LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Koskela, Ali K J"
  2. AU="Soledad Bárez-López"
  3. AU="Raser, K J"
  4. AU=Pons Douwe AU=Pons Douwe
  5. AU="Johnson, James W"
  6. AU="Menon, Pradeep A"
  7. AU="van Eyk, Clare L"
  8. AU="Portela, Ricardo Dias"
  9. AU="Ouyang, Wei"
  10. AU="Zwarthoff, Ellen C."
  11. AU="de Souza, G T"
  12. AU="Nagel, Sean J"
  13. AU="Patel, Devendra K"
  14. AU="Xie, B W"
  15. AU="Grandal-Platero, Marta"
  16. AU=Fetz Allison E.
  17. AU="Owens, Jeana"
  18. AU="Kohn, Samuel"
  19. AU="Saitoh, Yuji"
  20. AU="Chiarini, Elisabetta"
  21. AU="Bilodeau, Marc"
  22. AU=Arora Neelima AU=Arora Neelima
  23. AU="Eline Boghaert"
  24. AU=Hurwitz Naama
  25. AU="Trocha, Andrzej M"
  26. AU="Smits, Anthal I P M"
  27. AU=Milton Ross D.
  28. AU="Mónica Lopes-Marques"
  29. AU="Olasińska-Wiśniewska, Anna"
  30. AU="Michel, Alexander"
  31. AU="Ku, Chin-Jen"
  32. AU="Potts, Daniel"
  33. AU="Liu, Xiang"
  34. AU="Mire, Erik"
  35. AU="Ching-Yi Hu"

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel ; Online: Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-β2 are elevated in a Finnish wet age-related macular degeneration cohort.

    Liukkonen, Mikko P K / Paterno, Jussi J / Kivinen, Niko / Siintamo, Leea / Koskela, Ali K J / Kaarniranta, Kai

    Acta ophthalmologica

    2021  Band 100, Heft 5, Seite(n) e1153–e1162

    Abstract: Purpose: It has been hypothesized that epithelial-mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age-related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have ... ...

    Abstract Purpose: It has been hypothesized that epithelial-mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age-related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have been linked to AMD. We were interested in finding out whether systemic levels of EMT-associated markers were altered in the serum of wet AMD patients. Serum biomarkers associated with the various pathological processes of AMD may present an avenue towards identifying and characterizing the birth mechanisms of wet AMD, its progression and severity, paving the way towards the application of precision medicine.
    Methods: We chose to measure the serum levels of known biomarkers of EMT - EGF (epidermal growth factor), ET-1 (endothelin 1), IL-8 (interleukin 8), TGF-β1 and TGF-β2 (transforming growth factor-beta 1 and 2) and VEGF-A (vascular endothelial growth factor A) - using enzyme-linked immunosorbent assays. We measured them from 71 Finnish wet AMD patients who were receiving intravitreal anti-VEGF-A injection treatments, as well as 64 age-adjusted controls.
    Results: We found significantly elevated levels of ET-1, IL-8 and TGF-β2 in the serums of wet AMD patients.
    Conclusions: ET-1, IL-8 and TGF-β2 appear to be useful serum biomarkers in understanding active wet AMD. However, we cannot conclude that local retinal EMT-processes could be observed from the corresponding systemic serum biomarkers in patients undergoing anti-VEGF-A treatments.
    Mesh-Begriff(e) Biomarkers ; Epithelial-Mesenchymal Transition ; Finland ; Humans ; Interleukin-8 ; Transforming Growth Factor beta2/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Wet Macular Degeneration/diagnosis
    Chemische Substanzen Biomarkers ; Interleukin-8 ; Transforming Growth Factor beta2 ; Vascular Endothelial Growth Factor A
    Sprache Englisch
    Erscheinungsdatum 2021-10-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ul I Zs.90: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Variation in the anthocyanin concentration of wild populations of crowberries (Empetrum nigrum L subsp. hermaphroditum).

    Koskela, Ali K J / Anttonen, Mikko J / Soininen, Tuula H / Saviranta, Niina M M / Auriola, Seppo / Julkunen-Tiitto, Riitta / Karjalainen, Reijo O

    Journal of agricultural and food chemistry

    2010  Band 58, Heft 23, Seite(n) 12286–12291

    Abstract: Crowberry (Empetrum nigrum L.) is a relatively under-utilized wild berry that occurs widely throughout the northern hemisphere such as in Canada, Eurasia, and northern Europe. In this work, the anthocyanins of crowberries were analyzed from four ... ...

    Abstract Crowberry (Empetrum nigrum L.) is a relatively under-utilized wild berry that occurs widely throughout the northern hemisphere such as in Canada, Eurasia, and northern Europe. In this work, the anthocyanins of crowberries were analyzed from four geographically distinct crowberry populations in Finland using HPLC-DAD and HPLC-ESI/MS/MS. A total number of 15 anthocyanins were detected; 15 (11 structure elucidated) in all samples in order to profile-specific anthocyanin compositions throughout Finland. The major anthocyanin found in the samples collected from central and eastern Finland was delphinidin 3-galactoside accounting for more than 24% of the total anthocyanin content, while the cyanidin 3-galactoside was the major anthocyanin in the northernmost and in the western samples. Significant variation in the concentrations of different anthocyanins between and within crowberry populations were found suggesting that the synthesis of anthocyanins is modified by site-specific environmental conditions. The suitability of the crowberries as a potential source of health-promoting ingredients for incorporation into pharmaceutical and food industrial products is highlighted in this work due to the diverse anthocyanin profile.
    Mesh-Begriff(e) Anthocyanins/chemistry ; Ericaceae/chemistry ; Ericaceae/classification ; Finland ; Fruit/chemistry ; Fruit/classification ; Molecular Structure ; Plant Extracts/chemistry ; Tandem Mass Spectrometry
    Chemische Substanzen Anthocyanins ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2010-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/jf1037695
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1172: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Audio / Video: Variation in the Anthocyanin Concentration of Wild Populations of Crowberries (Empetrum nigrum L subsp. hermaphroditum)

    Koskela, Ali K.J / Anttonen, Mikko J / Soininen, Tuula H / Saviranta, Niina M.M / Auriola, Seppo / Julkunen-Tiitto, Riitta / Karjalainen, Reijo O

    Journal of agricultural and food chemistry. 2010 Dec. 8, v. 58, no. 23

    2010  

    Abstract: Crowberry (Empetrum nigrum L.) is a relatively under-utilized wild berry that occurs widely throughout the northern hemisphere such as in Canada, Eurasia, and northern Europe. In this work, the anthocyanins of crowberries were analyzed from four ... ...

    Abstract Crowberry (Empetrum nigrum L.) is a relatively under-utilized wild berry that occurs widely throughout the northern hemisphere such as in Canada, Eurasia, and northern Europe. In this work, the anthocyanins of crowberries were analyzed from four geographically distinct crowberry populations in Finland using HPLC-DAD and HPLC-ESI/MS/MS. A total number of 15 anthocyanins were detected; 15 (11 structure elucidated) in all samples in order to profile-specific anthocyanin compositions throughout Finland. The major anthocyanin found in the samples collected from central and eastern Finland was delphinidin 3-galactoside accounting for more than 24% of the total anthocyanin content, while the cyanidin 3-galactoside was the major anthocyanin in the northernmost and in the western samples. Significant variation in the concentrations of different anthocyanins between and within crowberry populations were found suggesting that the synthesis of anthocyanins is modified by site-specific environmental conditions. The suitability of the crowberries as a potential source of health-promoting ingredients for incorporation into pharmaceutical and food industrial products is highlighted in this work due to the diverse anthocyanin profile.
    Schlagwörter anthocyanins ; chemical concentration ; Empetrum nigrum ; food analysis ; fruit composition ; small fruits ; nutritive value ; nutrient content ; wild foods
    Sprache Englisch
    Erscheinungsverlauf 2010-1208
    Umfang p. 12286–12291.
    Dokumenttyp Artikel ; Audio / Video
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/jf1037695
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 1185: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang