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  1. Article ; Online: We asked the experts: Normalize challenges, build community, and develop mentorship: A guide for proactive institutional support for child rearing during surgical training.

    Colley, Alexis / Yap, Ava / Trang, Karen / Kornblith, Lucy Z / Varma, Madhulika G / Vu, Lan

    World journal of surgery

    2024  Volume 48, Issue 3, Page(s) 524–526

    MeSH term(s) Humans ; Child ; Mentors ; Child Rearing ; Surveys and Questionnaires
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1002/wjs.12095
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    Zs.A 1336: Show issues Location:
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  2. Article ; Online: The intersection of coagulation activation and inflammation after injury: What you need to know.

    Costantini, Todd W / Kornblith, Lucy Z / Pritts, Timothy / Coimbra, Raul

    The journal of trauma and acute care surgery

    2023  Volume 96, Issue 3, Page(s) 347–356

    MeSH term(s) Humans ; Blood Coagulation ; Inflammation
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000004190
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    Zs.A 127: Show issues Location:
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  3. Article ; Online: "Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Reply.

    Matthay, Zachary A / Fields, Alexander T / Kornblith, Lucy Z

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 11, Page(s) 2717–2718

    MeSH term(s) Humans ; Catecholamines ; Blood Platelets ; Platelet Aggregation Inhibitors
    Chemical Substances Catecholamines ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15869
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  4. Article ; Online: Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.

    Kornblith, Lucy Z / Sadhanandhan, Bindhya / Arun, Sreepriya / Long, Rebecca / Johnson, Alicia J / Noll, Jamie / Ramchand, C N / Olynyk, John K / Farrell, David H

    Blood cells, molecules & diseases

    2024  Volume 105, Page(s) 102825

    MeSH term(s) Humans ; Fibrinogen ; COVID-19/diagnosis ; Biomarkers ; Risk Factors ; Blood Coagulation Tests
    Chemical Substances Fibrinogen (9001-32-5) ; Biomarkers
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2024.102825
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    Zs.A 1138: Show issues Location:
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  5. Article ; Online: Response to Letter to the Editor submitted by Dr. Gando and Dr. Otomo re: Trauma-induced coagulopathy: The past, present, and future.

    Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

    Journal of thrombosis and haemostasis : JTH

    2019  Volume 17, Issue 9, Page(s) 1569–1571

    MeSH term(s) Blood Coagulation Disorders ; Humans ; Wounds and Injuries
    Language English
    Publishing date 2019-08-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14533
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  6. Article ; Online: Trauma-induced coagulopathy: The past, present, and future.

    Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

    Journal of thrombosis and haemostasis : JTH

    2019  Volume 17, Issue 6, Page(s) 852–862

    Abstract: Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result ... ...

    Abstract Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result in hemostatic failure, which has been identified as a multidimensional molecular, physiologic and clinical disorder termed trauma-induced coagulopathy (TIC). Understanding the biology of TIC is of utmost importance, as it is often responsible for uncontrolled bleeding, organ failure, thromboembolic complications, and death. Investigations have shown that TIC is characterized by multiple phenotypes of impaired hemostasis due to altered biology in clot formation and breakdown. These coagulopathies are attributable to tissue injury and shock, and encompass underlying endothelial, immune and inflammatory perturbations. Despite the recognition and identification of multiple mechanisms and mediators of TIC, and the development of targeted treatments, the mortality rates and associated morbidities due to hemorrhage after injury remain high. The purpose of this review is to examine the past and present understanding of the multiple distinct but highly integrated pathways implicated in TIC, in order to highlight the current knowledge gaps and future needs in this evolving field, with the aim of reducing morbidity and mortality after injury.
    MeSH term(s) Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/etiology ; Blood Coagulation Factors/metabolism ; Blood Platelets/physiology ; Endothelium/metabolism ; Exsanguination/blood ; Exsanguination/etiology ; Fibrinolysis ; Hemorrhage/blood ; Hemorrhage/etiology ; Hemostasis ; Humans ; Protein C/metabolism ; Shock, Hemorrhagic/blood ; Shock, Hemorrhagic/etiology ; Wounds and Injuries/blood ; Wounds and Injuries/complications
    Chemical Substances Blood Coagulation Factors ; Protein C
    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14450
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  7. Article ; Online: Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma-induced coagulopathy: The past, present, and future.

    Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

    Journal of thrombosis and haemostasis : JTH

    2019  Volume 17, Issue 9, Page(s) 1574–1576

    MeSH term(s) Blood Coagulation Disorders ; Humans ; Wounds and Injuries
    Language English
    Publishing date 2019-09-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14581
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  8. Article ; Online: Response: the whole is greater than the sum of its parts: hemostatic profiles of whole-blood variants.

    Kornblith, Lucy Z / Cohen, Mitchell Jay

    The journal of trauma and acute care surgery

    2014  Volume 77, Issue 6, Page(s) 1003–1004

    MeSH term(s) Blood Platelets/physiology ; Erythrocytes/physiology ; Hemostasis/physiology ; Humans ; Plasma/physiology
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000000475
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    Zs.A 127: Show issues Location:
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  9. Article ; Online: Alterations in platelet behavior after major trauma: adaptive or maladaptive?

    Vulliamy, Paul / Kornblith, Lucy Z / Kutcher, Matthew E / Cohen, Mitchell J / Brohi, Karim / Neal, Matthew D

    Platelets

    2020  Volume 32, Issue 3, Page(s) 295–304

    Abstract: Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior. During the acute post-injury phase, ... ...

    Abstract Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior. During the acute post-injury phase, platelets develop a state of impaired
    MeSH term(s) Blood Platelets/pathology ; Female ; Humans ; Male ; Platelet Count/methods ; Wounds and Injuries/blood
    Language English
    Publishing date 2020-01-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1718633
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    Zs.A 2888: Show issues Location:
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  10. Article ; Online: Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial.

    Walborn, Amanda T / Heath, Anna / Neal, Matthew D / Zarychanski, Ryan / Kornblith, Lucy Z / Hunt, Beverley J / Castellucci, Lana A / Hochman, Judith S / Lawler, Patrick R / Paul, Jonathan D

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 7, Page(s) 102203

    Abstract: Background: Patients hospitalized for COVID-19 are at high risk of thrombotic complications and organ failure, and often exhibit severe inflammation, which may contribute to hypercoagulability.: Objectives: To determine whether patients hospitalized ... ...

    Abstract Background: Patients hospitalized for COVID-19 are at high risk of thrombotic complications and organ failure, and often exhibit severe inflammation, which may contribute to hypercoagulability.
    Objectives: To determine whether patients hospitalized for COVID-19 experience differing frequencies of thrombotic and organ failure complications and derive variable benefits from therapeutic-dose heparin dependent on the extent of systemic inflammation and whether observed benefit from therapeutic-dose anticoagulation varies depending on the degree of systemic inflammation.
    Methods: We analyzed data from 1346 patients hospitalized for COVID-19 enrolled in the ATTACC and ACTIV-4a platforms who were randomized to therapeutic-dose heparin or usual care for whom levels of C-reactive protein (CRP) were reported at baseline.
    Results: Increased CRP was associated with worse patient outcomes, including a >98% posterior probability of increased organ support requirement, hospital length of stay, risk of 28-day mortality, and incidence of major thrombotic events or death (patients with CRP 40-100 mg/L or ≥100 mg/L compared to patients with CRP <40 mg/L). Patients with CRP 40 to 100 mg/L experienced the greatest degree of benefit from treatment with therapeutic doses of unfractionated or low molecular weight heparin compared with usual-care prophylactic doses. This was most significant for an increase in organ support-free days (odds ratio: 1.63; 95% confidence interval, 1.09-2.40; 97.9% posterior probability of beneficial effect), with trends toward benefit for other evaluated outcomes.
    Conclusion: Moderately ill patients hospitalized for COVID-19 with CRP between 40 mg/L and 100 mg/L derived the greatest benefit from treatment with therapeutic-dose heparin.
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.102203
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