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  1. AU="Koopmans, Nienke K"
  2. AU="Gartrell, Brian C"
  3. AU=Feyen B
  4. AU="Park, James S"
  5. AU="Han, SeungHye"
  6. AU="Verbić, Tatjana"
  7. AU="Abernethy, David"
  8. AU=Bianchi Claudio
  9. AU="Antonelli, Donna"
  10. AU="Patrick, Anna E"
  11. AU="Philippe J. Guerin"
  12. AU="Oygucu, I Hakan"
  13. AU="Salem, Mohammad"
  14. AU="Lotan, Dor"
  15. AU="Mattingly, M C K" AU="Mattingly, M C K"
  16. AU="Rastogi Ajay"
  17. AU="Deniz Kantar"
  18. AU="Stucky, Cheryl L"
  19. AU="Higashino, Kosaku"
  20. AU="Johnston, Sara C"
  21. AU=Fisayo Temitope
  22. AU="Buret, Laetitia"
  23. AU=Guirao Antonio
  24. AU="Tang, Anthony"
  25. AU="Garnelo, Luiza"
  26. AU=Sakanari J A AU=Sakanari J A
  27. AU="Ni, Fuchuan"
  28. AU="Anithachristy S Arumanayagam"
  29. AU="Melman, Dick"

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  1. Artikel ; Online: Een vrouw met intermitterende buikpijnklachten.

    van der Veen, Thea / Koopmans, Nienke K / Vrooland, Marc

    Nederlands tijdschrift voor geneeskunde

    2022  Band 166

    Abstract: This case concerns an older woman with severe colicky pain in the lower right abdomen with vomiting. She had experienced more mild episodes of this pain before. A contrast-enhanced computed tomography showed a whirl sign. This sign is suggestive of a ... ...

    Titelübersetzung An 80-year-old woman with intermittent abdominal pain.
    Abstract This case concerns an older woman with severe colicky pain in the lower right abdomen with vomiting. She had experienced more mild episodes of this pain before. A contrast-enhanced computed tomography showed a whirl sign. This sign is suggestive of a volvulus, in this case of the ileum. After surgery she was complaint-free.
    Mesh-Begriff(e) Female ; Humans ; Aged ; Aged, 80 and over ; Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Intestinal Volvulus/diagnosis ; Intestinal Volvulus/diagnostic imaging ; Ileum ; Tomography, X-Ray Computed/methods ; Vomiting
    Sprache Niederländisch
    Erscheinungsdatum 2022-11-30
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Non-invasive assessment of fluid responsiveness to guide fluid therapy in patients with sepsis in the emergency department: a prospective cohort study.

    Koopmans, Nienke K / Stolmeijer, Renate / Sijtsma, Ben C / van Beest, Paul A / Boerma, Christiaan E / Veeger, Nic J / Ter Avest, Ewoud

    Emergency medicine journal : EMJ

    2021  Band 38, Heft 6, Seite(n) 416–422

    Abstract: Background: Little is known about optimal fluid therapy for patients with sepsis without shock who present to the ED. In this study, we aimed to quantify the effect of a fluid challenge on non-invasively measured Cardiac Index (CI) in patients ... ...

    Abstract Background: Little is known about optimal fluid therapy for patients with sepsis without shock who present to the ED. In this study, we aimed to quantify the effect of a fluid challenge on non-invasively measured Cardiac Index (CI) in patients presenting with sepsis without shock.
    Methods: In a prospective cohort study, CI, stroke volume (SV) and systemic vascular resistance (SVR) were measured non-invasively in 30 patients presenting with sepsis without shock to the ED of a large teaching hospital in the Netherlands between May 2018 and March 2019 using the ClearSight system. After baseline measurements were performed, a passive leg raise (PLR) was done to simulate a fluid bolus. Measurements were then repeated 30, 60, 90 and 120 s after PLR. Finally, a standardised 500 mL NaCl 0.9% intravenous bolus was administered after which final measurements were done. Fluid responsiveness was defined as >15% increase in CI after a standardised fluid challenge.
    Measurements and main results: Seven out of 30 (23%) patients demonstrated a >15% increase in CI after PLR and after a 500 mL fluid bolus. Fluid responders had a higher estimated glomerular filtration rate (eGFR) (64 (44-78) vs 37 (23-47), p=0.009) but otherwise similar patient and treatment characteristics as non-responders. Baseline measurements of cardiac output (CO), CI, SV and SVR were unrelated to PLR fluid responsiveness. The change in CI after PLR was strongly positive correlated to the change in CI after a 500 mL NaCl 0.9% fluid bolus (r=0.88, p<0.001).
    Conclusion: The results of the present study demonstrate that in patients with sepsis in the absence of shock, three out of four patients do not demonstrate a clinically relevant increase in CI after a standardised fluid challenge. Non-invasive CO monitoring in combination with a PLR test has the potential to identify patients who might benefit from fluid resuscitation and may contribute to a better tailored treatment of these patients.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Cardiac Output ; Emergency Service, Hospital ; Female ; Fluid Therapy/methods ; Humans ; Male ; Netherlands ; Prospective Studies ; Sepsis/therapy ; Stroke Volume
    Sprache Englisch
    Erscheinungsdatum 2021-04-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2020-209771
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.

    Coenders, Alies / Koopmans, Nienke K / Broekhuijsen, Kim / Groen, Henk / Karstenberg-Kramer, Janna M A / van Goor, Kim / Groenewout, Mariette / van Loon, Aren J / Faas, Marijke M / van Pampus, Maria G

    European journal of obstetrics, gynecology, and reproductive biology

    2015  Band 187, Seite(n) 14–19

    Abstract: Objective: During the H1N1/09 pandemic, pregnant women in the Netherlands were vaccinated with an adjuvanted vaccine. During pregnancy, the maternal immune system changes to enable placental development and growth and acceptance of the semi-allogeneic ... ...

    Abstract Objective: During the H1N1/09 pandemic, pregnant women in the Netherlands were vaccinated with an adjuvanted vaccine. During pregnancy, the maternal immune system changes to enable placental development and growth and acceptance of the semi-allogeneic fetus. As an adjuvant is a pro-inflammatory substance, it may interfere with these immunological changes, resulting in poor placentation or placental growth, which may result in preeclampsia (PE) and fetal intra-uterine growth restriction (IUGR). This study investigated a possible association between adjuvanted H1N1/09 vaccination and the development of PE and/or IUGR.
    Study design: Case-control study. Cases were Dutch women with PE and/or IUGR occurring during H1N1/09 vaccination program. Controls had uncomplicated pregnancies during the same period. Maternal characteristics, pregnancy and neonatal outcomes were collected from medical files. Participants were contacted by telephone to enquire about vaccination. Data were analyzed using t-tests, Chi-square tests or Fisher's exact tests. Multivariate analysis was conducted to control for confounders.
    Results: We included 254 cases and 247 controls. Of the cases, 90 (35.4%) were vaccinated, compared to 87 (35.2%) of the controls (OR:1.009, 95% CI:0.70-1.46, p:0.961). The majority (73.5%) had been vaccinated in second and third trimester. In multivariate analysis, there were no confounders influencing these results. Exploratory subgroup analysis did not show an association between vaccination status in subgroups of women with either PE or IUGR.
    Conclusion: Our study showed no association between adjuvanted H1N1/09 vaccination and PE and/or IUGR.
    Mesh-Begriff(e) Adult ; Analysis of Variance ; Case-Control Studies ; Female ; Fetal Growth Retardation/epidemiology ; Fetal Growth Retardation/etiology ; Humans ; Infant, Newborn ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Netherlands ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/etiology ; Pregnancy ; Pregnancy Outcome
    Chemische Substanzen Influenza Vaccines
    Sprache Englisch
    Erscheinungsdatum 2015-04
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2015.01.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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