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  1. Article ; Online: Protocol for

    Barbosa, Guilherme O / Kornberg, Thomas B

    STAR protocols

    2022  Volume 3, Issue 1, Page(s) 101138

    Abstract: This protocol describes how to image time and spatially resolved time lapses of Drosophila air sac primordium (ASP) cytonemes ... ...

    Abstract This protocol describes how to image time and spatially resolved time lapses of Drosophila air sac primordium (ASP) cytonemes in
    MeSH term(s) Animals ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Imaginal Discs ; Signal Transduction ; Time-Lapse Imaging
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101138
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  2. Article ; Online: Distributing signaling proteins in space and time: the province of cytonemes.

    Kornberg, Thomas B

    Current opinion in genetics & development

    2017  Volume 45, Page(s) 22–27

    Abstract: During development, cells use specialized filopodia called cytonemes to deploy the signaling proteins that coordinate growth and direct morphogenesis. Cytonemes are dynamic structures that can extend long distances across tissues to either deliver or ... ...

    Abstract During development, cells use specialized filopodia called cytonemes to deploy the signaling proteins that coordinate growth and direct morphogenesis. Cytonemes are dynamic structures that can extend long distances across tissues to either deliver or take up signaling proteins. Signaling proteins transfer between cells at the tips of cytonemes where specific contacts termed morphogenetic synapses form. This review summarizes our current understanding of the roles and functions of cytonemes, and it explores some of the conceptual issues relevant to the cytoneme mechanism of contact-dependent cell-cell signaling.
    MeSH term(s) Animals ; Cell Communication ; Extracellular Matrix/metabolism ; Models, Theoretical ; Paracrine Communication ; Proteins/metabolism ; Pseudopodia/metabolism ; Signal Transduction
    Chemical Substances Proteins
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2017.02.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3240: Show issues Location:
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  3. Article ; Online: Scripting a place in time.

    Kornberg, Thomas B

    Developmental biology

    2017  Volume 447, Issue 1, Page(s) 24–27

    Abstract: Evidence in many experimental systems supports the idea that non-uniform distributions of morphogen proteins encode positional information in developing tissues. There is also strong evidence that morphogen dispersal is mediated by cytonemes and that ... ...

    Abstract Evidence in many experimental systems supports the idea that non-uniform distributions of morphogen proteins encode positional information in developing tissues. There is also strong evidence that morphogen dispersal is mediated by cytonemes and that morphogen proteins transfer from producing to receiving cells at morphogenetic synapses that form at sites of cytoneme contacts. This essay considers some implications of this mechanism and its relevance to various contexts including large single cells such as the pre-cellular Drosophila embryo and the ciliate Stentor.
    MeSH term(s) Animals ; Ciliophora/cytology ; Ciliophora/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/embryology ; Morphogenesis/physiology ; Protozoan Proteins/metabolism ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; Protozoan Proteins
    Language English
    Publishing date 2017-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2017.09.014
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  4. Article ; Online: Macrophages Help Cells Connect to Pattern Zebrafish Stripes.

    Kornberg, Thomas B

    Developmental cell

    2017  Volume 40, Issue 6, Page(s) 520–521

    Abstract: Mechanisms that disseminate the proteins that orchestrate organ and tissue development have been a major focus of cell and developmental biology. Reporting in Science, Eom and Parichy (2017) characterize the role that macrophages play in facilitating ... ...

    Abstract Mechanisms that disseminate the proteins that orchestrate organ and tissue development have been a major focus of cell and developmental biology. Reporting in Science, Eom and Parichy (2017) characterize the role that macrophages play in facilitating long-distance signaling between the cells that make stripes in the adult zebrafish.
    MeSH term(s) Animals ; Body Patterning ; Macrophages ; Signal Transduction ; Zebrafish ; Zebrafish Proteins
    Chemical Substances Zebrafish Proteins
    Language English
    Publishing date 2017--27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2017.03.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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  5. Article: Scripting a place in time

    Kornberg, Thomas B

    Developmental biology. 2019 Mar. 01, v. 447, no. 1

    2019  

    Abstract: Evidence in many experimental systems supports the idea that non-uniform distributions of morphogen proteins encode positional information in developing tissues. There is also strong evidence that morphogen dispersal is mediated by cytonemes and that ... ...

    Abstract Evidence in many experimental systems supports the idea that non-uniform distributions of morphogen proteins encode positional information in developing tissues. There is also strong evidence that morphogen dispersal is mediated by cytonemes and that morphogen proteins transfer from producing to receiving cells at morphogenetic synapses that form at sites of cytoneme contacts. This essay considers some implications of this mechanism and its relevance to various contexts including large single cells such as the pre-cellular Drosophila embryo and the ciliate Stentor.
    Keywords Drosophila ; proteins ; synapse ; tissues
    Language English
    Dates of publication 2019-0301
    Size p. 24-27.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2017.09.014
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    In stock of ZB MED Bonn / Germany

    Z 76/715: Show issues

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  6. Article ; Online: Hedgehog produced by the

    Hatori, Ryo / Kornberg, Thomas B

    Development (Cambridge, England)

    2020  Volume 147, Issue 22

    Abstract: Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of ... ...

    Abstract Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the
    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Imaginal Discs/cytology ; Imaginal Discs/metabolism ; Signal Transduction ; Wings, Animal/cytology ; Wings, Animal/embryology
    Chemical Substances Drosophila Proteins ; Hedgehog Proteins ; bnl protein, Drosophila ; hh protein, Drosophila (149291-21-4) ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.195974
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    Ub I Zs.183: Show issues Location:
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  7. Article ; Online: A Path to Pattern.

    Kornberg, Thomas B

    Current topics in developmental biology

    2016  Volume 116, Page(s) 551–567

    Abstract: The field of developmental biology is not the same one that I entered in 1975. At that time, it seemed that most of its practitioners used various kinds of microscopes to watch animals as they matured, described morphological details with impressive ... ...

    Abstract The field of developmental biology is not the same one that I entered in 1975. At that time, it seemed that most of its practitioners used various kinds of microscopes to watch animals as they matured, described morphological details with impressive temporal and spatial resolution, and recorded responses to physical and genetic insults. The number of genes whose mutant phenotypes offered insights into developmental mechanisms was small, the expression and functionalities of these genes were unknown, and because the extent of evolutionary conservation between different animals or even different organs in the same animal was also unknown, the vocabularies that were used to describe development were unique to each system. The distance between the descriptors and inferred molecular mechanisms was vast; it was a descriptive discipline. Today genome sequences are available for the animals that developmental biologists study, saturation genetic screens are possible, transgenesis offers powerful ways to modify genomes, and the proteins that direct and implement developmental processes can be imaged in real time. These advances have transformed the field into one that merges with cell biology, physiology, neurobiology, and immunology, and they have transformed our understanding of development. In this essay, I offer my perspectives and my sense of some principles that have emerged.
    MeSH term(s) Animals ; Biological Evolution ; Developmental Biology ; Gene Regulatory Networks ; Genome ; Humans ; Phenotype ; Proteins/genetics
    Chemical Substances Proteins
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2015.11.026
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  8. Article ; Online: The contrasting roles of primary cilia and cytonemes in Hh signaling.

    Kornberg, Thomas B

    Developmental biology

    2014  Volume 394, Issue 1, Page(s) 1–5

    Abstract: Hedgehog (Hh) is a paracrine signaling protein with major roles in development and disease. In vertebrates and invertebrates, Hh signal transduction is carried out almost entirely by evolutionarily conserved components, and in both, intercellular ... ...

    Abstract Hedgehog (Hh) is a paracrine signaling protein with major roles in development and disease. In vertebrates and invertebrates, Hh signal transduction is carried out almost entirely by evolutionarily conserved components, and in both, intercellular movement of Hh is mediated by cytonemes - specialized filopodia that serve as bridges that bring distant cells into contact. A significant difference is the role of the primary cilium, a slender, tubulin-based protuberance of many vertebrate cells. Although the primary cilium is essential for Hh signaling in cells that have one, most Drosophila cells lack a primary cilium. This perspective addresses the roles of primary cilia and cytonemes, and proposes that for Hh signaling, the role of primary cilia is to provide a specialized hydrophobic environment that hosts lipid-modified Hh and other components of Hh signal transduction after Hh has traveled from elsewhere in the cell. Implicit in this model is the idea that initial binding and uptake of Hh is independent of and segregated from the processes of signal transduction and activation.
    MeSH term(s) Animals ; Cell Communication ; Cilia/metabolism ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Hedgehog Proteins/metabolism ; Hydrophobic and Hydrophilic Interactions ; Microtubules/metabolism ; Pseudopodia/metabolism ; Signal Transduction
    Chemical Substances Drosophila Proteins ; Hedgehog Proteins ; hh protein, Drosophila (149291-21-4)
    Language English
    Publishing date 2014-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2014.07.015
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  9. Article ; Online: Cytonemes and the dispersion of morphogens.

    Kornberg, Thomas B

    Wiley interdisciplinary reviews. Developmental biology

    2014  Volume 3, Issue 6, Page(s) 445–463

    Abstract: Filopodia are cellular protrusions that have been implicated in many types of mechanosensory activities. Morphogens are signaling proteins that regulate the patterned development of embryos and tissues. Both have long histories that date to the ... ...

    Abstract Filopodia are cellular protrusions that have been implicated in many types of mechanosensory activities. Morphogens are signaling proteins that regulate the patterned development of embryos and tissues. Both have long histories that date to the beginnings of cell and developmental biology in the early 20th century, but recent findings tie specialized filopodia called cytonemes to morphogen movement and morphogen signaling. This review explores the conceptual and experimental background for a model of paracrine signaling in which the exchange of morphogens between cells is directed to sites where cytonemes directly link cells that produce morphogens to cells that receive and respond to them.
    MeSH term(s) Animals ; Diffusion ; Humans ; Imaginal Discs/metabolism ; Morphogenesis ; Pseudopodia/metabolism ; Signal Transduction ; Synapses/metabolism
    Language English
    Publishing date 2014-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1759-7692
    ISSN (online) 1759-7692
    DOI 10.1002/wdev.151
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  10. Article ; Online: Regulated delivery controls

    Hatori, Ryo / Wood, Brent M / Oliveira Barbosa, Guilherme / Kornberg, Thomas B

    eLife

    2021  Volume 10

    Abstract: Morphogen signaling proteins disperse across tissues to activate signal transduction in target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and Bone morphogenic protein homolog Decapentaplegic (Dpp) in ... ...

    Abstract Morphogen signaling proteins disperse across tissues to activate signal transduction in target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and Bone morphogenic protein homolog Decapentaplegic (Dpp) in the
    MeSH term(s) Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Imaginal Discs/metabolism ; Morphogenesis ; Signal Transduction ; Wings, Animal/embryology ; Wnt1 Protein/genetics ; Wnt1 Protein/metabolism
    Chemical Substances Drosophila Proteins ; Hedgehog Proteins ; Wnt1 Protein ; dpp protein, Drosophila ; wg protein, Drosophila ; hh protein, Drosophila (149291-21-4)
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.71744
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