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  1. AU="Koopmans, Marion Pg"
  2. AU=Poole Stephen
  3. AU="Kislova, Maria"
  4. AU="Balducelli, Emma"
  5. AU="Mudrak, Nathan J"
  6. AU="Fagundes, Addller Oliveira"
  7. AU="Qi, Xiaoli" AU="Qi, Xiaoli"
  8. AU="Durymanov, Mikhail"
  9. AU=Yin Wenzhe
  10. AU=Vlachos Ioannis S.
  11. AU=Grundy Scott M
  12. AU="Koumoutsea, Evangelia Vlachodimitropoulou"
  13. AU="Almen, Aimee"
  14. AU="Howard, Dianna S."
  15. AU="Elizete Rizzo"
  16. AU="El Sayegh, Suzanne"
  17. AU="Vaittinen, Tiina"
  18. AU="Khir, Amir S"
  19. AU=Patterson Andrew D
  20. AU="Kim, Joyce Mary"
  21. AU="Saribay, S Adil"
  22. AU="Couderc, M."
  23. AU="Macerlane de Lira Silva"
  24. AU=Neal Michael S
  25. AU="Nakai, Kozo"
  26. AU="Debatin, Jörg F."
  27. AU="Plant, Laura"
  28. AU="Manuel Tisminetzky"
  29. AU="Monaco, Carlo"
  30. AU="Srivastava, Rupesh"
  31. AU="Nathan, Jaimie D"
  32. AU="Schnegelberger, Regina D"
  33. AU=Doshi Paresh
  34. AU="Cecilia Hognon"
  35. AU="Mason, Jeremy K."
  36. AU=Hasumi Hisashi
  37. AU="Swati Sethi"
  38. AU="Martin G. Myers, Jr."
  39. AU="Marcus-Sekura, Carol"
  40. AU="Petagine, Lucy"
  41. AU="Jessa R. Alexander"
  42. AU=Rauner Martina
  43. AU="Richlen, Mindy L"
  44. AU="Merghani, Nada M"
  45. AU=Splitt M P
  46. AU="Zlatanović, Gordana"

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  1. Artikel ; Konferenzbeitrag: Selected papers from the ESCV and ESVV joint symposium on zoonoses in Madrid

    Koopmans, Maria Petronella Gerarda

    Journal of clinical virology 58 ,2, S. 341 - 362

    [7 September 2012]

    2013  

    Körperschaft European Society of Veterinary Cardiology
    European Society for Veterinary Virology
    Verfasserangabe guest ed.: Marion Koopmans
    Überordnung Journal of clinical virology
    Sprache Englisch
    Erscheinungsort Amsterdam [u.a.]
    Erscheinungsland Niederlande
    Dokumenttyp Artikel ; Konferenzbeitrag
    HBZ-ID HT017812604
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: The significance of mosquito saliva in arbovirus transmission and pathogenesis in the vertebrate host

    Visser, Imke / Koenraadt, Constantianus J.M. / Koopmans, Marion P.G. / Rockx, Barry

    One Health. 2023 Feb. 12, p.100506-

    2023  , Seite(n) 100506–

    Abstract: Due to changes in climate, numerous mosquito species are continuously extending their geographical distributions, posing potential new public health threats as arbovirus infections emerge in these new areas. During probing and feeding on the vertebrate ... ...

    Abstract Due to changes in climate, numerous mosquito species are continuously extending their geographical distributions, posing potential new public health threats as arbovirus infections emerge in these new areas. During probing and feeding on the vertebrate host, a mosquito can inject both arbovirus and saliva into the skin of the host. The presence of mosquito saliva in the host skin during arbovirus transmission contributes to high viral titers in the skin, enhanced viremia, and rapid dissemination of the virus to target organs. This enhanced phenotype effectuated by the presence of mosquito saliva in the skin can be partly ascribed to a polarization of the local immune balance towards a Th2 response, an increased permeability of the dermal endothelium, and the influx of virus-susceptible immune cells to the bite site. However, the complete identification and characterization of immunomodulatory salivary proteins from different mosquito species and the mechanisms by which these salivary proteins exert their effects synergistically or antagonistically remains to be further explored. Moreover, the effect of new virus-vector combinations on the outcome of arbovirus infection in a new host is limited. Here, we review the immunomodulatory effects of mosquito saliva in the skin and the proposed mechanisms by which mosquito saliva enhances arbovirus pathogenesis in the vertebrate host, and discuss potential differences between Aedes and Culex mosquito species, the main vectors for medically important arboviruses. Gaining more insight into the effect of mosquito saliva in the vector-virus-host triad aids in predicting the potential transmission risk and disease severity of emerging vector-borne diseases.
    Schlagwörter Aedes ; Culex ; arboviruses ; climate ; disease severity ; endothelium ; pathogenesis ; permeability ; phenotype ; public health ; risk ; saliva ; vertebrates ; viremia ; Arbovirus ; Mosquito saliva ; Transmission
    Sprache Englisch
    Erscheinungsverlauf 2023-0212
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100506
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Buch: Food-borne viruses

    Koopmans, Maria Petronella Gerarda

    progress and challenges

    (Emerging issues in food safety)

    2008  

    Verfasserangabe ed. by Marion P.G. Koopmans
    Serientitel Emerging issues in food safety
    Sprache Englisch
    Umfang XII, 245 S. : Ill., graph. Darst.
    Verlag ASM Press
    Erscheinungsort Washington, DC
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references and index ; Historic overview of food virology / Dean O. Cliver -- Food-borne viruses: state of the art / Marc-Alain Widdowson and Jan Vinjé -- Enterically tansmitted hepatitis / Rakesh Aggarwal -- The challenge of estimating the burden of an underreported disease / Sarah J. O'Brien -- Emerging food-borne viral diseases / Erwin Duizer and Marion Koopmans -- Viral evolution and its relevance for food-borne virus epidemiology / Esteban Domingo and Harry Vennema -- Rethinking virus detection in food / Rosa M. Pintó and Albert Bosch -- Binding and inactivation of viruses on and in food, with a focus on the role of the matrix / Françoise S. Le Guyader and Robert L. Atmar -- Codex : risk analysis framework to reduce virus in food risks / Jaap Jansen -- Risk assessment of viruses in food : opportunities and challenges / Arie H. Havelaar and Saskia A. Rutjes
    HBZ-ID HT015675196
    ISBN 978-1-555-81464-9 ; 1-555-81464-6
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

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  4. Artikel ; Online: Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity.

    Aguilar-Bretones, Muriel / Fouchier, Ron Am / Koopmans, Marion Pg / van Nierop, Gijsbert P

    The Journal of clinical investigation

    2023  Band 133, Heft 1

    Abstract: Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19). This immunity may further be shaped by cross-reactivity ... ...

    Abstract Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19). This immunity may further be shaped by cross-reactivity with common cold coronaviruses. Mutations arising in S that are associated with altered intrinsic virus properties and immune escape result in the continued circulation of SARS-CoV-2 variants. Potentially, vaccine updates will be required to protect against future variants of concern, as for influenza. To offer potent protection against future variants, these second-generation vaccines may need to redirect immunity to epitopes associated with immune escape and not merely boost immunity toward conserved domains in preimmune individuals. For influenza, efficacy of repeated vaccination is hampered by original antigenic sin, an attribute of immune memory that leads to greater induction of antibodies specific to the first-encountered variant of an immunogen compared with subsequent variants. In this Review, recent findings on original antigenic sin are discussed in the context of SARS-CoV-2 evolution. Unanswered questions and future directions are highlighted, with an emphasis on the impact on disease outcome and vaccine design.
    Mesh-Begriff(e) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Influenza, Human ; Antibodies, Viral ; Antibodies, Neutralizing
    Chemische Substanzen Antibodies, Viral ; Antibodies, Neutralizing
    Sprache Englisch
    Erscheinungsdatum 2023-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI162192
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The significance of mosquito saliva in arbovirus transmission and pathogenesis in the vertebrate host

    Visser, Imke / Koenraadt, Constantianus J.M. / Koopmans, Marion P.G. / Rockx, Barry

    One Health

    2023  Band 16

    Abstract: Due to changes in climate, numerous mosquito species are continuously extending their geographical distributions, posing potential new public health threats as arbovirus infections emerge in these new areas. During probing and feeding on the vertebrate ... ...

    Abstract Due to changes in climate, numerous mosquito species are continuously extending their geographical distributions, posing potential new public health threats as arbovirus infections emerge in these new areas. During probing and feeding on the vertebrate host, a mosquito can inject both arbovirus and saliva into the skin of the host. The presence of mosquito saliva in the host skin during arbovirus transmission contributes to high viral titers in the skin, enhanced viremia, and rapid dissemination of the virus to target organs. This enhanced phenotype effectuated by the presence of mosquito saliva in the skin can be partly ascribed to a polarization of the local immune balance towards a Th2 response, an increased permeability of the dermal endothelium, and the influx of virus-susceptible immune cells to the bite site. However, the complete identification and characterization of immunomodulatory salivary proteins from different mosquito species and the mechanisms by which these salivary proteins exert their effects synergistically or antagonistically remains to be further explored. Moreover, the effect of new virus-vector combinations on the outcome of arbovirus infection in a new host is limited. Here, we review the immunomodulatory effects of mosquito saliva in the skin and the proposed mechanisms by which mosquito saliva enhances arbovirus pathogenesis in the vertebrate host, and discuss potential differences between Aedes and Culex mosquito species, the main vectors for medically important arboviruses. Gaining more insight into the effect of mosquito saliva in the vector-virus-host triad aids in predicting the potential transmission risk and disease severity of emerging vector-borne diseases.
    Schlagwörter Arbovirus ; Mosquito saliva ; Pathogenesis ; Transmission
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsland nl
    Dokumenttyp Artikel ; Online
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands

    Streng, Kiki / de Best, Pauline A. / Timen, Aura / Koopmans, Marion P.G. / van der Poel, Wim H.M. / Sikkema, Reina S.

    One Health. 2023 June, v. 16 p.100507-

    2023  

    Abstract: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a ... ...

    Abstract Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and acquisition of animal samples is hampered by practical, ethical, and legal barriers, of which there is currently no clear overview. Therefore, the three aims of this study are (1) to map potentially available collections of animal samples, (2) to assess possibilities and barriers for reuse of these samples and (3) to assess possibilities and barriers for active animal and environmental sampling in the Netherlands. A literature search was performed to identify ongoing sampling activities and opportunities for reuse or active sampling. Semi-structured interviews with stakeholder organizations were conducted to gain further insight into the three research questions. Various sample collections of surveillance, diagnostic and research activities exist in the Netherlands. Sample size, coverage, storage methods and type of samples collected differs per animal species which influences reuse suitability. Organizations are more likely to share samples, for reuse in outbreak investigations, when they have a pre-existing relationship with the requesting institute. Identified barriers for sharing were, among others, unfamiliarity with legislation and unsuitable data management systems. Active sampling of animals or the environment is possible through several routes. Related barriers are acquiring approval from animal- or property owners, conflicts with anonymization, and time needed to acquire ethical approval. The animal sample collections identified would be very valuable for use in outbreak investigations. Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration and biobanking. Proactive setting up of ethical approvals will allow for rapid animal sample collection to identify EID hosts and potential spillovers.
    Schlagwörter animals ; ethics ; information management ; laws and regulations ; monitoring ; risk assessment ; sample size ; stakeholders ; Netherlands ; One health ; Outbreak investigation ; Emerging diseases ; Zoonoses
    Sprache Englisch
    Erscheinungsverlauf 2023-06
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100507
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel: Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater

    Heijnen, Leo / Elsinga, Goffe / de Graaf, Miranda / Molenkamp, Richard / Koopmans, Marion P.G. / Medema, Gertjan

    Science of the total environment. 2021 Dec. 10, v. 799

    2021  

    Abstract: Wastewater surveillance has shown to be a valuable and efficient tool to obtain information about the trends of COVID-19 in the community. Since the recent emergence of new variants, associated with increased transmissibility and/or antibody escape ( ... ...

    Abstract Wastewater surveillance has shown to be a valuable and efficient tool to obtain information about the trends of COVID-19 in the community. Since the recent emergence of new variants, associated with increased transmissibility and/or antibody escape (variants of concern), there is an urgent need for methods that enable specific and timely detection and quantification of the occurrence of these variants in the community. In this study, we demonstrate the use of RT-ddPCR on wastewater samples for specific detection of mutation N501Y. This assay enabled simultaneous enumeration of lineage B.1.351 (containing the 501Y mutation) and Wild Type (WT, containing 501N) SARS-CoV-2 RNA. Detection of N501Y was possible in samples with mixtures of WT with low proportions of B.1.351 (0.5%) and could accurately determine the proportion of N501Y and WT in mixtures of SARS-CoV-2 RNA. The application to raw sewage samples from the cities of Amsterdam and Utrecht demonstrated that this method can be applied to wastewater samples. The emergence of N501Y in Amsterdam and Utrecht wastewater aligned with the emergence of B.1.1.7 as causative agent of COVID-19 in the Netherlands, indicating that RT-ddPCR of wastewater samples can be used to monitor the emergence of the N501Y mutation in the community. It also indicates that RT-ddPCR could be used for sensitive and accurate monitoring of current (like K417N, K417T, E484K, L452R) or future mutations present in SARS-CoV-2 variants of concern. Monitoring these mutations can be used to obtain insight in the introduction and spread of VOC and support public health decision-making regarding measures to limit viral spread or allocation of testing or vaccination.
    Schlagwörter COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; decision making ; droplets ; environment ; etiological agents ; monitoring ; mutation ; public health ; sewage ; vaccination ; wastewater ; Netherlands
    Sprache Englisch
    Erscheinungsverlauf 2021-1210
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.149456
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Worldwide trends in COVID-19 related attacks against healthcare

    Duffhues, Willeke / Barten, Dennis / De Cauwer, Harald / Mortelmans, Luc / van Osch, Frits / Tin, Derrick / Koopmans, Marion P.G. / Ciottone, Gregory

    medRxiv

    Abstract: Background: During the COVID-19 pandemic, violence targeting healthcare reportedly increased. Attacks against healthcare have the potential to impair the public health response and threaten the availability of healthcare services. However, there is ... ...

    Abstract Background: During the COVID-19 pandemic, violence targeting healthcare reportedly increased. Attacks against healthcare have the potential to impair the public health response and threaten the availability of healthcare services. However, there is little systematic understanding of the extent and characteristics of healthcare attacks in the setting of a pandemic. This study aimed to investigate global trends regarding COVID-19 related attacks against healthcare from January 2020 until January 2023. Methodology: COVID-19 related incidents that occurred between January 2020 and January 2023 were extracted from the Safeguarding Health in Conflict Coalition database and screened for eligibility. Data collected per incident included temporal factors; country; setting; attack and weapon type; perpetrator; motive; number of healthcare workers (HCWs) and patients killed, injured or kidnapped; and whether the incident caused damage to a health facility. Results: This study identified 255 COVID-19 related attacks against healthcare. The attacks occurred globally and throughout the course of the pandemic. Incidents were heterogeneous with regards to motives, attack types and outcomes. At least 18 HCWs were killed, 147 HCWs were injured and 86 facilities were damaged or destroyed. There were two periods with a peak incidence of reports. The first peak occurred during the beginning of the pandemic, and predominantly concerned stigma-related attacks against healthcare. The second peak, in 2021, was mainly composed of conflict-related attacks in Myanmar, and attacks targeting the global vaccination campaign. Conclusion: COVID-19 related attacks against healthcare occurred globally and in a variety of settings throughout the course of the pandemic. The findings of this study can be used to prevent and mitigate healthcare attacks during the ongoing and future pandemics.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2023-07-23
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2023.07.18.23292819
    Datenquelle COVID19

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  9. Artikel ; Online: The pathology of co-infection with Usutu virus and Plasmodium spp. in naturally infected Eurasian blackbirds (Turdus merula)

    Agliani, Gianfilippo / Giglia, Giuseppe / de Bruin, Erwin / van Mastrigt, Tjomme / Blom, Rody / Sikkema, Reina S. / Kik, Marja / Koopmans, Marion P.G. / Gröne, Andrea / Van den Brand, Judith M.A.

    One Health. 2023 June, v. 16 p.100534-

    2023  

    Abstract: Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus causing mortality in Eurasian blackbirds (Turdus merula) in Europe. In dead blackbirds, avian malaria co-infection due to mosquito-borne hemosporidians (e.g., Plasmodium spp.) has been reported. ... ...

    Abstract Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus causing mortality in Eurasian blackbirds (Turdus merula) in Europe. In dead blackbirds, avian malaria co-infection due to mosquito-borne hemosporidians (e.g., Plasmodium spp.) has been reported. In humans, a similar co-infection of a flavivirus, Dengue virus, and Plasmodium spp. is causing increased severity of clinical disease. Currently, the effects of co-infection of arboviruses and hemosporidians in blackbirds remain unclear. This study investigates the rate of USUV and Plasmodium spp. co-infection in found-dead blackbirds (n = 203) from 2016 to 2020 in the Netherlands. Presence of Plasmodium spp. was evaluated by cytology (43/203; 21,2%), histopathology (94/186; 50,5%) and qPCR (179/203; 88,1%). The severity of histological lesions in USUV and Plasmodium spp. co-infected dead blackbirds (121/203; 59,6%) were compared with those in Plasmodium spp. single-infected cases. Additionally, since no knowledge is present on the infection rate on live birds and mosquitoes in the Netherlands, a small group of live blackbirds (n = 12) and selected in the field-collected mosquito pools (n = 96) in 2020 were tested for the presence of Plasmodium spp. The latter was detected in the tested live blackbirds by qPCR (8/10; 80%), and cytology (3/11; 27,3%) and in the mosquito pools by qPCR (18/96; 18,7%). For this study, co-infection between USUV and Plasmodium spp. was observed only in the dead blackbirds. The high Plasmodium spp. presence, associated with lower lesions score, in single infected found dead birds suggest a predominantly smaller pathogenic role as single agent. On the other hand, the higher histological lesion scores observed in USUV and Plasmodium spp. co-infected birds suggests a major pathogenic role for the virus or an increased severity of the lesions due to a possible interplay of the two agents.
    Schlagwörter Culicidae ; Dengue virus ; Plasmodium ; Turdus merula ; Usutu virus ; arboviruses ; avian malaria ; cell biology ; histology ; histopathology ; mixed infection ; mortality ; Netherlands ; Zoonosis ; Co-infection ; Flaviviruses
    Sprache Englisch
    Erscheinungsverlauf 2023-06
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100534
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Rapid response screening for emerging zoonotic pathogens, barriers and opportunities

    Streng, Kiki / de Best, Pauline A. / Timen, Aura / Koopmans, Marion P.G. / van der Poel, Wim H.M. / Sikkema, Reina S.

    One Health

    A study for enhanced preparedness of the Netherlands

    2023  Band 16

    Abstract: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a ... ...

    Abstract Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and acquisition of animal samples is hampered by practical, ethical, and legal barriers, of which there is currently no clear overview. Therefore, the three aims of this study are (1) to map potentially available collections of animal samples, (2) to assess possibilities and barriers for reuse of these samples and (3) to assess possibilities and barriers for active animal and environmental sampling in the Netherlands. Methods: A literature search was performed to identify ongoing sampling activities and opportunities for reuse or active sampling. Semi-structured interviews with stakeholder organizations were conducted to gain further insight into the three research questions. Results: Various sample collections of surveillance, diagnostic and research activities exist in the Netherlands. Sample size, coverage, storage methods and type of samples collected differs per animal species which influences reuse suitability. Organizations are more likely to share samples, for reuse in outbreak investigations, when they have a pre-existing relationship with the requesting institute. Identified barriers for sharing were, among others, unfamiliarity with legislation and unsuitable data management systems. Active sampling of animals or the environment is possible through several routes. Related barriers are acquiring approval from animal- or property owners, conflicts with anonymization, and time needed to acquire ethical approval. Conclusion: The animal sample collections identified would be very valuable for use in outbreak investigations. Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration ...
    Schlagwörter Animals ; Emerging diseases ; Netherlands ; One health ; Outbreak investigation ; Zoonoses
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsland nl
    Dokumenttyp Artikel ; Online
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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