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Article: Tracheal complications of mechanical ventilation for COVID-19: a plot twist for survivors.

Badovinac, Sonja / Popović, Filip / Glodić, Goran / Baričević, Denis / Srdić, Dražena / Džubur, Feđa / Koršić, Marta / Samaržija, Miroslav

ERJ open research

2023 Volume 9, Issue 2

Abstract: Tracheal complications should be suspected in mechanically ventilated COVID-19 survivors with respiratory symptoms. Treatment requires a multimodal approach of interventional bronchoscopy and surgery with tight follow-up due to a high rate of restenosis. ...

Abstract	Tracheal complications should be suspected in mechanically ventilated COVID-19 survivors with respiratory symptoms. Treatment requires a multimodal approach of interventional bronchoscopy and surgery with tight follow-up due to a high rate of restenosis.
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00478-2022
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Article ; Online: Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer

Ljubicic Lidija / Janzic Urska / Unk Mojca / Terglav Ana Sophie / Mohorcic Katja / Seiwerth Fran / Bitar Lela / Badovinac Sonja / Plestina Sanja / Korsic Marta / Kukulj Suzana / Samarzija Miroslav / Jakopovic Marko

Radiology and Oncology, Vol 57, Iss 3, Pp 397-

a multicenter retrospective real-world analysis

2023 Volume 404

Abstract: The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/− ... ...

Abstract	The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/− ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option.
Keywords	advanced nsclc ; antiangiogenic therapy ; docetaxel ; nintedanib ; real-world data ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Serum leptin and skeletal differences between obese and non-obese patients with chronic obstructive pulmonary disease.

Koršić, Marta / Kušec, Vesna

Obesity facts

2014 Volume 7, Issue 6, Page(s) 399–407

Abstract: Objective: Chronic obstructive pulmonary disease (COPD) affects body composition, adipokine secretion, and skeletal integrity. The aim was to determine the association between leptin, body mass (BM) and body composition parameters - fat mass (FM) and ... ...

Abstract	Objective: Chronic obstructive pulmonary disease (COPD) affects body composition, adipokine secretion, and skeletal integrity. The aim was to determine the association between leptin, body mass (BM) and body composition parameters - fat mass (FM) and fat mass index (FMI), lean tissue mass (LTM), lean tissue mass index (LTMI) and bone mineral density (BMD) in 67 male COPD patients. Methods: BM, body composition and biochemical indicators were measured or calculated using standard methods. Data were analyzed according to groups: non-obese (N = 48, BMI 21.0-29.9 kg/m(2)) and obese (N = 19, BMI ≥ 30.0 kg/m(2)). Results: In the non-obese group statistically significant correlations were observed: negative ones of age with most BMD T scores, positive ones of BMI with all T scores, FM, FMI, LTMI and leptin, of FMI with leptin and all T scores, and of LTMI with most T scores. In the obese group also statistically significant correlations were found: positive ones of BMI with FMI, LTM, leptin and T scores (trochanter, total hip); of FMI with leptin; and of leptin with total hip T score. Conclusion: A positive relationship between FMI and BMD was found only in non-obese but not in obese COPD patients. Leptin concentration was associated positively with the total hip T score only in obese COPD patients, suggesting its protective role on the skeleton of obese COPD patients.
MeSH term(s)	Absorptiometry, Photon ; Adult ; Aged ; Aged, 80 and over ; Body Composition ; Bone Density ; Bone and Bones/metabolism ; Female ; Humans ; Leptin/blood ; Male ; Middle Aged ; Obesity/blood ; Obesity/complications ; Obesity/metabolism ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/metabolism
Chemical Substances	Leptin
Language	English
Publishing date	2014
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	2417831-7
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000369990
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Article ; Online: Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis.

Ljubicic, Lidija / Janzic, Urska / Unk, Mojca / Terglav, Ana Sophie / Mohorcic, Katja / Seiwerth, Fran / Bitar, Lela / Badovinac, Sonja / Plestina, Sanja / Korsic, Marta / Kukulj, Suzana / Samarzija, Miroslav / Jakopovic, Marko

Radiology and oncology

2023 Volume 57, Issue 3, Page(s) 397–404

Abstract: Background: The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after ... ...

Abstract	Background: The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/- ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option. Patients and methods: A multicenter retrospective trial of real-life treatment patterns and outcomes of patients with advanced lung adenocarcinoma treated with docetaxel plus nintedanib after the failure of ICI and/or ChT was performed. Patients from 2 Slovenian and 1 Croatian oncological center treated between June 2014 and August 2022 were enrolled. We assessed objective response (ORR), disease control rate (DCR), median progression free survival (PFS), median overall survival (OS), and safety profile of treatment. Results: There were 96 patients included in the analysis, with ORR of 18.8%, DCR of 57.3%, median PFS of 3.0 months (95% CI: 3.0-5.0 months), and a median OS of 8.0 months (95% CI: 7.0-10.0 months). The majority of patients (n = 47,49%) received docetaxel plus nintedanib as third-line therapy. The ORR for this subset of patients was 19.1%, with a DCR of 57.4%. The highest response rate was observed in patients who received second-line docetaxel plus nintedanib after first-line combination of ChT-ICI therapy (n = 24), with an ORR of 29.2% and DCR of 66.7% and median PFS of 4.0 months (95% CI: 3.0-8.0 months). Fifty-three patients (55.2%) experienced adverse events (AEs), most frequently gastrointestinal; diarrhea (n = 29, 30.2%), and increased liver enzyme levels (n = 17, 17.7%). Conclusions: The combination of docetaxel and nintedanib can be considered an effective therapy option with an acceptable toxicity profile for patients with advanced NSCLC after the failure of ICI +/- ChT.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Docetaxel/therapeutic use ; Retrospective Studies ; Lung Neoplasms/drug therapy ; Lung
Chemical Substances	Docetaxel (15H5577CQD) ; nintedanib (G6HRD2P839)
Language	English
Publishing date	2023-09-04
Publishing country	Poland
Document type	Multicenter Study ; Journal Article
ZDB-ID	1128829-2
ISSN	1581-3207 ; 0485-893X ; 1318-2099
ISSN (online)	1581-3207
ISSN	0485-893X ; 1318-2099
DOI	10.2478/raon-2023-0040
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Article ; Online: Risk factors and severity of functional impairment in long COVID: a single-center experience in Croatia.

Banić, Marko / Janković Makek, Mateja / Samaržija, Miroslav / Muršić, Davorka / Boras, Zagorka / Trkeš, Vesna / Baričević, Denis / Koršić, Marta / Basara, Latinka / Jalušić Glunčić, Tajana / Vukić Dugac, Andrea

Croatian medical journal

2022 Volume 63, Issue 1, Page(s) 27–35

Abstract: Aim: To determine the frequency of common symptoms in long COVID and their effect on the quality of life, and to determine the factors contributing to a more severe long COVID.: Methods: The study enrolled 266 patients who were either referred to ... ...

Abstract	Aim: To determine the frequency of common symptoms in long COVID and their effect on the quality of life, and to determine the factors contributing to a more severe long COVID. Methods: The study enrolled 266 patients who were either referred to long-COVID outpatient clinic or were inpatients undergoing rehabilitation. The data were collected between December 2020 and May 2021. We evaluated the symptoms experienced during acute and long COVID and comorbidities. Functional status was assessed with Post Covid Functional Status (PCFS). Results: The final sample consisted of 261 patients. After acute COVID-19 period (>4 weeks), almost 80% of patients had impaired functional status. Only 21.5% reported no functional impairment (0 on PCFS scale). A higher PCFS score was associated with female sex (P<0.001) and oxygen therapy requirement during acute disease (P=0.001). However, it was not associated with having a pre-existing lung disease (P=0.749). Disease severity did not pose a risk for developing a more severe long COVID. Conclusion: Women were at greater risk for developing greater functional impairment in long COVID, although we have no explanation why. Malignant disease and hypertension also presented a risk factor for greater functional impairment. More studies are warranted to determine if patients with certain lung disease are more susceptible to long COVID.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Croatia/epidemiology ; Female ; Humans ; Quality of Life ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2022-03-01
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1157623-6
ISSN	1332-8166 ; 0353-9504
ISSN (online)	1332-8166
ISSN	0353-9504
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Article ; Online: Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial.

Badovinac, Sonja / Glodić, Goran / Sabol, Ivan / Džubur, Feđa / Makek, Mateja Janković / Baričević, Denis / Koršić, Marta / Popović, Filip / Srdić, Dražena / Samaržija, Miroslav

Chest

2022 Volume 163, Issue 4, Page(s) 985–993

Abstract: Background: The most commonly used topical hemostatic agents during flexible bronchoscopy (FB) are cold saline and adrenaline. Data on use of other agents such as tranexamic acid (TXA) for this purpose are limited.: Research question: Is TXA ... ...

Abstract	Background: The most commonly used topical hemostatic agents during flexible bronchoscopy (FB) are cold saline and adrenaline. Data on use of other agents such as tranexamic acid (TXA) for this purpose are limited. Research question: Is TXA effective and safe in controlling iatrogenic bleeding during FB compared with adrenaline? Study design and methods: We conducted a cluster-randomized, double-blind, single-center trial in a tertiary teaching hospital. Patients were randomized in weekly clusters to receive up to three applications of TXA (100 mg, 2 mL) or adrenaline (0.2 mg, 2 mL, 1:10000) after hemostasis failure after three applications of cold saline (4 ° C, 5 mL). Crossover was allowed (for up to three further applications) before proceeding with other interventions. Bleeding severity was graded by the bronchoscopist using a visual analog scale (VAS; 1 = very mild, 10 = severe). Results: A total of 2,033 FBs were performed and 130 patients were randomized successfully to adrenaline (n = 65) or TXA (n = 65), whereas 12 patients had to be excluded for protocol violations (two patients from the adrenaline arm and 10 patients from TXA arm). Bleeding was stopped in 83.1% of patients (54/65) in both groups (P = 1). The severity of bleeding and number of applications needed for bleeding control were similar in both groups (adrenaline: mean VAS score, 4.9 ± 1.3 [n = 1.8 ± 0.8]; TXA: mean VAS score, 5.3 ± 1.4 [n = 1.8 ± 0.8]). Both adrenaline and TXA were more successful in controlling moderate bleeding (86.7% and 88.7%, respectively) than severe bleeding (40% and 58.3%, respectively; P = .008 and P = .012, respectively) and required more applications for severe bleeding (3.0 ± 0 and 2.4 ± 0.5, respectively) than moderate bleeding (1.7 ± 0.8 and 1.7 ± 0.8, respectively) control (P = .006 and P = .002, respectively). We observed no drug-related adverse events in either group. Interpretation: We found no significant difference between adrenaline and TXA for controlling noncatastrophic iatrogenic endobronchial bleeding after cold saline failure, adding to the body of evidence that TXA can be used safely and effectively during FB. Trial registry: ClinicalTrials.gov; No.: NCT04771923; URL: www. Clinicaltrials: gov.
MeSH term(s)	Humans ; Tranexamic Acid/therapeutic use ; Bronchoscopy ; Epinephrine/therapeutic use ; Stroke ; Double-Blind Method ; Hospitals, Teaching ; Iatrogenic Disease ; Antifibrinolytic Agents/therapeutic use
Chemical Substances	Tranexamic Acid (6T84R30KC1) ; Epinephrine (YKH834O4BH) ; Antifibrinolytic Agents
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.10.013
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Article ; Online: Talc pleurodesis improves survival of patients with malignant pleural effusions: case-control study.

Korsic, Marta / Badovinac, Sonja / Cucevic, Branka / Janevski, Zoran

Wiener klinische Wochenschrift

2015 Volume 127, Issue 23-24, Page(s) 963–969

Abstract: Aim: The aim of this study is to investigate whether there was a considerable difference in the survival of patients with malignant pleural effusion (MPE) depending on the pleural effusion treatment option.: Methods: One hundred and seven patients ... ...

Abstract	Aim: The aim of this study is to investigate whether there was a considerable difference in the survival of patients with malignant pleural effusion (MPE) depending on the pleural effusion treatment option. Methods: One hundred and seven patients with proven MPE (metastatic lung and breast cancer) were included in the retrospective study. Fifty six patients were treated with talc pleurodesis and a control group of 51 patients with similar characteristics (in age, sex and disease) were treated with serial thoracentesis. The patients of both groups underwent chemotherapy and/or radiotherapy. The overall survival and the survival in subgroups of patients with different tumour types and different performance status (PS) equal 1, 2 and 3 were compared. Results: The patients who underwent talc pleurodesis had a longer average survival interval (MS) than the patients without such a treatment (n = 56; MS = 21,5 and n = 51; MS = 9 weeks, respectively; p < 0.001). The best results were achieved in patients with PS 1 (n = 16; MS = 35.5 and n = 10; MS = 11 weeks in the groups with and without talc pleurodesis, respectively; p < 0,001) and PS 2 (n = 27; MS = 21 and n = 30; MS = 10 weeks in the groups with and without talc pleurodesis, respectively; p < 0.001), whereas talc pleurodesis was not effective in PS 3 patients (n = 13; MS = 10 and n = 11; MS = 7 weeks in the groups with and without talc pleurodesis, respectively; p = 0.08). Patients with the breast cancer showed a longer average survival interval after pleurodesis than those with the lung cancer (n = 12; MS = 37.5 and n = 4; MS = 20 weeks in the group with the breast cancer and with the lung cancer, respectively; p < 0.001), whereas the median survival was not significantly different between those patients without pleurodesis (n = 10; MS = 10 and n = 41; MS = 9 weeks in the group with the breast cancer and lung cancer, respectively; p = 0.11). Conclusion: The patients treated with talc pleurodesis had a significantly longer average survival than the patients without such a treatment, especially in the group with the breast cancer and in groups with better performance status. This may indicate that talc pleurodesis, apart from its symptomatic effect on the cessation of pleural effusion, may have a direct antitumour effect as well.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Croatia/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion, Malignant/mortality ; Pleural Effusion, Malignant/therapy ; Pleurodesis/methods ; Pleurodesis/mortality ; Prevalence ; Retrospective Studies ; Risk Factors ; Survival Rate ; Talc/administration & dosage ; Tissue Adhesives/administration & dosage ; Treatment Outcome
Chemical Substances	Tissue Adhesives ; Talc (14807-96-6)
Language	English
Publishing date	2015-12
Publishing country	Austria
Document type	Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-015-0716-8
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Article ; Online: Nivolumab-induced synchronous occurrence of myositis and hypothyroidism in a patient with squamous cell lung cancer.

Badovinac, Sonja / Korsic, Marta / Zarkovic, Kamelija / Mursic, Davorka / Roglic, Mihovil / Jakopovic, Marko / Samarzija, Miroslav

Immunotherapy

2018 Volume 10, Issue 6, Page(s) 427–431

Abstract: Aim: Alongside the proven efficacy, immunotherapy in treatment of malignant diseases can cause immune-related adverse events different from commonly known chemotherapy-related toxicities.: Case presentation: During nivolumab treatment of metastatic ... ...

Abstract	Aim: Alongside the proven efficacy, immunotherapy in treatment of malignant diseases can cause immune-related adverse events different from commonly known chemotherapy-related toxicities. Case presentation: During nivolumab treatment of metastatic squamous cell lung cancer, the patient developed a symptomatic inflammatory myositis confirmed with muscle biopsy and primary hypothyroidism. After initiation of corticosteroids and thyroid hormone replacement, the clinical and laboratory improvement occurred. To the best of our knowledge, this is the first description of a case of nivolumab-induced synchronous manifestation of immune-related myositis and hypothyroidism. Conclusion: Immunotherapy can trigger a wide spectrum of immune-related adverse events that could occur simultaneously. If not detected and treated, these events could become severe or even fatal and require clinicians' awareness and routine check-ups.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biopsy ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Female ; Hormone Replacement Therapy ; Humans ; Hypothyroidism/diagnosis ; Hypothyroidism/etiology ; Hypothyroidism/prevention & control ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Middle Aged ; Myositis/diagnosis ; Myositis/etiology ; Myositis/prevention & control ; Neoplasms, Squamous Cell/diagnosis ; Neoplasms, Squamous Cell/drug therapy ; Nivolumab/adverse effects ; Nivolumab/therapeutic use ; Programmed Cell Death 1 Receptor/immunology ; Thyroid Hormones/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Antineoplastic Agents ; Programmed Cell Death 1 Receptor ; Thyroid Hormones ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2018-03-21
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2017-0174
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Article: Serum Leptin and Skeletal Differences between Obese and Non-Obese Patients with Chronic Obstructive Pulmonary Disease

Koršić, Marta / Kušec, Vesna

Obesity Facts

2014 Volume 7, Issue 6, Page(s) 399–407

Institution	Clinic for Lung Disease, Clinical Hospital Centre Zagreb, Zagreb, Croatia Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract	Objective: Chronic obstructive pulmonary disease (COPD) affects body composition, adipokine secretion, and skeletal integrity. The aim was to determine the association between leptin, body mass (BM) and body composition parameters - fat mass (FM) and fat mass index (FMI), lean tissue mass (LTM), lean tissue mass index (LTMI) and bone mineral density (BMD) in 67 male COPD patients. Methods: BM, body composition and biochemical indicators were measured or calculated using standard methods. Data were analyzed according to groups: non-obese (N = 48, BMI 21.0-29.9 kg/m2) and obese (N = 19, BMI ≥ 30.0 kg/m2Results: In the non-obese group statistically significant correlations were observed: negative ones of age with most BMD T scores, positive ones of BMI with all T scores, FM, FMI, LTMI and leptin, of FMI with leptin and all T scores, and of LTMI with most T scores. In the obese group also statistically significant correlations were found: positive ones of BMI with FMI, LTM, leptin and T scores (trochanter, total hip); of FMI with leptin; and of leptin with total hip T score. Conclusion: A positive relationship between FMI and BMD was found only in non-obese but not in obese COPD patients. Leptin concentration was associated positively with the total hip T score only in obese COPD patients, suggesting its protective role on the skeleton of obese COPD patients.
Keywords	Body mass ; Body mass index ; Fat mass ; Fat mass index ; Lean tissue mass ; Lean tissue mass index ; 25-OH vitamin D ; Leptin ; Bone mineral density
Language	English
Publishing date	2014-11-26
Publisher	S. Karger GmbH
Publishing place	Freiburg, Germany
Document type	Article
ZDB-ID	2417831-7
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000369990
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Article ; Online: Ruxolitinib as monotherapy in a patient with anaplastic lymphoma kinase positive lung adenocarcinoma.

Koršić, Marta / Muršić, Davorka / Badovinac, Sonja / Roglić, Mihovil / Jakopović, Marko / Zupančić Šalek, Silva / Samaržija, Miroslav

Anti-cancer drugs

2019 Volume 30, Issue 10, Page(s) 1061–1063

Abstract: We present unusual treatment outcome in a 59-year-old male diagnosed with metastatic lung adenocarcinoma with a very good response to ruxolitinib as monotherapy. In June 2017, this patient was diagnosed with myeloproliferative neoplasm - Janus-associated ...

Abstract	We present unusual treatment outcome in a 59-year-old male diagnosed with metastatic lung adenocarcinoma with a very good response to ruxolitinib as monotherapy. In June 2017, this patient was diagnosed with myeloproliferative neoplasm - Janus-associated kinases 2 positive - and in December 2017 ruxolitinib therapy was started. At the same time, patient was diagnosed with lung adenocarcinoma in the left lower lobe with positive anaplastic lymphoma kinase mutation and with right lower lobe metastasis. Because of partial regression of tumor size noted on the computed tomography (CT) scans during tumor investigation, we did not apply any therapy for lung adenocarcinoma. A follow-up CT scan done in March 2018 showed further size reduction of tumor lesion in lower left lobe (91%), while follow-up CT scan done in June 2018 showed further size reduction of tumor lesion in lower right lobe (82%).
MeSH term(s)	Adenocarcinoma of Lung/diagnostic imaging ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/metabolism ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/metabolism ; Antineoplastic Agents/therapeutic use ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Pyrazoles/therapeutic use ; Tomography, X-Ray Computed
Chemical Substances	Antineoplastic Agents ; Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1065301-6
ISSN	1473-5741 ; 0959-4973
ISSN (online)	1473-5741
ISSN	0959-4973
DOI	10.1097/CAD.0000000000000822
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