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  1. Article ; Online: The dual neural effects of oxytocin in autistic youth: results from a randomized trial.

    Korisky, Adi / Goldstein, Abraham / Gordon, Ilanit

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 16304

    Abstract: Recent discoveries have highlighted the effects of oxytocin (OT) on social behavior and perception among autistic individuals. However, a gap persists in the literature regarding the potential effects of OT and the neural temporal dynamics due to OT ... ...

    Abstract Recent discoveries have highlighted the effects of oxytocin (OT) on social behavior and perception among autistic individuals. However, a gap persists in the literature regarding the potential effects of OT and the neural temporal dynamics due to OT administration. We explored the effect of OT on autistic individuals using magnetoencephalography (MEG), focusing on M100, M170, and M250, social perception-related components that tend to show atypical patterns in autistic individuals. Twenty-five autistic adolescents participated in this randomized, double-blind MEG study. Autistic individuals arrived at the lab twice and received an acute dose of intranasal OT or placebo in each session. During the scans, participants were asked to identify pictures of social and non-social stimuli. Additionally, 23 typically developing (TD) adolescents performed the same task in the MEG as a benchmark that allowed us to better characterize neural regions of interest and behavioral results for this age group in this task. A source-model beamformer analysis revealed that OT enhanced neural activity for social stimuli in frontal regions during M170. Additionally, in each of the preselected time windows, OT increased activation in the left hemisphere, regardless of the content of the presented stimuli. We suggest that OT increased the processing of social stimuli through two separate mechanisms. First, OT increased neural activity in a nonspecific manner, allowing increased allocation of attention toward the stimuli. Second, OT enhanced M170 activity in frontal regions only in response to social stimuli. These results reveal the temporal dynamics of the effects of OT on the early stages of social and non-social perception in autistic adolescents.Trial registration: This study was a part of a project registered as clinical trial October 27th, 2021. ClinicalTrials.gov Identifier: NCT05096676.
    MeSH term(s) Adolescent ; Autistic Disorder/drug therapy ; Humans ; Magnetoencephalography ; Oxytocin/pharmacology ; Social Behavior ; Social Perception
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-19524-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oxytocin impacts top-down and bottom-up social perception in adolescents with ASD: a MEG study of neural connectivity.

    Korisky, Adi / Gordon, Ilanit / Goldstein, Abraham

    Molecular autism

    2022  Volume 13, Issue 1, Page(s) 36

    Abstract: Background: In the last decade, accumulative evidence has shown that oxytocin can modulate social perception in typically developed individuals and individuals diagnosed with autism. While several studies show that oxytocin (OT) modulates neural ... ...

    Abstract Background: In the last decade, accumulative evidence has shown that oxytocin can modulate social perception in typically developed individuals and individuals diagnosed with autism. While several studies show that oxytocin (OT) modulates neural activation in social-related neural regions, the mechanism that underlies OT effects in ASD is not fully known yet. Despite evidence from animal studies on connections between the oxytocinergic system and excitation/inhibition neural balance, the influence of OT on oscillatory responses among individuals with ASD has been rarely examined. To bridge these gaps in knowledge, we investigated the effects of OT on both social and non-social stimuli while focusing on its specific influence on the neural connectivity between three socially related neural regions-the left and right fusiform and the medial frontal cortex.
    Methods: Twenty-five adolescents with ASD participated in a wall-established social task during a randomized, double-blind placebo-controlled MEG and OT administration study. Our main task was a social-related task that required the identification of social and non-social-related pictures. We hypothesized that OT would modulate the oscillatory connectivity between three pre-selected regions of interest to be more adaptive to social processing. Specifically, we focused on alpha and gamma bands which are known to play an important role in face processing and top-down/bottom-up balance.
    Results: Compared to placebo, OT reduced the connectivity between the medial frontal cortex and the fusiform in the low gamma more for social stimuli than for non-social ones, a reduction that was correlated with individuals' performance in the task. Additionally, for both social and non-social stimuli, OT increased the connectivity in the alpha and beta bands.
    Limitations: Sample size was determined based on sample sizes previously reported in MEG in clinical populations, especially OT administration studies in combination with neuroimaging in ASD. We were limited in our capability to recruit for such a study, and as such, the sample size was not based on a priori power analysis. Additionally, we limited our analyses to specific neural bands and regions. To validate the current results, future studies may be needed to explore other parameters using whole-brain approaches in larger samples.
    Conclusion: These results suggest that OT influenced social perception by modifying the communication between frontal and posterior regions, an attenuation that potentially impacts both social and non-social early perception. We also show that OT influences differ between top-down and bottom-up processes, depending on the social context. Overall, by showing that OT influences both social-related perception and overall attention during early processing stages, we add new information to the existing understanding of the impact of OT on neural processing in ASD. Furthermore, by highlighting the influence of OT on early perception, we provide new directions for treatments for difficulties in early attentional phases in this population. Trial registration Registered on October 27, 2021-Retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT05096676 (details on clinical registration can be found in www.
    Clinicaltrial: gov , unique identifier: NCT05096676 ).
    MeSH term(s) Administration, Intranasal ; Animals ; Autistic Disorder/diagnostic imaging ; Autistic Disorder/drug therapy ; Double-Blind Method ; Facial Recognition/physiology ; Magnetic Resonance Imaging/methods ; Oxytocin/pharmacology ; Social Perception
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540930-X
    ISSN 2040-2392 ; 2040-2392
    ISSN (online) 2040-2392
    ISSN 2040-2392
    DOI 10.1186/s13229-022-00513-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neurophysiological Patterns of Attention and Distraction during Realistic Virtual-Reality Classroom Learning in Adults with and without ADHD.

    Levy, Orel / Hackmon, Shirley Libman / Zvilichovsky, Yair / Korisky, Adi / Bidet-Caulet, Aurelie / Schweitzer, Julie B / Golumbic, Elana Zion

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Many people, and particularly those diagnosed with ADHD, report difficulties maintaining attention and proneness to distraction during classroom learning. However, the behavioral, neural and physiological basis of attention in realistic learning contexts ...

    Abstract Many people, and particularly those diagnosed with ADHD, report difficulties maintaining attention and proneness to distraction during classroom learning. However, the behavioral, neural and physiological basis of attention in realistic learning contexts is not well understood, since current clinical and scientific tools used for evaluating and quantifying the constructs of "distractibility" and "inattention", are removed from the real-life experience in organic classrooms. Here we introduce a novel Virtual Reality (VR) platform for studying students' brain activity and physiological responses as they immerse in realistic frontal classroom learning. Using this approach, we studied whether adults with and without ADHD (N=49) exhibit differences in neurophysiological metrics associated with sustained attention, such as speech-tracking of the teacher's voice, power of alpha-oscillations and levels of arousal, as well as responses to potential disturbances by background sound-events in the classroom. Under these ecological conditions, we find that adults with ADHD exhibit higher auditory neural response to background sounds relative to their control-peers, which also contributed to explaining variance in the severity of ADHD symptoms, together with higher power of alpha-oscillations and more frequent gaze-shifts around the classroom. These results are in-line with higher sensitivity to irrelevant stimuli in the environment and increased mind-wandering/boredom. At the same time, both groups exhibited similar learning outcomes and showed similar neural tracking of the teacher's speech. This suggests that in this context, attention may not operate as a zero-sum game and that allocating some resources to irrelevant stimuli does not always detract from performing the task at hand. Given the dire need for more objective, dimensional and ecologically-valid measures of attention and its real-life deficits, this work provides new insights into the neurophysiological manifestations of attention and distraction experienced in real-life contexts, while challenging some prevalent notions regarding the nature of attentional challenges experienced by those with ADHD.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.17.590012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: I feel you: Prepandemic physiological synchrony and emotional contagion during COVID-19.

    Mayo, Oded / Horesh, Danny / Korisky, Adi / Milstein, Nir / Zadok, Ester / Tomashin, Alon / Gordon, Ilanit

    Emotion (Washington, D.C.)

    2022  Volume 23, Issue 3, Page(s) 753–763

    Abstract: The COVID-19 pandemic has a major impact on mental well-being and interpersonal relationships. Nonetheless, little is known about the complex interactions between one's overall perceived interpersonal closeness and physiological or psychological aspects ... ...

    Abstract The COVID-19 pandemic has a major impact on mental well-being and interpersonal relationships. Nonetheless, little is known about the complex interactions between one's overall perceived interpersonal closeness and physiological or psychological aspects of interpersonal functioning. This study aimed to understand the interaction between perceived interpersonal closeness during COVID-19 and interpersonal mechanisms in predicting well-being. We focused on two interpersonal mechanisms, one physiological and the other psychological: (a) prepandemic physiological synchrony, a physiological measure of interpersonal coupling, and (b) peripandemic emotional contagion, one's tendency to "catch" others' emotions. One hundred fifty-five participants took part in the study. Cardiological interbeat interval synchrony was collected 1.5 to 3 years prior to the beginning of the COVID pandemic in two previous lab studies. Participants were recontacted during the pandemic, this time to complete several questionnaires tapping into perceived interpersonal closeness, tendency for emotional contagion, and psychological well-being during COVID. As hypothesized, overall perceived interpersonal closeness was positively related to well-being. Moreover, this effect was moderated by one's tendency for emotional contagion or by physiological synchrony. Thus, individuals with higher emotional contagion scores or higher physiological synchrony had higher well-being if their interpersonal closeness was perceived as greater. Conversely, their well-being was lower if they perceived their interpersonal closeness as weaker. These results emphasize that individuals may be differentially susceptible to the effects of their relationships on their well-being. Future mental health interventions should consider both the quality of one's perceived interpersonal closeness and the extent to which one is sensitive to others' emotional experiences. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Emotions/physiology ; Interpersonal Relations ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102391-8
    ISSN 1931-1516 ; 1528-3542
    ISSN (online) 1931-1516
    ISSN 1528-3542
    DOI 10.1037/emo0001122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pre-pandemic autonomic nervous system activity predicts mood regulation expectancies during COVID-19 in Israel.

    Gordon, Ilanit / Horesh, Danny / Milstein, Nir / Tomashin, Alon / Mayo, Oded / Korisky, Adi

    Psychophysiology

    2021  Volume 58, Issue 11, Page(s) e13910

    Abstract: Despite the unfolding impact of the COVID-19 pandemic on psychological well-being, there is a lack of prospective studies that target physiological markers of distress. There is a need to examine physiological predictors from the pre-pandemic period to ... ...

    Abstract Despite the unfolding impact of the COVID-19 pandemic on psychological well-being, there is a lack of prospective studies that target physiological markers of distress. There is a need to examine physiological predictors from the pre-pandemic period to identify and treat individuals at-risk. In this study, our aim was to use pre-pandemic markers of autonomic nervous system (ANS) parasympathetic and sympathetic regulation to predict individuals' psychological well-being during the crisis. We also assessed the role of mood regulation expectancies as a mediator of the association between pre-pandemic physiological measures and COVID-related well-being. In May to June 2020, 185 Israeli adults completed online questionnaires assessing their mood regulation expectancies since COVID-19 began, and their current well-being. These individuals had participated in lab studies 1.5-3 years prior to this assessment, where their physiological measures were taken, including respiratory sinus arrhythmia (RSA) and skin conductance level (SCL). RSA was positively related to mood regulation expectancies during COVID-19 (b = 3.46, 95% CI [0.84, 6.05]). Mood regulation expectancies, in turn, positively predicted well-being during the crisis (b = 0.021, 95% CI [0.016, 0.027]). The mediation was significant and moderated by SCL (index = -0.09, 95% CI [-0.02, -0.0001]), such that it was strongest for individuals with low SCL. We point to pre-pandemic physiological mechanisms underlying individuals' mental well-being during the COVID-19 pandemic. These findings have theoretical, diagnostic, and clinical implications that may refine our understanding of the physiological basis of resilience to the COVID-19 pandemic and thus may be implemented to identify and assist individuals in these times.
    MeSH term(s) Adolescent ; Adult ; Affect ; Autonomic Nervous System/physiology ; Autonomic Nervous System/physiopathology ; COVID-19 ; Emotional Regulation ; Female ; Galvanic Skin Response ; Humans ; Israel ; Male ; Mental Health ; Motivation ; Respiratory Sinus Arrhythmia ; SARS-CoV-2 ; Young Adult
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.13910
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: A dual-brain approach for understanding the neuralmechanisms that underlie the comforting effects of social touch.

    Korisky, Adi / Eisenberger, Naomi I / Nevat, Michael / Weissman-Fogel, Irit / Shamay-Tsoory, Simone G

    Cortex; a journal devoted to the study of the nervous system and behavior

    2020  Volume 127, Page(s) 333–346

    Abstract: Across different cultures, social touch is used to alleviate distress. Here we adopt a dual-brain approach with fMRI to examine whether social touch involves similar activations between the suffering 'target' and the empathizer in brain regions related ... ...

    Abstract Across different cultures, social touch is used to alleviate distress. Here we adopt a dual-brain approach with fMRI to examine whether social touch involves similar activations between the suffering 'target' and the empathizer in brain regions related to emotional sharing such as the observation-execution (mirror) network. To inspect the neural underpinnings of the effects of social touch on pain, we scanned romantic couples during a task that required one partner (the empathizer) to hold the target's hand as the latter experienced painful thermal stimulation. Empathizers and target participants were scanned sequentially, in two counterbalanced phases. Results revealed that hand-holding reduced the pain of the target participant, compared to the severity of pain in a control condition (holding a rubber ball). Importantly, during social touch we found striking shared activations between the target and empathizer in the inferior parietal lobule (IPL), a region related to the observation-execution network. The brain-to-brain analysis further revealed a positive correlation of IPL activation levels between the target and the empathizer. Finally, psychophysiological interaction (PPI) analysis in the target showed that the IPL activity during social touch was positively coupled with activity in the dorsomedial prefrontal cortex, a region that has been implicated in emotion regulation, suggesting that the interaction between the observation-execution network and emotion regulation network may contribute to pain reduction during social touch.
    MeSH term(s) Brain/diagnostic imaging ; Brain Mapping ; Humans ; Magnetic Resonance Imaging ; Touch ; Touch Perception
    Language English
    Publishing date 2020-03-11
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2020.01.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 687: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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