would only prevent about half of the conversions to fovea off. Superotemporal retinal detachments extending to near the arcades are most at risk and might warrant posturing to limit spread of the detachment in the preoperative period.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Ambulatory Surgical Procedures ; Disease Progression ; Female ; Fovea Centralis ; Humans ; Male ; Middle Aged ; Retinal Detachment/pathology ; Retinal Detachment/physiopathology ; Retinal Detachment/surgery ; Retrospective Studies ; Risk Factors ; Time-to-Treatment ; Treatment Outcome ; Visual Acuity/physiology
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2016-309178
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Article ; Online: Medical Conditions in Former Professional American-Style Football Players Are Associated With Self-Reported Clinical Features of Traumatic Encephalopathy Syndrome.

Grashow, Rachel / Eagle, Shawn R / Terry, Douglas P / DiGregorio, Heather / Baggish, Aaron L / Weisskopf, Marc G / Kontos, Anthony / Okonkwo, David O / Zafonte, Ross

Neurotrauma reports

2024 Volume 5, Issue 1, Page(s) 376–386

Abstract: Consensus criteria for traumatic encephalopathy syndrome (TES) specify that at least one core clinical feature of cognitive impairment (CI; e.g., difficulties with memory, executive function) or neurobehavioral dysregulation (ND; e.g., explosiveness, ... ...

Abstract	Consensus criteria for traumatic encephalopathy syndrome (TES) specify that at least one core clinical feature of cognitive impairment (CI; e.g., difficulties with memory, executive function) or neurobehavioral dysregulation (ND; e.g., explosiveness, rage, and mood lability) be present and not fully accounted for by other health disorders. Associations between self-reported symptoms that mirror the core clinical features of TES-and how they may be related to concomitant medical conditions-remain unclear. The purpose of this study was to evaluate the association of medical conditions and football exposures with TES clinical features (CI
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2689-288X
ISSN (online)	2689-288X
DOI	10.1089/neur.2024.0008
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Article ; Online: Performance Validity Testing in Patients Presenting to a Specialty Clinic With a Mild Traumatic Brain Injury.

Sherry, Natalie / Ernst, Nathan / French, Jonathan E / Eagle, Shawn / Collins, Michael / Kontos, Anthony

The Journal of head trauma rehabilitation

2021 Volume 37, Issue 3, Page(s) E135–E143

Abstract: Objective: To evaluate predictors of performance validity testing (PVT) and clinical outcome in patients presenting to a specialty clinic with a mild traumatic brain injury (mTBI).: Setting: An outpatient mTBI specialty clinic.: Participants: ... ...

Abstract	Objective: To evaluate predictors of performance validity testing (PVT) and clinical outcome in patients presenting to a specialty clinic with a mild traumatic brain injury (mTBI). Setting: An outpatient mTBI specialty clinic. Participants: Seventy-six (47% female) patients aged 16 to 66 (mean = 40.58, SD = 14.18) years within 3 to 433 days (mean = 30.63, SD = 54.88, median = 17.00) of a suspected mTBI between 2018 and 2019. Design: A cross-sectional, observational study comparing patients who passed PVT (n = 43) with those who failed (n = 33). A logistic regression (LR) was conducted to evaluate factors that predicted failed PVT. Independent-samples t tests and general linear model were used to evaluate PVT groups on clinical outcomes. The LR with a receiver operating characteristic (ROC) curve was conducted to evaluate embedded validity indicators. Main measures: Performance validity testing, computerized neurocognitive testing, vestibular/oculomotor screening, symptom reports. Results: At their initial clinic visit 43% of patients failed PVT. PVT failure was predicted by presence of secondary gain (odds ratio [OR] = 8.11, P = .02), while a history of mental health predicted passing of PVT (OR = 0.29, P = .08). Those who failed PVT performed significantly worse on computerized neurocognitive testing (P < .05) and took an average of 33 days longer to return to work (P = .02). There was no significant difference (P = .20) in recovery time between failed/passed PVT groups when covarying for those who sustained a work injury. Word memory learning percentage less than 69% and design memory learning percentage less than 50% accurately classified patients who failed PVT (area under the ROC curve = 0.74; P < .001). Conclusion: Secondary gain was the best predictor of failed PVT. Patients presenting for mTBI evaluation and rehabilitation who fail PVT demonstrate worse performance on cognitive testing and take longer to return to work post-injury, but recover in a similar time frame compared with those who pass PVT. Clinicians should be cautious in discounting patients who yield invalid test results, as these patients appear to be able to achieve recovery in a treatment setting.
MeSH term(s)	Ambulatory Care Facilities ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Cross-Sectional Studies ; Female ; Humans ; Male ; Neuropsychological Tests ; ROC Curve ; Reproducibility of Results
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	639221-0
ISSN	1550-509X ; 0885-9701
ISSN (online)	1550-509X
ISSN	0885-9701
DOI	10.1097/HTR.0000000000000692
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Article: Office-based concussion evaluation, diagnosis, and management: adult.

Charek, Daniel B / Collins, Michael / Kontos, Anthony

Handbook of clinical neurology

2018 Volume 158, Page(s) 91–105

Abstract: Concussion is a major public health concern, with an estimated 1.6-3.8 million sport-related concussions occurring annually in the United States. Although the majority of injured athletes recover within 7-21 days, 20-30% of athletes experience protracted ...

Abstract	Concussion is a major public health concern, with an estimated 1.6-3.8 million sport-related concussions occurring annually in the United States. Although the majority of injured athletes recover within 7-21 days, 20-30% of athletes experience protracted recovery spanning more than a month, suggesting as many as 320,000-760,000 athletes may experience prolonged symptoms. This highlights the need for efficacious clinical interventions to facilitate recovery. While concussion was historically conceptualized as a homogeneous injury, a more nuanced understanding has recently emerged and led to a refined approach of categorizing concussions into clinical trajectories or symptom profiles. These categorizations correspond with targeted rehabilitation strategies focused on specific symptom clusters and deficits. Multidisciplinary teams, with collaborating neuropsychologists, neurologists, neurosurgeons, sports medicine physicians, athletic trainers, and physical therapists, are valuable to concussion management due to the heterogeneous nature of the injury. This chapter will provide an overview of a multimodal, clinical profile-based approach to assessment and targeted treatment of athletes with sport-related concussion. We describe a profile-based model for conceptualizing the injury, review relevant modifying factors, discuss components of a comprehensive assessment, and examine targeted treatment approaches.
MeSH term(s)	Adult ; Athletic Injuries/etiology ; Brain Concussion/diagnosis ; Brain Concussion/epidemiology ; Brain Concussion/etiology ; Brain Concussion/therapy ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Disease Management ; Humans ; Mood Disorders/diagnosis ; Mood Disorders/etiology ; Ocular Motility Disorders/diagnosis ; Ocular Motility Disorders/etiology ; Trauma Severity Indices ; Vestibular Diseases/diagnosis ; Vestibular Diseases/etiology
Language	English
Publishing date	2018-11-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-63954-7.00010-0
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Article ; Online: Causative factors of liver fibrosis in HIV-infected patients. A single center study.

Androutsakos, Theodoros / Schina, Maria / Pouliakis, Abraham / Kontos, Athanasios / Sipsas, Nikolaos / Hatzis, Gregorios

BMC gastroenterology

2020 Volume 20, Issue 1, Page(s) 91

Abstract: Background: Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was to identify risk factors for ... ...

Abstract	Background: Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was to identify risk factors for liver fibrosis/cirrhosis in a cohort of Greek HIV-infected patients. Methods: Patients attending the HIV outpatient clinic of Pathophysiology Department at «Laiko» General Hospital in Athens, Greece, between December 2014 and December 2017 were eligible for inclusion. Inclusion criteria were confirmed HIV infection and age > 18 years. Exclusion criteria were Body-Mass index (BMI) > 40, liver metastases of malignant diseases and concurrent or previous chemotherapy. Liver stiffness (LS) was measured using Vibration Controlled Transient Elastography (TE) and laboratory tests were acquired in all patients. Patients were classified in 2 groups: those with mild or no fibrosis (equivalent to Metavir score F0-F2) and those with significant fibrosis (equivalent to Metavir score F3-F4). Results: A total of 187 consecutive patients were included in this study. Median TE value was 5.1 kilopascals (KPa) (range 2.8-26.3), with 92.5% (173/187) of the patients having no/mild fibrosis and 7.4% (14/187) significant fibrosis. On multivariate logistic regression analysis older patient's age, abnormal serum aspartate aminotransferase (AST) value, Hepatitis C virus (HCV) infection, alcohol abuse, CD4/CD8 ratio and an increased number of liver related events (LREs) were significantly correlated with liver fibrosis/cirrhosis. Conclusions: In our cohort of HIV-infected individuals HCV/HIV co-infection, older age, alcohol abuse and CD4/CD8 ratio seem to correlate with fibrogenesis in the liver.
MeSH term(s)	Acute Disease ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alcoholism/epidemiology ; Aspartate Aminotransferases/blood ; CD4-CD8 Ratio ; Causality ; Chemical and Drug Induced Liver Injury/epidemiology ; Coinfection/blood ; Coinfection/epidemiology ; Elasticity Imaging Techniques ; Female ; Greece/epidemiology ; HIV Infections/blood ; HIV Infections/epidemiology ; Hepatitis C, Chronic/epidemiology ; Hepatitis, Viral, Human/epidemiology ; Humans ; Hyperbilirubinemia/epidemiology ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/epidemiology ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Young Adult
Chemical Substances	Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-020-01230-1
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Article ; Online: Increased Platelet Aggregation in Children and Adolescents with Sleep-disordered Breathing.

Kontos, Anna / Willoughby, Scott / Lushington, Kurt / Martin, James / Wabnitz, David / Dorrian, Jill / Kennedy, Declan

American journal of respiratory and critical care medicine

2020 Volume 202, Issue 11, Page(s) 1560–1566

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adenoidectomy ; Adenoids/pathology ; Adolescent ; Case-Control Studies ; Child ; Endothelial Cells ; Female ; Humans ; Male ; Palatine Tonsil/pathology ; Platelet Aggregation ; Platelet Function Tests ; Polysomnography ; Sleep Apnea Syndromes/blood ; Sleep Apnea Syndromes/pathology ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/surgery ; Tonsillectomy ; Vascular Resistance
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201911-2229OC
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Article ; Online: Effectiveness of Oral Nirmatrelvir/Ritonavir vs. Intravenous Three-Day Remdesivir in Preventing Progression to Severe COVID-19: A Single-Center, Prospective, Comparative, Real-Life Study.

Basoulis, Dimitrios / Tsakanikas, Aristeidis / Gkoufa, Aikaterini / Bitsani, Aikaterini / Karamanakos, Georgios / Mastrogianni, Elpida / Georgakopoulou, Vasiliki E / Makrodimitri, Sotiria / Voutsinas, Pantazis-Michail / Lamprou, Panagiota / Kontos, Athanasios / Tsiakas, Stathis / Gamaletsou, Maria N / Marinaki, Smaragdi / Sipsas, Nikolaos V

Viruses

2023 Volume 15, Issue 7

Abstract: Background: Nirmatrelvir/ritonavir (NMV/r) and three-day course remdesivir (3RDV) have been approved as early treatments for COVID-19 outpatients not requiring supplemental oxygen. Real-life data on the efficacy of antivirals among immunocompromised ... ...

Abstract	Background: Nirmatrelvir/ritonavir (NMV/r) and three-day course remdesivir (3RDV) have been approved as early treatments for COVID-19 outpatients not requiring supplemental oxygen. Real-life data on the efficacy of antivirals among immunocompromised patients or directly comparing their effectiveness in preventing hospitalization and/or death are scarce. Methods: Prospective, observational study conducted in a tertiary care hospital, from 1 January 2022 until 15 March 2023, during the prevalence of the Omicron variant. Inverse probability of treatment weighting (IPTW) was used to account for differences between treatment groups. Results: We included 521, mainly immunocompromised (56%), patients in our analysis; 356 (68.3%) received 3RDV and 165 (31.7%) NMV/r. Overall, 15/521 (2.9%) patients met the primary end-point of hospitalization at 30 days (3RDV arm: 10/356, 2.8% vs. NMV/r arm: 5/165, 3%, Conclusion: In our patient population of high-risk, mainly immunocompromised, vaccinated patients during the prevalence of the Omicron variant, NMV/r and 3RDV were equally effective early treatments for the prevention of hospitalization and/or death.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Drug Treatment ; Prospective Studies ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Antiviral Agents/therapeutic use
Chemical Substances	nirmatrelvir (7R9A5P7H32) ; remdesivir (3QKI37EEHE) ; Ritonavir (O3J8G9O825) ; Antiviral Agents
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15071515
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