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  1. Book: Demenzdiagnostik

    Stemmler, Mark / Kornhuber, Johannes

    (Kompendien Psychologische Diagnostik ; Band 16)

    2018  

    Author's details Mark Stemmler, Johannes Kornhuber
    Series title Kompendien Psychologische Diagnostik ; Band 16
    Kompendien psychologische Diagnostik
    Collection Kompendien psychologische Diagnostik
    Keywords Demenzielle Erkrankung ; Psychologische Diagnostik ; Diagnostik ; Neuropsychologie ; Alzheimer ; Gerontologie ; Geriatrie ; Psychiatrie ; Neurologie ; Altern ; Demenz
    Subject Diagnostik ; Diagnostische Psychologie ; Psychodiagnostik ; Anoia ; Dementia ; Chronische Verwirrtheit
    Subject code 150
    Language German
    Size 186 Seiten, Illustrationen
    Edition 1. Auflage
    Publisher Hogrefe
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    HBZ-ID HT019585104
    ISBN 978-3-8017-2760-4 ; 3-8017-2760-2 ; 9783840927607 ; 9783844427608 ; 3840927609 ; 3844427600
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2018 A 1009 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Valence-dependent effects of neuropeptide Y on the expression of conditioned fear and anxiety-like behavior: Involvement of the bed nucleus of the stria terminalis.

    Kornhuber, Johannes / Zoicas, Iulia

    Neuropharmacology

    2024  Volume 246, Page(s) 109847

    Abstract: Neuropeptide Y (NPY) has anxiolytic-like effects and facilitates the extinction of cued and contextual fear in rodents. We have previously shown that intracerebroventricular administration of NPY reduces the expression of social fear via simultaneous ... ...

    Abstract Neuropeptide Y (NPY) has anxiolytic-like effects and facilitates the extinction of cued and contextual fear in rodents. We have previously shown that intracerebroventricular administration of NPY reduces the expression of social fear via simultaneous activation of Y1 and Y2 receptors in a mouse model of social fear conditioning (SFC). In the present study, we investigated whether the anteroventral bed nucleus of the stria terminalis (BNSTav) mediates these effects of NPY, given the important role of BNSTav in regulating anxiety- and fear-related behaviors. We show that while NPY (0.1 nmol/0.2 μl/side) did not reduce the expression of SFC-induced social fear in male CD1 mice, it reduced the expression of both cued and contextual fear by acting on Y2 but not on Y1 receptors within the BNSTav. Prior administration of the Y2 receptor antagonist BIIE0246 (0.2 nmol/0.2 μl/side) but not of the Y1 receptor antagonist BIBO3304 trifluoroacetate (0.2 nmol/0.2 μl/side) blocked the effects of NPY on the expression of cued and contextual fear. Similarly, NPY exerted non-social anxiolytic-like effects in the elevated plus maze test but not social anxiolytic-like effects in the social approach avoidance test by acting on Y2 receptors and not on Y1 receptors within the BNSTav. These results suggest that administration of NPY within the BNSTav exerts robust Y2 receptor-mediated fear-reducing and anxiolytic-like effects specifically in non-social contexts and add a novel piece of evidence regarding the neural underpinnings underlying the effects of NPY on conditioned fear and anxiety-like behavior.
    MeSH term(s) Male ; Mice ; Animals ; Neuropeptide Y/pharmacology ; Neuropeptide Y/metabolism ; Receptors, Neuropeptide Y/metabolism ; Anti-Anxiety Agents/pharmacology ; Septal Nuclei/metabolism ; Anxiety/drug therapy ; Fear ; Anterior Thalamic Nuclei/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y ; Anti-Anxiety Agents
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2024.109847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Demenzerkrankungen und Morbus Alzheimer

    Kornhuber, Johannes

    (UNI-MED Science)

    2005  

    Author's details [Johannes Kornhuber ...]
    Series title UNI-MED Science
    Keywords Senile Demenz ; Alzheimerkrankheit
    Subject Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease ; Altersdemenz ; Dementia senilis ; Altersverwirrtheit ; Altersverwirrung ; Alter ; Greisenalter ; Altersschwachsinn ; Altersblödsinn
    Language German
    Size 124 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014589866
    ISBN 3-89599-802-8 ; 978-3-89599-802-7
    Database Catalogue ZB MED Medicine, Health

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    2005 A 6000 order for loan Magazin

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  4. Article ; Online: Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma.

    Mühle, Christiane / Kornhuber, Johannes

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Alterations of sphingolipids and their metabolizing enzymes play a role in various diseases. However, peripheral biomarkers for such changes are limited. Particularly, in the increasingly reported involvement of neutral sphingomyelinase (NSM) with four ... ...

    Abstract Alterations of sphingolipids and their metabolizing enzymes play a role in various diseases. However, peripheral biomarkers for such changes are limited. Particularly, in the increasingly reported involvement of neutral sphingomyelinase (NSM) with four described isoforms in tissues or cells, a peripheral marker is lacking. We here describe the detection of an NSM activity in human serum and plasma samples which hydrolyses fluorescently labeled sphingomyelin to ceramide in a time- and volume-dependent manner. Reaction rates were linear up to 10 days, and serum volumes above 2 vol-% were inhibitory. Biochemical properties were different from acid sphingomyelinase (ASM) with respect to detergent specificity (sodium deoxycholate), pH profile (pH 7-9), and cation dependence: Serum NSM activity was inhibited by EDTA ≥ 1 µM and restored in EDTA-anticoagulated plasma with the addition of ≥ 100 µM Co
    MeSH term(s) Adult ; Humans ; Sphingomyelin Phosphodiesterase ; Edetic Acid/pharmacology ; Sphingolipids ; Ceramides ; Sphingomyelins ; Biomarkers
    Chemical Substances Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Edetic Acid (9G34HU7RV0) ; Sphingolipids ; Ceramides ; Sphingomyelins ; Biomarkers
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blind – ohne es zu bemerken.

    Kornhuber, Johannes

    Fortschritte der Neurologie-Psychiatrie

    2019  Volume 87, Issue 2, Page(s) 90–91

    Title translation Blind - without noticing.
    MeSH term(s) Agnosia/complications ; Agnosia/psychology ; Blindness, Cortical/complications ; Blindness, Cortical/physiopathology ; Blindness, Cortical/psychology ; Humans ; Mental Competency ; Metacognition ; Self Concept
    Language German
    Publishing date 2019-02-25
    Publishing country Germany
    Document type Editorial
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-0802-9679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Warum sind Suizide stationärer Patienten so belastend?

    Kornhuber, Johannes

    Fortschritte der Neurologie-Psychiatrie

    2018  Volume 86, Issue 4, Page(s) 211–212

    Title translation Why are suicides of inpatients so burdensome?
    MeSH term(s) Hospitals, Psychiatric ; Humans ; Inpatients/psychology ; Mental Disorders/psychology ; Risk Assessment ; Suicide/psychology
    Language German
    Publishing date 2018-04-24
    Publishing country Germany
    Document type Editorial
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-0564-8822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gustav Nikolaus Specht (1860–1940): psychiatric practice, research and teaching during a change of psychiatric paradigm before and after Kraepelin.

    Braun, Birgit / Kornhuber, Johannes

    History of psychiatry

    2022  Volume 33, Issue 2, Page(s) 143–162

    Abstract: Gustav Specht (1860-1940) developed academic psychiatry in Erlangen. After studying medicine in Würzburg, Munich and Berlin, he became assistant medical director in the mental asylum of Erlangen. In 1897 he was appointed extraordinary, and in 1903 ... ...

    Abstract Gustav Specht (1860-1940) developed academic psychiatry in Erlangen. After studying medicine in Würzburg, Munich and Berlin, he became assistant medical director in the mental asylum of Erlangen. In 1897 he was appointed extraordinary, and in 1903 ordinary, Professor of Psychiatry. A good clinician and teacher, Specht worked during a time of paradigm change in psychiatry. He was an expert in chronic mania, and introduced the concept of the 'grumbler's delusion'. Paranoia he believed to be the core problem of psychopathology and considered the depressive syndrome as an 'exogenous-type' of reaction. For him, trauma was important in the genesis of mental illness, and his 'hystero-melancholy' anticipated the concept of borderline personality disorder.
    MeSH term(s) Depression ; History, 20th Century ; Hospitals, Psychiatric/history ; Humans ; Paranoid Disorders ; Psychiatry/history ; Psychopathology
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X211069755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acid Sphingomyelinase Is a Modulator of Contextual Fear.

    Zoicas, Iulia / Kornhuber, Johannes

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Acid sphingomyelinase (ASM) regulates a variety of physiological processes and plays an important role in emotional behavior. The role of ASM in fear-related behavior has not been investigated so far. Using transgenic mice overexpressing ASM (ASMtg) and ... ...

    Abstract Acid sphingomyelinase (ASM) regulates a variety of physiological processes and plays an important role in emotional behavior. The role of ASM in fear-related behavior has not been investigated so far. Using transgenic mice overexpressing ASM (ASMtg) and ASM deficient mice, we studied whether ASM regulates fear learning and expression of cued and contextual fear in a classical fear conditioning paradigm, a model used to investigate specific attributes of post-traumatic stress disorder (PTSD). We show that ASM does not affect fear learning as both ASMtg and ASM deficient mice display unaltered fear conditioning when compared to wild-type littermates. However, ASM regulates the expression of contextual fear in a sex-specific manner. While ASM overexpression enhances the expression of contextual fear in both male and female mice, ASM deficiency reduces the expression of contextual fear specifically in male mice. The expression of cued fear, however, is not regulated by ASM as ASMtg and ASM deficient mice display similar tone-elicited freezing levels. This study shows that ASM modulates the expression of contextual fear but not of cued fear in a sex-specific manner and adds a novel piece of information regarding the involvement of ASM in hippocampal-dependent aversive memory.
    MeSH term(s) Animals ; Conditioning, Classical/physiology ; Cues ; Fear/physiology ; Female ; Male ; Memory/physiology ; Mice ; Sphingomyelin Phosphodiesterase/genetics
    Chemical Substances Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ein neuer werkbiographischer Ansatz zu Karl Leonhard: Seine Rolle als Psychiater im Nationalsozialismus und seine wissenschaftliche Prägung durch die „Erlanger Schule“.

    Braun, Birgit / Kornhuber, Johannes

    Fortschritte der Neurologie-Psychiatrie

    2022  Volume 91, Issue 1-02, Page(s) 24–31

    Abstract: Aim: The aim of this study was to present a new approach to the life and oeuvre of Karl Leonhard, focussing on his role as a psychiatrist during the period of national socialism and on his scientific affiliation to the "Erlangen school".: Method: For ...

    Title translation A New Approach to the Life and Oeuvre of Karl Leonhard: His Role as a Psychiatrist under National Socialism and the Influence of "Erlangen School" on his Scientific Position.
    Abstract Aim: The aim of this study was to present a new approach to the life and oeuvre of Karl Leonhard, focussing on his role as a psychiatrist during the period of national socialism and on his scientific affiliation to the "Erlangen school".
    Method: For the first time, documents from Franconian archives have been evaluated.
    Results: At the University Hospital of Psychiatry in Erlangen, Leonhard described psychopathological states in a very detailed manner as a main component of his phenomenological approach. Although Leonhard was classified as a "follower" during his denazification, temporarily he was "incriminated" due to a denunciation.
    Conclusion: Leonhard as an opportunist supported the NS racial hygiene without any actual eugenic orientation. Further studies are needed to clarify Leonhard's proclaimed active opposition to NS "euthanasia".
    MeSH term(s) Humans ; History, 20th Century ; National Socialism ; Psychiatry/education ; Psychopathology ; Schools ; Eugenics ; Germany
    Language German
    Publishing date 2022-04-11
    Publishing country Germany
    Document type Historical Article ; English Abstract ; Journal Article
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-1685-0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Therapierefraktäre erstmalige Depression im mittleren Lebensalter.

    Grotemeyer, Alexander / Kornhuber, Johannes / Spitzer, Philipp

    Der Nervenarzt

    2023  Volume 94, Issue 9, Page(s) 855–858

    Title translation Treatment-resistant first-time depression in middle age.
    MeSH term(s) Humans ; Middle Aged ; Depression
    Language German
    Publishing date 2023-08-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-023-01530-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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