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  1. AU="Kostopoulos, Ioannis"
  2. AU=Kumar Adarsh
  3. AU="Millar, Amanda"
  4. AU="da Cruz Perez, Danyel Elias"
  5. AU="Henry des Tureaux, Thierry"
  6. AU="Mária Bucová"
  7. AU="Darling, Corbin"
  8. AU="Rosenthal, Philip"
  9. AU="Farley, John M B"
  10. AU="Longo, Lauren O"
  11. AU="Ogawa, Kumiko"
  12. AU="Min Gyu Lee"

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  1. Dissertation / Habilitation ; Online: Mucin and human milk oligosaccharides utilization

    Kostopoulos, Ioannis

    a strategy of Akkermansia muciniphila to ensure survival in the human gut

    2021  

    Abstract: The research in this thesis aims to understand the mechanism used by Akkermansia muciniphila to survive and thrive in the complex and competitive ecosystems of the human gut. We evaluated the ability of A. muciniphila to utilize and degrade HMOs and ... ...

    Abstract The research in this thesis aims to understand the mechanism used by Akkermansia muciniphila to survive and thrive in the complex and competitive ecosystems of the human gut. We evaluated the ability of A. muciniphila to utilize and degrade HMOs and mucin glycans as a carbohydrate specialist and the advantage of this phenotype in this highly competitive environment. As it has been demonstrated, A. muciniphila can have an important role in human (metabolic) health and it is essential to understand the functions and resilience of A. muciniphila in such communities. This can further expand our knowledge on the benefits that A. muciniphila can bring for human health, but potentially also help to design (nutritional) therapies to support A. muciniphila’s activity in the gut to even further support human health.In Chapter 1, a brief overview of the human intestinal microbiota is provided, focusing on the host-derived glycans that affect the physiology and composition of the gut microbiota. Furthermore, A. muciniphila, a resident of the mucosal layer in the gut, is introduced. The capacity of A. muciniphila to use glycoside hydrolases (GHs) to degrade glycosidic linkages found in mucin and human milk oligosaccharides (HMOs) constituted the motivation for the research described in this thesis.Chapter 2 provides an overview on the presence and functionality of A. muciniphila in different parts of the gastrointestinal tract. Akkermansia muciniphila has been found in human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. Hypothetical functions of A. muciniphila in these different niches are proposed, highlighting also that further research is needed to fully understand the versatile roles that A. muciniphila may have in the digestive tract.In Chapter 3 we hypothesized that the presence of A. muciniphila in infant’s intestine is the result of its ability to use its glycan degrading enzymes to break down HMOs. After growth of A. muciniphila in human milk, we identified HMOs ...
    Schlagwörter Life Science
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Verlag Wageningen University
    Erscheinungsland nl
    Dokumenttyp Dissertation / Habilitation ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Guest editorial

    Lodorfos, George Konstadopoulou Anastasia Kostopoulos Ioannis Rizomyliotis Ioannis Wu Junjie

    Journal of Global Responsibility

    Abstract: First and the foremost, universities and businesses will need to address new or amplified existing societal issues, such as poverty, unemployment, isolation, mental health problems, a lack of digital literacy and many others and re-invent their ... ...

    Abstract First and the foremost, universities and businesses will need to address new or amplified existing societal issues, such as poverty, unemployment, isolation, mental health problems, a lack of digital literacy and many others and re-invent their institutional roles in society For organisations to embrace ethically and socially responsible thinking, the provision of social responsibility education is essential (Cornelius et al , 2007) [ ]education providers and particularly business schools have a duty to embrace their responsibility not only by implementing ethical processes but also by providing responsible education, which would ideally act as a catalyst to stimulate socially and ethically managed business organisations (Cornelius et al , 2007) [ ]the studies could and should be replicated in other national, cultural and industry contexts and their conclusions be validated through the employment of different methodologies [ ]other relevant themes should be explored, such as ethical consumption, green marketing, ethical and servant leadership and responsible and inclusive education;to develop a holistic view on the role of HE, universities and businesses in relation to responsibility and sustainability in the modern post-pandemic society
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #906704
    Datenquelle COVID19

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  3. Artikel ; Online: Diffuse Large B-Cell Lymphoma With Clear Cell Morphology.

    Sotiriou, Sotiris / Koletsa, Triantafyllia / Kostopoulos, Ioannis

    International journal of surgical pathology

    2018  Band 27, Heft 6, Seite(n) 649–651

    Mesh-Begriff(e) Aged ; Biopsy ; Endometrial Neoplasms/surgery ; Female ; Humans ; Hysterectomy ; Incidental Findings ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mesentery/pathology ; Peritoneal Neoplasms/diagnosis ; Peritoneal Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2018-11-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896918814303
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Cytogenetic Profile of Primary and Secondary Plasma Cell Leukemia: Etiopathogenetic Perspectives, Prognostic Impact and Clinical Relevance to Newly Diagnosed Multiple Myeloma with Differential Circulating Clonal Plasma Cells.

    Papadhimitriou, Stefanos I / Terpos, Evangelos / Liapis, Konstantinos / Pavlidis, Dimitrios / Marinakis, Theodoros / Kastritis, Efstathios / Dimopoulos, Meletios-Athanasios / Tsitsilonis, Ourania E / Kostopoulos, Ioannis V

    Biomedicines

    2022  Band 10, Heft 2

    Abstract: Plasma cell leukemia (PCL) is a rare and aggressive plasma cell dyscrasia that may appear as de-novo leukemia (pPCL) or on the basis of a pre-existing multiple myeloma (MM), called secondary plasma cell leukemia (sPCL). In this prospective study, we have ...

    Abstract Plasma cell leukemia (PCL) is a rare and aggressive plasma cell dyscrasia that may appear as de-novo leukemia (pPCL) or on the basis of a pre-existing multiple myeloma (MM), called secondary plasma cell leukemia (sPCL). In this prospective study, we have applied a broad panel of FISH probes in 965 newly diagnosed MM (NDMM) and 44 PCL cases of both types to reveal the particular cytogenetic differences among the three plasma cell dyscrasias. In order to evaluate the frequency and patterns of clonal evolution, the same FISH panel was applied both at diagnosis and at the time of first relapse for 81 relapsed MM patients and both at MM diagnosis and during sPCL transformation for the 19 sPCL cases described here. pPCL was characterized by frequent
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020209
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Dynamic metabolic interactions and trophic roles of human gut microbes identified using a minimal microbiome exhibiting ecological properties.

    Shetty, Sudarshan A / Kostopoulos, Ioannis / Geerlings, Sharon Y / Smidt, Hauke / de Vos, Willem M / Belzer, Clara

    The ISME journal

    2022  Band 16, Heft 9, Seite(n) 2144–2159

    Abstract: Microbe-microbe interactions in the human gut are influenced by host-derived glycans and diet. The high complexity of the gut microbiome poses a major challenge for unraveling the metabolic interactions and trophic roles of key microbes. Synthetic ... ...

    Abstract Microbe-microbe interactions in the human gut are influenced by host-derived glycans and diet. The high complexity of the gut microbiome poses a major challenge for unraveling the metabolic interactions and trophic roles of key microbes. Synthetic minimal microbiomes provide a pragmatic approach to investigate their ecology including metabolic interactions. Here, we rationally designed a synthetic microbiome termed Mucin and Diet based Minimal Microbiome (MDb-MM) by taking into account known physiological features of 16 key bacteria. We combined 16S rRNA gene-based composition analysis, metabolite measurements and metatranscriptomics to investigate community dynamics, stability, inter-species metabolic interactions and their trophic roles. The 16 species co-existed in the in vitro gut ecosystems containing a mixture of complex substrates representing dietary fibers and mucin. The triplicate MDb-MM's followed the Taylor's power law and exhibited strikingly similar ecological and metabolic patterns. The MDb-MM exhibited resistance and resilience to temporal perturbations as evidenced by the abundance and metabolic end products. Microbe-specific temporal dynamics in transcriptional niche overlap and trophic interaction network explained the observed co-existence in a competitive minimal microbiome. Overall, the present study provides crucial insights into the co-existence, metabolic niches and trophic roles of key intestinal microbes in a highly dynamic and competitive in vitro ecosystem.
    Mesh-Begriff(e) Bacteria/genetics ; Gastrointestinal Microbiome/physiology ; Humans ; Microbiota ; Mucins ; RNA, Ribosomal, 16S/genetics
    Chemische Substanzen Mucins ; RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2022-06-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2406536-5
    ISSN 1751-7370 ; 1751-7362
    ISSN (online) 1751-7370
    ISSN 1751-7362
    DOI 10.1038/s41396-022-01255-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Z 7773: Hefte anzeigen

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  6. Artikel ; Online: Belantamab mafodotin, lenalidomide and dexamethasone in transplant-ineligible patients with newly diagnosed multiple myeloma: Part 1 results of a phase I/II study.

    Terpos, Evangelos / Gavriatopoulou, Maria / Ntanasis-Stathopoulos, Ioannis / Malandrakis, Panagiotis / Fotiou, Despina / Migkou, Magdalini / Theodorakakou, Foteini / Spiliopoulou, Vasiliki / Kostopoulos, Ioannis V / Syrigou, Rodanthi-Eleni / Eleutherakis-Papaiakovou, Evangelos / Gkolfinopoulos, Stavros / Tsitsilonis, Ourania E / Kastritis, Efstathios / Dimopoulos, Meletios A

    Haematologica

    2024  

    Abstract: Preclinical and clinical data demonstrate synergy between belantamab mafodotin (belamaf) and immunomodulatory drugs with limited overlapping toxicities. We investigated the safety and efficacy of belamaf with lenalidomide 25mg on days 1-21 every 28 days ... ...

    Abstract Preclinical and clinical data demonstrate synergy between belantamab mafodotin (belamaf) and immunomodulatory drugs with limited overlapping toxicities. We investigated the safety and efficacy of belamaf with lenalidomide 25mg on days 1-21 every 28 days and dexamethasone 40mg weekly (belamaf-Rd) in transplant ineligible patients with newly diagnosed multiple myeloma. 36 patients (median age 72.5 years) were randomized to receive belamaf at three different doses (2.5/1.9/1.4 mg/kg) every 8 weeks (q8w). Dosing schedule was extended to every 12 weeks (q12w) to account for ocular toxicity. Most common ≥ Grade (Gr) 3 adverse events were fatigue (n=21, 58.3%), rash (n=6, 16.7%), diarrhea (n=8, 22.2%) and COVID-19 (n=5, 13.9%). Gr 3-4 ocular adverse events (OAEs), comprising of visual acuity decline from baseline and/or keratopathy, were reported in 39/216(18.1%)/ 33/244(13.5%)/ 26/207(12.6%) ophthalmological assessments in cohorts 2.5/1.9/1.4 mg/kg. Importantly, Gr 3-4 keratopathy was identified in 9/216 (4.2%)/ 1/244(0.4%)/ 1/207(0.5%) assessments. Most patients (32/36, 88.9%) were treated in the extended q12w schedule, where dose holds due to OAEs were 40, 33 and 16 in cohorts 2.5/1.9/1.4. Overall, ≥VGPR and ≥CR rates were 83.3% and 52.8%, without significant differences among cohorts. Over a median follow-up of 20.3 months no disease progression was reported; 6 patients discontinued treatment due to infection-related death (n=4 COVID-19, n=2 pneumonia) and 1 patient withdrew consent. Based on toxicity/efficacy balance, the recommended phase 2 dose was 1.9 mg/kg q8w, extended to q12w for toxicity. Belamaf-Rd, with the extended schedule for belamaf, has shown important clinical activity and a significant improvement of OAEs with minimal impact on vision-related functioning in an elderly, non-transplant eligible population.
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284347
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Efficacy and immune modulation associated with the addition of IMiDs to Daratumumab backbone in multiple myeloma patients refractory to both drug classes: resetting synergistic activity.

    Kostopoulos, Ioannis V / Fotiou, Despina / Gavriatopoulou, Maria / Rousakis, Pantelis / Ntanasis-Stathopoulos, Ioannis / Panteli, Chrysanthi / Malandrakis, Panagiotis / Migkou, Magdalini / Angelis, Nikolaos / Kanellias, Nikolaos / Eleutherakis-Papaiakovou, Evangelos / Theodorakakou, Foteini / Krevvata, Maria / Terpos, Evangelos / Dimopoulos, Meletios-Athanasios / Tsitsilonis, Ourania / Kastritis, Efstathios

    Blood cancer journal

    2024  Band 14, Heft 1, Seite(n) 26

    Mesh-Begriff(e) Humans ; Multiple Myeloma/drug therapy ; Immunomodulating Agents ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemische Substanzen daratumumab (4Z63YK6E0E) ; Immunomodulating Agents ; Antibodies, Monoclonal ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-024-00988-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin.

    Efentakis, Panagiotis / Choustoulaki, Angeliki / Kwiatkowski, Grzegorz / Varela, Aimilia / Kostopoulos, Ioannis V / Tsekenis, George / Ntanasis-Stathopoulos, Ioannis / Georgoulis, Anastasios / Vorgias, Constantinos E / Gakiopoulou, Harikleia / Briasoulis, Alexandros / Davos, Constantinos H / Kostomitsopoulos, Nikolaos / Tsitsilonis, Ourania / Dimopoulos, Meletios Athanasios / Terpos, Evangelos / Chłopicki, Stefan / Gavriatopoulou, Maria / Andreadou, Ioanna

    Basic research in cardiology

    2024  

    Abstract: Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab's (Pem's) ... ...

    Abstract Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab's (Pem's) cardiotoxicity in vivo, seeking for translational prevention means. Cytotoxicity was investigated in primary cardiomyocytes and splenocytes, incubated with ipilimumab, Pem and avelumab. Pem's cross-reactivity was assessed by circular dichroism (CD) on biotechnologically produced human and murine PD-1 and in silico. C57BL6/J male mice received IgG4 or Pem for 2 and 5 weeks. Echocardiography, histology, and molecular analyses were performed. Coronary blood flow velocity mapping and cardiac magnetic resonance imaging were conducted at 2 weeks. Human EA.hy926 endothelial cells were incubated with Pem-conditioned media from human mononuclear cells, in presence and absence of statins and viability and molecular signaling were assessed. Atorvastatin (20 mg/kg, daily) was administered in vivo, as prophylaxis. Only Pem exerted immune-related cytotoxicity in vitro. Pem's cross-reactivity with the murine PD-1 was confirmed by CD and docking. In vivo, Pem initiated coronary endothelial and diastolic dysfunction at 2 weeks and systolic dysfunction at 5 weeks. At 2 weeks, Pem induced ICAM-1 and iNOS expression and intracardiac leukocyte infiltration. At 5 weeks, Pem exacerbated endothelial activation and triggered cardiac inflammation. Pem led to immune-related cytotoxicity in EA.hy926 cells, which was prevented by atorvastatin. Atorvastatin mitigated functional deficits, by inhibiting endothelial dysfunction in vivo. We established for the first time an in vivo model of Pem-induced cardiotoxicity. Coronary endothelial dysfunction precedes Pem-induced cardiotoxicity, whereas atorvastatin emerges as a novel prophylactic therapy.
    Sprache Englisch
    Erscheinungsdatum 2024-03-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-024-01046-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Buch: Business-to-business marketing communication

    Rizomyliotis, Ioannis / Konstantoulaki, Kleopatra / Kostopoulos, Ioannis

    value and efficiency considerations in recessionary times

    (Palgrave pivot)

    2017  

    Verfasserangabe Ioannis Rizomyliotis, Kleopatra Konstantoulaki, Ioannis Kostopoulos
    Serientitel Palgrave pivot
    Schlagwörter Business-to-Business-Marketing ; B-to-B-Marketing ; Werbeplanung ; Konjunktur ; Werbewirkung ; Italien ; Zypern ; Griechenland
    Sprache Englisch
    Umfang xiii, 92 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Dokumenttyp Buch
    ISBN 331958782X ; 9783319587820 ; 9783319587837 ; 3319587838
    Datenquelle ECONomics Information System

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  10. Artikel: Minimal Residual Disease in Multiple Myeloma: Current Landscape and Future Applications With Immunotherapeutic Approaches.

    Kostopoulos, Ioannis V / Ntanasis-Stathopoulos, Ioannis / Gavriatopoulou, Maria / Tsitsilonis, Ourania E / Terpos, Evangelos

    Frontiers in oncology

    2020  Band 10, Seite(n) 860

    Abstract: The basic principle that deeper therapeutic responses lead to better clinical outcomes in cancer has emerged technologies capable of detecting rare residual tumor cells. The need for ultra-sensitive approaches for minimal residual disease (MRD) detection ...

    Abstract The basic principle that deeper therapeutic responses lead to better clinical outcomes in cancer has emerged technologies capable of detecting rare residual tumor cells. The need for ultra-sensitive approaches for minimal residual disease (MRD) detection is particularly evident in Multiple Myeloma (MM), where patients will ultimately relapse despite the achievement of complete remission, which is commonplace due to remarkable therapeutic advances. Consequently, current response criteria on MM have been amended based on MRD status and MRD negativity is now considered the most dominant prognostic factor and the most valuable indicator for a subsequent relapse. However, there are particular limitations and several aspects for MRD assessment that remain open. This review summarizes current data on MRD in the clinical management of MM, highlights open issues and discusses the challenges and the endless opportunities arising for both patients and clinicians. Furthermore, it focuses on the current status of MRD in clinical trials, its dynamics in addressing debatable aspects in the clinical handling and its potential role as the prevailing factor for future MRD-driven tailored therapies.
    Sprache Englisch
    Erscheinungsdatum 2020-05-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00860
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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