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  1. Article ; Online: Invasive cortical stimulation.

    Ogbuji, Richard / Kopell, Brian Harris

    International review of neurobiology

    2021  Volume 159, Page(s) 23–45

    Abstract: The field of neuromodulation, at its essence, aims to apply electrical stimulation to the brain to ameliorate various pathology. Many methods of applying this stimulation exist, including invasive and non-invasive means. In the realm of invasive ... ...

    Abstract The field of neuromodulation, at its essence, aims to apply electrical stimulation to the brain to ameliorate various pathology. Many methods of applying this stimulation exist, including invasive and non-invasive means. In the realm of invasive stimulation, stimulation of the cortex remains one of the earliest techniques investigated, yet one of the most underutilized today. Evidence for the efficacy of direct invasive cortical stimulation continues to mount, especially in recent years. In this chapter we will review the evidence for the use of invasive cortical stimulation as it applies to neuropathic pain, epilepsy, psychiatric disease, movement disorders, tinnitus, and post-stroke recovery, as well explore some potential mechanisms and future directions of the technique.
    MeSH term(s) Brain Diseases/physiopathology ; Brain Diseases/therapy ; Deep Brain Stimulation ; Humans ; Treatment Outcome
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2021.03.001
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  2. Article ; Online: Commentary: Susceptibility Sensitive Magnetic Resonance Imaging Displays Pallidofugal and Striatonigral Fiber Tracts.

    Kopell, Brian Harris / Rasouli, Jonathan J

    Operative neurosurgery (Hagerstown, Md.)

    2019  Volume 12, Issue 4, Page(s) 339

    Language English
    Publishing date 2019-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/NEU.0000000000001250
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  3. Article ; Online: Commentary: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Deep Brain Stimulations for Obsessive-Compulsive Disorder: Update of the 2014 Guidelines.

    Rezai, Ali R / Ranjan, Manish / Figee, Martijn / Kopell, Brian Harris

    Neurosurgery

    2021  Volume 88, Issue 6, Page(s) E554–E555

    MeSH term(s) Deep Brain Stimulation ; Humans ; Neurosurgeons ; Obsessive-Compulsive Disorder/therapy
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab078
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  4. Article ; Online: The Adjunctive Use of Vancomycin Powder Appears Safe and May Reduce the Incidence of Surgical-Site Infections After Deep Brain Stimulation Surgery.

    Rasouli, Jonathan J / Kopell, Brian Harris

    World neurosurgery

    2016  Volume 95, Page(s) 9–13

    Abstract: Background: Postoperative surgical-site infections (SSIs) are a common complication after deep brain stimulation (DBS) surgery, occurring at a quoted rate of approximately 1%-9%. Intraoperative vancomycin powder has demonstrated efficacy in reducing ... ...

    Abstract Background: Postoperative surgical-site infections (SSIs) are a common complication after deep brain stimulation (DBS) surgery, occurring at a quoted rate of approximately 1%-9%. Intraoperative vancomycin powder has demonstrated efficacy in reducing SSIs after cranial and spinal surgery; however, its use during DBS surgery has yet to be established. In this study, we describe the senior author's experience with the use of intraoperative vancomycin powder to prevent SSIs after DBS surgery.
    Methods: We retrospectively examined the incidence of SSI in 297 patients who underwent DBS surgery at the Mount Sinai Health System from September 2012 to December 2015. All patients underwent a uniform perioperative antiseptic protocol, including thorough skin cleansing, intravenous anticephalosporin antibiotics, copious irrigation, and the application of topical vancomycin powder (1 g) before skin closure. Patient information was obtained through a review of electronic medical records. Primary outcome was the incidence of SSI, which was defined per the standards of the Centers for Disease Control and Prevention and confirmed with wound cultures.
    Results: Four patients developed clinical signs and symptoms of SSI (1.3%); all were men with Parkinson disease. The primary organism responsible was Staphylococcus aureus (75%). Two patients presented with neurostimulator infections, and 2 presented with parietal connector-site infections between 2 months and 1 year after initial surgery. No patients in our series developed topical or systemic reactions attributable to the use of vancomycin powder.
    Conclusions: In our experience, vancomycin powder has demonstrated safety and efficacy as an adjunct medication for infection prophylaxis after DBS surgery. Further prospective studies with larger patient cohorts are warranted.
    MeSH term(s) Administration, Topical ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis/methods ; Burkholderia Infections/drug therapy ; Burkholderia Infections/epidemiology ; Burkholderia cepacia ; Cefuroxime/therapeutic use ; Deep Brain Stimulation ; Device Removal ; Doxycycline/therapeutic use ; Dystonia/therapy ; Humans ; Incidence ; Intraoperative Care ; Male ; Middle Aged ; Neurosurgical Procedures ; Parkinson Disease/therapy ; Powders ; Prosthesis Implantation ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Retrospective Studies ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Powders ; Vancomycin (6Q205EH1VU) ; Doxycycline (N12000U13O) ; Cefuroxime (O1R9FJ93ED)
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.07.063
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  5. Article ; Online: Commentary: Neurosurgery and the Ongoing American Opioid Crisis.

    Yaeger, Kurt A / Rothrock, Robert J / Kopell, Brian Harris

    Neurosurgery

    2018  Volume 82, Issue 4, Page(s) E79–E90

    Language English
    Publishing date 2018-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyx584
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  6. Article ; Online: Use of cortical stimulation in neuropathic pain, tinnitus, depression, and movement disorders.

    Panov, Fedor / Kopell, Brian Harris

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2014  Volume 11, Issue 3, Page(s) 564–571

    Abstract: Medical treatment must strike a balance between benefit and risk. As the field of neuromodulation develops, decreased invasiveness, in combination with maintenance of efficacy, has become a goal. We provide a review of the history of cortical stimulation ...

    Abstract Medical treatment must strike a balance between benefit and risk. As the field of neuromodulation develops, decreased invasiveness, in combination with maintenance of efficacy, has become a goal. We provide a review of the history of cortical stimulation from its origins to the current state. The first part discusses neuropathic pain and the nonpharmacological treatment options used. The second part covers transitions to tinnitus, believed by many to be another deafferentation disorder, its classification, and treatment. The third part focuses on major depression. The fourth section concludes with the discussion of the use of cortical stimulation in movement disorders. Each part discusses the development of the field, describes the current care protocols, and suggests future avenues for research needed to advance neuromodulation.
    MeSH term(s) Cerebral Cortex/physiopathology ; Deep Brain Stimulation/history ; Depressive Disorder, Major/history ; Depressive Disorder, Major/therapy ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Movement Disorders/history ; Movement Disorders/therapy ; Neuralgia/history ; Neuralgia/therapy ; Tinnitus/history ; Tinnitus/therapy ; Transcranial Magnetic Stimulation/history
    Language English
    Publishing date 2014-05-23
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-014-0283-0
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  7. Article ; Online: Nonpharmacological therapies for neurologic devices.

    Lozano, Andres M / Kopell, Brian Harris

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2014  Volume 11, Issue 3, Page(s) 463–464

    MeSH term(s) Deep Brain Stimulation/instrumentation ; Electrodes, Implanted ; Humans ; Nervous System Diseases/therapy ; Radiosurgery/instrumentation ; Ultrasonography, Interventional/instrumentation
    Language English
    Publishing date 2014-06-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-014-0290-1
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  8. Article ; Online: Letter: Commentary: Utilization of Quantitative Susceptibility Mapping for Direct Targeting of the Subthalamic Nucleus During Deep Brain Stimulation Surgery.

    Kopell, Brian Harris / Dimov, Alexey / Rasouli, Jonathan / Wang, Yi

    Operative neurosurgery (Hagerstown, Md.)

    2018  Volume 15, Issue 4, Page(s) 44

    MeSH term(s) Deep Brain Stimulation ; Humans ; Neuropsychological Tests ; Parkinson Disease ; Subthalamic Nucleus
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opy138
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  9. Article: Parkinsonism and dystonia in Lubag disease respond well to high pulse width/low-frequency globus pallidus interna DBS.

    Miravite, Joan / Deik, Andres / Swan, Matthew / Sarva, Harini / Kopell, Brian Harris / Severt, William Lawrence

    Neurology. Clinical practice

    2018  Volume 5, Issue 6, Page(s) 480–483

    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000130
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  10. Article ; Online: Beyond "poke & hope": the next steps for DBS for psychiatric disorders.

    Kopell, Brian Harris / Halverson, Jerry

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2009  Volume 120, Issue 11, Page(s) 1879–1880

    MeSH term(s) Deep Brain Stimulation/instrumentation ; Deep Brain Stimulation/standards ; Humans ; Mental Disorders/psychology ; Mental Disorders/therapy ; Movement Disorders/psychology ; Movement Disorders/therapy
    Language English
    Publishing date 2009-11
    Publishing country Netherlands
    Document type Comment ; Editorial
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2009.08.008
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