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Article ; Online: Rothia Mucilaginosa Endophthalmitis Associated With iStent Inject Implantation.

Lam, Helena / Khundkar, Tahsin / Koozekanani, Dara / Nazari, Hossein K

2022 Volume 31, Issue 6, Page(s) e37–e40

Abstract: Postoperative endophthalmitis caused by Rothia mucilaginosa, a gram-positive, coagulase-negative Micrococcaceae of the oropharyngeal flora, is rare and all previously reported intraocular implant-related cases have resulted in evisceration. R. ... ...

Abstract	Postoperative endophthalmitis caused by Rothia mucilaginosa, a gram-positive, coagulase-negative Micrococcaceae of the oropharyngeal flora, is rare and all previously reported intraocular implant-related cases have resulted in evisceration. R. mucilaginosa endophthalmitis has also not been described with any glaucoma implant device. Here, the authors report a case of subacute R. mucilaginosa endophthalmitis after phacoemulsification with implantation of an intraocular lens and the iStent inject (Glaukos). The infection was managed with intravitreal antibiotic injections, pars plana vitrectomy, and intraocular lens and iStent explantations. This was followed by a second pars plana vitrectomy and silicone oil tamponade for a tractional retinal detachment. Nine months after the initial presentation, vision in the affected eye was partially preserved, and the globe remained intact. R. mucilaginosa infections are associated with grave outcomes due to biofilm formation on infected implants, and as such, removal of infected implants is advised.
MeSH term(s)	Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy ; Endophthalmitis/etiology ; Humans ; Intraocular Pressure ; Micrococcaceae ; Vitrectomy/adverse effects
Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000002033
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Article ; Online: Title: BILATERAL UVEITIS AND HYPOTONY FOLLOWING TREATMENT WITH TOPICAL CIDOFOVIR.

Santilli, Christopher M / Koozekanani, Dara / Armbrust, Karen R

Retinal cases & brief reports

2020

Abstract: Purpose: To report a case of bilateral uveitis and hypotony associated with topical cidofovir treatment.: Methods: Case report.: Results: A 59-year-old diabetic male with HIV/AIDS presented with photophobia, ocular pain, and decreased vision. He ... ...

Abstract	Purpose: To report a case of bilateral uveitis and hypotony associated with topical cidofovir treatment. Methods: Case report. Results: A 59-year-old diabetic male with HIV/AIDS presented with photophobia, ocular pain, and decreased vision. He was found to have bilateral hypotony, anterior uveitis, and serous choroidal detachments. Infectious disease workup, patient-reported history, and review of the patient's electronic medication list did not identify the etiology. Treatment with intensive topical corticosteroids led to resolution of uveitis and choroidal effusions within 3 months and resolution of hypotony within 9 months. Two years after his initial presentation, the patient developed acute recurrence of bilateral hypotony, anterior uveitis, and serous choroidal detachments shortly after intravenous cidofovir treatment. Careful re-evaluation of the patient's outside medical records revealed that he had initiated treatment for rectal herpes simplex virus with compounded topical cidofovir one month prior to his initial presentation. Conclusion: To our knowledge, this is the first reported case of topical cidofovir causing ocular toxicity. Compounded and topical medications, like cidofovir in this case, may not appear on a patient's electronic medication list, so a focused review of outside medical records may be beneficial when a particular medication toxicity is suspected.
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001101
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Article ; Online: CHOROIDAL NEVUS ASSOCIATED WITH VITELLIFORM DEPOSITION IN A PATIENT WITH AUTOSOMAL DOMINANT BEST DYSTROPHY.

Adams, Olufemi E / Siddiqui, Yousuf / Simmons, Michael A / Tang, Peter H / Koozekanani, Dara D

Retinal cases & brief reports

2022 Volume 18, Issue 1, Page(s) 120–123

Abstract: Background/purpose: To describe the clinical, optical coherence tomography (OCT), fundus autofluorescence and ultrasound findings of a patient with a choroidal nevus actively exuding vitelliform material in the setting of autosomal dominant Best ... ...

Abstract	Background/purpose: To describe the clinical, optical coherence tomography (OCT), fundus autofluorescence and ultrasound findings of a patient with a choroidal nevus actively exuding vitelliform material in the setting of autosomal dominant Best dystrophy (BD). Methods: The patient's clinical course was followed over time with ophthalmic examinations and multimodal imaging. Results: A 71-year-old male patient with BD was referred for evaluation of a choroidal nevus in the right eye. Dilated fundoscopic examination showed a small pigmented choroidal nevus in the temporal periphery. Over a 3-year period, the nevus developed progressive deposition of vitelliform material along its inferior border. Meanwhile, OCT and fundus photography showed only slight growth. Ultrasound showed no change in height; basal measurements were confounded by the increased vitelliform deposits. Genetic testing confirmed a heterozygous mutation in the BEST1 gene and electrophysiology was consistent with BD. Conclusions: Dysfunction of the retinal pigment epithelium associated with BD may cause novel presentations of other conditions such as choroidal nevi. The implication for malignant transformation of a choroidal nevus associated with vitelliform deposit accumulation in this context is unknown.
MeSH term(s)	Male ; Humans ; Aged ; Vitelliform Macular Dystrophy/complications ; Vitelliform Macular Dystrophy/diagnosis ; Vitelliform Macular Dystrophy/genetics ; Retinal Pigment Epithelium/pathology ; Choroid Neoplasms/diagnosis ; Choroid Neoplasms/pathology ; Nevus, Pigmented/pathology ; Tomography, Optical Coherence/methods ; Nevus ; Skin Neoplasms/pathology ; Bestrophins
Chemical Substances	BEST1 protein, human ; Bestrophins
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001328
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Article ; Online: Analysis of dose to the macula, optic disc, and lens in relation to vision toxicities - A retrospective study using COMS eye plaques.

Oare, Courtney / Sun, Susan / Dusenbery, Kathryn / Reynolds, Margaret / Koozekanani, Dara / Gerbi, Bruce / Ferreira, Clara

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2022 Volume 101, Page(s) 71–78

Abstract: Purpose: The aim of this study was to relate common toxicity endpoints with dose to the macula, optic disc, and lens for uveal melanoma patients treated with Iodine-125 Collaborative Ocular Melanoma Study (COMS) eye plaque brachytherapy.: Methods: A ... ...

Abstract	Purpose: The aim of this study was to relate common toxicity endpoints with dose to the macula, optic disc, and lens for uveal melanoma patients treated with Iodine-125 Collaborative Ocular Melanoma Study (COMS) eye plaque brachytherapy. Methods: A cohort of 52 patients treated at a single institution between 2005 and 2019 were retrospectively reviewed. Demographics, dosimetry, and clinical outcomes were recorded. Univariate, relative risk, and Kaplan-Meier analyses were performed to relate dose to toxicity endpoints including retinopathy, vision decline, and cataracts. Results: By the end of follow up (Median = 3.6 years, Range = 0.4 - 13.5 years), 65 % of eyes sustained radiation retinopathy, 40 % demonstrated moderate vision decline (>5 Snellen lines lost), and 56 % developed cataracts. Significant (p < 0.05) risk estimates exist for retinopathy and VA decline for doses >52 Gy to the macula and >42 Gy to the optic disc. Moreover, dose to the lens > 16 Gy showed a significant risk for cataract formation. Kaplan-Meier analysis demonstrated significantly different incidence of radiation retinopathy for > 52 Gy to the macula and > 42 Gy to the optic disc. In addition, the Kaplan-Meier analysis showed significantly different incidence of cataract formation for patients with lens dose > 16 Gy. Conclusions: Dose-effect relationships exist for the macula and optic disc with respect to the loss of visual acuity and the development of retinopathy. To better preserve vision after treatment, further research is needed to reduce macula, optic disc, and lens doses while maintaining tumor control.
MeSH term(s)	Brachytherapy/methods ; Cataract/etiology ; Eye Injuries ; Eye Neoplasms ; Humans ; Iodine Radioisotopes/therapeutic use ; Melanoma/radiotherapy ; Optic Disk/pathology ; Optic Disk/radiation effects ; Radiation Injuries/etiology ; Radiotherapy Dosage ; Retinal Diseases/chemically induced ; Retinal Diseases/complications ; Retrospective Studies
Chemical Substances	Iodine Radioisotopes
Language	English
Publishing date	2022-08-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2022.08.001
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Article ; Online: Bilateral Ocular Ischemic Syndrome in the Setting of Chronic Angle Closure Glaucoma.

Naravane, Ameay V / Mallory, Paul W / Boysen, Jess / Koozekanani, Dara / Lee, Michael S

Journal of glaucoma

2021 Volume 30, Issue 5, Page(s) e262–e264

Abstract: We report novel case of a 57-year-old woman who developed bilateral ocular ischemic syndrome in the setting of chronic angle closure glaucoma without associated angle neovascularization. Detailed is a course in which markedly prolonged, elevated ... ...

Abstract	We report novel case of a 57-year-old woman who developed bilateral ocular ischemic syndrome in the setting of chronic angle closure glaucoma without associated angle neovascularization. Detailed is a course in which markedly prolonged, elevated intraocular pressure led to significantly reduced arterial perfusion at the level of the central retinal artery, leading to the clinical picture of ocular ischemic syndrome.
MeSH term(s)	Female ; Glaucoma, Angle-Closure/complications ; Glaucoma, Angle-Closure/diagnosis ; Humans ; Intraocular Pressure ; Middle Aged ; Retinal Artery ; Tonometry, Ocular ; Vascular Diseases
Language	English
Publishing date	2021-01-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000001767
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Article ; Online: OCT Fluid Segmentation using Graph Shortest Path and Convolutional Neural Network

Rashno, Abdolreza / Koozekanani, Dara D / Parhi, Keshab K

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2018 Volume 2018, Page(s) 3426–3429

Abstract: Diagnosis and monitoring of retina diseases related to pathologies such as accumulated fluid can be performed using optical coherence tomography (OCT). OCT acquires a series of 2D slices (Bscans). This work presents a fully-automated method based on ... ...

Abstract	Diagnosis and monitoring of retina diseases related to pathologies such as accumulated fluid can be performed using optical coherence tomography (OCT). OCT acquires a series of 2D slices (Bscans). This work presents a fully-automated method based on graph shortest path algorithms and convolutional neural network (CNN) to segment and detect three types of fluid including sub-retinal fluid (SRF), intra-retinal fluid (IRF) and pigment epithelium detachment (PED) in OCT Bscans of subjects with age-related macular degeneration (AMD) and retinal vein occlusion (RVO) or diabetic retinopathy. The proposed method achieves an average dice coefficient of 76.44%, 92.25% and 82.14% in Cirrus, Spectralis and Topcon datasets, respectively. The effectiveness of the proposed methods was also demonstrated in segmenting fluid in OCT images from the 2017 Retouch challenge.
MeSH term(s)	Diabetic Retinopathy ; Humans ; Neural Networks, Computer ; Retina ; Retinal Vein Occlusion ; Tomography, Optical Coherence
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2018.8512998
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Article ; Online: Hemifacial Spasm in an Argus II Retinal Prosthesis Patient.

Sun, Susan Y / Mammo, Danny A / Koozekanani, Dara D / Montezuma, Sandra R

Journal of vitreoretinal diseases

2019 Volume 4, Issue 4, Page(s) 325–326

Abstract: Purpose: A 59-year-old man with retinitis pigmentosa, who received an Argus II retinal prosthesis in the left eye 3 years prior, presented with left-sided involuntary facial contractions that occurred only after turning on the Argus II device.: ... ...

Abstract	Purpose: A 59-year-old man with retinitis pigmentosa, who received an Argus II retinal prosthesis in the left eye 3 years prior, presented with left-sided involuntary facial contractions that occurred only after turning on the Argus II device. Methods: A case report. Results: Given that this patient's reported and visualized lower eyelid twitching corresponds to the location of the external region of the implanted coil, we hypothesize that heat or wirelessly transmitted electrical signals from the external coil to the implanted coil may induce spasm of the facial nerve and thus play a role in hemifacial spasm onset. Conclusions: To our knowledge, this is the first report of hemifacial spasm associated with Argus II use.
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Case Reports
ISSN	2474-1272
ISSN (online)	2474-1272
DOI	10.1177/2474126419890497
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Article ; Online: Presumed mast cell choroidal infiltrate in aggressive systemic mastocytosis.

Tran, Tu M / Najafi, Mehdi / Ambros, Tadeu / Pulido, Jose S / Ustun, Celalettin / Koozekanani, Dara

American journal of ophthalmology case reports

2020 Volume 18, Page(s) 100614

Abstract: Purpose: To report a rare case of a unilateral choroidal mast cell infiltration in a patient with aggressive systemic mastocytosis (ASM).: Observations: The patient is a man in his fifties with a diagnosis of ASM. He developed visual complaints in ... ...

Abstract	Purpose: To report a rare case of a unilateral choroidal mast cell infiltration in a patient with aggressive systemic mastocytosis (ASM). Observations: The patient is a man in his fifties with a diagnosis of ASM. He developed visual complaints in the right eye associated with an area of subretinal fluid on fundus examination. Visual acuity at presentation was 20/150 in the right eye and 20/25 in the left eye. After ophthalmic and radiologic imaging workup, the patient was diagnosed with presumed choroidal mast cell infiltrate. The index of suspicion was high due to the prior ASM diagnosis. External beam radiation and intravitreal injection treatments were offered but the patient declined. The patient was switched from interferon to a new targeted systemic therapy for ASM, midostaurin. Despite some mixed, temporary response in systemic symptoms/signs of ASM at four months, the choroidal lesion and subretinal fluid were stable with visual acuity at 20/125. Conclusion and importance: Mast cell choroidal infiltration in ASM should be considered as part of the differential with acute/subacute vision changes. Diagnosis requires exclusion of other possibilities with ocular imaging and in this case, monitoring for development of other malignancies in which there were none. Midostaurin's ocular response was not on par with systemic response. Additional localized ocular therapies may be required.
Language	English
Publishing date	2020-02-04
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2020.100614
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Article ; Online: Automated detection of neovascularization for proliferative diabetic retinopathy screening.

Roychowdhury, Sohini / Koozekanani, Dara D / Parhi, Keshab K

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2017 Volume 2016, Page(s) 1300–1303

Abstract: Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and ... ...

Abstract	Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and elsewhere (NVE) separately to achieve low false positive rates of neovascularization classification. First, the OD region and blood vessels are extracted. Next, the major blood vessel segments in the 1-OD diameter region are classified for NVD, and minor blood vessel segments elsewhere are classified for NVE. For NVD and NVE classifications, optimal region-based feature sets of 10 and 6 features, respectively, are used. The proposed method achieves classification sensitivity, specificity and accuracy for NVD and NVE of 74%, 98.2%, 87.6%, and 61%, 97.5%, 92.1%, respectively. Also, the proposed method achieves 86.4% sensitivity and 76% specificity for screening images with PDR from public and local data sets. Thus, the proposed NVD and NVE detection methods can play a key role in automated screening and prioritization of patients with diabetic retinopathy.
MeSH term(s)	Diabetic Retinopathy/diagnosis ; Humans ; Optic Disk ; Retinal Neovascularization/diagnosis ; Sensitivity and Specificity
Language	English
Publishing date	2017-03-08
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2016.7590945
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Article: Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases.

Ramírez-Márquez, Estefanía / Ayala Rodríguez, Sofía C / Santiago, Alejandra / De Jesus, Edgar / Requejo Figueroa, Guillermo A / Riskalla, Mona M / Ryan, Meghan E / Koozekanani, Dara / Oliver, Armando L

Journal of clinical medicine

2023 Volume 12, Issue 22

Abstract: This study describes a cohort of patients presenting with histocompatibility leukocyte antigen (HLA)-A29-associated retinal vasculitis without choroidal lesions that may share clinical features with birdshot retinochoroiditis. The methods include a ... ...

Abstract	This study describes a cohort of patients presenting with histocompatibility leukocyte antigen (HLA)-A29-associated retinal vasculitis without choroidal lesions that may share clinical features with birdshot retinochoroiditis. The methods include a retrospective chart review of patients presenting with HLA-A29-associated retinal vasculitis without choroidal lesions. The data on the patients were entered retrospectively into a new database and analyzed. Four patients who had HLA-A29-associated retinal vasculitis without choroidal lesions were identified. The median age at presentation was 40 years (range: 14-71); 75% were female. At presentation, all four patients had a visual acuity of 20/50 or better in both eyes. All the eyes had mild vitritis, three eyes (37.5%) had cystoid macular edema, and two eyes (25%) had optic disc edema. All the patients required treatment with systemic steroids and immunosuppressive therapy. HLA-A29-associated retinal vasculitis without choroidal lesions appears to share many clinical features with birdshot chorioretinitis, including the need for systemic immunosuppressive therapy. Whether this entity represents an early form of birdshot retinochoroiditis or a more localized variant of the disease is a topic for additional studies.
Language	English
Publishing date	2023-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12227023
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