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Article ; Online: Editorial: slow progress to optimising H. pylori eradication treatment with antisecretory drugs-authors' reply.

Ang, Daphne / Koo, Seok-Hwee

2022 Volume 56, Issue 6, Page(s) 1076–1077

MeSH term(s)	Gastrointestinal Agents/therapeutic use ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Peptic Ulcer/drug therapy
Chemical Substances	Gastrointestinal Agents
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17167
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Article ; Online: Evaluating simulator sickness and acceptability of virtual reality prototype in pain management in hospitalized patients.

Li, Lydia Weiling / Beng, Michael Hock / Singh, Prit Anand / Koo, Seok Hwee / Sng, Ban Leong

Pain management

2024 Volume 14, Issue 2, Page(s) 53–63

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Pain Management/methods ; Analgesics, Opioid ; Chronic Pain/therapy ; Anxiety/therapy ; Virtual Reality
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2617136-3
ISSN	1758-1877 ; 1758-1869
ISSN (online)	1758-1877
ISSN	1758-1869
DOI	10.2217/pmt-2023-0072
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Article: A Study of Analytical and Clinical Sensitivity of Aptima SARS-CoV-2 Assay (Hologic) and Proposals of Complementary Tests for SARS-CoV-2 Detection in Low Viral Load Specimens

La, My-Van / Koo, Seok Hwee / Jiang, Boran / Heng, Ying Xuan / Tan, Thean Yen

Current microbiology. 2022 Jan., v. 79, no. 1

2022

Abstract: Early and accurate detection of SARS-CoV-2 is important for diagnosis and transmission control. The use of high-throughput and automated testing allows laboratories to better deliver diagnostic testing given manpower and resource limitations. We ... ...

Abstract	Early and accurate detection of SARS-CoV-2 is important for diagnosis and transmission control. The use of high-throughput and automated testing allows laboratories to better deliver diagnostic testing given manpower and resource limitations. We validated the clinical and analytical performance of the Hologic Panther Aptima SARS-CoV-2 assay with an emphasis on detection of specimens with low viral loads. The clinical performance was evaluated using 245 clinical specimens, against a comparator PCR-based laboratory developed test (LDT). The analytical performance was determined by replicate testing of contrived samples in a ten-fold dilution series (CT values 32–42, based on LDT). The Aptima assay had 96.7% overall percent agreement, 100% negative percent agreement and 88.1% positive percent agreement. It was able to consistently detect SARS-CoV-2 in contrived samples with CT = 32 by LDT (calculated 2354 copies/mL). The 95% limit of detection of the Aptima assay was estimated to be at LDT CT = 33 (equivalent to 870 copies/mL). The relative light units (RLU) × 1000 for 52 true positive clinical specimens was 962.2 ± 181.5, and that for the 186 true negative specimens was 264.6 ± 14.3. The Aptima assay was a reliable method with a high overall percent agreement against our comparator LDT. We propose that samples reported as negative by the Aptima assay with RLU > 350 be tested by a secondary method, in order to improve detection of samples with very low viral loads.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; detection limit ; microbiology ; polymerase chain reaction ; viral load
Language	English
Dates of publication	2022-01
Size	p. 29.
Publishing place	Springer US
Document type	Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-021-02730-3
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Article ; Online: Bioinspired bi-phasic 3D nanoflowers of MgO/Mg(OH)

Agarwal, Ashutosh / Senevirathna, Hasanthi L / Koo, Seok Hwee / Wong, Crystal Shie Lyeen / Lim, Terence Sey Kiat / Ng, Foo Cheong / Anariba, Franklin / Wu, Ping

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13290

Abstract: By roughly mimicking the surface architectural design of dragonfly wings, novel bi-phasic 3D nanoflowers of MgO/Mg(OH) ...

Abstract	By roughly mimicking the surface architectural design of dragonfly wings, novel bi-phasic 3D nanoflowers of MgO/Mg(OH)
MeSH term(s)	Animals ; Magnesium Oxide/pharmacology ; Anti-Bacterial Agents/pharmacology ; Odonata ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Escherichia coli
Chemical Substances	melamine (N3GP2YSD88) ; Magnesium Oxide (3A3U0GI71G) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40336-w
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Article ; Online: Rapid and Accurate Antimicrobial Susceptibility Testing Using Label-Free Electrical Impedance-Based Microfluidic Platform.

Chen, Jiahong / Zhong, Jianwei / Chang, Yifu / Zhou, Yinning / Koo, Seok Hwee / Tan, Thean Yen / Lei, Hongtao / Ai, Ye

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 20, Issue 6, Page(s) e2303352

Abstract: Antimicrobial resistance has become a serious threat to the global public health. Accurate and rapid antimicrobial susceptibility testing (AST) allows evidence-based prescribing of antibiotics to improve patient care and clinical outcomes. Current ... ...

Abstract	Antimicrobial resistance has become a serious threat to the global public health. Accurate and rapid antimicrobial susceptibility testing (AST) allows evidence-based prescribing of antibiotics to improve patient care and clinical outcomes. Current culture-based AST assays are inherently limited by the doubling time of bacterial reproduction, which require at least 24 h to have a decisive result. Herein, a label-free electrical impedance-based microfluidic platform designed to expedite and streamline AST procedure for clinical practice is presented. Following a 30-min exposure of bacterial samples to antibiotics, the presented high-throughput, single-bacterium level impedance characterization platform enables a rapid 2-min AST assay. The platform facilitates accurate analysis of individual bacterial viability, as indicated by changes in electrical characteristics, thereby enabling the determination of antimicrobial resistance. Moreover, the potential clinical applicability of this platform is demonstrated by testing different E. coli strains against five antibiotics, yielding 100% categorical agreements compared to standard culture methods.
MeSH term(s)	Humans ; Microfluidics ; Electric Impedance ; Escherichia coli ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Bacteria
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202303352
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Article ; Online: A Study of Analytical and Clinical Sensitivity of Aptima SARS-CoV-2 Assay (Hologic) and Proposals of Complementary Tests for SARS-CoV-2 Detection in Low Viral Load Specimens.

La, My-Van / Koo, Seok Hwee / Jiang, Boran / Heng, Ying Xuan / Tan, Thean Yen

Current microbiology

2021 Volume 79, Issue 1, Page(s) 29

Abstract	Early and accurate detection of SARS-CoV-2 is important for diagnosis and transmission control. The use of high-throughput and automated testing allows laboratories to better deliver diagnostic testing given manpower and resource limitations. We validated the clinical and analytical performance of the Hologic Panther Aptima SARS-CoV-2 assay with an emphasis on detection of specimens with low viral loads. The clinical performance was evaluated using 245 clinical specimens, against a comparator PCR-based laboratory developed test (LDT). The analytical performance was determined by replicate testing of contrived samples in a ten-fold dilution series (C
MeSH term(s)	COVID-19 ; Humans ; Molecular Diagnostic Techniques ; RNA, Viral ; SARS-CoV-2 ; Sensitivity and Specificity ; Viral Load
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-021-02730-3
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Article ; Online: Development of a rapid multiplex PCR assay for the detection of common pathogens associated with community-acquired pneumonia.

Koo, Seok Hwee / Jiang, Boran / Lim, Pei Qi / La, My-Van / Tan, Thean Yen

Transactions of the Royal Society of Tropical Medicine and Hygiene

2021 Volume 115, Issue 12, Page(s) 1450–1455

Abstract: Background: Community-acquired pneumonia (CAP) is one of the most common infectious diseases and is a significant cause of mortality and morbidity globally. A microbial cause was not determined in a sizable percentage of patients with CAP; there are ... ...

Abstract	Background: Community-acquired pneumonia (CAP) is one of the most common infectious diseases and is a significant cause of mortality and morbidity globally. A microbial cause was not determined in a sizable percentage of patients with CAP; there are increasing data to suggest regional differences in bacterial aetiology. We devised a multiplex real-time PCR assay for detecting four microorganisms (Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae and Burkholderia pseudomallei) of relevance to CAP infections in Asia. Methods: Analytical validation was accomplished using bacterial isolates (n=10-33 of each target organism for analytical sensitivity and n=117 for analytical sensitivity) and clinical validation using 58 culture-positive respiratory tract specimens. Results: The qPCR assay exhibited 100% analytical sensitivity and analytical specificity, and 100% clinical sensitivity and 94-100% clinical specificity. The limit of detection and efficiency for the multiplex PCR assay were 3-33 CFU/mL and 93-110%, respectively. The results showed that the PCR-based method had higher sensitivity than traditional culture-based methods. The assay also demonstrated an ability to semiquantify bacterial loads. Conclusion: We have devised a reliable laboratory-developed multiplex qPCR assay, with a turnaround time of within one working day, for detection of four clinically important CAP-associated microorganisms in Asia. The availability of a test with improved diagnostic capabilities potentially leads to an informed choice of antibiotic usage and appropriate management of the patient to achieve a better treatment outcome and financial savings.
MeSH term(s)	Community-Acquired Infections/diagnosis ; Humans ; Multiplex Polymerase Chain Reaction ; Pneumonia, Bacterial/diagnosis ; Sensitivity and Specificity ; Streptococcus pneumoniae/genetics
Language	English
Publishing date	2021-05-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trab079
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Article ; Online: Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.

Koo, Seok Hwee / Soon, Gaik Hong / Pruvost, Alain / Benech, Henri / Ang, Tiing Leong / Lee, Edmund Jon Deoon / Ang, Daphne Shih Wen

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 7, Page(s) 815–826

Abstract: The primary objectives of this study were to investigate the suitability of a 6-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) to be used as a tool for assessing the activity of drug metabolizing enzymes and ... ...

Abstract	The primary objectives of this study were to investigate the suitability of a 6-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) to be used as a tool for assessing the activity of drug metabolizing enzymes and transporters, and examine differences in the way drugs are handled among groups with different genetic regulation of these processes. This was a single-center, open-label, phase I clinical study involving 20 young, healthy Chinese volunteers (equal gender distribution). The subjects were administered a single, oral dose of the 6-probe cocktail and serum samples were collected to assess the disposition of the different probe substrates and produced metabolites. The serum samples were analyzed using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry technology. The DNA samples were subjected to whole exome sequencing. Nineteen healthy volunteers completed the study. The 6-probe cocktail was safe and well-tolerated by all the subjects. The parent substrates and metabolites-caffeine (paraxanthine), dextromethorphan (dextrorphan), digoxin, midazolam (1-hydroxy-midazolam), omeprazole (5-hydroxy-omeprazole), and tolbutamide (4-hydroxy-tolbutamide)-were within the detectable window. Genetic variations known to alter drug metabolism (CYP2D610, CYP2C192, CYP2C193, and CYP2C93) were identified and generally correlated with phenotypic status. The 6-probe cocktail appeared to be suitable for assessing drug metabolizing activities. This, in conjunction with individual genetics, will pave the way for the implementation of personalized medicine in clinical practice. This will hopefully improve efficacy and reduce the incidence of adverse drug reactions.
MeSH term(s)	Caffeine ; China ; Cytochrome P-450 CYP2C19 ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Dextromethorphan ; Digoxin ; Drug Interactions ; Healthy Volunteers ; Humans ; Midazolam ; Omeprazole ; Tolbutamide
Chemical Substances	Caffeine (3G6A5W338E) ; Dextromethorphan (7355X3ROTS) ; Digoxin (73K4184T59) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Tolbutamide (982XCM1FOI) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Omeprazole (KG60484QX9) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2022-04-08
Publishing country	Germany
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02235-1
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Article ; Online: Evaluation of the clinical sensitivity and specificity of the BD Max™ Enteric Bacterial Panel for molecular detection of pathogens for acute gastroenteritis in the Singaporean population.

Koo, Seok Hwee / Heng, Ying Xuan / Jiang, Boran / Ng, Lily Siew Yong / Sim, Diana Miao Fang / Tan, Thean Yen

Journal of microbiological methods

2022 Volume 197, Page(s) 106478

Abstract: Purpose: Acute gastroenteritis (AGE) is caused by a wide range of pathogens. Culture methods for the detection of bacterial pathogens is time consuming and labour intensive. This study compared a same-day-to-result commercial molecular method using BD ... ...

Abstract	Purpose: Acute gastroenteritis (AGE) is caused by a wide range of pathogens. Culture methods for the detection of bacterial pathogens is time consuming and labour intensive. This study compared a same-day-to-result commercial molecular method using BD Max™ Enteric Bacterial Panel against conventional culture and laboratory-developed PCR assays (LDTs), and characterised the epidemiology of bacterial AGE in Singapore. Methodology: PCRs for Campylobacter spp., Salmonella spp., Shigella spp./Enteroinvasive Escherichia coli (EIEC) and Shiga toxin-producing E. coli (STEC)/Shigella dysenteriae were performed on the BD Max™ platform. Concurrent routine bacterial culture ("reference standard") was performed for Campylobacter, Salmonella, Shigella, Vibrio and Aeromonas spp. In the event of a discrepancy, an "expanded reference standard" (bacterial culture with LDT) was used. Results: There were 299 stool specimens in the study, with no bacterial pathogens detected in 190 samples (63.5%). The positive samples (n = 109,36.5%) were detected with Salmonella (n = 57,19.1%), Campylobacter (n = 28,9.4%), Vibrio parahaemolyticus (n = 6,2.0%), Shigella/EIEC (n = 6,2.0%), ETEC (n = 4,1.3%), STEC (n = 2,0.7%), Aeromonas (n = 2,0.7%), Plesiomonas shigelloides (n = 1,0.3%) and 3(1.0%) co-infections. Compared to the "expanded reference standard", conventional culture missed 38/112 (33.9%) pathogens. Conversely, testing by BD Max™ alone failed to detect 17 pathogens. BD Max™ reported seven (2.3%) false-positive results. Conclusions: BD Max™ increased the detection rate of bacterial AGE pathogens in the panel, but was limited by the absence of detection capability for Vibrio and Aeromonas spp.
MeSH term(s)	Aeromonas ; Campylobacter ; Diarrhea/microbiology ; Escherichia coli ; Feces/microbiology ; Gastroenteritis/diagnosis ; Gastroenteritis/microbiology ; Humans ; Molecular Diagnostic Techniques/methods ; Salmonella ; Sensitivity and Specificity ; Shigella/genetics ; Singapore
Language	English
Publishing date	2022-04-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2022.106478
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Article: Evaluation of the clinical sensitivity and specificity of the BD Max™ Enteric Bacterial Panel for molecular detection of pathogens for acute gastroenteritis in the Singaporean population

Koo, Seok Hwee / Heng, Ying Xuan / Jiang, Boran / Ng, Lily Siew Yong / Sim, Diana Miao Fang / Tan, Thean Yen

Journal of microbiological methods. 2022 June, v. 197

2022

Abstract: Acute gastroenteritis (AGE) is caused by a wide range of pathogens. Culture methods for the detection of bacterial pathogens is time consuming and labour intensive. This study compared a same-day-to-result commercial molecular method using BD Max™ ... ...

Abstract	Acute gastroenteritis (AGE) is caused by a wide range of pathogens. Culture methods for the detection of bacterial pathogens is time consuming and labour intensive. This study compared a same-day-to-result commercial molecular method using BD Max™ Enteric Bacterial Panel against conventional culture and laboratory-developed PCR assays (LDTs), and characterised the epidemiology of bacterial AGE in Singapore. PCRs for Campylobacter spp., Salmonella spp., Shigella spp./Enteroinvasive Escherichia coli (EIEC) and Shiga toxin-producing E. coli (STEC)/Shigella dysenteriae were performed on the BD Max™ platform. Concurrent routine bacterial culture (“reference standard”) was performed for Campylobacter, Salmonella, Shigella, Vibrio and Aeromonas spp. In the event of a discrepancy, an “expanded reference standard” (bacterial culture with LDT) was used. There were 299 stool specimens in the study, with no bacterial pathogens detected in 190 samples (63.5%). The positive samples (n = 109,36.5%) were detected with Salmonella (n = 57,19.1%), Campylobacter (n = 28,9.4%), Vibrio parahaemolyticus (n = 6,2.0%), Shigella/EIEC (n = 6,2.0%), ETEC (n = 4,1.3%), STEC (n = 2,0.7%), Aeromonas (n = 2,0.7%), Plesiomonas shigelloides (n = 1,0.3%) and 3(1.0%) co-infections. Compared to the “expanded reference standard”, conventional culture missed 38/112 (33.9%) pathogens. Conversely, testing by BD Max™ alone failed to detect 17 pathogens. BD Max™ reported seven (2.3%) false-positive results. BD Max™ increased the detection rate of bacterial AGE pathogens in the panel, but was limited by the absence of detection capability for Vibrio and Aeromonas spp.
Keywords	Aeromonas ; Campylobacter ; Plesiomonas shigelloides ; Salmonella ; Shiga toxin-producing Escherichia coli ; Singapore ; Vibrio parahaemolyticus ; bacterial culture ; epidemiology ; gastroenteritis ; labor ; reference standards
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2022.106478
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