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  1. Article ; Online: Challenging Best Practice of Atopic Dermatitis.

    Arkwright, Peter D / Koplin, Jennifer J

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 5, Page(s) 1391–1393

    MeSH term(s) Humans ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/therapy ; Practice Patterns, Physicians'
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.03.023
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    Zs.A 7086: Show issues Location:
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  2. Article ; Online: Impact of a Decade of Research Into Atopic Dermatitis.

    Arkwright, Peter D / Koplin, Jennifer J

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 1, Page(s) 63–71

    Abstract: The last decade has seen an unprecedented pace of change, particularly of clinical research in atopic dermatitis (AD). This review summarizes some key discoveries. Over the last 10 years, nearly half of all studies investigated the efficacy and safety of ...

    Abstract The last decade has seen an unprecedented pace of change, particularly of clinical research in atopic dermatitis (AD). This review summarizes some key discoveries. Over the last 10 years, nearly half of all studies investigated the efficacy and safety of novel therapeutic agents, particularly biologics and small molecules. Clear demonstration of benefit in clinical trials with no significant safety concerns provided strong evidence leading to subsequent Food and Drug Administration approval and routine use of the anti-IL-4 receptor alpha antagonist dupilumab in patients 6 months and older, the selective Janus kinase 1 (JAK1) inhibitors upadacitinib for patients 12 years and older and abrocitinib, the IL-13 antagonist tralokinumab, and the JAK1/2 inhibitor baricitinib for adults 18 years and older. Several other drugs are in the pipeline. Other areas under the spotlight have been trials of skin moisturizers and probiotics in the prevention of AD, investigating the role of filaggrin and skin barrier function and the role of skin and gut microbiome, with Staphylococcus aureus second immunoglobulin-binding protein having been found to uniquely trigger allergic skin responses in AD. Skin microbiome, epidermal metabolites/structural components, and local inflammatory biomarkers are now commonly assessed using genomic and proteomic analysis of tape strips rather than more invasive biopsy to identify factors such as C-C motif chemokine ligand-17 that correlate with disease severity and response to therapy. Overall, the last decade has ushered in a new and exciting era in our understanding, diagnosis, and treatment of this common allergic skin disease.
    MeSH term(s) Adult ; Humans ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/diagnosis ; Proteomics ; Skin/pathology ; Microbiota ; Hypersensitivity
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.09.021
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  3. Article ; Online: Striving for Evidence-Based Management of Food Allergies.

    Arkwright, Peter D / Koplin, Jennifer J

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 1, Page(s) 56–58

    MeSH term(s) Food Hypersensitivity/diagnosis ; Food Hypersensitivity/therapy ; Humans
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.09.040
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  4. Article ; Online: Atopic Dermatitis: Aiming for Total Disease Control.

    Arruda, L Karla / Koplin, Jennifer J

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 4, Page(s) 1508–1509

    MeSH term(s) Dermatitis, Atopic/diagnosis ; Eczema ; Humans
    Language English
    Publishing date 2021-04-10
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.02.030
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  5. Article ; Online: Managing Atopic Dermatitis in Patients With Skin of Color.

    Davis, Carla M / Flohr, Carsten / Gupta, Meera R / Koplin, Jennifer J

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 5, Page(s) 1376–1383

    Abstract: Managing atopic dermatitis (AD) in patients with skin of color presents unique challenges for the clinician. There is increasing evidence that AD has higher prevalence, persistence, and severity among skin of color populations. This is likely to be ... ...

    Abstract Managing atopic dermatitis (AD) in patients with skin of color presents unique challenges for the clinician. There is increasing evidence that AD has higher prevalence, persistence, and severity among skin of color populations. This is likely to be partly related to differences in living conditions and exposure to irritants and allergens, among other factors. Assessment of AD severity in patients with darker skin can be challenging, in particular the assessment of erythema, leading to the potential for underscoring AD severity. Variations in disease have also been described, with the potential for a greater risk of inflammation-induced nodularity and hyper- or hypopigmentation. Management challenges include variable adherence to treatment, potential disparities in access to health care, and differences in the metabolism of cyclosporine. Optimal management of AD in patients with skin of color requires a tailored approach. Here, we review approaches to diagnosing AD, evaluating extent and severity with subjective and objective measures, considering treatment options for patients with skin of color, and highlighting areas for improvement in AD care for skin of color populations.
    MeSH term(s) Humans ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/therapy ; Skin Pigmentation ; Skin ; Erythema ; Allergens
    Chemical Substances Allergens
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.03.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An Overview of Environmental Risk Factors for Food Allergy.

    Peters, Rachel L / Mavoa, Suzanne / Koplin, Jennifer J

    International journal of environmental research and public health

    2022  Volume 19, Issue 2

    Abstract: IgE-mediated food allergy is an increasing public health concern in many regions around the world. Although genetics play a role in the development of food allergy, the reported increase has occurred largely within a single generation and therefore it is ...

    Abstract IgE-mediated food allergy is an increasing public health concern in many regions around the world. Although genetics play a role in the development of food allergy, the reported increase has occurred largely within a single generation and therefore it is unlikely that this can be accounted for by changes in the human genome. Environmental factors must play a key role. While there is strong evidence to support the early introduction of allergenic solids to prevent food allergy, this is unlikely to be sufficient to prevent all food allergy. The purpose of this review is to summarize the evidence on risk factors for food allergy with a focus the outdoor physical environment. We discuss emerging evidence of mechanisms that could explain a role for vitamin D, air pollution, environmental greenness, and pollen exposure in the development of food allergy. We also describe the recent extension of the dual allergen exposure hypothesis to potentially include the respiratory epithelial barrier in addition to the skin. Few existing studies have examined the relationship between these environmental factors with objective measures of IgE-mediated food allergy and further research in this area is needed. Future research also needs to consider the complex interplay between multiple environmental factors.
    MeSH term(s) Air Pollution ; Allergens ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/etiology ; Humans ; Pollen ; Risk Factors
    Chemical Substances Allergens
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19020722
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  7. Article ; Online: Real-World LEAP Implementation.

    Koplin, Jennifer J / Soriano, Victoria X / Peters, Rachel L

    Current allergy and asthma reports

    2022  Volume 22, Issue 6, Page(s) 61–66

    Abstract: Purpose of review: In 2015, findings from the Learning Early About Peanut allergy (LEAP) trial provided the first convincing evidence that peanut allergy may be preventable through early peanut introduction into the infant diet. Here we discuss ... ...

    Abstract Purpose of review: In 2015, findings from the Learning Early About Peanut allergy (LEAP) trial provided the first convincing evidence that peanut allergy may be preventable through early peanut introduction into the infant diet. Here we discuss implementation of the LEAP study findings around the world and emerging evidence of the impacts on infant feeding and food allergy.
    Recent findings: The LEAP findings led to rapid changes in allergy prevention guidelines internationally to recommend early peanut introduction. There is now emerging evidence that this has been followed by a substantial increase in early peanut introduction to infants. Studies investigating the impact of these changes in infant feeding practices on the prevalence of peanut allergy are underway. The LEAP trial represented a significant step forwards in food allergy prevention and new research over the past 5 years has provided insights into how best to implement this intervention in the real world.
    MeSH term(s) Allergens ; Arachis ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/prevention & control ; Humans ; Infant ; Peanut Hypersensitivity/epidemiology ; Peanut Hypersensitivity/prevention & control ; Prevalence
    Chemical Substances Allergens
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-022-01032-3
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  8. Article ; Online: Food Allergy: More Than Peanut.

    Koplin, Jennifer J / Davis, Carla M

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 1, Page(s) 68–69

    MeSH term(s) Arachis ; Food Hypersensitivity/diagnosis ; Humans ; Peanut Hypersensitivity/diagnosis
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.11.001
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  9. Article ; Online: Explaining the link between maternal lipid profiles and food allergy in offspring.

    Koplin, Jennifer J / Peters, Rachel L

    The Journal of allergy and clinical immunology

    2019  Volume 144, Issue 3, Page(s) 661–662

    MeSH term(s) Female ; Food Hypersensitivity ; Humans ; Maternal Nutritional Physiological Phenomena ; Triglycerides
    Chemical Substances Triglycerides
    Language English
    Publishing date 2019-07-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2019.06.043
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  10. Article ; Online: Early peanut introduction: To test or not to test?

    Koplin, Jennifer J / McWilliam, Vicki / Soriano, Victoria X / Peters, Rachel L

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 130, Issue 5, Page(s) 565–570

    Abstract: Objective: To review recent evidence and international guidelines on early peanut introduction for preventing peanut allergy and provide an update on the status of the debate around testing before early peanut introduction.: Data sources: Review of ... ...

    Abstract Objective: To review recent evidence and international guidelines on early peanut introduction for preventing peanut allergy and provide an update on the status of the debate around testing before early peanut introduction.
    Data sources: Review of published literature documenting: infant feeding guidelines; impact of early peanut introduction on peanut allergy; risk factors for peanut allergy; and impact of early peanut introduction guidelines on infant feeding practices and allergy.
    Study selection: We used a narrative approach and present both pro and con arguments for testing before peanut introduction. Data from randomized controlled trials and post-hoc analyses of these trials and observational studies were included.
    Results: Allergy prevention guidelines around the world now consistently recommend introducing peanut into an infant's diet before 12 months of age for countries with high peanut allergy prevalence. In the US, guidelines recently shifted away from recommending allergy testing before introduction for those at risk of peanut allergy. There is evidence primarily from Australia that recommending early introduction without prior testing is safe and effective in increasing early peanut introduction for both high and low-risk infants, although the subsequent reduction in peanut allergy prevalence at the population level was less than expected.
    Conclusion: Current evidence supports recommending early peanut introduction without routinely testing for peanut allergy. If testing is offered, this should be based on shared decision making between families and practitioners and only be undertaken where there is provision for rapid access to definitive diagnosis including oral food challenges.
    MeSH term(s) Infant ; Humans ; Peanut Hypersensitivity/diagnosis ; Peanut Hypersensitivity/epidemiology ; Peanut Hypersensitivity/prevention & control ; Arachis ; Risk Factors ; Diet ; Allergens ; Food Hypersensitivity/epidemiology
    Chemical Substances Allergens
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.02.004
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