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  1. Article: Evoliutsiia meditsinskogo éticheskogo kodeksa v SSSR i za rubezhom (printsipy i ikh realizatsiia).

    Kosarev, I I

    Vestnik Akademii meditsinskikh nauk SSSR

    1980  , Issue 4, Page(s) 47–52

    Title translation Evolution of the medical ethical code in the USSR and abroad (principles and practice).
    MeSH term(s) Ethics, Medical/history ; History, 19th Century ; History, 20th Century ; USSR ; United States
    Language Russian
    Publishing date 1980
    Publishing country Russia (Federation)
    Document type Comparative Study ; Historical Article ; Journal Article
    ZDB-ID 127157-x
    ISSN 0002-3027 ; 0042-4544
    ISSN 0002-3027 ; 0042-4544
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 744: Show issues Location:
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  2. Article ; Online: Probiotic Properties of Lactobacillus crispatus 2,029: Homeostatic Interaction with Cervicovaginal Epithelial Cells and Antagonistic Activity to Genitourinary Pathogens.

    Abramov, Vyacheslav / Khlebnikov, Valentin / Kosarev, Igor / Bairamova, Guldana / Vasilenko, Raisa / Suzina, Natalia / Machulin, Andrey / Sakulin, Vadim / Kulikova, Natalia / Vasilenko, Nadezhda / Karlyshev, Andrey / Uversky, Vladimir / Chikindas, Michael L / Melnikov, Vyacheslav

    Probiotics and antimicrobial proteins

    2014  Volume 6, Issue 3-4, Page(s) 165–176

    Abstract: Lactobacillus crispatus 2029 isolated upon investigation of vaginal lactobacilli of healthy women of reproductive age was selected as a probiotic candidate. The aim of the present study was elucidation of the role of L. crispatus 2029 in resistance of ... ...

    Abstract Lactobacillus crispatus 2029 isolated upon investigation of vaginal lactobacilli of healthy women of reproductive age was selected as a probiotic candidate. The aim of the present study was elucidation of the role of L. crispatus 2029 in resistance of the female reproductive tract to genitourinary pathogens using cervicovaginal epithelial model. Lactobacillus crispatus 2029 has surface layers (S-layers), which completely surround cells as the outermost component of their envelope. S-layers are responsible for the adhesion of lactobacilli on the surface of cervicovaginal epithelial cells. Study of interactions between L. crispatus 2029 and a type IV collagen, a major molecular component of epithelial cell extracellular matrix, showed that 125I-labeled type IV collagen binds to lactobacilli with high affinity (Kd = (8.0 ± 0.7) × 10(-10) M). Lactobacillus crispatus 2029 consistently colonized epithelial cells. There were no toxicity, epithelial damage and apoptosis after 24 h of colonization. Electronic microscope images demonstrated intimate association between L. crispatus 2029 and epithelial cells. Upon binding to epithelial cells, lactobacilli were recognized by toll-like 2/6 receptors. Lactobacillus crispatus induced NF-κB activation in epithelial cells and did not induce expression of innate immunity mediators IL-8, IL-1β, IL-1α and TNF-α. Lactobacillus crispatus 2029 inhibited IL-8 production in epithelial cells induced by MALP-2 and increased production of anti-inflammatory cytokine IL-6, maintaining the homeostasis of female reproductive tract. Lactobacillus crispatus 2029 produced H2O2 and provided wide spectrum of antagonistic activity increasing colonization resistance to urinary tract infections by bacterial vaginosis and vulvovaginal candidiasis associated agents.
    MeSH term(s) Bacterial Adhesion ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/microbiology ; Female ; Homeostasis/drug effects ; Humans ; Hydrogen Peroxide/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Interleukin-8/genetics ; Interleukin-8/immunology ; Lactobacillus/growth & development ; Lactobacillus/physiology ; NF-kappa B/genetics ; NF-kappa B/immunology ; Probiotics/pharmacology ; Vagina/cytology ; Vagina/drug effects ; Vagina/immunology
    Chemical Substances Interleukin-6 ; Interleukin-8 ; NF-kappa B ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2014-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-014-9164-4
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  3. Article: Vernost' meditsinskomu dolgu.

    Kosarev, I I

    Fel'dsher i akusherka

    1973  Volume 38, Issue 5, Page(s) 42–43

    Title translation Loyalty to medical duty.
    MeSH term(s) Ethics, Medical
    Language Russian
    Publishing date 1973-05
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 41138-3
    ISSN 0014-9772
    ISSN 0014-9772
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: K voprosu o rentabel'nosti Tsentral'nykh nauchno-issledovatel'skikh laboratoriĭ meditsinskikh vuzov.

    Kosarev, I I

    Laboratornoe delo

    1970  Volume 7, Page(s) 442–444

    Title translation Profitableness of Central Scientific-Research Laboratories of Medical Schools.
    MeSH term(s) Costs and Cost Analysis ; Laboratories ; Research ; Schools, Medical ; USSR
    Language Russian
    Publishing date 1970
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128774-6
    ISSN 0023-6748
    ISSN 0023-6748
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  5. Article: Aktual'nye étiko-deontologicheskie voprosy sovremennoĭ meditsiny.

    Iunovidov, I M / Kosarev, I I

    Fel'dsher i akusherka

    1983  Volume 48, Issue 8, Page(s) 59–61

    Title translation Current ethical and deontological problems of modern medicine.
    MeSH term(s) Ethics, Medical ; Morals ; USSR
    Language Russian
    Publishing date 1983-08
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 41138-3
    ISSN 0014-9772
    ISSN 0014-9772
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  6. Article: Variations of the effect of insulin on neutrophil respiratory burst. The role of tyrosine kinases and phosphatases.

    Safronova, V G / Gabdoulkhakova, A G / Miller, A V / Kosarev, I V / Vasilenko, R N

    Biochemistry. Biokhimiia

    2000  Volume 66, Issue 8, Page(s) 840–849

    Abstract: The priming effect of insulin on the fMLP-induced respiratory burst of mouse neutrophils as well as the involvement of tyrosine protein kinases and phosphatases in this process have been studied. Peritoneal evoked neutrophils of NMRI strain mice were ... ...

    Abstract The priming effect of insulin on the fMLP-induced respiratory burst of mouse neutrophils as well as the involvement of tyrosine protein kinases and phosphatases in this process have been studied. Peritoneal evoked neutrophils of NMRI strain mice were incubated with 0.01-100 nM insulin for 1-60 min at 22, 30, or 37 degrees C and activated by 0.1-50 microM N-formyl-methionyl-leucyl-phenylalanine (fMLP). The production of reactive oxygen species (ROS) by neutrophils was monitored by luminol-dependent chemiluminescence. We found that 125I-labeled insulin binding by mouse neutrophils occurred with saturation and high affinity. Insulin itself did not change the basal level of the ROS production but could modulate fMLP-induced respiratory burst. The effect of insulin depended on temperature and duration of pretreatment of the neutrophils with insulin and the concentration combination of the insulin and fMLP. The tyrosine kinase inhibitor tyrphostin 51 decreased the fMLP-induced respiratory burst significantly. Insulin did not change the fMLP response of neutrophils pretreated with tyrphostin. However, the effect of tyrphostin on the response to 50 microM fMLP was considerably decreased in neutrophils treated with insulin. There was no such effect during activation by 5 microM fMLP, for which the priming effect of insulin was not observed. Insulin did not increase the fMLP-induced respiratory burst in neutrophils treated with the protein phosphatase inhibitors orthovanadate and pyrophosphate. If the inhibitors were added after insulin, the combined effect was nearly additive. It is possible that priming by insulin of the fMLP-induced respiratory burst is triggered by tyrosine phosphorylation, realized with its participation, and involves the signaling pathways initiated by tyrosine phosphorylation but subsequently is not dependent on the latter. The role of protein phosphatases in priming by insulin is of little importance. The data indirectly confirm the idea that priming of the neutrophil respiratory burst is a result of crosstalk of signaling pathways of the insulin and fMLP receptors with the participation of tyrosine phosphorylation.
    MeSH term(s) Animals ; Binding Sites ; Chemotaxis/physiology ; Insulin/metabolism ; Insulin/pharmacology ; Luminescent Measurements ; Male ; Mice ; Neutrophils/metabolism ; Peptides/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Respiratory Burst/drug effects ; Respiratory Burst/physiology
    Chemical Substances Insulin ; Peptides ; Reactive Oxygen Species ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2000-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1023/a:1011944400908
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    Zs.A 220: Show issues Location:
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  7. Article: Iz opyta vospitatel'noĭ raboty so studentami na kafedrakh sotsial'noĭ gigieny i organizatsii zdravookhraneniia

    Kosarev, I I / Bondarenko, E D

    Sovetskoe zdravookhranenie

    1975  , Issue 4, Page(s) 65–68

    Title translation Experience in educational work with students at departments of social hygiene and public health organization.
    MeSH term(s) Communism ; Curriculum ; Education, Medical, Undergraduate ; Ethics, Medical ; Public Health/education
    Language Russian
    Publishing date 1975
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 128566-x
    ISSN 0038-5239
    ISSN 0038-5239
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    Zs.B 970: Show issues Location:
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  8. Article: Sovershenstvovat' rabotu studentskikh nauchnykh obshchestv.

    Kosarev, I I / Starulis, A

    Sovetskaia meditsina

    1973  Volume 36, Issue 12, Page(s) 116–119

    Title translation Improving the work of students' scientific societies.
    MeSH term(s) Moscow ; Societies ; Societies, Scientific ; Students, Medical ; Students, Pharmacy
    Language Russian
    Publishing date 1973-12
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128565-8
    ISSN 0038-5077
    ISSN 0038-5077
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  9. Article: O prepodavanii deontologii v meditsinskom vuze.

    Karlsen, N G / Kosarev, I I

    Sovetskoe zdravookhranenie

    1971  Volume 30, Issue 4, Page(s) 46–49

    Title translation Instruction in deontology in a medical school.
    MeSH term(s) Education, Medical ; Ethics, Medical ; Methods ; USSR
    Language Russian
    Publishing date 1971
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128566-x
    ISSN 0038-5239
    ISSN 0038-5239
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  10. Article: K istorii s'ezdov zemskikh vracheĭ Tul'skoĭ gubernii.

    Kopyt, N Ia / Kosarev, I I

    Sovetskoe zdravookhranenie

    1971  Volume 30, Issue 11, Page(s) 60–66

    Title translation History of the congresses of Zemstvo physicians in the Tula district.
    MeSH term(s) Congresses as Topic/history ; History, 19th Century ; History, 20th Century ; Public Health/history ; Russia (Pre-1917)
    Language Russian
    Publishing date 1971
    Publishing country Russia (Federation)
    Document type Historical Article ; Journal Article
    ZDB-ID 128566-x
    ISSN 0038-5239
    ISSN 0038-5239
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