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  1. Article: [The opinions of social workers concerning means of development of medical social care of population].

    Korolev, M A

    Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

    2022  Volume 30, Issue 2, Page(s) 259–263

    Abstract: The article reflects main problems and opinions of social workers about possibilities of improving medical social care of population and providing social medical services. This group of specialists is forced to implement significant amount of work that ... ...

    Abstract The article reflects main problems and opinions of social workers about possibilities of improving medical social care of population and providing social medical services. This group of specialists is forced to implement significant amount of work that is not regulated by their official duties. The lack of necessary competencies does not allow social workers to provide medical social assistance to consumers of medical social services to sufficient extent. To ensure interaction between medical and social workers largely falls on shoulders of the latter ones. They have to undertake a number of medical functions (examination, temporary stop of bleeding, blood pressure measurement, etc.). It conceives appropriate to transfer some of functions of junior and paramedical staff to social workers. The study results can be applied as methodological basis of increasing accessibility of medical social care and provided social and medical services to various groups of population.
    MeSH term(s) Humans ; Patient Care ; Social Support ; Social Work ; Social Workers
    Language Russian
    Publishing date 2022-04-19
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1483853-9
    ISSN 0869-866X
    ISSN 0869-866X
    DOI 10.32687/0869-866X-2022-30-2-259-263
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    Zs.A 5088: Show issues Location:
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  2. Article: The Interleukine-17 Cytokine Family: Role in Development and Progression of Spondyloarthritis, Current and Potential Therapeutic Inhibitors.

    Davydova, Anna / Kurochkina, Yuliya / Goncharova, Veronika / Vorobyeva, Mariya / Korolev, Maksim

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory rheumatic diseases with a predilection for the spinal and sacroiliac joints, which include axial spondyloarthritis, psoriatic arthritis, reactive arthritis, arthritis associated with ... ...

    Abstract Spondyloarthritis (SpA) encompasses a group of chronic inflammatory rheumatic diseases with a predilection for the spinal and sacroiliac joints, which include axial spondyloarthritis, psoriatic arthritis, reactive arthritis, arthritis associated with chronic inflammatory bowel disease, and undifferentiated spondyloarthritis. The prevalence of SpA in the population varies from 0.5 to 2%, most commonly affecting young people. Spondyloarthritis pathogenesis is related to the hyperproduction of proinflammatory cytokines (TNFα, IL-17A, IL-23, etc.). IL-17A plays a key role in the pathogenesis of spondyloarthritis (inflammation maintenance, syndesmophites formation and radiographic progression, enthesites and anterior uveitis development, etc.). Targeted anti-IL17 therapies have established themselves as the most efficient therapies in SpA treatment. The present review summarizes literature data on the role of the IL-17 family in the pathogenesis of SpA and analyzes existing therapeutic strategies for IL-17 suppression with monoclonal antibodies and Janus kinase inhibitors. We also consider alternative targeted strategies, such as the use of other small-molecule inhibitors, therapeutic nucleic acids, or affibodies. We discuss advantages and pitfalls of these approaches and the future prospects of each method.
    Language English
    Publishing date 2023-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051328
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  3. Article ; Online: Intracellular organelles remodeling in myocardial endotheliocytes in COVID-19: an autopsy-based study.

    Bgatova, Nataliya / Savchenko, Sergey / Lamanov, Alexei / Taskaeva, Iuliia / Ayzikovich, Boris / Gritcinger, Valentina / Letyagin, Andrey / Korolev, Maksim

    Ultrastructural pathology

    2024  Volume 48, Issue 1, Page(s) 66–74

    Abstract: It is known that the unfavorable outcome in patients infected with SARS-CoV-2 may be associated with the development of complications caused by heart damage due to the direct virus action. The mechanism of these cardiovascular injuries caused by SARS-CoV- ...

    Abstract It is known that the unfavorable outcome in patients infected with SARS-CoV-2 may be associated with the development of complications caused by heart damage due to the direct virus action. The mechanism of these cardiovascular injuries caused by SARS-CoV-2 infection has not been fully understood; however, the study of COVID-19-associated myocardial microcirculatory dysfunction can represent the useful strategy to solving this challenge. Thus, here we aimed to study the ultrastructural organization of endothelial cells of myocardial capillaries in patients with COVID-19. The morphology of endotheliocytes of the myocardial blood capillaries in patients with COVID-19 was studied on cardiac autopsy material using transmission electron microscopy. The endotheliocytes of myocardial capillaries in patients with COVID-19 were characterized by the abundant rough endoplasmic reticulum (ER) membranes, the Golgi complex, and free polysomal complexes of ribosomes and lipids. The presence of double membrane vesicles with virions and zippered ER was detected in the cytoplasm of endotheliocytes. The revealed endothelial ultrastructural changes indicate the remodeling of intracellular membranes during SARS-CoV-2 infection. Our findings confirm the formation of virus-induced structures in myocardial endothelial cells considered critical for viral replication and assembly. The data may elucidate the mechanisms of endothelial dysfunction development in patients with COVID-19 to provide potential targets for drug therapy.
    MeSH term(s) Humans ; COVID-19 ; Endoplasmic Reticulum/ultrastructure ; Endothelial Cells ; Microcirculation ; SARS-CoV-2 ; Autopsy
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 603269-2
    ISSN 1521-0758 ; 0191-3123
    ISSN (online) 1521-0758
    ISSN 0191-3123
    DOI 10.1080/01913123.2023.2286977
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  4. Article ; Conference proceedings: Poem In Children

    Korolev, M / Fedotov, L / Ogloblin, A / Mamedov, S / Fedotov, B

    Endoscopy

    2021  Volume 53, Issue S 01

    Event/congress ESGE Days 2021, Going virtual. Staying real., 2021-03-25
    Language English
    Publishing date 2021-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0041-1724945
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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  5. Article: Antioxidant properties of soils and associated vegetation in the polar urals

    Shamrikova, E.V. / Shevchenko, O.G. / Zhangurov, E.V. / Korolev, M.A.

    Catena. 2022 Jan., v. 208

    2022  

    Abstract: The increase in global air temperatures and climate aridization, associated with climate change, contribute to the biodegradation of soil organic matter (SOM) which is crucial for the ecosystems in cold and humid environments. SOM of the high-latitude ... ...

    Abstract The increase in global air temperatures and climate aridization, associated with climate change, contribute to the biodegradation of soil organic matter (SOM) which is crucial for the ecosystems in cold and humid environments. SOM of the high-latitude mountain systems might be more vulnerable to temperature growth compared to that of plain landscapes due to higher soil drainage and solar irradiation. Thus, it is important to study the biochemical processes underlying the conservation of biomolecules of organic residues in these environments. Even though antioxidants might in principle contribute to stabilization of SOM, at the moment there is no established theory about the sources of soil antioxidant activity (AOA) and the mechanisms of its realization. In particular, in the relevant literature there is no data on the AOA of cryogenic soils. In this study we assess the antioxidant activity (radical scavenging activity and the ability to inhibit the initiated lipid peroxidation) of soil extracts from mountain tundra and meadows in Polar Ural (Russia) in model biological substrate. We show that SOM from sites with closed vegetation is less susceptible to oxidative degradation due to the high content of amino acids, organic forms of C and N including their water-soluble fractions, and low C/N ratio. On sites with scarce vegetation, soils exhibit low AOA and are vulnerable to the increase in temperature and aeration. Decreased AOA, low productivity of tundra plant communities, and the occurrence of large bare spots (up to 70% of the habitat) make these ecosystems most sensitive to climate change.
    Keywords Russia ; aeration ; air ; antioxidant activity ; antioxidants ; biodegradation ; catenas ; climate change ; cold ; drainage ; habitats ; latitude ; lipid peroxidation ; soil ; soil organic matter ; solar radiation ; tundra ; water solubility
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 519608-5
    ISSN 1872-6887 ; 0008-7769 ; 0341-8162
    ISSN (online) 1872-6887 ; 0008-7769
    ISSN 0341-8162
    DOI 10.1016/j.catena.2021.105722
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    In stock of ZB MED Bonn / Germany

    Z 3389: Show issues

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  6. Article: [The response to the article of E. A. Korymasov concerning the article "proceedings of the organization of treatment and diagnostic assistance in non-varicose gastrointestinal bleedings"].

    Korolev, M P

    Vestnik khirurgii imeni I. I. Grekova

    2013  Volume 172, Issue 4, Page(s) 87–89

    MeSH term(s) Diagnostic Imaging/methods ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Hemostasis, Surgical/methods ; Humans ; Periodicals as Topic
    Language Russian
    Publishing date 2013
    Publishing country Russia (Federation)
    Document type Letter
    ZDB-ID 603433-0
    ISSN 0042-4625
    ISSN 0042-4625
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    Zs.B 747: Show issues Location:
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  7. Article ; Online: Clinical Diagnostic Value of Dkk-1 Level in Ankylosing Spondylitis: Comparison of Test Systems Based on Aptamers and Antibodies.

    Vorobyeva, M A / Shatunova, E A / Kolpakov, K I / Kurochkina, Yu D / Korolev, M A

    Bulletin of experimental biology and medicine

    2022  Volume 173, Issue 3, Page(s) 317–321

    Abstract: In ankylosing spondylitis, the pathological metabolism of the bone tissue is regulated by various proteins; of these, Dkk-1 protein, an antagonist of the Wnt-signaling pathway, is of particular interest. We compared the methods of Dkk-1 detection in the ... ...

    Abstract In ankylosing spondylitis, the pathological metabolism of the bone tissue is regulated by various proteins; of these, Dkk-1 protein, an antagonist of the Wnt-signaling pathway, is of particular interest. We compared the methods of Dkk-1 detection in the blood serum of patients with ankylosing spondylitis (conventional ELISA and aptamer/antibody assay) and analyzed the relationship between Dkk-1 level and structural progression of ankylosing spondylitis and secondary osteoporosis. Dkk-1 levels in patients were significantly increased and depended on the stage of the disease, but not on the presence/absence of osteoporosis. Thus, Dkk-1 is a potential serum marker of progression of ankylosing spondylitis reflecting a tendency to structural progression of the disease before the appearance of radiographic changes. The results obtained by both methods practically coincided, which suggests good prospects for applying DNA aptamer-based test system.
    MeSH term(s) Antibodies ; Biomarkers ; Humans ; Intercellular Signaling Peptides and Proteins ; Osteoporosis ; Spondylitis, Ankylosing/diagnosis ; Wnt Signaling Pathway
    Chemical Substances Antibodies ; Biomarkers ; Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-022-05541-z
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    Zs.A 56: Show issues Location:
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  8. Article ; Conference proceedings: Work Of The Endoscopic Department Of A Multi-Specialty Hospital In The Context Of A Pandemic Covid-19

    Antipova, M / Rusanov, D / Ogloblin, A / Zarubova, I / Taronishvili, A / Korolev, M

    Endoscopy

    2021  Volume 53, Issue S 01

    Event/congress ESGE Days 2021, Going virtual. Staying real., 2021-03-25
    Language English
    Publishing date 2021-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0041-1724979
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  9. Article: Composition of Water Extracts from Plant Material and Soils on Calcareous Rocks and of Surface Water in the Northern Part of the Polar Urals

    Shamrikova, E. V. / Zhangurov, E. V. / Kubik, O. S. / Korolev, M. A.

    Eurasian soil science. 2021 Aug., v. 54, no. 8

    2021  

    Abstract: A comparative analysis of the chemical composition and properties of water-soluble compounds of the soils on calcareous rocks, aboveground phytomass, and waters is performed for the northern part of the Bolshoi Paipudynsky Ridge (Polar Urals, Russia). ... ...

    Abstract A comparative analysis of the chemical composition and properties of water-soluble compounds of the soils on calcareous rocks, aboveground phytomass, and waters is performed for the northern part of the Bolshoi Paipudynsky Ridge (Polar Urals, Russia). Potassium and calcium ions (45–60 and 30–45%, respectively) are prevalent in the water extracts of plant material. From the O horizon to mineral horizons, the content of Ca²⁺ ions in water extracts increases from 50–70 to 80–90% with a concurrent decrease in the content of K⁺ ions from 12–34% (O horizon) to zero (mineral horizons). Uniform compositions of surface waters and water extracts of lower soil horizons reflect the specific features inherited from the soils of the catchment area. The properties of the group of humus horizons—gray-humus (AY), mucky–dark-humus (AH), and mucky (H)—are most variable. The water extracts of the phytomass contain 8–106 g/kg Cₒᵣg, 0.4–5.8 g/kg Nₒᵣg, and 1.5–32 g/kg soluble salts. The contents of all these components in water extracts by the O horizon decreases by 1–1.5 orders of magnitude and further by 1–2 orders of magnitude in the mineral horizons. The surface waters are ultrafresh. In the absence of organic compounds, their acid–base properties are mainly controlled by carbonates and bicarbonates of alkaline and alkaline- earth metals.
    Keywords Russia ; calcium ; humus ; organic horizons ; phytomass ; potassium ; surface water ; water solubility ; watersheds
    Language English
    Dates of publication 2021-08
    Size p. 1161-1175.
    Publishing place Pleiades Publishing
    Document type Article
    ZDB-ID 1131509-x
    ISSN 1556-195X ; 1064-2293
    ISSN (online) 1556-195X
    ISSN 1064-2293
    DOI 10.1134/S1064229321080159
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    Z 1293: Show issues

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  10. Article ; Conference proceedings: DIAGNOSIS AND TREATMENT OF PATIENTS SUFFERING FROM AUTOIMMUNE DISEASES OF THE ESOPHAGUS, COMPLICATED BY BENIGH STRICTURE

    Korolev, M / Fedotov, L / Ogloblin, A / Fedotov, B / Luchinina, D

    Endoscopy

    2019  Volume 51, Issue 04

    Event/congress ESGE Days 2019, Prague, Czech Republic, 2019-04-04
    Language English
    Publishing date 2019-03-18
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0039-1681886
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