LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Book ; Thesis: Functional expression of tandem pore domain potassium channels in oligodendroglial cells

    Korr, Sabrina

    2015  

    Author's details vorgelegt von Sabrina Korr
    Language English
    Size VII, 110 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2015
    Note Zsfassung in dt. Sprache
    HBZ-ID HT019119740
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 MB 22 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The K

    Albrecht, Stefanie / Korr, Sabrina / Nowack, Luise / Narayanan, Venu / Starost, Laura / Stortz, Franziska / Araúzo-Bravo, Marcos J / Meuth, Sven G / Kuhlmann, Tanja / Hundehege, Petra

    Glia

    2019  Volume 67, Issue 5, Page(s) 870–883

    Abstract: In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult ... ...

    Abstract In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult oligodendroglial progenitor cells; a process called remyelination. However, remyelination often fails in multiple sclerosis due to insufficient recruitment and differentiation of oligodendroglial precursor cells. A pivotal role for the two-pore-domain potassium (K
    MeSH term(s) Anesthetics, Local/pharmacology ; Animals ; Animals, Newborn ; Bupivacaine/pharmacology ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Movement/drug effects ; Cell Movement/genetics ; Cells, Cultured ; Cuprizone/toxicity ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/genetics ; Demyelinating Diseases/pathology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Monoamine Oxidase Inhibitors/toxicity ; Myelin Proteins/genetics ; Myelin Proteins/metabolism ; Myelin Proteins/ultrastructure ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Oligodendrocyte Precursor Cells/drug effects ; Oligodendrocyte Precursor Cells/physiology ; Oligodendrocyte Precursor Cells/ultrastructure ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism ; Oligodendroglia/physiology ; Oligodendroglia/ultrastructure ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Transcription Factors/metabolism ; Transcription Factors/pharmacology
    Chemical Substances Anesthetics, Local ; Monoamine Oxidase Inhibitors ; Myelin Proteins ; Nerve Tissue Proteins ; Potassium Channels, Tandem Pore Domain ; Transcription Factors ; potassium channel subfamily K member 3 (1HQ3YCN4GS) ; Cuprizone (5N16U7E0AO) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.23577
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A receptor fusion protein for the inhibition of murine oncostatin M

    Vogt Michael / Korr Sabrina / Küster Andrea / Brolund Liv / Müller-Newen Gerhard

    BMC Biotechnology, Vol 11, Iss 1, p

    2011  Volume 3

    Abstract: Abstract Background Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors useful ... ...

    Abstract Abstract Background Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors useful in anti-cytokine therapy and cytokine research. Results We constructed receptor fusion proteins (RFP) consisting of the ligand binding domains of the murine oncostatin M (mOSM) receptor subunits mOSMR and mgp130 connected by a flexible linker as potential mOSM inhibitors. mgp130 is a shared cytokine receptor that is also used by other cytokines such as IL-6 and leukemia inhibitory factor (LIF). In this study we compare four types of mOSM-RFPs that contain either domains D1-D3 or domains D2-D3 of mgp130 and are arranged in two ways. Domain D1 of mgp130 turned out to be dispensable for mOSM-binding. However, the arrangement of the two receptor subunits is essential for the inhibitory activity. We found mOSM induced STAT3 phosphorylation to be suppressed only when the mOSMR fragment was fused in front of the mgp130 fragment. Conclusions mOSM-RFP consisting of D1-D4 of mOSMR and D2-D3 of mgp130 is a highly potent and specific inhibitor of mOSM. Since mOSM-RFP is encoded by a single gene it offers numerous possibilities for specific cytokine inhibition in gene delivery approaches based on viral vectors, transgenic animals and finally gene therapy.
    Keywords Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
    Subject code 616
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: A receptor fusion protein for the inhibition of murine oncostatin M.

    Brolund, Liv / Küster, Andrea / Korr, Sabrina / Vogt, Michael / Müller-Newen, Gerhard

    BMC biotechnology

    2011  Volume 11, Page(s) 3

    Abstract: Background: Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors useful in anti- ...

    Abstract Background: Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors useful in anti-cytokine therapy and cytokine research.
    Results: We constructed receptor fusion proteins (RFP) consisting of the ligand binding domains of the murine oncostatin M (mOSM) receptor subunits mOSMR and mgp130 connected by a flexible linker as potential mOSM inhibitors. mgp130 is a shared cytokine receptor that is also used by other cytokines such as IL-6 and leukemia inhibitory factor (LIF). In this study we compare four types of mOSM-RFPs that contain either domains D1-D3 or domains D2-D3 of mgp130 and are arranged in two ways. Domain D1 of mgp130 turned out to be dispensable for mOSM-binding. However, the arrangement of the two receptor subunits is essential for the inhibitory activity. We found mOSM induced STAT3 phosphorylation to be suppressed only when the mOSMR fragment was fused in front of the mgp130 fragment.
    Conclusions: mOSM-RFP consisting of D1-D4 of mOSMR and D2-D3 of mgp130 is a highly potent and specific inhibitor of mOSM. Since mOSM-RFP is encoded by a single gene it offers numerous possibilities for specific cytokine inhibition in gene delivery approaches based on viral vectors, transgenic animals and finally gene therapy.
    MeSH term(s) Animals ; Antibodies/metabolism ; Blotting, Western ; Cloning, Molecular ; Gene Expression Regulation/drug effects ; HEK293 Cells ; Humans ; Mice ; Oncostatin M/antagonists & inhibitors ; Oncostatin M Receptor beta Subunit/chemistry ; Oncostatin M Receptor beta Subunit/metabolism ; Protein Structure, Tertiary/genetics ; RNA, Messenger/analysis ; Receptors, Interleukin-6/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction
    Chemical Substances Antibodies ; Oncostatin M Receptor beta Subunit ; Osmr protein, mouse ; RNA, Messenger ; Receptors, Interleukin-6 ; Recombinant Fusion Proteins ; STAT3 Transcription Factor ; Stat3 protein, mouse ; Oncostatin M (106956-32-5)
    Language English
    Publishing date 2011-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1472-6750
    ISSN (online) 1472-6750
    DOI 10.1186/1472-6750-11-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.

    Ehrlich, Marc / Hallmann, Anna-Lena / Reinhardt, Peter / Araúzo-Bravo, Marcos J / Korr, Sabrina / Röpke, Albrecht / Psathaki, Olympia E / Ehling, Petra / Meuth, Sven G / Oblak, Adrian L / Murrell, Jill R / Ghetti, Bernardino / Zaehres, Holm / Schöler, Hans R / Sterneckert, Jared / Kuhlmann, Tanja / Hargus, Gunnar

    Stem cell reports

    2015  Volume 5, Issue 1, Page(s) 83–96

    Abstract: Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients' brains, the underlying ... ...

    Abstract Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients' brains, the underlying mechanisms of neurodegeneration in FTD are poorly understood. Here, we derived induced pluripotent stem cells (iPSCs) from individuals with FTD-associated MAPT mutations and differentiated them into mature neurons. Patient iPSC-derived neurons demonstrated pronounced TAU pathology with increased fragmentation and phospho-TAU immunoreactivity, decreased neurite extension, and increased but reversible oxidative stress response to inhibition of mitochondrial respiration. Furthermore, FTD neurons showed an activation of the unfolded protein response, and a transcriptome analysis demonstrated distinct, disease-associated gene expression profiles. These findings indicate distinct neurodegenerative changes in FTD caused by mutant TAU and highlight the unique opportunity to use neurons differentiated from patient-specific iPSCs to identify potential targets for drug screening purposes and therapeutic intervention.
    MeSH term(s) Cell Differentiation/genetics ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Mitochondria/metabolism ; Mitochondria/pathology ; Mutation ; Neurites/pathology ; Oxidative Stress/genetics ; Unfolded Protein Response/genetics ; tau Proteins/biosynthesis ; tau Proteins/genetics
    Chemical Substances tau Proteins
    Language English
    Publishing date 2015-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2015.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation.

    Ruck, Tobias / Bittner, Stefan / Gross, Catharina C / Breuer, Johanna / Albrecht, Stefanie / Korr, Sabrina / Göbel, Kerstin / Pankratz, Susann / Henschel, Christian M / Schwab, Nicholas / Staszewski, Ori / Prinz, Marco / Kuhlmann, Tanja / Meuth, Sven G / Wiendl, Heinz

    PloS one

    2013  Volume 8, Issue 11, Page(s) e81455

    Abstract: Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4( ...

    Abstract Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(+) T cells with elevated levels of markers for migration, activation, and cytolytic capacity especially when derived from MS patients. Furthermore, CD4(+)NKG2D(+) cells produce high levels of proinflammatory IFN-γ and IL-17 upon stimulation. NKG2D promotes the capacity of CD4(+)NKG2D(+) cells to migrate across endothelial cells in an in vitro model of the blood-brain barrier. CD4(+)NKG2D(+) T cells are enriched in the cerebrospinal fluid of MS patients, and a significant number of CD4(+) T cells in MS lesions coexpress NKG2D. We further elucidated the role of CD4(+)NKG2D(+) T cells in the mouse system. NKG2D blockade restricted central nervous system migration of T lymphocytes in vivo, leading to a significant decrease in the clinical and pathologic severity of experimental autoimmune encephalomyelitis, an animal model of MS. Blockade of NKG2D reduced killing of cultivated mouse oligodendrocytes by activated CD4(+) T cells. Taken together, we identify CD4(+)NKG2D(+) cells as a subpopulation of T helper cells with enhanced migratory, encephalitogenic and cytotoxic properties involved in inflammatory CNS lesion development.
    MeSH term(s) Blood-Brain Barrier ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; Chemotaxis, Leukocyte ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Humans ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; NK Cell Lectin-Like Receptor Subfamily K/immunology ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Signal Transduction
    Chemical Substances KLRK1 protein, human ; NK Cell Lectin-Like Receptor Subfamily K
    Language English
    Publishing date 2013-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0081455
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top