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  1. Article ; Online: Incidental presentation of appendix neuroendocrine tumor: Long-term results from a single institution.

    Süleyman, Marlen / Senlikci, Abdullah / Durhan, Abdullah / Kosmaz, Koray

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2023  Volume 29, Issue 9, Page(s) 972–977

    Abstract: Background: Appendix neuroendocrine tumors (NETs) are the most common tumors of the appendix and are most often diagnosed incidentally. The aim of this study was to retrospectively evaluate appendix NETs diagnosed incidentally in our clinic.: Methods!# ...

    Title translation İnsidental saptanan apendiks nöroendokrin tümörleri: Tek merkezin uzun dönem sonuçları.
    Abstract Background: Appendix neuroendocrine tumors (NETs) are the most common tumors of the appendix and are most often diagnosed incidentally. The aim of this study was to retrospectively evaluate appendix NETs diagnosed incidentally in our clinic.
    Methods: Of 8304 patients who underwent appendectomy with the diagnosis of acute appendicitis in Ankara Training and Re-search Hospital, General Surgery Clinic between January 2009 and January 2022, 33 had histopathology results evaluated as appendix NET, and a retrospective analysis was made of these cases. The patients were evaluated in terms of age, gender, tumor infiltration, tumor location, tumor size, surgical margin, tumor World Health Organization grade, surgery performed, lymph node metastasis, Ki67 index, number of mitosis, follow-up time, and survival.
    Results: The rate of appendix NET was found to be 0.4%. The 33 cases comprised 15 (45.5%) males and 18 (54.5%) females with a mean age of 35.48 years (range: 16-84 years). Positive surgical margin was determined in 1 (3.03%) case, in which right hemicolectomy was performed. All other cases were followed up after appendectomy. The median follow-up was 89 (7-145) months. No recurrence was observed in any case. Mortality developed during follow-up in one case due to non-tumoral causes.
    Conclusion: Appendix NETs are generally asymptomatic and appear incidentally after appendectomy due to acute appendicitis. Appendix NETs diagnosed incidentally are generally below 2 cm and have a good prognosis.
    MeSH term(s) Female ; Male ; Humans ; Adult ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/surgery ; Appendiceal Neoplasms/diagnosis ; Appendiceal Neoplasms/surgery ; Retrospective Studies ; Appendix ; Appendicitis/diagnosis ; Appendicitis/surgery
    Language English
    Publishing date 2023-09-07
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2023.78038
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    Zs.A 6718: Show issues Location:
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  2. Article ; Online: Impact of Muscle Mass Depletion on Surgical Outcomes in Patients with Primary High-grade Serous Ovarian Cancer Undergoing CRS and HIPEC.

    Mercan, Umit / Gulpinar, Basak / Ersen, Ogun / Kosmaz, Koray / Durhan, Abdullah / Unal, Ali Ekrem

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 31, Issue 11, Page(s) 1314–1319

    Abstract: Objective: To investigate the effect of sarcopenia on surgical outcomes in patients with primary high-grade serous ovarian cancer undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC).: Study design: ... ...

    Abstract Objective: To investigate the effect of sarcopenia on surgical outcomes in patients with primary high-grade serous ovarian cancer undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC).
    Study design: Descriptive study.
    Place and duration of study: Department of Surgical Oncology, Faculty of Medicine, Ankara University Ankara, Turkey,  from January 2013 to January 2020.
    Methodology: Forty patients, who underwent CRS and HIPEC with the diagnosis of primary high-grade serous ovarian cancer and peritoneal carcinomatosis were included in the study. Preoperative staging CT images were used to determine total psoas ındex values by measuring psoas muscle area at the level of L3 vertebra. Patients with total psoas ındex values below the cut-off levels were considered sarcopenic. Demographic, clinicopathological and perioperative results were compared between sarcopenic and non-sarcopenic patients.
    Results: Serious postoperative complications (36.4% vs. 6.9%, p=0.039)  and infective (54.5% vs. 17.2%, p=0.042) and pulmonary (72.7% vs. 34.5%, p=0.040 complications were significantly higher in sarcopenic patients. Hospital stay [20(12-25) vs. 12(9-16.5) days, p=0.017] and ICU stay [4(2-6) vs. 2(1-2.5) days, p=0.013)] were found to be longer in sarcopenic patients. In univariate analysis, advanced age (OR: 1.40 95% CI: 1.07-1.84; p=0.021) and sarcopenia (OR: 7.71% 95 CI: 1.17-51.06; p=0.039) were significantly associated with serious postoperative complications. The presence of sarcopenia (OR: 0.050 95% CI: 0.004-0.675; p=0.024) was found to be independent predictor of serious postoperative complications.
    Conclusion: Sarcopenia can easily be diagnosed without additional cost or radiation exposure with routine preoperative staging CT images. Identification of sarcopenic ovarian cancer patients in preoperative period may affect patient selection, predictability of possible serious complications, elective operation preparation process with a combination of nutrition and exercise therapy, thus postoperative complication rates may be reduced and short-term results may be improved. Key Words: Cytoreductive surgery, Ovarian cancer, Sarcopenia.
    MeSH term(s) Combined Modality Therapy ; Female ; Humans ; Hyperthermia, Induced ; Hyperthermic Intraperitoneal Chemotherapy ; Muscles ; Ovarian Neoplasms/therapy ; Peritoneal Neoplasms/complications ; Peritoneal Neoplasms/therapy ; Retrospective Studies ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2021-10-23
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2021.11.1314
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    Zs.A 6532: Show issues Location:
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  3. Article ; Online: An Evaluation of the Effect of Preoperative Inflammation-based Factors on Survival in Gastric Cancer Patients.

    Durhan, Abdullah / Senlikci, Abdullah / Kosmaz, Koray / Erguder, Ender / Mercan, Umit / Suleyman, Marlen

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 31, Issue 3, Page(s) 282–287

    Abstract: Objective: To investigate the predictive effect of preoperative inflammatory factors on overall survival (OS) in patients diagnosed with gastric adenocarcinoma (GAC).: Study design: Observational study.: Place and duration of study: Department of ... ...

    Abstract Objective: To investigate the predictive effect of preoperative inflammatory factors on overall survival (OS) in patients diagnosed with gastric adenocarcinoma (GAC).
    Study design: Observational study.
    Place and duration of study: Department of General Surgery, Ankara Training and Research Hospital, between January 2011 and October 2020.
    Methodology: A retrospective examination of 207 patients was made from the demographic, preoperative, and postoperative clinical pathology records of patients diagnosed with GAC. Demographic data, pathological tumor-node-metastasis (TNM) staging, preoperative inflammatory factors including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and aspartate transaminase (AST)-alanine aminotransaminase (ALT) ratio, red cell distribution width (RDW), and hypoalbuminemia were statistically analysed in respect of the effect on OS.
    Results: Overall survival was determined to be significantly shorter in patients with age >65 years (p = 0.001), advanced TNM stage (p <0.001), tumor size >4.7 cm (p = 0.007), AST-ALT ratio >1.21 (p = 0.017), and hypoalbuminemia (<35 g / L) (p = 0.018). In Cox regression analysis for all factors affecting OS, age >65 years (p = 0.002) and TNM stage 1B (p = 0.004) and 2A (p = 0.039) were determined as independent predictors of survival. The values of NLR, PLR, and RDW were not statistically significant between the groups with and without mortality (p=0.066, p=0.283, p=0.501, respectively).
    Conclusion: Inflammation-based factors including AST-ALT ratio and albumin can help assess prognosis in patients with gastric cancer in standard clinical preoperative tests. Key Words: Gastric cancer, Inflammation-based factors, Aspartate transaminase-alanine aminotransaminase ratio, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, Albumin, Tumor-node-metastasis staging, Overall survival.
    MeSH term(s) Aged ; Blood Platelets ; Humans ; Inflammation ; Lymphocytes/pathology ; Neoplasm Staging ; Neutrophils/pathology ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2021-01-05
    Publishing country Pakistan
    Document type Journal Article ; Observational Study
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2021.03.282
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  4. Article: The effect on morbidity of the use of prophylactic abdominal drain following elective laparoscopic cholecystectomy.

    Bostanci, Mustafa Taner / Saydam, Mehmet / Kosmaz, Koray / Tastan, Baki / Bostanci, Erdal Birol / Akoglu, Musa

    Pakistan journal of medical sciences

    2019  Volume 35, Issue 5, Page(s) 1306–1311

    Abstract: Background and objective: To evaluate the clinical role of the routine use of a drain in an elective laparoscopic cholecystectomy operation applied to patients with symptomatic cholelithiasis not showing acute inflammation.: Method: Following ... ...

    Abstract Background and objective: To evaluate the clinical role of the routine use of a drain in an elective laparoscopic cholecystectomy operation applied to patients with symptomatic cholelithiasis not showing acute inflammation.
    Method: Following laparoscopic removal of the gallbladder, patients were separated into two groups of 30 each, either with subhepatic drain placement or without. The presence of subhepatic fluid collection was evaluated with transabdominal ultrasonography (USG) at 24 hours postoperatively and on the 7th day. The other parameters evaluated were postoperative morbidity, shoulder and abdominal pain.
    Results: No statistically significant difference was found between the two groups in respect of demographic characteristics and operative details. The median pain score was determined to be statistically significantly higher in the group with a drain applied compared to the group without a drain (p=0.007). In the comparison between the groups of fluid collection on USG at 24 hours and shoulder pain persisting until the 7th day, although seen less in the group with no drain applied, no statistically significant difference was determined (p=0.065, p=0.159). In the examinations made on the 7th day, no hematoma or significant fluid collection was determined on USG and no wound infection was observed in any patient of either group.
    Conclusion: The routine application of prophylactic subhepatic drain in laparoscopic cholecystectomy procedure did not show any benefit to the patient.
    Language English
    Publishing date 2019-08-23
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.35.5.291
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    Zs.A 3948: Show issues Location:
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  5. Article ; Online: The effect of Ankaferd blood stopper on liver damage in experimental obstructive jaundice

    Koşmaz, Koray / Durhan, Abdullah / Süleyman, Marlen / Ünal, Yılmaz / Bostancı, Mustafa Taner / Yiğit Haskaraca, Tuğba / Ersak, Can / Şener, Mehmet / Kuşabbi, İlknur Alkan / Eser, Eylem Pınar / Hücümenoğlu, Sema

    Turkish journal of medical sciences

    2021  Volume 51, Issue 3, Page(s) 1472–1480

    Abstract: Background/aims: To evaluate the potential protective effects of Ankaferd blood stopper (ABS) in an experimental obstructive jaundice (OJ) model.: Materials and methods: The study included 26 female rats, which were divided into 3 groups. The sham ... ...

    Abstract Background/aims: To evaluate the potential protective effects of Ankaferd blood stopper (ABS) in an experimental obstructive jaundice (OJ) model.
    Materials and methods: The study included 26 female rats, which were divided into 3 groups. The sham group, consisting of 10 rats, (group 1) only received solely laparotomy. In the control group, consisting of 8 rats, (group 2), ligation was applied to the biliary tract and no treatment was implemented. In the treatment group, consisting of 8 rats, (group 3), following ligation of biliary tract, 0.5 mL/day ABS was given for 10 days. Liver tissue and blood samples were taken for histopathological and biochemical examination.
    Results: Compared to group 2, group 3 had higher aspartate aminotransferase (AST), total oxidant status (TOS) malondialdehyde (MDA), fluorescent oxidant products (FOP), and lower expression of albumin and total antioxidant status (TAS) (P < 0.05). In histopathological analysis, the mean scores of all histopathological parameters (fibrosis, portal inflammation, confluent necrosis, interphase activity, bile duct proliferation) have statistical significance between group 2 and group 3 (P < 005).
    Conclusions: ABS has promising results in the treatment of experimental OJ because of its antioxidant and antiinflammatory properties. It may be used in clinical practice after more extensive studies about the effects of ABS on OJ.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Chemical and Drug Induced Liver Injury ; Female ; Jaundice, Obstructive/drug therapy ; Liver/drug effects ; Oxidants ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar
    Chemical Substances Antioxidants ; Oxidants ; Plant Extracts ; ankaferd blood stopper
    Language English
    Publishing date 2021-06-28
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2007-298
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    Zs.A 3242: Show issues Location:
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  6. Article ; Online: Comparison of Common Surgical Procedures in Non-complicated Pilonidal Sinus Disease, a 7-Year Follow-Up Trial.

    Caliskan, Mujgan / Kosmaz, Koray / Subasi, Ismail Ege / Acar, Aylin / Evren, Ismail / Bas, Gurhan / Atayoglu, Ali Timucin

    World journal of surgery

    2019  Volume 44, Issue 4, Page(s) 1091–1098

    Abstract: Background: Pilonidal disease is a common problem in primary health care which may require immediate surgical referral. Although various management options have been proposed, so far there is no gold standard treatment. The aim of the present study was ... ...

    Abstract Background: Pilonidal disease is a common problem in primary health care which may require immediate surgical referral. Although various management options have been proposed, so far there is no gold standard treatment. The aim of the present study was to determine which of the following techniques was superior as regards postoperative complications and recurrence, midline unshifted adipofascial turn-over flap, midline shifted adipofascial turn-over flap or Karydakis flap.
    Methods: A randomized clinical trial was conducted in the Department of General Surgery. Patients with non-complicated pilonidal sinus were enrolled in the study from April 2009 to January 2012. All patients were randomized the day of surgery at the coordinating center by means of a computer program. Patients were randomized to receive midline unshifted adipofascial turn-over flap, midline shifted adipofascial turn-over flap or Karydakis flap. All procedures were performed under local anesthesia and patients were discharged 6 h after surgery. Demographic characteristics, skin color, body hair type, family history, preoperative complaints and duration of symptoms, cyst size, intraoperative iatrogenic cyst rupture, the presence of a tuft of hairs in the cyst, surgical techniques, duration of drainage, length of hospital stay, postoperative complications and recurrence were evaluated.
    Results: One hundred and ninety-two patients with non-complicated pilonidal sinus were enrolled. Seventy-two patients were randomized to midline unshifted adipofascial turn-over flap, 67 patients to midline shifted adipofascial turn-over flap and 53 patients to Karydakis flap. The mean age was 25.66 ± 7.67 years. At 76-month follow-up, the overall complications and recurrence rates were not significantly different between groups (p > 0.05).
    Conclusion: In cases of non-complicated pilonidal sinus, we recommend surgical management using local anesthesia, outpatient surgery and the surgical approach with which the surgeon is most familiar.
    MeSH term(s) Adolescent ; Adult ; Female ; Follow-Up Studies ; Humans ; Length of Stay ; Male ; Pilonidal Sinus/surgery ; Postoperative Complications/etiology ; Recurrence ; Surgical Flaps ; Young Adult
    Language English
    Publishing date 2019-12-14
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-019-05331-1
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    Zs.A 1336: Show issues Location:
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  7. Article ; Online: The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice.

    Unal, Yilmaz / Tuncal, Salih / Kosmaz, Koray / Kucuk, Berkay / Kismet, Kemal / Cavusoglu, Turgut / Celepli, Pinar / Senes, Mehmet / Yildiz, Selin / Hucumenoglu, Sema

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2018  Volume 32, Issue 3, Page(s) 238–244

    Abstract: Purpose/Aim of the study: Inflammation and oxidative stress are two significant factors affecting the degree of liver damage in obstructive jaundice. The aim of this study was to evaluate the effect of calcium dobesilate (CaDob), an effective antioxidant ...

    Abstract Purpose/Aim of the study: Inflammation and oxidative stress are two significant factors affecting the degree of liver damage in obstructive jaundice. The aim of this study was to evaluate the effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on damage to liver caused by experimental obstructive jaundice.
    Materials and methods: 30 rats in total were randomly placed into three groups, each group consisting of 10 rats. The sham group (Group 1) only received solely laparotomy. In the control group (Group 2), ligation was applied to the biliary tract and no treatment was implemented. In the CaDob group (Group 3), following ligation of the biliary tract, 100 mg/kg/day CaDob was implemented via an orogastric tube for a 10-day period. Liver tissue and blood samples were taken for histopathological and biochemical examination.
    Results: The CaDob group had significantly lower test values for serum liver functions when compared to the control group. Statistically lower levels of tissue malondialdehyde (MDA) and fluorescent oxidation products (FOP) were detected in the CaDob group, and the CaDob group had significantly higher levels of sulfydryl (SH) than the control group. Histopathological scores in the CaDob group were found out to be statistically less than the scores the control group received (p < 0.05).
    Conclusions: CaDob treatment repaired the histpatological changes induced by bile duct ligation. The hepatoprotective effects of CaDob can be associated with its antioxidant properties of the drug.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Calcium Dobesilate/pharmacology ; Calcium Dobesilate/therapeutic use ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Humans ; Jaundice, Obstructive/drug therapy ; Jaundice, Obstructive/etiology ; Jaundice, Obstructive/pathology ; Liver/drug effects ; Liver/pathology ; Liver/physiopathology ; Liver Function Tests ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Treatment Outcome
    Chemical Substances Antioxidants ; Calcium Dobesilate (5921X1560Q)
    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2018.1451936
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    Zs.A 2364: Show issues Location:
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  8. Article ; Online: Assessment of Ankaferd Blood Stopper in experimental liver ischemia reperfusion injury

    Durhan, Abdullah / Koşmaz, Koray / Süleyman, Marlen / Tez, Mesut / Şenlikci, Abdullah / Ersak, Can / Ünal, Yilmaz / Pekcici, Recep / Karaahmet, Fatih / Şeneş, Mehmet / Alkan Kuşabbi, Ilknur / Eser, Eylem Pinar / Hücümenoğlu, Sema

    Turkish journal of medical sciences

    2020  Volume 50, Issue 5, Page(s) 1421–1427

    Abstract: Background/aim: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver ischemia reperfusion injury (IRI) model.: Materials and methods: The study was carried out on 30 female rats separated into 3 groups ... ...

    Abstract Background/aim: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver ischemia reperfusion injury (IRI) model.
    Materials and methods: The study was carried out on 30 female rats separated into 3 groups as sham, control (IRI), and treatment (IRI + ABS) groups. In the IRI + ABS group, 0.5 mL/day ABS was given for 7 days before surgery. In the IRI and IRI + ABS groups, the hepatic pedicle was clamped for 30 min to apply ischemia. Then, after opening the clamp, 90-min reperfusion of the liver was provided. Blood and liver tissue samples were taken for biochemical and histopathological analyses.
    Results: Compared to the sham group, the IRI group had significantly higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total oxidant status (TOS), malondialdehyde (MDA), fluorescent oxidant products (FOP) and lower expression of albumin and total antioxidant status (TAS) (P < 0.05). Compared to the IRI group, the IRI+ABS group showed lower expression of AST, ALT, TOS, MDA and FOP and higher expression of albumin and TAS (P < 0.05). In the histopathological analysis, congestion scores were statistically significantly lower in the IRI + ABS group than in the IRI group.
    Conclusions: ABS has a strong hepatoprotective effect due to its antioxidant and antiinflammatory effects and could therefore be used as a potential therapeutic agent for IRI.
    Language English
    Publishing date 2020-08-26
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2004-240
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  9. Article: Assessment of the effect of calcium dobesilate in experimental liver ischemia-reperfusion injury.

    Ünal, Yılmaz / Küçük, Berkay / Tuncal, Salih / Koşmaz, Koray / Çavuşoğlu, Nadir Turgut / Kısmet, Kemal / Şeneş, Mehmet / Celepli, Pınar / Durak, Murat / Hücümenoğlu, Sema

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2018  Volume 24, Issue 5, Page(s) 391–397

    Abstract: Background: This study investigates the protective effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on experimental liver ischemia-reperfusion injury (IRI).: Methods: Forty rats were divided into four groups. ...

    Abstract Background: This study investigates the protective effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on experimental liver ischemia-reperfusion injury (IRI).
    Methods: Forty rats were divided into four groups. In Group 1, (sham), only hepatic pedicle was induced. In Group 2 (control), hepatic pedicle was reperfused for 90 min after being clamped for 60 min. No treatment was given in Group 1 and 2. In Group 3 (perioperative CaDob), 100 mg/kg CaDob was given 2 hours prior to the operation in which hepatic pedicle was reperfused for 90 min following a 60-min clamp. In Group 4 (preoperative CaDob), after 100 mg/kg/day CaDob was given for 10 days before the operation, hepatic pedicle was clamped for 60 min and reperfused for 90 minutes. At the end of these procedures, blood and liver tissue samples were collected for biochemical and histopathological assessment.
    Results: Liver function tests and tissue oxidative stress parameters were significantly lower in the preoperative and perioperative treatment groups than the control group. Furthermore, it was observed that histopathological injury in the control group significantly decreased in both perioperative and preoperative treatment groups.
    Conclusion: Calcium dobesilate demonstrated a significant hepatoprotective effect in terms of its antioxidant and anti-inflammatory effects.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Calcium Dobesilate/pharmacology ; Liver/drug effects ; Liver Diseases/metabolism ; Oxidative Stress/drug effects ; Rats ; Reperfusion Injury/metabolism
    Chemical Substances Antioxidants ; Calcium Dobesilate (5921X1560Q)
    Language English
    Publishing date 2018-10-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1306-696X
    ISSN 1306-696X
    DOI 10.5505/tjtes.2018.33238
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  10. Article ; Online: Evaluating factors affecting survival in colon and rectum cancer: A prospective cohort study with 161 patients.

    Kalcan, Suleyman / Sisik, Abdullah / Basak, Fatih / Hasbahceci, Mustafa / Kilic, Ali / Kosmaz, Koray / Kivanc, Ali Ediz / Kudas, Ilyas / Bas, Gurhan / Alimoglu, Orhan

    Journal of cancer research and therapeutics

    2017  Volume 14, Issue 2, Page(s) 416–420

    Abstract: Context: Colorectal cancers are frequent among cancers of gastrointestinal system. Whether there are any differences between survival in rectum and colon cancer patients is controversial.: Aims: In this study, we aimed to compare survival in ... ...

    Abstract Context: Colorectal cancers are frequent among cancers of gastrointestinal system. Whether there are any differences between survival in rectum and colon cancer patients is controversial.
    Aims: In this study, we aimed to compare survival in surgically treated rectum and colon cancers and determine the factors affecting survival.
    Subjects and methods: The patients with colon and rectum cancer operated between 2009 and 2013 were examined retrospectively using prospective database. Patients were categorized as colon and rectum according to the tumor's location. Survival was identified as the primary outcome. Kaplan-Meier survival analysis and log-rank tests in survival assessment were used.
    Results: One hundred and sixty-one patients with a mean age of 62.8 ± 12.7 years were included in the study. Male/female ratio was 1.6. Colon and rectum patients were counted as 92 (%57.1) and 69 (%42.9), respectively. Both groups were similar in demographic data (P > 0.05). It was observed that in 46 months (mean) of follow-up, 39.7% (n: 64) died, and 60.3% (n: 97) survived. Median survival time was 79 months, and 5-year cumulative survival rate was 60.8%. Five-year cumulative survival rates in stages for 1, 2, 3 and 4 were 88.2%, 64.7%, 48.5%, and 37.0%, respectively. It was noted that median survival time for colon cancer was 78 months and for rectum cancer was 79 months. Five-year cumulative survival rates for colon and rectum cancers were calculated as 56.7% and 63.4%, respectively. There were no significant differences in colon and rectum cancers in the means of survival rate (P: 0.459).
    Conclusions: While location of colorectal cancers shows no significant effect on survival, treatment in the early stages increases survival rate.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Survival Analysis ; Survival Rate
    Language English
    Publishing date 2017-05-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.199390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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