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Article ; Online: Reply: Considering All Indicators of Clinical Outcome in Patients Undergoing TAVR.

Koseki, Keita / Yoon, Sung-Han / Makkar, Raj

2022 Volume 15, Issue 5, Page(s) 566–567

MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/surgery ; Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2022.02.005
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Article ; Online: Abnormal wire's trajectory during edge-to-edge mitral valve repair-a rare case report of inferior vena cava anomaly.

Koren, Ofir / Patel, Vivek / Koseki, Keita / Natanzon, Sharon Shalom / Friedman, John / Makkar, Raj R

European heart journal. Case reports

2022 Volume 6, Issue 2, Page(s) ytac060

Abstract: Background: Inferior vena cava (IVC) anomalies are rare and diagnosed incidentally as most patients are asymptomatic. We present a case where an abnormal course of the wire during percutaneous mitral valve repair revealed abnormal IVC anatomy leading to ...

Abstract	Background: Inferior vena cava (IVC) anomalies are rare and diagnosed incidentally as most patients are asymptomatic. We present a case where an abnormal course of the wire during percutaneous mitral valve repair revealed abnormal IVC anatomy leading to procedure termination. We summarized all IVC anomalies relevant to cardiovascular physicians and designed a simplified tool to illustrate their course for differential diagnosis. Case summary: A 78-year-old female presented with severe and symptomatic mitral regurgitation. The heart team decided to proceed with a percutaneous option, considering the patient's high surgical risk. While ascending from the femoral vein, the wire took an abnormal course to the left side of the vertebrae and continued beyond the cardiac silhouette downwards the right atrium (RA). We decided to abort the procedure due to the high risk for vascular complications assuming the need to cross it with the device's delivery system. Retrospective computed tomography analysis revealed an interrupted IVC at the level of the renal vasculature and azygos continuation toward the RA via a dilated superior vena cava. The patient was referred to surgery and had successful mitral and tricuspid valve repair and was discharged home in good health. Discussion: The increased number of minimally invasive percutaneous procedures, especially for valvular heart disease, mandates a profound understanding of the arterial, and venous system anatomy. Inferior vena cava anomalies represent a group of anomalies with different paths and variations and have a tremendous impact on all aspects of the procedure.
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytac060
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Article: [A Case of Gastric Endocrine Carcinoma].

Matsunaga, Hiroko / Aoyagi, Haruhiko / Koseki, Keita / Watanabe, Ichiro / Nishi, Naoto / Ito, Masashi

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 48, Issue 13, Page(s) 1658–1660

Abstract: The patient was an 80-year-old man, hospitalized with poor appetite, light-headedness, and black stool. Esophagogastroduodenoscopy showed an ulcerative lesion in cardia, and the tumor was diagnosed as gastric cancer using the biopsy specimens. The ... ...

Abstract	The patient was an 80-year-old man, hospitalized with poor appetite, light-headedness, and black stool. Esophagogastroduodenoscopy showed an ulcerative lesion in cardia, and the tumor was diagnosed as gastric cancer using the biopsy specimens. The patient underwent a gastrectomy with D1-node dissection. Pathologically, the small tumor cells infiltrated the muscularis propria of the gastric wall, and these tumor cells immunohistochemically showed a positive reaction for synaptophysin. Therefore, the tumor was diagnosed as small cell-neuroendocrine carcinoma of the stomach. Metastasis was not observed in regional lymph nodes, and the TNM classification was defined as pStage ⅠB. After surgery, adjuvant chemotherapy was not performed. The patient is well without recurrence for more than 7 months after the surgery. We experienced and report a case of gastric endocrine cell carcinoma that underwent resection and provide a review of the literature.
MeSH term(s)	Aged, 80 and over ; Carcinoma, Small Cell ; Gastrectomy ; Humans ; Lymph Node Excision ; Lymph Nodes ; Male ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery
Language	Japanese
Publishing date	2022-01-19
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of Diffuse Large B Cell Lymphoma of the Extrahepatic Bile Duct Cholangiocarcinoma].

Matsunaga, Hiroko / Aoyagi, Haruhiko / Ono, Hiroaki / Tsukuda, Kazuki / Koseki, Keita / Watanabe, Ichiro / Nishi, Naoto / Ito, Masashi

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 49, Issue 13, Page(s) 1464–1466

Abstract: The patient was an 81-year-old man who was hospitalized with poor appetite and obstructive jaundice. An abdominal CT scan showed remarkable thickening of the wall from the cystic duct to extrahepatic bile duct. Endoscopic retrograde ... ...

Abstract	The patient was an 81-year-old man who was hospitalized with poor appetite and obstructive jaundice. An abdominal CT scan showed remarkable thickening of the wall from the cystic duct to extrahepatic bile duct. Endoscopic retrograde cholangiopancreatography( ERCP)revealed stricture at the extrahepatic bile duct. Cholangiocarcinoma was diagnosed and pancreaticoduodenectomy was performed. The histopathological diagnosis was diffuse large B cell lymphoma (DLBCL). The patient was stable after the operation. We present a case report describing the resection of DLBCL of the extrahepatic bile duct along with a review of the literature.
MeSH term(s)	Male ; Humans ; Aged, 80 and over ; Bile Ducts, Extrahepatic/surgery ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/diagnosis ; Lymphoma, Large B-Cell, Diffuse/surgery ; Cholangiocarcinoma/diagnosis ; Cholangiopancreatography, Endoscopic Retrograde ; Bile Ducts, Intrahepatic/pathology
Language	Japanese
Publishing date	2023-01-24
Publishing country	Japan
Document type	Review ; Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Quality of Life, Procedural Success, and Clinical Outcomes following Transcatheter Mitral Valve Repair.

Natanzon, Sharon Shalom / Koseki, Keita / Kaewkes, Danon / Koren, Ofir / Patel, Vivek / Nakamura, Mamoo / Chakravarty, Tarun / Makkar, Raj

International journal of clinical practice

2023 Volume 2023, Page(s) 1977911

Abstract: Background: Limited data exist regarding the association between the quality of life (QoL) and clinical outcomes following transcatheter mitral valve repair (TMVr). We aimed to evaluate the prognostic significance of QoL assessment following TMVr and to ...

Abstract	Background: Limited data exist regarding the association between the quality of life (QoL) and clinical outcomes following transcatheter mitral valve repair (TMVr). We aimed to evaluate the prognostic significance of QoL assessment following TMVr and to characterize those who had procedural success, yet reported a low Kansas City Cardiomyopathy Questionnaire (KCCQ-12) score. Methods: We reported the experience of Cedars-Sinai Medical Center patients between 2013 and 2020. Patients were allocated into four groups according to the 30-day KCCQ: <25, 25-49, 50-74, and ≥75. Primary outcome included 1-year all-cause death or heart failure (HF) hospitalizations. We also examined the association between QoL and the primary outcome in those with procedural success. Results: A total of 555 patients were included in our analysis, median follow-up of 650 days (IQR 243-1113). The lower KCCQ groups had a higher prevalence of functional mitral regurgitation (65%, 60%, 56%, and 43%, Conclusion: QoL following TMVr is a powerful prognostic factor. KCCQ assessment is an important indicator for identifying patients prone to adverse outcomes even after procedural success.
MeSH term(s)	Humans ; Quality of Life ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Treatment Outcome ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology ; Heart Failure ; Cardiac Catheterization/adverse effects
Language	English
Publishing date	2023-03-06
Publishing country	India
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1155/2023/1977911
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Article ; Online: Implications of Mitral Annular Calcification on Outcomes Following Mitral Transcatheter Edge-to-Edge Repair.

Shechter, Alon / Lee, Mirae / Kaewkes, Danon / Patel, Vivek / Koren, Ofir / Chakravarty, Tarun / Koseki, Keita / Nagasaka, Takashi / Skaf, Sabah / Makar, Moody / Makkar, Raj R / Siegel, Robert J

Circulation. Cardiovascular interventions

2024 Volume 17, Issue 2, Page(s) e013424

Abstract: Background: Limited data exist regarding the impact of mitral annular calcification (MAC) on outcomes of transcatheter edge-to-edge repair for mitral regurgitation (MR).: Methods: We retrospectively analyzed 968 individuals (median age, 79 [ ... ...

Abstract	Background: Limited data exist regarding the impact of mitral annular calcification (MAC) on outcomes of transcatheter edge-to-edge repair for mitral regurgitation (MR). Methods: We retrospectively analyzed 968 individuals (median age, 79 [interquartile range, 70-86] years; 60.0% males; 51.8% with functional MR) who underwent an isolated, first-time intervention. Stratified by MAC extent per baseline transthoracic echocardiogram, the cohort was assessed for residual MR, functional status, all-cause mortality, heart failure hospitalizations, and mitral reinterventions post-procedure. Results: Patients with above-mild MAC (n=101; 10.4%) were older and more likely to be female, exhibited a greater burden of comorbidities, and presented more often with severe, primary MR. Procedural aspects and technical success rate were unaffected by MAC magnitude, as was the significant improvement from baseline in MR severity and functional status along the first postprocedural year. However, the persistence of above-moderate MR or functional classes III and IV at 1 year and the cumulative incidence of reinterventions at 2 years were overall more pronounced within the above-mild MAC group (significant MR or functional impairment, 44.7% versus 29.9%, Conclusions: Mitral transcatheter edge-to-edge repair in patients with and without above-mild MAC is equally feasible and safe; however, its postprocedural course is less favorable among those with primary MR.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Retrospective Studies ; Heart Valve Prosthesis Implantation ; Treatment Outcome ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Heart Valve Diseases ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Calcinosis/diagnostic imaging ; Calcinosis/surgery ; Cardiac Catheterization ; Heart Failure
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2450797-0
ISSN	1941-7632 ; 1941-7640
ISSN (online)	1941-7632
ISSN	1941-7640
DOI	10.1161/CIRCINTERVENTIONS.123.013424
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Article ; Online: Prognostic Value of Left Ventricular Global Longitudinal Strain in Transcatheter Edge-to-Edge Repair for Chronic Primary Mitral Regurgitation.

Shechter, Alon / Hong, Gloria J / Kaewkes, Danon / Patel, Vivek / Visrodia, Parth / Tacon, P Ryan / Koren, Ofir / Koseki, Keita / Nagasaka, Takashi / Skaf, Sabah / Makar, Moody / Chakravarty, Tarun / Makkar, Raj R / Siegel, Robert J

European heart journal. Cardiovascular Imaging

2024

Abstract: Aims: Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic ... ...

Abstract	Aims: Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic primary MR. Methods and results: We conducted a single-center, retrospective analysis of 323 consecutive patients undergoing isolated, first-time procedures. Stratified by baseline LVGLS quartiles (≤-19%, -18.9-(-16)%, -15.9-(-12)%, > -12%), the cohort was evaluated for the primary composite outcome of all-cause mortality or heart failure hospitalizations, as well as secondary endpoints consisting of mitral reinterventions and the persistence of significant residual MR and/or functional disability - all along the first year after intervention. Subjects with worse (i.e., less negative) LVGLS exhibited higher comorbidity, more advanced HF, and elevated procedural risk. Post-TEER, those belonging to the worst LVGLS quartile group sustained increased mortality (16.9 vs 6.3%, Log-Rank p = 0.005, HR 1.75, 95% CI 1.08-4.74, p = 0.041) and, when affected by LV dysfunction/dilatation, more primary outcome events (21.1 vs 11.5%, Log-Rank p = 0.037, HR 1.68, 95% CI 1.02-5.46, p = 0.047). No association was demonstrated with other endpoints. Upon exploratory analysis, 1-month postprocedural LVGLS directly correlated with and was worse than its baseline counterpart by 1.6%, and a more impaired 1-month value - but not the presence/extent of deterioration - conferred heightened risk for the primary outcome. Conclusion: TEER for chronic primary MR is feasible, safe, and efficacious irrespective of baseline LVGLS. Yet, worse baseline LVGLS forecasts a less favorable postprocedural course, presumably reflecting a higher-risk patient profile.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeae083
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Article ; Online: Dimension reduction of microbiome data linked Bifidobacterium and Prevotella to allergic rhinitis.

Komaki, Shohei / Sahoyama, Yukari / Hachiya, Tsuyoshi / Koseki, Keita / Ogata, Yusuke / Hamazato, Fumiaki / Shiozawa, Manabu / Nakagawa, Tohru / Suda, Wataru / Hattori, Masahira / Kawakami, Eiryo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7983

Abstract: Dimension reduction has been used to visualise the distribution of multidimensional microbiome data, but the composite variables calculated by the dimension reduction methods have not been widely used to investigate the relationship of the human gut ... ...

Abstract	Dimension reduction has been used to visualise the distribution of multidimensional microbiome data, but the composite variables calculated by the dimension reduction methods have not been widely used to investigate the relationship of the human gut microbiome with lifestyle and disease. In the present study, we applied several dimension reduction methods, including principal component analysis, principal coordinate analysis (PCoA), non-metric multidimensional scaling (NMDS), and non-negative matrix factorization, to a microbiome dataset from 186 subjects with symptoms of allergic rhinitis (AR) and 106 controls. All the dimension reduction methods supported that the distribution of microbial data points appeared to be continuous rather than discrete. Comparison of the composite variables calculated from the different dimension reduction methods showed that the characteristics of the composite variables differed depending on the distance matrices and the dimension reduction methods. The first composite variables calculated from PCoA and NMDS with the UniFrac distance were strongly associated with AR (FDR adjusted P = 2.4 × 10
MeSH term(s)	Humans ; Bifidobacterium ; Prevotella ; Gastrointestinal Microbiome ; Multidimensional Scaling Analysis ; Rhinitis, Allergic
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57934-x
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Article ; Online: Mitral Transcatheter Edge-to-Edge Repair in Nonagenarians.

Shechter, Alon / Chakravarty, Tarun / Kornowski, Ran / Kaewkes, Danon / Patel, Vivek / Taheri, Homa / Nagasaka, Takashi / Koren, Ofir / Koseki, Keita / Skaf, Sabah / Makar, Moody / Makkar, Raj R / Siegel, Robert J

The Canadian journal of cardiology

2024

Abstract: Background: There are scarce data regarding mitral transcatheter edge-to-edge repair (TEER) in individuals aged 90 years and above. We aimed to evaluate patient characteristics, procedural aspects, and outcomes in this rapidly growing group.: Methods!# ...

Abstract	Background: There are scarce data regarding mitral transcatheter edge-to-edge repair (TEER) in individuals aged 90 years and above. We aimed to evaluate patient characteristics, procedural aspects, and outcomes in this rapidly growing group. Methods: We retrospectively studied a single-centre database of 967 isolated, first-time interventions, 103 (10.7%) of which were performed in nonagenarians. Outcomes included all-cause mortality, heart failure (HF) hospitalizations, and the persistence of significant mitral regurgitation (MR) or New York Heart Association functional class III/IV during the first postprocedural year. Analyses were repeated on a 204-patient, propensity score-matched subcohort, controlling for MitraScore elements, sex, race, MR etiology, functional status, atrial fibrillation/flutter, and procedural urgency. Results: Compared with subjects below 90 years of age, nonagenarians were more likely to be white women of higher socioeconomic status; had a higher interventional risk, driven mainly by age and chronic kidney disease; presented more often with primary MR (71.8 vs 39.1%, P < 0.001); and exhibited less advanced biochemical/echocardiographic indices of cardiac remodelling. Further, their procedures were more commonly nonurgent and used fewer devices. A similarly high (> 97%) technical success rate was achieved in the 2 study groups. Likewise, no intergroup differences were observed in the rates or cumulative incidences of any of the explored endpoints, and neither of the outcomes' risks was associated with age 90 and above. Comparable outcomes were also noted in the propensity score-matched subgroups. Conclusions: In our experience, mitral TEER was equally feasible, safe, and efficacious in patients below and above 90 years of age.
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2024.01.033
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Article: [A Case of Disseminated Myelocarcinoma with Bone Metastasis 15 Years after Mastectomy and Relatively Long-Term Survival through Multidisciplinary Treatment].

Aoyagi, Haruhiko / Higuchi, Katsuyoshi / Matsunaga, Hiroko / Koseki, Keita / Watanabe, Ichiro / Nishi, Naoto / Nihei, Zenro / Itoh, Masashi / Sakamoto, Haruko

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 48, Issue 13, Page(s) 1592–1594

Abstract: The patient was a 62-year-old woman who had undergone mastectomy in August 2003 for cancer of the right breast. In addition to radiation therapy in the remaining breast, chemotherapy and endocrine therapy were subsequently performed. The patient had a 10- ...

Abstract	The patient was a 62-year-old woman who had undergone mastectomy in August 2003 for cancer of the right breast. In addition to radiation therapy in the remaining breast, chemotherapy and endocrine therapy were subsequently performed. The patient had a 10-year recurrence-free postoperative course followed by annual surveillance. Beginning in 2016, an elevation in the serum level of tumor markers was detected; however, no accumulations were found in PET-CT over 2 consecutive years(2016 and 2017). Thereafter, serum levels of tumor markers continued to rise, and a PET-CT in 2018 revealed costal accumulations leading to a diagnosis of late-stage bone metastasis in postoperative year 15. Although hormone therapy was resumed, a continuing rise in the serum level of tumor markers led to a diagnosis of diffuse bone metastasis by MRI in 2019. Treatment with abemaciclib was initiated, and with effective radiotherapy, the PS was maintained at 0-1, serum levels of tumor markers decreased, and the lesions themselves continued at SD. However, in June 2020, multiple liver metastases appeared in an abdominothoracic CT scan. The patient refused chemotherapy; this, a BSC policy was adopted. Acute hemolytic anemia occurred immediately thereafter, and the PS gradually deteriorated. The patient died in September 2020, 17 years and 1 month after surgery.
MeSH term(s)	Bone Neoplasms/therapy ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy ; Middle Aged ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography
Language	Japanese
Publishing date	2022-01-19
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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