Article ; Online: Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance.
2019 Volume 139, Issue 5, Page(s) 913–936
Abstract: Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single- ... ...
Abstract | Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68 |
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MeSH term(s) | Animals ; Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Central Nervous System Neoplasms/metabolism ; Central Nervous System Neoplasms/pathology ; Drug Resistance, Neoplasm/physiology ; Female ; Humans ; Macrophages/pathology ; Male ; Mice, Transgenic ; Neoplasm Recurrence, Local/pathology ; Rhabdoid Tumor/genetics ; Tumor Microenvironment/physiology |
Chemical Substances | Biomarkers, Tumor |
Language | English |
Publishing date | 2019-12-17 |
Publishing country | Germany |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1079-0 |
ISSN | 1432-0533 ; 0001-6322 |
ISSN (online) | 1432-0533 |
ISSN | 0001-6322 |
DOI | 10.1007/s00401-019-02116-7 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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