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  1. Article ; Online: DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease.

    Kost, Sara E F / Saleh, Ali / Yuan, Shek H / Kuzio, Bozena / Gibson, Spencer B / Yang, Lin / Banerji, Versha / Johnston, James B / Katyal, Sachin

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 20

    MeSH term(s) Humans ; Biomarkers ; Chromosome Deletion ; DNA ; DNA-Activated Protein Kinase/metabolism ; DNA-Binding Proteins/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Prognosis ; Drug Resistance, Neoplasm ; Chromosomes, Human, Pair 11
    Chemical Substances Biomarkers ; DNA (9007-49-2) ; DNA-Activated Protein Kinase (EC 2.7.11.1) ; DNA-Binding Proteins
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-022-00781-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A novel spliced variant of the TIN2 shelterin is present in chronic lymphocytic leukemia.

    Ishdorj, Ganchimeg / Kost, Sara E F / Beiggi, Sara / Zang, Yunli / Gibson, Spencer B / Johnston, James B

    Leukemia research

    2017  Volume 59, Page(s) 66–74

    Abstract: The shelterin proteins play important roles in telomere maintenance and genome stability. These proteins have been found to be mutated in many cancers including CLL. Herein, we demonstrate here the presence of a novel spliced isoform of TIN2S in chronic ... ...

    Abstract The shelterin proteins play important roles in telomere maintenance and genome stability. These proteins have been found to be mutated in many cancers including CLL. Herein, we demonstrate here the presence of a novel spliced isoform of TIN2S in chronic lymphocytic leukemia (CLL), related to deletion of exon 2 in the TIN2 gene. The expressions of spliced TIN2S mRNA varied widely in CLL and there was an inverse relationship between the mRNA levels of full-length TIN2S and the spliced moiety. Small amounts of spliced TIN2S were also observed in normal B cells but not in T cells. Spliced TIN2S appeared dysfunctional, as immunoprecipitation studies showed the typical association of TRF2 and TIN2 in normal lymphocytes but not in CLL cells. Moreover, whereas TRF2 localized to the nucleus in normal lymphocytes, it was present in both nuclei and cytoplasm in CLL cells. The levels of spliced TIN2S increased with age and in 3 of 8 patients increased over time. The presence of the spliced variant failed to be related to telomere length in CLL suggesting other functions for this protein. Further studies are required to determine the etiology and biological significance of this unique spliced TIN2S variant.
    MeSH term(s) Age Factors ; Cell Nucleus/chemistry ; Cytoplasm/chemistry ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphocytes/metabolism ; Protein Binding ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; RNA, Messenger ; Telomere/ultrastructure ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism ; Telomeric Repeat Binding Protein 2/metabolism ; Time Factors
    Chemical Substances Protein Isoforms ; RNA, Messenger ; TERF2 protein, human ; TINF2 protein, human ; Telomere-Binding Proteins ; Telomeric Repeat Binding Protein 2 ; shelterin, human
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2017.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1321: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia.

    Kost, Sara E F / Saleh, Ali / Mejia, Edgard M / Mostafizar, Marina / Bouchard, Eric D J / Banerji, Versha / Marshall, Aaron J / Gibson, Spencer B / Johnston, James B / Katyal, Sachin

    Cancers

    2019  Volume 11, Issue 10

    Abstract: ...

    Abstract :
    Language English
    Publishing date 2019-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11101519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Buccal cell telomere length is not a useful marker for comorbidities in chronic lymphocytic leukemia.

    Yang, Lin / Kost, Sara E F / Beiggi, Sara / Zhang, Yunli / Schmidt, Robert / Nugent, Zoann / Marshall, Aaron / Banerji, Versha / Gibson, Spencer B / Johnston, James B

    Leukemia research

    2019  Volume 86, Page(s) 106220

    MeSH term(s) Aged ; Biomarkers, Tumor/genetics ; Case-Control Studies ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Male ; Mouth Mucosa/metabolism ; Mouth Mucosa/pathology ; Prognosis ; Severity of Illness Index ; Telomere Homeostasis/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-08-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2019.106220
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1321: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cross-resistance and synergy with bendamustine in chronic lymphocytic leukemia.

    Kost, Sara E F / Bouchard, Eric D J / LaBossière, Élise / Ye, Xibiao / Queau, Michelle L / Liang, William S / Banerji, Versha / Gibson, Spencer B / Katyal, Sachin / Johnston, James B

    Leukemia research

    2016  Volume 50, Page(s) 63–71

    Abstract: Bendamustine (BEN) has structural similarities to an alkylating agent and a nucleoside analog, and effective against tumor cells that are resistant to standard therapy. In this study we compared the activities of BEN against that of the alkylating agent, ...

    Abstract Bendamustine (BEN) has structural similarities to an alkylating agent and a nucleoside analog, and effective against tumor cells that are resistant to standard therapy. In this study we compared the activities of BEN against that of the alkylating agent, chlorambucil (CLB), and the nucleoside analogs, fludarabine (FLU) and deoxyadenosine/pentostatin (dADO/PEN), in primary chronic lymphocytic leukemia (CLL) cells in vitro. Cross-resistance was observed between BEN, CLB and FLU, with previously treated patients or those with a deletion 17p being most resistant. In contrast, some resistant CLL cells retained moderate sensitivity to dADO/PEN. Like FLU and CLB, BEN induced apoptosis through both the mitochondrial and death receptor pathways. There was a greater increase in DNA double-strand breaks (DSB) following FLU, as compared to BEN and CLB. Synergistic cytotoxicity was seen on combining BEN or CLB with FLU or dADO/PEN, but not when combining BEN with CLB. These results demonstrate that BEN acts as an alkylating agent, demonstrates cross-resistance to CLB and FLU and resistance to cells with a del 17p. Synergistic cytotoxic activity was seen between BEN and dADO/PEN suggesting that the combination of BEN and PEN should be evaluated in the clinic.
    MeSH term(s) Adenosine Deaminase Inhibitors ; Antineoplastic Agents, Alkylating/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Bendamustine Hydrochloride/therapeutic use ; Chlorambucil/therapeutic use ; DNA Breaks, Double-Stranded/drug effects ; Deoxyadenosines/therapeutic use ; Drug Synergism ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Pentostatin/therapeutic use ; Tumor Cells, Cultured
    Chemical Substances Adenosine Deaminase Inhibitors ; Antineoplastic Agents, Alkylating ; Deoxyadenosines ; Chlorambucil (18D0SL7309) ; Pentostatin (395575MZO7) ; Bendamustine Hydrochloride (981Y8SX18M) ; 2'-deoxyadenosine (P582C98ULC)
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2016.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1321: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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